Omeprazole (PriLOSEC) Flashcards
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Questions and Answers

What is the generic name of PriLOSEC?

  • omeprazole (correct)
  • lansoprazole
  • pantoprazole
  • rabeprazole
  • What is the therapeutic classification of omeprazole?

    antiulcer agent

    What is the pharmacologic classification of omeprazole?

    proton-pump inhibitor

    What are the primary indications for omeprazole?

    <p>GERD or maintenance of healing in erosive esophagitis, duodenal ulcers, short-term treatment of active benign gastric ulcer, OTC: heartburn occurring more than 2x weekly</p> Signup and view all the answers

    What is one of the actions of omeprazole?

    <p>Binds to an enzyme on gastric parietal cells in the presence of gastric acidic pH, preventing the final transport of hydrogen ions into the gastric lumen</p> Signup and view all the answers

    What therapeutic effect does omeprazole have?

    <p>Diminished accumulation of acid in the gastric lumen with lessened gastroesophageal reflux, healing of duodenal ulcer</p> Signup and view all the answers

    Lab tests may indicate an increase in ___ and ___ levels due to omeprazole.

    <p>AST, ALT</p> Signup and view all the answers

    What are some adverse reactions associated with omeprazole?

    <p>C-DIFF associated diarrhea (life threatening), abdominal pain (most common)</p> Signup and view all the answers

    What are the contraindications for using omeprazole?

    <p>Hypersensitivity, discontinue in breastfeeding; use cautiously in liver disease, high dose usage for a year or more increases risk of hip, wrist, and spine fractures, use for more than 3 yrs increases risk of B12 deficiency</p> Signup and view all the answers

    What nursing implications should be assessed for a patient taking omeprazole?

    <p>Assess for occult blood, emesis, and gastric aspirate; monitor bowel function for signs of C-DIFF</p> Signup and view all the answers

    What client teaching should be provided for omeprazole?

    <p>May cause occasional drowsiness or dizziness; notify HCP of medications and avoid irritants; report severe symptoms to HCP.</p> Signup and view all the answers

    Study Notes

    Omeprazole (PriLOSEC) Overview

    • Generic name: omeprazole
    • Trade name: PriLOSEC
    • Classification: antiulcer agent (therapeutic); proton-pump inhibitor (pharmacologic)

    Indications

    • Used for Gastroesophageal Reflux Disease (GERD) and for maintaining healing in erosive esophagitis
    • Addresses duodenal ulcers and provides short-term treatment for active benign gastric ulcers
    • Available OTC for heartburn occurring more than twice weekly

    Mechanism of Action

    • Binds to an enzyme on gastric parietal cells at acidic pH
    • Prevents transport of hydrogen ions into the gastric lumen, reducing acid accumulation

    Therapeutic Effects

    • Decreased acid levels in the gastric lumen
    • Reduction in gastroesophageal reflux
    • Promotes healing of duodenal ulcers

    Laboratory Tests

    • Regular monitoring of CBC with differential, liver enzymes (AST, ALT, alkaline phosphatase, bilirubin)
    • Monitor INR and PT time in patients on warfarin
    • Watch for hypomagnesemia
    • Serum gastrin concentration may rise in initial weeks of treatment

    Adverse Reactions

    • Gastrointestinal risks include life-threatening C. Difficile Associated Diarrhea (CDAD)
    • Common side effect: abdominal pain

    Contraindications

    • Avoid in patients with hypersensitivity to omeprazole
    • Discontinue use in breastfeeding women
    • Caution advised in patients with liver disease
    • Long-term use (over one year) may heighten risk of hip, wrist, and spine fractures
    • Extended use (over three years) increases risk of vitamin B12 deficiency

    Nursing Implications

    • Assess for signs of gastrointestinal bleeding (occult blood, emesis)
    • Monitor bowel function closely; report diarrhea, cramping, fever, or bloody stools as they may indicate CDAD

    Client Teaching

    • Inform patients that drug may cause drowsiness or dizziness
    • Advise to notify healthcare provider of all medications, vitamins, or supplements, especially St. John's Wort
    • Recommend avoidance of alcohol, aspirin, NSAIDs, and irritating foods
    • Instruct patients to report any black, tarry stool, diarrhea, abdominal pain, or persistent headaches, especially if stools contain blood, pus, or mucus
    • Advise against self-treating diarrhea due to potential severity

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    Description

    Test your knowledge on Omeprazole, also known as PriLOSEC, through these flashcards. Learn about its generic name, therapeutic classification, pharmacologic classification, and indications for use. This interactive quiz is perfect for students in pharmacology or healthcare fields.

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