Obesity and Metabolic Syndrome Overview
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Questions and Answers

What is the main long-term effect of rising leptin levels in the body?

  • Is less potent than insulin in appetite regulation
  • Inhibits NPY release (correct)
  • Stimulates hunger
  • Promotes weight loss in starvation

According to the 'Critical size hypothesis,' what happens when a fat cell reaches its maximum size?

  • New pre-adipocytes are recruited for fat storage (correct)
  • The cell divides into smaller cells
  • Insulin promotes cell growth
  • Leptin levels increase in the body

Which of the following is a chronic disease NOT associated with obesity according to the text?

  • Stroke
  • Hernia (correct)
  • Gout
  • Osteoarthritis

What is the primary criteria for diagnosing metabolic syndrome based on the provided text?

<p>Low high-density lipoprotein cholesterol (HDL) below 60 mg/dL (A)</p> Signup and view all the answers

How does adipokines contribute to hypertension in obese individuals?

<p>They enhance thrombosis formation (B)</p> Signup and view all the answers

What is the target for treatment mentioned in the text for severe obesity?

<p>Semaglutide (C)</p> Signup and view all the answers

What is considered abnormal or excessive fat accumulation that may impair health?

<p>Overweight and obesity (D)</p> Signup and view all the answers

Which of the following is not a cause of obesity mentioned in the text?

<p>Regular exercise (D)</p> Signup and view all the answers

What is the classification of obesity for individuals aged 19 years and older based on BMI?

<p>BMI ≥ 40 kg/m2 (D)</p> Signup and view all the answers

Which of the following is NOT a factor contributing to obesity according to the text?

<p>Regular consumption of fruits and vegetables (D)</p> Signup and view all the answers

What assessment method is used to classify obesity for individuals aged 19 years and older according to the text?

<p>BMI measurement (B)</p> Signup and view all the answers

Which genetic factor is mentioned in the text as contributing to obesity?

<p>'Fatso gene' (A)</p> Signup and view all the answers

What is the initial step in the pathogenesis of atherosclerosis?

<p>Endothelial injury and dysfunction (C)</p> Signup and view all the answers

Which type of lipoproteins mainly accumulate in the vessel wall in atherosclerosis?

<p>LDL (B)</p> Signup and view all the answers

What leads to increased vascular permeability, leukocyte adhesion, and thrombosis in atherosclerosis?

<p>Endothelial injury and dysfunction (A)</p> Signup and view all the answers

Which process involves smooth muscle cell recruitment from either the media or circulating precursors in atherosclerosis?

<p>Factor release inducing smooth muscle cell recruitment (A)</p> Signup and view all the answers

What initiates the transformation of monocytes into macrophages and foam cells in atherosclerosis?

<p>Endothelial injury and dysfunction (D)</p> Signup and view all the answers

Which event occurs after the accumulation of lipoproteins in the vessel wall in atherosclerosis?

<p>Monocyte adhesion to the endothelium (D)</p> Signup and view all the answers

What are the characteristics of unstable atherosclerotic plaques compared to stable plaques?

<p>Thin caps, large lipid cores, dense inflammatory infiltrates (C)</p> Signup and view all the answers

Which component is NOT typically found in stable atherosclerotic plaques?

<p>Large lipid cores (B)</p> Signup and view all the answers

What is the main constituent of an atherosclerotic plaque as described in the text?

<p>Smooth muscle cells (C)</p> Signup and view all the answers

Which process primarily drives atherogenesis according to the text?

<p>Vessel wall injury (D)</p> Signup and view all the answers

What is the likely complication or natural history indicated by the arrow in the image of atherosclerotic plaques A and B?

<p>Plaque rupture (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of stable atherosclerotic plaques?

<p>Large lipid cores (A)</p> Signup and view all the answers

What is the primary cause of atheromas?

<p>Protrusion into vessel lumens (B)</p> Signup and view all the answers

How do atherosclerotic plaques affect blood flow?

<p>Increase the risk of thrombosis (B)</p> Signup and view all the answers

What is a characteristic feature of atheromatous plaques?

<p>Presence of friable lipid cores covered by fibrous caps (B)</p> Signup and view all the answers

Which type of arteries are mainly affected by atherosclerosis?

<p>Large arteries like the aorta and medium-sized arteries (D)</p> Signup and view all the answers

What is the risk factor that multiplies the risk of atherosclerosis sevenfold?

<p>Hyperlipidemia, hypertension, and smoking combined (D)</p> Signup and view all the answers

How do atheromatous plaques contribute to aneurysm formation?

<p>By weakening the vessel wall and causing ischemic injury (A)</p> Signup and view all the answers

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