Nutrient Absorption in the GI Tract

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Questions and Answers

In what part of the small intestine does most nutrient absorption take place?

  • Esophagus
  • Colon
  • Duodenum and jejunum (correct)
  • Ileum

Which of the following is the primary function of bile salts in fat digestion?

  • Converting large fat globules into a lipid emulsion (correct)
  • Absorbing fatty acids directly into the bloodstream
  • Hydrolyzing triglycerides into fatty acids and glycerol
  • Transporting chylomicrons into the lymphatic system

How are chylomicrons transported from the intestinal cells?

  • Directly into the bloodstream via capillaries
  • Into the lymphatic system (correct)
  • Via the hepatic portal system to the liver
  • Through the intestinal lumen

What is the main role of the large intestine in digestion?

<p>To absorb water and electrolytes from indigestible food residue (B)</p> Signup and view all the answers

What stimulates the defecation reflex?

<p>Distension of the rectum (D)</p> Signup and view all the answers

Which of the following transport mechanisms requires energy to move substances across the intestinal cell membrane?

<p>Active transport (D)</p> Signup and view all the answers

What is the role of the Na+/K+ pump in carbohydrate absorption?

<p>To create a sodium gradient that drives glucose absorption via the SGLT symporter (A)</p> Signup and view all the answers

Which of the following best describes the role of lacteals in nutrient absorption?

<p>They absorb and transport fats that are too large to be absorbed by blood capillaries. (B)</p> Signup and view all the answers

How does the absorption of calcium and iron differ from the absorption of other nutrients in the small intestine?

<p>Their absorption is adjusted based on the body's needs, while others are fully absorbed regardless. (D)</p> Signup and view all the answers

What is the primary source of intestinal gases?

<p>Bacterial fermentation in the colon (C)</p> Signup and view all the answers

Which of the following is a characteristic of the colon's absorption process?

<p>It mainly absorbs water and electrolytes, with less absorptive surface area compared to the small intestine. (D)</p> Signup and view all the answers

In the context of fat absorption, what is the fate of excess chylomicrons (CMs) after delivering lipid components to tissues?

<p>They are taken up by the liver and repackaged into VLDL and LDL. (A)</p> Signup and view all the answers

In the context of carbohydrate absorption, what is the role of GLUT2?

<p>It facilitates the diffusion of glucose out of intestinal cells into the blood. (B)</p> Signup and view all the answers

What is the correct order of events in fat absorption after the formation of micelles?

<p>Micelles diffuse into intestinal cells → triglycerides are re-synthesized → chylomicrons are formed → chylomicrons enter lymphatics (D)</p> Signup and view all the answers

The ileocecal valve's primary function is to:

<p>Prevent backflow of colonic contents into the small intestine. (B)</p> Signup and view all the answers

What is the significance of a high HDL:LDL ratio for cardiovascular health?

<p>It reduces the risk of heart attack by promoting cholesterol removal from blood vessels. (A)</p> Signup and view all the answers

Which of the following best describes the 'mass movements' in the large intestine?

<p>They are strong, propulsive contractions that occur several times a day to move feces forward. (B)</p> Signup and view all the answers

During the defecation reflex, what role does the internal anal sphincter play?

<p>It relaxes involuntarily in response to rectal distension. (A)</p> Signup and view all the answers

Which of the following is a consequence of the age-related decrease in epithelial stem cell division rate in the GI tract?

<p>Greater susceptibility to damage and less efficient tissue repair (D)</p> Signup and view all the answers

How does the composition of feces reflect the processes in the large intestine?

<p>Feces are mostly water with a small fraction of solids made up largely of bacteria and indigestible material. (C)</p> Signup and view all the answers

In the context of intestinal gas formation, which statement is most accurate?

<p>The type of food consumed and the characteristics of colonic bacteria significantly influence the composition of intestinal gas. (C)</p> Signup and view all the answers

Which alteration in gastrointestinal function is most directly related to decreased smooth muscle tone associated with aging?

