Podcast
Questions and Answers
When do deciduous (baby) teeth begin to develop?
When do deciduous (baby) teeth begin to develop?
What is ectomesenchyme tissue derived from?
What is ectomesenchyme tissue derived from?
Which of the following is not a stage of tooth morphogenesis?
Which of the following is not a stage of tooth morphogenesis?
What causes the cells within the dental lamina to proliferate and invaginate?
What causes the cells within the dental lamina to proliferate and invaginate?
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Which tissue components are involved in tooth development?
Which tissue components are involved in tooth development?
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When do permanent teeth begin to develop?
When do permanent teeth begin to develop?
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What is the third stage of tooth development?
What is the third stage of tooth development?
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Which type of cells form the stellate reticulum in the cap stage of tooth development?
Which type of cells form the stellate reticulum in the cap stage of tooth development?
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What role do enamel knots play in tooth development?
What role do enamel knots play in tooth development?
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Where do ectomesenchymal cells mainly accumulate during the cap stage of tooth development?
Where do ectomesenchymal cells mainly accumulate during the cap stage of tooth development?
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What event characterizes the Bell Stage of tooth development?
What event characterizes the Bell Stage of tooth development?
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What new cell type is formed between the stellate reticulum and inner enamel epithelium during tooth development?
What new cell type is formed between the stellate reticulum and inner enamel epithelium during tooth development?
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Study Notes
Odontogenesis (Teeth Development)
- Deciduous teeth develop in week 6-7 of in-utero life
- Permanent teeth develop in week 14 of in-utero life
- Permanent teeth have successional lamina, which is not present in deciduous teeth
Tooth Development Stages
- Teeth start to develop in week 6 from 2 tissue components: primitive oral epithelium (derived from ectoderm) and ectomesenchyme (derived from craniofacial neural crest cells)
- Primitive oral epithelium thickens, creating primary epithelial bands, one on each jaw
- Each primary epithelial band splits into two: inner/lingual dental lamina and outer/buccal vestibular lamina
Signal Proteins
- FGF, BMP, and EDA cause cells within the dental lamina to proliferate and invaginate, forming dental placodes (enlarged projections within the dental lamina)
Tooth Morphogenesis (Tooth Shape Formation)
- The interaction between epithelium and mesenchymal tissues goes through 3 stages: bud, cap, and bell
- During morphogenesis, the tooth undergoes different shape formations, resulting in various tooth shapes
Bud Stage
- Dental placode proliferates, forming a bud-like structure (tooth bud)
- Tooth bud attaches to oral epithelium by the dental lamina
- Ectomesenchymal cells cluster around the tooth bud, causing condensation of the ectomesenchymal cells (beneath the bud)
Cap Stage
- 3 different epithelial cells form: inner enamel epithelium, outer enamel epithelium, and stellate reticulum
- Inner enamel epithelium lines the inner enamel central depression
- Outer enamel epithelium lines the sides of the cap
- Stellate reticulum secretes glycosaminoglycans, attracting water and pushing on the cell membrane, turning them into a star shape
Enamel Knots
- Non-dividing cells within the enamel organ, acting as a signalling centre
- Regulate the formation of the cusps of the tooth
- The number and location of enamel knots determine the number and location of cusps
Bell Stage
- Enamel organ continues to grow
- The invagination (indent) in the cap deepens, forming the cervical loop
- The cervical loop is at each tip of the enamel organ (root-like shape)
- The cervical loop is where the inner and outer epithelium meet (at the root ends)
- Cells between the stellate reticulum and inner enamel epithelium differentiate into a new cell called stratum intermedium (spindle shape)
- Stellate reticulum starts to collapse
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Description
Learn about the timeline of deciduous and permanent tooth development during in-utero life, as well as the different tissue components involved in odontogenesis.
