Questions and Answers
What is the generic name of PriLOSEC?
What is the therapeutic classification of omeprazole?
antiulcer agent
What is the pharmacologic classification of omeprazole?
proton-pump inhibitor
What are the primary indications for omeprazole?
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What is one of the actions of omeprazole?
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What therapeutic effect does omeprazole have?
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Lab tests may indicate an increase in ___ and ___ levels due to omeprazole.
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What are some adverse reactions associated with omeprazole?
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What are the contraindications for using omeprazole?
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What nursing implications should be assessed for a patient taking omeprazole?
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What client teaching should be provided for omeprazole?
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Study Notes
Omeprazole (PriLOSEC) Overview
- Generic name: omeprazole
- Trade name: PriLOSEC
- Classification: antiulcer agent (therapeutic); proton-pump inhibitor (pharmacologic)
Indications
- Used for Gastroesophageal Reflux Disease (GERD) and for maintaining healing in erosive esophagitis
- Addresses duodenal ulcers and provides short-term treatment for active benign gastric ulcers
- Available OTC for heartburn occurring more than twice weekly
Mechanism of Action
- Binds to an enzyme on gastric parietal cells at acidic pH
- Prevents transport of hydrogen ions into the gastric lumen, reducing acid accumulation
Therapeutic Effects
- Decreased acid levels in the gastric lumen
- Reduction in gastroesophageal reflux
- Promotes healing of duodenal ulcers
Laboratory Tests
- Regular monitoring of CBC with differential, liver enzymes (AST, ALT, alkaline phosphatase, bilirubin)
- Monitor INR and PT time in patients on warfarin
- Watch for hypomagnesemia
- Serum gastrin concentration may rise in initial weeks of treatment
Adverse Reactions
- Gastrointestinal risks include life-threatening C. Difficile Associated Diarrhea (CDAD)
- Common side effect: abdominal pain
Contraindications
- Avoid in patients with hypersensitivity to omeprazole
- Discontinue use in breastfeeding women
- Caution advised in patients with liver disease
- Long-term use (over one year) may heighten risk of hip, wrist, and spine fractures
- Extended use (over three years) increases risk of vitamin B12 deficiency
Nursing Implications
- Assess for signs of gastrointestinal bleeding (occult blood, emesis)
- Monitor bowel function closely; report diarrhea, cramping, fever, or bloody stools as they may indicate CDAD
Client Teaching
- Inform patients that drug may cause drowsiness or dizziness
- Advise to notify healthcare provider of all medications, vitamins, or supplements, especially St. John's Wort
- Recommend avoidance of alcohol, aspirin, NSAIDs, and irritating foods
- Instruct patients to report any black, tarry stool, diarrhea, abdominal pain, or persistent headaches, especially if stools contain blood, pus, or mucus
- Advise against self-treating diarrhea due to potential severity
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Description
Test your knowledge on Omeprazole, also known as PriLOSEC, through these flashcards. Learn about its generic name, therapeutic classification, pharmacologic classification, and indications for use. This interactive quiz is perfect for students in pharmacology or healthcare fields.