<p>Weakened general motility and contractions, potentially resulting in constipation and other digestive issues. (A)</p> Signup and view all the answers

A researcher discovers a novel genetic mutation that completely disables the SGLT1/2 symporter in intestinal cells. What is the MOST LIKELY consequence of this mutation?

<p>Significant reduction in glucose and galactose absorption, leading to impaired energy intake. (A)</p> Signup and view all the answers

Imagine a hypothetical scenario where an individual's lymphatic vessels are completely blocked throughout the body. Which of the following nutrients would be MOST affected in terms of absorption and initial transport?

<p>Long-chain triglycerides (D)</p> Signup and view all the answers

In which region of the small intestine does the majority of nutrient absorption take place?

<p>Duodenum and jejunum (B)</p> Signup and view all the answers

What structural modification significantly increases the surface area for absorption in the small intestine?

<p>Microvilli (A)</p> Signup and view all the answers

By which transport mechanism does glucose enter the blood from intestinal cells?

<p>Facilitated Diffusion using GLUT2 (C)</p> Signup and view all the answers

What is the function of the Na+/K+ pump in the context of carbohydrate absorption in the small intestine?

<p>Maintains the sodium gradient to facilitate SGLT function (D)</p> Signup and view all the answers

What role do bile salts play in the digestion of fats?

<p>Emulsifying large fat globules into smaller droplets (A)</p> Signup and view all the answers

How are chylomicrons transported from the intestinal cells into the body?

<p>Into the lymphatic system (D)</p> Signup and view all the answers

From where do intestinal gases primarily originate?

<p>Bacterial fermentation (D)</p> Signup and view all the answers

Which of the following describes a key difference between the absorptive surface of the colon compared to the small intestine?

<p>The colon has a smoother surface and less absorptive area (D)</p> Signup and view all the answers

What is the primary role of the large intestine in digestion and absorption?

<p>Water and electrolyte absorption (A)</p> Signup and view all the answers

What directly stimulates the defecation reflex?

<p>Distension of the rectum (B)</p> Signup and view all the answers

Which of the following is the main function of the ileocecal valve?

<p>To prevent backflow of colonic contents into the small intestine (B)</p> Signup and view all the answers

What is the primary mechanism by which the colon absorbs sodium?

<p>Active transport (C)</p> Signup and view all the answers

What role does the liver play in the processing of absorbed nutrients?

<p>It directs blood from the capillary network to the hepatic portal system for nutrient processing (C)</p> Signup and view all the answers

Which of the following best describes the movement of water in the colon?

<p>Following sodium absorption via osmosis (D)</p> Signup and view all the answers

What is the impact of decreased smooth muscle tone on gastrointestinal function in the elderly?

<p>Weaker general motility and contractions (C)</p> Signup and view all the answers

Which of the following is a consequence of a high LDL level?

<p>Increased risk of LDL plaque formation (D)</p> Signup and view all the answers

What are 'mass movements' in the large intestine?

<p>Rapid contractions that propel feces forward (A)</p> Signup and view all the answers

What effect does aging have on the epithelial stem cell division rate in the GI tract?

<p>Decreases stem cell division rate (D)</p> Signup and view all the answers

What substances are synthesized by bacteria in the colon?

<p>B vitamins and vitamin K (D)</p> Signup and view all the answers

Following lipase hydrolyzation of triglycerides, the resulting fatty acids and monoglycerides are transported to the intestinal cell via:

<p>Micelles (B)</p> Signup and view all the answers

What is the specific fate of excess chylomicrons (CMs) after they have delivered their lipid components to tissues?

<p>Uptake by the liver and repackaging into VLDL and LDL (B)</p> Signup and view all the answers

The migrating motor complex is disrupted in a patient. Knowing this will alter the normal flow of contents in the small intestine, what is the MOST LIKELY impact on nutrient absorption?

