Pathway 13-2-2 Cells of the Pulp - Odontoblast Process

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Questions and Answers

What is the main structural component that extends from the odontoblast cell body into the odontoblastic process?

Plasma membrane

Lamina limitans

Mitochondria

Microtubules and microfilaments (correct)

What is between the limiting membrane (lamina limitans) on the tubule and the plasma membrane of the odontoblast process?

Cytoplasmic extension

Intercellular matrix

Peritubular space

A Narrow space that might be non-existent at constricted areas. (correct)

Which component is theorized to play a role in the cytoplasmic extension or transport of materials in the odontoblast process?

Microfilaments

Mitochondria

Collagen fibrils

Microtubules (correct)

What anatomical structure surrounds the odontoblastic processes within the dentinal tubules?

Peritubular dentin Signup and view all the answers

Where is the odontoblastic process most controversially believed to penetrate within the dentin?

The inner third and Throughout the entire thickness Signup and view all the answers

Which part of the odontoblastic process occasionally contains mitochondria?

In the Process that passes through predentin Signup and view all the answers

What potential clinical significance arises from understanding the extent of odontoblast processes in teeth?

Estimating impact of restorative procedures Signup and view all the answers

⭐️What may the spaces created by localized constrictions in the odontoblastic process contain?

Collagen fibrils and ground substance Signup and view all the answers

What was previously thought regarding the penetration of odontoblast processes into dentin?

It is present in the full thickness of dentin Signup and view all the answers

⭐️What is identified as the electron-dense limiting membrane lining the peritubular dentin matrix?

Lamina limitans Signup and view all the answers

What does the presence of tubulin in the dentinal tubules suggest?

The odontoblast processes extend throughout the thickness of dentin. Signup and view all the answers

What observation was made regarding odontoblast processes in rat molars?

They only extend to the outer dentin in early development stages. Signup and view all the answers

Why is dentin considered a vital tissue?

Destruction impacts the vitality of the pulp. Signup and view all the answers

What is the implication of the fixed postmitotic nature of odontoblasts?

They cannot undergo further cell division once fully differentiated. Signup and view all the answers

What role do proteins from odontoblasts play in dentin?

They remain fixed in place within the tubule walls. Signup and view all the answers

In an attempt to find out if Process reach the DEJ an Experiment was deisgned. 靠染protein。 What method was used to observe tubulin in odontoblast processes?

monoclonal antibody directed against microtubules Signup and view all the answers

What is suggested about the relationship between odontoblast lifespan and pulp functionality?

B + C Signup and view all the answers

Which statement is true regarding the dentin matrix?

It is fixed in structure with no turnover. Signup and view all the answers

In the experiments attempting to show Process extending to DEJ: what is suggested when we see 染色 at the DEJ?

Focal microscopy 染色 are just due to tubules contain many proteins originally derived from odontoblasts that no longer remain at that site. Signup and view all the answers

What study method clarified the disagreement about the extent of odontoblast processes?

Confocal microscopy. Signup and view all the answers

What is the view of process length historically?

Full length to DEJ Signup and view all the answers

What conclusion does Transmission electron studies suggest process as being limited to the inner third of the dentin. What are the bias?

All the above Signup and view all the answers

What do SCANNING electron studies show?

A+ B Signup and view all the answers

Newest monoclonal antibodie studies results are? what are the bias?

All correct Signup and view all the answers

Study image

1 Signup and view all the answers

Study Notes

Odontoblast Process

The odontoblast process forms within the dentinal tubule and coordinates the formation of peritubular dentin.
Microtubules and microfilaments are the main components of the odontoblast process and its lateral branches.
The tubules are filled with dentin matrix and surrounded by a limiting membrane, the lamina limitans.
The odontoblast process is in close proximity to the dentinal tubule wall, but there are occasional constrictions leading to spaces between the wall and the process.
These spaces can contain collagen fibrils and ground substance.
The extent of the odontoblast process has been a topic of debate, but recent studies using immunoreactivity and confocal microscopy suggest that the process extends throughout the thickness of dentin, especially during early stages of tooth development.
Though the odontoblast process is not found throughout the entire thickness of dentin in mature teeth, the proteins derived from odontoblasts can be found throughout the tubules.
Dentin matrix has no turnover, which means these proteins remain fixed in place, highlighting the importance of the odontoblast process in maintaining a vital dentin.
The odontoblast is a fixed postmitotic cell, meaning it cannot divide after differentiation. This means its lifespan is related to the lifespan of the pulp. However, its metabolic activity can change.

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