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Oligodendrogliomada kötü prognoza liênilmiş histolojik özellikler nelerdir?
Oligodendrogliomada kötü prognoza liênilmiş histolojik özellikler nelerdir?
Oligodendrogliomada cerrahi tedavi nasıl bir sonuca sahiptir?
Oligodendrogliomada cerrahi tedavi nasıl bir sonuca sahiptir?
Oligodendrogliomada radyoterapi ve kemoterapi nasıl bir sonuca sahiptir?
Oligodendrogliomada radyoterapi ve kemoterapi nasıl bir sonuca sahiptir?
Oligodendrogliomada prognoza hangi faktörlere bağlıdır?
Oligodendrogliomada prognoza hangi faktörlere bağlıdır?
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Oligodendrogliomada FOLLOW-UP süresinin uzunluğunun özellikleri nelerdir?
Oligodendrogliomada FOLLOW-UP süresinin uzunluğunun özellikleri nelerdir?
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Oligodendroglioma tanısı için hangi moleküler kriterler esas olarak önemlidir?
Oligodendroglioma tanısı için hangi moleküler kriterler esas olarak önemlidir?
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Oligodendroglioma hastalarının prognozunu etkileyen klinisyen faktörler hangileridir?
Oligodendroglioma hastalarının prognozunu etkileyen klinisyen faktörler hangileridir?
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Oligodendroglioma tratamiento seçenekleri arasında hangi kombinasyon en iyi prognoz vermektedir?
Oligodendroglioma tratamiento seçenekleri arasında hangi kombinasyon en iyi prognoz vermektedir?
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Oligodendroglioma rekürrensinde hangi yayma düzeni görülür?
Oligodendroglioma rekürrensinde hangi yayma düzeni görülür?
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Oligodendroglioma hastalarında hangi durum kötü prognoz vermektedir?
Oligodendroglioma hastalarında hangi durum kötü prognoz vermektedir?
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Oligodendroglioma hastalarının median hayatta kalma süreleri nedir?
Oligodendroglioma hastalarının median hayatta kalma süreleri nedir?
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IDH-mutant ve 1p/19q-codeleted CNS WHO grade 3 oligodendrogliomas'da yüksek mitotik sayısının prognostik değeri nedir?
IDH-mutant ve 1p/19q-codeleted CNS WHO grade 3 oligodendrogliomas'da yüksek mitotik sayısının prognostik değeri nedir?
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CNS WHO grade 2 oligodendrogliomas'da median OS nedir?
CNS WHO grade 2 oligodendrogliomas'da median OS nedir?
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CDKN2A homozygous deletion olmayan případlerde hangi encontrar bulgusu prognostik değere sahiptir?
CDKN2A homozygous deletion olmayan případlerde hangi encontrar bulgusu prognostik değere sahiptir?
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IDH-mutant ve TERT promoter mutant gliomas'da hangi CNS WHO grade'da longer survival times görülür?
IDH-mutant ve TERT promoter mutant gliomas'da hangi CNS WHO grade'da longer survival times görülür?
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IDH-mutant ve 1p/19q-codeleted oligodendrogliomas'da hangi bulgu kötü prognoza işaret eder?
IDH-mutant ve 1p/19q-codeleted oligodendrogliomas'da hangi bulgu kötü prognoza işaret eder?
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CNS WHO grade 3 oligodendrogliomas'da hangi faktör prognostik değere sahiptir?
CNS WHO grade 3 oligodendrogliomas'da hangi faktör prognostik değere sahiptir?
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Higher tumour mutation burden in IDH-mutant gliomas is associated with?
Higher tumour mutation burden in IDH-mutant gliomas is associated with?
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Which genetic marker has been reported as a marker of poor prognosis in oligodendrogliomas?
Which genetic marker has been reported as a marker of poor prognosis in oligodendrogliomas?
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What is the primary concern that leads to deferring radiotherapy and chemotherapy in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas of CNS WHO grade 2?
What is the primary concern that leads to deferring radiotherapy and chemotherapy in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas of CNS WHO grade 2?
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In patients with CNS WHO grade 3 tumours, what is the usual treatment approach after surgery?
In patients with CNS WHO grade 3 tumours, what is the usual treatment approach after surgery?
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What did the European Organisation for Research and Treatment of Cancer (EORTC) 22845 trial show regarding adjuvant radiotherapy in patients with progressive CNS WHO grade 2 gliomas?
What did the European Organisation for Research and Treatment of Cancer (EORTC) 22845 trial show regarding adjuvant radiotherapy in patients with progressive CNS WHO grade 2 gliomas?
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What did long-term follow-up data from randomized trials show regarding the impact of radiotherapy plus PCV chemotherapy in patients with CNS WHO grade 3 oligodendrogliomas?
What did long-term follow-up data from randomized trials show regarding the impact of radiotherapy plus PCV chemotherapy in patients with CNS WHO grade 3 oligodendrogliomas?
