Obesity Treatment Medications Overview
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Questions and Answers

Which of the following is NOT a type of anti-obesity drug currently in development?

  • Cholesterol-lowering agents (correct)
  • Gut hormones and incretin targets
  • Anti-obesity vaccines
  • Centrally acting agents

Which of the following is a dual action GLP-1/glucagon receptor agonist?

  • Tesofensine
  • Oxyntomodulin (correct)
  • Velneperit
  • Setmelanotide

What type of receptor is targeted by cannabinoid type-1 receptor blockers?

  • Neuropeptide Y receptor
  • Fibroblast growth factor 21 receptor
  • Glucagon-like peptide-1 receptor
  • Cannabinoid type-1 receptor (correct)

Which of the following is a triple agonist?

<p>Tri-agonist 1706 (D)</p> Signup and view all the answers

What is the mechanism of action of the methionine aminopeptidase 2 inhibitor beloranib?

<p>Inhibiting methionine aminopeptidase 2 (D)</p> Signup and view all the answers

Which of the following is a potential adverse effect of using lorcaserin with drugs that affect serotonin?

<p>Increased potential for serotonin syndrome (C)</p> Signup and view all the answers

What is the main purpose of anorexiants in the treatment of obesity?

<p>To stimulate satiety centers in the brain (C)</p> Signup and view all the answers

Which of the following anorexiants was voluntarily withdrawn from the U.S. market due to cardiovascular side effects in October 2010?

<p>Sibutramine (D)</p> Signup and view all the answers

Why were fenfluramine (Pondimin) and dexfenfluramine (Redux) removed from the market in 1997?

<p>They caused fatal cardiac and pulmonary adverse reactions (B)</p> Signup and view all the answers

What is the pharmacodynamic mechanism of anorexiants in the treatment of obesity?

<p>By stimulating satiety centers in the brain (B)</p> Signup and view all the answers

Which of the following anorexiants is chemically and pharmacologically related to amphetamines?

<p>Benzphetamine (C)</p> Signup and view all the answers

Which two drugs are available for chronic weight management as unique combinations?

<p>Phentermine and topiramate (D)</p> Signup and view all the answers

What is the primary mechanism of action of lorcaserin in promoting satiety?

<p>Activation of 5-HT2C receptors in the hypothalamus (C)</p> Signup and view all the answers

Which of the following statements about the pharmacokinetics of anorexiants is correct?

<p>Anorexiants are absorbed in the stomach and small intestine and have a longer duration of action in the extended-release form (D)</p> Signup and view all the answers

Which of the following is a known contraindication for the use of anorexiants?

<p>All of the above (D)</p> Signup and view all the answers

What is the mechanism of action of topiramate in combination with phentermine for weight loss?

<p>The exact mechanism is unknown, but topiramate is known to cause appetite suppression and satiety (C)</p> Signup and view all the answers

Which of the following is a potential adverse effect of lorcaserin?

<p>Hypoglycemia in patients with type 2 diabetes mellitus on antidiabetic therapy (B)</p> Signup and view all the answers

What is the primary route of administration for liraglutide?

<p>Subcutaneous (C)</p> Signup and view all the answers

Which of the following is a contraindication for the use of liraglutide?

<p>Both a and b (B)</p> Signup and view all the answers

What is the typical half-life of anorexiants?

<p>8-20 hours (D)</p> Signup and view all the answers

Which of the following adverse reactions is commonly associated with the use of liraglutide?

<p>Nausea, vomiting, and diarrhea (C)</p> Signup and view all the answers

What is the main concern with long-term use of anorexiants?

<p>Potential for tolerance and dependence (D)</p> Signup and view all the answers

Which of the following is NOT a potential adverse effect associated with liraglutide?

<p>Hypoglycemia (C)</p> Signup and view all the answers

What is the recommended course of treatment duration for anorexiants?

<p>No longer than 6 months (A)</p> Signup and view all the answers

Which of the following statements regarding lorcaserin is TRUE?

<p>It should be used with caution with serotonergic agents (B)</p> Signup and view all the answers

Which of the following anorexiants is considered one of the safest for patients with mild to moderate hypertension or angina pectoris?

<p>Diethylpropion (D)</p> Signup and view all the answers

What is the recommended starting dose of liraglutide in the first week?

<p>0.6 mg (C)</p> Signup and view all the answers

Which of the following statements regarding anorexiants and evening dosing is TRUE?

<p>Evening dosing should generally be avoided due to the likelihood of insomnia (D)</p> Signup and view all the answers

Which of the following is a potential drug interaction associated with anorexiants?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following statements regarding liraglutide administration is TRUE?

<p>It can be taken at any time of day, without regard to mealtimes (B)</p> Signup and view all the answers

Which of the following is a potential adverse effect associated with liraglutide?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following anorexiants is NOT a stimulant?

<p>Lorcaserin (C)</p> Signup and view all the answers

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