30 Questions
Where does odontoblast differentiation occur?
Along the boundary between the epithelial cells of the enamel organ and the ectomesenchymal cells of the dental papilla
What is the role of signalling molecules and growth factors in odontoblast differentiation?
They attract undifferentiated cells of the dental papilla to the boundary
What happens to ectomesenchymal cells adjacent to the epithelial boundary?
They elongate and develop organelles for protein synthesis
What is the final result of odontoblast differentiation?
The secretion of the dentine matrix
What is the orientation of epithelial cells relative to the boundary with the enamel organ?
Oriented relative to the boundary
What happens to ectomesenchymal cells closest to the boundary with the cells of the enamel organ?
They elongate, polarize, and differentiate into odontoblasts
What type of collagen is present in the mantle predentine matrix?
Type III
What is the orientation of type I collagen fibrils in the circumpulpal predentine?
Parallel to the secretory surface
What is left behind in the matrix by the odontoblasts?
An odontoblast process
What separates the odontoblast layer from the mineralized dentine?
Unmineralized, collagen-rich predentine matrix
What promotes hydroxyapatite crystal growth in dentine mineralization?
_matrix vesicles containing phosphate-sequestering enzymes and proteins
During dentinogenesis, when does dentine matrix production begin?
Before enamel matrix production
What is the function of matrix vesicles secreted by odontoblasts?
To promote hydroxyapatite crystal growth
What type of mineralization occurs in circumpulpal dentine?
Linear and globular mineralization
What is the significance of incremental growth lines in dentine?
They signify changes in odontoblast activity over time
What is unique about dentine deposition compared to enamel?
Dentine deposition occurs for many years following tooth eruption
What type of mineralization occurs in mantle dentine?
Globular (calcospheric) mineralization
What is the role of odontoblasts in dentinogenesis?
To secrete matrix vesicles that promote mineralization
What type of lines represent supra-daily, non-rhythmic variations in dentine production?
Contour lines of Owen
What can cause changes in dentine deposition rates?
All of the above
What is the name of the lines that are formed by the coincidence of secondary curvatures of dentine tubules during dentinogenesis?
Lines of von Ebner
What is the purpose of this lecture?
To distinguish between different incremental and non-incremental lines found in dentine
What type of lines are preserved in ground sections but not in paraffin sections?
Lines of von Ebner
What is the result of hypomineralisation during dentinogenesis?
Changes in dentine deposition rates
What do the incremental growth lines in dentine signify?
Daily variations in dentine production
What is the average width of incremental line growth in human dentine?
4-5 µm
What do the Andresen lines represent in dentine?
Multi-day incremental lines spaced 6-10 days apart
What do tetracycline labeling experiments show about Andresen lines?
They are long-period (multi-day) lines
What is the significance of the collagenous matrix in dentine growth?
It represents structural variations in dentine growth
According to Emken et al. (2021), what is the significance of incremental growth lines in dentine?
They represent daily variations in dentine production
Learn about the process of odontoblast differentiation in dentinogenesis, including the role of signalling molecules and growth factors. This quiz is based on Ten Cate's Oral Histology, 8th Edition, Fig. 8-11.
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