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Which of the following genetic markers has no impact on outcome in oligodendrogliomas?
Which of the following genetic markers has no impact on outcome in oligodendrogliomas?
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What proportion of gliomas correspond to IDH-mutant and 1p/19q-codeleted oligodendrogliomas in older studies?
What proportion of gliomas correspond to IDH-mutant and 1p/19q-codeleted oligodendrogliomas in older studies?
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What is the median survival time for patients with CNS WHO grade 3 IDH-mutant and 1p/19q-codeleted oligodendroglioma treated with radiotherapy and PCV chemotherapy?
What is the median survival time for patients with CNS WHO grade 3 IDH-mutant and 1p/19q-codeleted oligodendroglioma treated with radiotherapy and PCV chemotherapy?
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Which clinical factor is associated with a more favourable outcome in oligodendroglioma?
Which clinical factor is associated with a more favourable outcome in oligodendroglioma?
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What is the common pattern of recurrence in oligodendroglioma?
What is the common pattern of recurrence in oligodendroglioma?
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What is the significance of IDH mutation and 1p/19q codeletion in oligodendroglioma?
What is the significance of IDH mutation and 1p/19q codeletion in oligodendroglioma?
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What is the molecular diagnostic criterion that is essential for oligodendroglioma diagnosis?
What is the molecular diagnostic criterion that is essential for oligodendroglioma diagnosis?
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In IDH-mutant and 1p/19q-codeleted CNS WHO grade 3 oligodendrogliomas, what is linked to shorter PFS and OS?
In IDH-mutant and 1p/19q-codeleted CNS WHO grade 3 oligodendrogliomas, what is linked to shorter PFS and OS?
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What is associated with shorter survival in IDH-mutant gliomas including oligodendrogliomas?
What is associated with shorter survival in IDH-mutant gliomas including oligodendrogliomas?
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Which genetic marker has been reported as a marker of poor prognosis in oligodendrogliomas?
Which genetic marker has been reported as a marker of poor prognosis in oligodendrogliomas?
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In CNS WHO grade 3 oligodendrogliomas, what is associated with shorter overall survival?
In CNS WHO grade 3 oligodendrogliomas, what is associated with shorter overall survival?
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What is the prognostic significance of microvascular proliferation and/or necrosis in oligodendrogliomas?
What is the prognostic significance of microvascular proliferation and/or necrosis in oligodendrogliomas?
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What is the primary concern that leads to deferring radiotherapy and chemotherapy in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas of CNS WHO grade 2?
What is the primary concern that leads to deferring radiotherapy and chemotherapy in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas of CNS WHO grade 2?
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In patients with CNS WHO grade 3 tumours, what is the usual treatment approach after surgery?
In patients with CNS WHO grade 3 tumours, what is the usual treatment approach after surgery?
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In patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas, what is the median OS for CNS WHO grade 2 and grade 3 tumours, respectively?
In patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas, what is the median OS for CNS WHO grade 2 and grade 3 tumours, respectively?
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What is the significance of IDH mutation and TERT promoter mutation in gliomas?
What is the significance of IDH mutation and TERT promoter mutation in gliomas?
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What did the European Organisation for Research and Treatment of Cancer (EORTC) 22845 trial show regarding adjuvant radiotherapy in patients with progressive CNS WHO grade 2 gliomas?
What did the European Organisation for Research and Treatment of Cancer (EORTC) 22845 trial show regarding adjuvant radiotherapy in patients with progressive CNS WHO grade 2 gliomas?
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Which genetic alteration has no impact on outcome in oligodendrogliomas?
Which genetic alteration has no impact on outcome in oligodendrogliomas?
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What is the influence of CNS WHO grade on survival in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas?
What is the influence of CNS WHO grade on survival in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas?
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What is the implication of contrast enhancement on imaging in IDH-mutant CNS WHO grade 2 and 3 gliomas, including oligodendrogliomas?
What is the implication of contrast enhancement on imaging in IDH-mutant CNS WHO grade 2 and 3 gliomas, including oligodendrogliomas?
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What is the significance of histological features such as necrosis and microvascular proliferation in oligodendrogliomas?
What is the significance of histological features such as necrosis and microvascular proliferation in oligodendrogliomas?
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What is the impact of greater extent of resection on the overall survival of patients with CNS WHO grade 2 oligodendroglioma?
What is the impact of greater extent of resection on the overall survival of patients with CNS WHO grade 2 oligodendroglioma?
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What is the significance of 1p/19q codeletion in oligodendrogliomas?
What is the significance of 1p/19q codeletion in oligodendrogliomas?
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What is the primary concern that leads to deferring radiotherapy and chemotherapy in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas of CNS WHO grade 2?
