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Leptin as an Anti-Obesity Treatment

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Questions and Answers

What is the critical brain area for energy balance and leptin sensitivity?

Cerebellum

Arcuate Nucleus (correct)

Medulla Oblongata

Hippocampus

Which type of neurons in the arcuate nucleus decrease appetite?

Glutamatergic neurons

NPY/AgRP neurons

GABAergic neurons

POMC neurons (correct)

What hormone opposes leptin's inhibitory action by activating NPY/AgRP neurons?

Insulin

Cortisol

Ghrelin (correct)

Adrenaline

What is frequently used as a marker to assess the effectiveness of leptin signaling?

Phosphorylated STAT3 Signup and view all the answers

Which type of neurons in the arcuate nucleus increase appetite?

NPY/AgRP neurons Signup and view all the answers

What was used to visualize neuronal activity in real-time during feeding behavior experiments?

"Calcium sensor, a mutated GFP fused with calmodulin" Signup and view all the answers

What is the therapeutic potential of leptin in combating obesity?

Reducing body weight in individuals with leptin deficiency Signup and view all the answers

Why was the efficacy of leptin as an anti-obesity drug questioned in subsequent studies?

Obese individuals exhibit hyperleptinemia. Signup and view all the answers

What is the primary feature of leptin resistance?

Failure of the body to respond to high levels of circulating leptin Signup and view all the answers

How is leptin resistance believed to develop?

Gradually over time as individuals age and gain weight Signup and view all the answers

What initiates the leptin signaling cascade in the body?

Leptin receptor dimerization Signup and view all the answers

What aspect of leptin remains a complex challenge in neuroendocrinology despite research efforts?

The molecular mechanisms of leptin resistance Signup and view all the answers