<p>Decreased overall efficiency of nutrient absorption (C)</p> Signup and view all the answers

How would a drug that selectively inhibits the activity of pancreatic lipase impact the absorption of dietary fats?

<p>Prevent the hydrolysis of triglycerides into fatty acids and monoglycerides. (B)</p> Signup and view all the answers

An individual with a rare genetic defect has intestinal cells that lack the ability to synthesize or express apolipoproteins. What is the MOST LIKELY consequence of this?

<p>Inability to form chylomicrons, leading to fat malabsorption (C)</p> Signup and view all the answers

In the small intestine, which of the following mechanisms primarily drives the absorption of monosaccharides?

<p>Active transport via the SGLT symporter and facilitated diffusion via GLUT2 (A)</p> Signup and view all the answers

Which specialized structural feature significantly enhances absorption within the small intestine?

<p>The presence of microvilli on epithelial cells (C)</p> Signup and view all the answers

How does the absorption of water in the colon primarily occur?

<p>Following the osmotic gradient created by solute absorption (C)</p> Signup and view all the answers

Following their synthesis within intestinal cells, how are chylomicrons transported?

<p>Via lacteals into the lymphatic system (A)</p> Signup and view all the answers

What is the primary function of bile salts in the process of fat digestion?

<p>Emulsifying large fat globules into smaller droplets (D)</p> Signup and view all the answers

What role does the migrating motor complex play in nutrient absorption?

<p>It propels undigested material and bacteria towards the colon, preventing bacterial overgrowth in the small intestine. (B)</p> Signup and view all the answers

The primary source of intestinal gases is:

<p>Gases produced by bacterial fermentation in the colon (A)</p> Signup and view all the answers

What is the fate of excess chylomicrons after they have delivered lipids to tissues?

<p>They are taken up by the liver and repackaged into VLDL and LDL. (B)</p> Signup and view all the answers

The ileocecal valve primarily functions to:

<p>Prevent the backflow of colonic contents into the small intestine. (A)</p> Signup and view all the answers

In the colon, bacteria synthesize:

<p>B vitamins and vitamin K (D)</p> Signup and view all the answers

How does a high HDL:LDL ratio typically impact cardiovascular health?

<p>Decreases the risk of heart attack (A)</p> Signup and view all the answers

A drug that selectively inhibits the activity of pancreatic lipase would MOST directly affect the:

<p>Hydrolysis of triglycerides (C)</p> Signup and view all the answers

How would a complete blockage of lymphatic vessels throughout the body MOST directly impact nutrient absorption?

<p>Significantly reduce the absorption of dietary fats (D)</p> Signup and view all the answers

What is the role of GLUT2 in carbohydrate absorption?

<p>It facilitates the diffusion of glucose out of the intestinal cell and into the bloodstream. (D)</p> Signup and view all the answers

What is the immediate consequence of a mutation that disables the SGLT1/2 symporter in intestinal cells?

<p>Impaired uptake of glucose and galactose (C)</p> Signup and view all the answers

In the small intestine, specialized transport mechanisms are in place for the absorption of:

<p>Vitamin B12 and bile salts (D)</p> Signup and view all the answers

Why does very little absorption take place in the ileum?

<p>The ileum has already absorbed most of the contents, with specialised transport for B12 and bile salts. (B)</p> Signup and view all the answers

In the context of carbohydrate absorption, what is the role of the Na+/K+ pump?

<p>Maintains the sodium gradient necessary for SGLT symporter activity (A)</p> Signup and view all the answers

Which of the following best describes the primary characteristic of nutrient absorption in the duodenum and jejunum?

<p>Most nutrient absorption occurs in these regions. (C)</p> Signup and view all the answers

What structural feature of the small intestine greatly enhances the absorptive surface area?