What is the primary concern that leads to deferring radiotherapy and chemotherapy in patients with IDH-mutant and 1p/19q-codeleted oligodendrogliomas of CNS WHO grade 2?
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What is the significance of molecularly defined oligodendroglioma in terms of prognosis?
What is the significance of molecularly defined oligodendroglioma in terms of prognosis?
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What is the impact of leaving some tumour tissue behind on the survival of patients with oligodendroglioma?
What is the impact of leaving some tumour tissue behind on the survival of patients with oligodendroglioma?
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Study Notes
Tanı Kriterleri
- Oligodendroglioma tanısı için gerekli ve arzu edilen kriterler bulunmaktadır.
Evreleme ve Prognoz
- Oligodendroglioma'ların Hayatta kalma süreleri, İDH mutasyonu ve 1p/19q kodletionu bulunanların daha uzun sürdüğü görülmüştür.
- Medyan hayatta kalma süresi, 10 yıldan fazla olarak tespit edilmiştir.
- İyi/respond to tedavi ve median hayatta kalma süresi 14 yıldan fazla olarak tespit edilmiştir.
Klinik Faktörler
- Genç yaşta tanı konulan hastaların daha iyi hayatta kalma süreleri vardır.
- Frontal lob lokasyonu, seizure ile başlayan hastaların daha iyi hayatta kalma süreleri vardır.
- Yüksek postoperatif Karnofsky skoru ve makroskopik olarak tam cerrahi çıkarmanın daha iyi hayatta kalma süreleri vardır.
Görüntüleme
- Kontrast geliştirme, kötü prognoza işaret etmektedir.
- Beyin cerrahisi sonrası, tümörün büyüme hızına göre prognoza ilişkin bulunmuştur.
Cerrahi
- Daha geniş cerrahi reseksiyon, daha uzun hayatta kalma süresi ile ilişkili bulunmuştur.
- Ancak, tümör dokusunu bırakmak, oligodendroglioma'ların sağkalım süresine daha az etki etmektedir.
Histolojik Özellikler
- Nekroz, yüksek mitotik aktivite, artmış hücrelilik, nükleer atipi, hücresel pleomorfizm ve mikrovasküler proliferasyon, kötü prognoza işaret etmektedir.
- Yüksek mitotik count, kısa PFS ve OS ile ilişkili bulunmuştur.
WHO Derecelendirme
- CNS WHO derecelendirme, oligodendroglioma'ların prognozu için önemli bir belirleyici faktörüdür.
Tanımlama Kriterleri
- IDH-mutant ve 1p/19q-codeleted oligodendrogliomalardaPrognoz ve tedaviye olumlu yanıt vermewiązıyla ilişkilidir.
- 10 yıldan fazla median survival süresi görülmektedir.
Prognoz ve Prediksiyon
- Yaşlı hastalarda, frontal lobe lokalizasyonu, seizure ile prezantasyon, yüksek postoperatif Karnofsky skoru, makroskobik komple resection gibi klinik faktörler, daha iyi prognoz ile ilişkilidir.
- Yüksek mitotik count (≥ 2.5 mitoses/mm²), kısa PFS ve OS ile ilişkilidir.
- Mikrovasküler proliferasyon ve/veya nekrozun varlığı, prognoz için anlamlıdır.
CNS WHO Grading
- Older studies, CNS WHO grade 3 oligodendrogliomalarda, kötü prognoz ile ilişkilidir.
- IDH-mutant ve 1p/19q-codeleted CNS WHO grade 2 oligodendrogliomalarda, median OS 188 ay iken, grade 3 oligodendrogliomalarda 119 aydır.
- Yüksek tümör mutasyon yükü, kısa survival süresi ile ilişkilidir.
Tedavi
- IDH-mutant ve 1p/19q-codeleted oligodendrogliomalarda, optimal postoperatif tedavi, tartışmalı bir konudur.
- Radiotherapy ve chemotherapy, genellikle)tumour progressionına kadar ertelenir.
- Symptomatik ve.progressive tumours, CNS WHO grade 3 tumours, or large residual tumours after surgery gibi durumlarda, immediate further treatment ile tedavi edilir.
Görüntüleme
- Kontrast enhancemanı varlığında, kötü prognoz ile ilişkilidir.
- Increased growth rate on follow-up MRI, anaplasia gibi histolojik özelliklerle ilişkili olan microvascular proliferasyon ve yüksek mitotik count ile ilişkilidir.
Cerrahi
- Greater extent of resection, longer overall survival (OS) ve PFS ile ilişkilidir.
- Extensive resections, improved outcomes ile ilişkili iken, leaving some tumour tissue behind, oligodendroglioma hastalarında daha az etki gösterir.
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Description
Onkolojide tanı kriterleri, állıgilerin staging süreci ve prognoz hakkında bilgi sağlayan bir quizz. Histopatolojik tanılar ve moleküler stratifikasyon hakkında detaylı bilgi içeriyor.
