Oral Candidosis

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Questions and Answers

Which factor is not listed as a predisposing factor to candidal infection?

  • Diabetes mellitus
  • Stress (correct)
  • Malnutrition/malabsorption
  • Age

What is the normal presence of Candida albicans in healthy mouths attributed to?

  • Excessive saliva production
  • Symbiotic relationship with lactobacillus acidophilus (correct)
  • Poor oral hygiene
  • High sugar diet

What is the most common oral fungal infection in humans?

  • Candidiasis (correct)
  • Aspergillosis
  • Histoplasmosis
  • Cryptococcosis

What is the defined term for multiple diseases caused by the yeast fungus Candida?

<p>Oral Candidiasis (C)</p> Signup and view all the answers

What percentage of healthy people carry the infection of Candida albicans without clinical manifestations?

<p>90% (A)</p> Signup and view all the answers

What limits the proliferation of Candida albicans in the mouth?

<p>Acid production by lactobacillus acidophilus (B)</p> Signup and view all the answers

In which group is the immune system not well developed, leading to a predisposition for candidal infection?

<p>Newborn infants (B)</p> Signup and view all the answers

Which antifungal agent is available as a cream and oral gel under the brand Daktarin?

<p>Miconazole (D)</p> Signup and view all the answers

Which antifungal agent is contraindicated in acute liver disease and pregnancy?

<p>Ketoconazole (D)</p> Signup and view all the answers

Which antifungal agent is administered intravenously for deep and systemic candidosis?

<p>Amphotericin (D)</p> Signup and view all the answers

Which antifungal agent is used with caution with anticoagulant, antiepileptic, and antidiabetic medications?

<p>Fluconazole (C)</p> Signup and view all the answers

Which antifungal agent is effective in angular stomatitis and should be taken 2 hours after antacids?

<p>Ketoconazole (A)</p> Signup and view all the answers

Which antifungal agent acts by forming holes in the fungal cell membranes causing cell lysis?

<p>Nystatin (B)</p> Signup and view all the answers

Which antifungal agent is available as 200 mg tablet and as a cream?

<p>Ketoconazole (C)</p> Signup and view all the answers

Which antifungal agent is used for superficial, deep, and systemic mycosis?

<p>Fluconazole (A)</p> Signup and view all the answers

Which antifungal agent is to be sucked four times a day or applied as a 3% ointment several times a day?

<p>Nystatin (A)</p> Signup and view all the answers

Which factor can lead to secondary candida infection due to decreased salivary IgA?

<p>Xerostomia (A)</p> Signup and view all the answers

Which condition can cause oral candidiasis by decreasing neutrophil function and blood flow?

<p>Diabetes mellitus (A)</p> Signup and view all the answers

Which drug type can lead to oral candidiasis?

<p>Contraceptive pills (B)</p> Signup and view all the answers

Which form of candidosis is most frequently encountered, typically affecting infants, immunocompromised adults, and older individuals?

<p>Acute pseudomembranous (A)</p> Signup and view all the answers

Which condition can lead to postoperative oral candidiasis?

<p>Lack of oral hygiene (D)</p> Signup and view all the answers

Which factor can decrease lymphocytes and phagocytic activity, leading to oral candidiasis?

<p>Malnutrition and malabsorption (D)</p> Signup and view all the answers

Which disease can lead to oral candidiasis due to the effect of cytotoxic drugs on the immune system?

<p>Leukemia (A)</p> Signup and view all the answers

What is a potential cause of angular cheilitis?

<p>Nutritional deficiencies (A)</p> Signup and view all the answers

Which antifungal treatment is recommended for mixed or recurrent infections of angular cheilitis?

<p>Miconazole gel (A)</p> Signup and view all the answers

What is a characteristic symptom of median rhomboid glossitis?

<p>Pink rhomboid area lacking lingual papillae (A)</p> Signup and view all the answers

Why is systemic therapy considered for symptomatic median rhomboid glossitis?

<p>Topical antifungal therapy is ineffective (B)</p> Signup and view all the answers

What is chronic hyperplastic candidosis associated with?

<p>Heavy smoking in middle-aged men (C)</p> Signup and view all the answers

What characterizes chronic mucocutaneous candidosis (CMCC)?

<p>Recurrent Candida infections due to impaired cell-mediated immunity (A)</p> Signup and view all the answers

Which antifungal drug is mentioned as part of the treatment for oral candidosis?

<p>Fluconazole (A)</p> Signup and view all the answers

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Study Notes

Oral Candidosis: Types, Etiology, and Treatment

  • Angular cheilitis is caused by reduced vertical face height due to old dentures, severe attrition of natural dentition, nutritional deficiencies, oral dryness, or drooling.
  • Topical antifungal treatment for angular cheilitis includes nystatin or amphotericin suspension and cream, while miconazole gel is used for mixed or recurrent infections.
  • Median rhomboid glossitis is a symptomless, pink rhomboid area lacking lingual papillae, associated with immunosuppression, corticosteroid inhalers, tobacco use, dry mouth, or diabetes.
  • Systemic therapy is considered for symptomatic median rhomboid glossitis, as topical antifungal therapy is ineffective.
  • Chronic hyperplastic candidosis, potentially malignant, presents as a thick, white plaque with rough surface and is associated with heavy smoking in middle-aged men.
  • Chronic mucocutaneous candidosis (CMCC) is characterized by recurrent Candida infections due to impaired cell-mediated immunity and can be caused by thymic aplasia, endocrinopathies, or defective cell-mediated immunity.
  • CMCC types include familial, diffuse candidal granuloma, candidosis endocrinopathy syndrome, late-onset CMCC, and CMCC associated with primary immunodeficiency or HIV infection.
  • CMCC treatment includes imidazole antifungal drugs, but it responds poorly to topical treatment and rapidly reappears after discontinuation.
  • Rare systemic fungal infections of the mouth include aspergillosis, histoplasmosis, blastomycosis, cryptococcosis, paracoccidioidomycosis, and mucormycosis.
  • The diagnosis of candidosis involves a case history, clinical examination, bacterial smear and culture, candidal antibody titer, and biopsy for candidal leukoplakia.
  • Treatment of oral candidosis includes eliminating predisposing factors, using topical or systemic antifungal agents, and adjusting the duration of treatment based on the type of candidosis.
  • Antifungal agents for oral candidosis include nystatin, amphotericin, imidazole antifungal agents (miconazole, ketoconazole, fluconazole, itraconazole), and chlorhexidine. Nystatin can be administered as a suspension or pastille.

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