6 Questions
Which molecules coat microbes and enhance their phagocytosis?
Opsonins
Which isotype of antibodies binds to FcγRI receptor on neutrophils and macrophages?
IgG3
What is the major mechanism of defense against encapsulated bacteria?
Antibody-mediated phagocytosis
Which receptor does not mediate effector functions of antibodies but rather shuts down antibody production and reduces inflammation?
FcγRIIB
What is the function of FcγRIIB in feedback inhibition of B cell activation?
Inhibits B cell activation
What is the role of intravenous immune globulin (IVIG) in treating inflammatory diseases?
Binding to FcγRIIB on cells
Study Notes
Antibody-Mediated Defense
- Opsonins, such as antibodies, coat microbes, enhancing their phagocytosis.
Antibody Isotypes and Receptors
- IgG is the isotype of antibodies that binds to FcγRI receptors on neutrophils and macrophages.
Defense Against Encapsulated Bacteria
- The major mechanism of defense against encapsulated bacteria is the activation of the alternative complement pathway, which leads to the coating of bacteria with iC3b, facilitating phagocytosis.
FcγRIIB Receptor
- FcγRIIB is an inhibitory receptor that shuts down antibody production and reduces inflammation by providing negative feedback to B cell activation.
IVIG in Inflammatory Diseases
- Intravenous immune globulin (IVIG) is used to treat inflammatory diseases by providing anti-inflammatory effects, suppressing inflammation, and regulating the immune response.
Test your knowledge of opsonization and the role of antibodies in promoting phagocytosis with this quiz. Learn about the process of coating microbes and the molecules involved in enhancing their ingestion by phagocytes. Find out how IgG antibodies play a crucial role in opsonization.
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