Oral Controlled Release Formulations Lecture

What is not a type of controlled release formulation?

Targetted-release tablets or capsules (enteric-coated, colonic-targetted)
Constant-release (sustained / extended) tablets or capsules
Immediate-release tablets or capsules (correct)
Pulsatile-release tablets or capsules

Which of the following is not a reason for using controlled release formulations?

Effective targeting
Minimizing toxicity and unwanted effects
Decreasing drug absorption (correct)
Improving consistency in drug action

Which of the following is not a common type of oral controlled release formulation?

Targetted-release tablets or capsules (enteric-coated, colonic-targetted)
Constant-release (sustained / extended) tablets or capsules
Pulsatile-release tablets or capsules (correct)
Osmotic-release tablets or capsules

Which of the following is not a benefit of using controlled release formulations?

Decreasing drug effectiveness (C) Signup and view all the answers

Which of the following is not a mathematical analysis of drug release from oral controlled release formulations?

Second-order release kinetics (C) Signup and view all the answers

Which of the following is not a step in the formulation and manufacture of oral controlled release formulations?

Direct compression of active ingredient (B) Signup and view all the answers

What is the primary function of an enteric coating in colonic targeting formulations?

To delay the onset of drug release until the colon (D) Signup and view all the answers

What is the most common matrix material used in particulates systems?

Hydroxypropyl-methylcellulose (HPMC) (B) Signup and view all the answers

What is the primary reason for not including a disintegrant in matrix systems?

To prolong drug release (C) Signup and view all the answers

Which manufacturing process is preferred for particulates systems?

Direct compression (D) Signup and view all the answers

What is the primary challenge in formulating controlled release systems?

Matching GI transient time with drug release (A) Signup and view all the answers

What advice is given to patients taking controlled release systems?

Swallow the tablets whole and do not chew (B) Signup and view all the answers

What does Tmax refer to in pharmacokinetics?

The time after dosing at which the maximum concentration of drug is reached (B) Signup and view all the answers

Which system forms a viscous gel that allows drug diffusion and erosion for release?

Matrix systems (D) Signup and view all the answers

What is the purpose of a semipermeable water-insoluble membrane in controlled-release formulations?

To allow controlled drug release over time (C) Signup and view all the answers

Why is a disintegrant not required in reservoir systems?

To maintain the integrity of the core tablet (B) Signup and view all the answers

What is the main difference between matrix and reservoir systems in controlled-release formulations?

The mechanism of drug release (A) Signup and view all the answers

Which type of drug is more suitable for release from matrix systems?

Water-soluble drugs (B) Signup and view all the answers

What leads to uneven blood levels and therapeutic responses in typical immediate-release formulations?

Multiple doses per day (A) Signup and view all the answers

Why is the therapeutic window an important concept in pharmacokinetics?

To establish safe and effective drug dosing levels (A) Signup and view all the answers

'Constant-release' and 'sustained-release' formulations aim to achieve what effect in controlled-release formulations?

Improve patient compliance with dosing regimens (C) Signup and view all the answers

What does AUC represent in pharmacokinetics terminology?

The area under the concentration-time curve (B) Signup and view all the answers