<p>Abundant microvilli on epithelial cells. (C)</p> Signup and view all the answers

Which transport mechanism is responsible for moving glucose against its concentration gradient into intestinal cells?

<p>Active transport via SGLT1. (D)</p> Signup and view all the answers

What is the role of the Na+/K+ pump in the absorption of glucose in the small intestine?

<p>Maintains the sodium gradient to facilitate glucose absorption. (A)</p> Signup and view all the answers

Bile salts facilitate fat digestion by:

<p>Emulsifying large fat globules into smaller droplets. (C)</p> Signup and view all the answers

How are chylomicrons transported from intestinal cells into the bloodstream?

<p>Through lacteals into the lymphatic system. (B)</p> Signup and view all the answers

What is the primary source of gases in the intestine?

<p>Bacterial fermentation in the colon. (B)</p> Signup and view all the answers

How does the absorptive surface of the colon differ from that of the small intestine?

<p>The colon has a smoother luminal surface with less absorptive area. (A)</p> Signup and view all the answers

The colon's primary role in digestion and absorption is to:

<p>Absorb water and electrolytes. (D)</p> Signup and view all the answers

What triggers the defecation reflex?

<p>Distension of the rectum. (D)</p> Signup and view all the answers

What is the main function of the ileocecal valve?

<p>To prevent the backflow of colonic contents into the small intestine. (D)</p> Signup and view all the answers

The primary mechanism by which the colon absorbs sodium is:

<p>Active transport. (C)</p> Signup and view all the answers

What is the role of the liver in the processing of absorbed nutrients?

<p>Detoxification and metabolism of absorbed substances. (C)</p> Signup and view all the answers

How does water movement occur in the colon?

<p>Through osmosis following the absorption of solutes. (D)</p> Signup and view all the answers

Excess LDL (low-density lipoprotein) can lead to:

<p>Buildup of plaques in blood vessels, increasing the risk of atherosclerosis. (A)</p> Signup and view all the answers

What is the effect of aging on the epithelial stem cell division rate in the GI tract?

<p>It decreases, making the epithelium more vulnerable to damage. (A)</p> Signup and view all the answers

Following the breakdown of triglycerides by lipase, how do the resulting fatty acids and monoglycerides enter intestinal cells?

<p>Simple diffusion through the plasma membrane. (A)</p> Signup and view all the answers

After delivering lipid components to tissues, excess chylomicrons (CMs) are primarily:

<p>Taken up by the liver and repackaged into VLDL and LDL. (B)</p> Signup and view all the answers

In carbohydrate absorption, energy for the Na+/glucose cotransporter is directly derived from?

<p>The Na+ electrochemical gradient. (B)</p> Signup and view all the answers

What is the MOST LIKELY consequence of significant damage to the intestinal lacteals?

<p>Malabsorption of digested fats. (B)</p> Signup and view all the answers

A patient presents with symptoms suggesting impaired absorption of vitamin B12. Where is the defect most likely located?

<p>Ileum. (A)</p> Signup and view all the answers

Which of the following is the LEAST accurate statement concerning the large intestine?

<p>It is the primary site of nutrient absorption in the GI tract. (B)</p> Signup and view all the answers

Which of the following is NOT directly absorbed by the small intestine?

<p>Polysaccharides (D)</p> Signup and view all the answers

What is the primary function of the hepatic portal system?

<p>To direct blood from the intestinal capillaries to the liver for nutrient processing (D)</p> Signup and view all the answers

How do the components of micelles cross the intestinal cell membrane?

<p>Simple diffusion due to their lipid-soluble nature (A)</p> Signup and view all the answers

What is the role of pancreatic lipase in fat digestion?

<p>Hydrolyzing triglycerides into fatty acids and monoglycerides (D)</p> Signup and view all the answers

Where are bile salts reabsorbed in the small intestine?

<p>Ileum (C)</p> Signup and view all the answers

Which of the following is the direct energy source for the Na+/glucose cotransporter (SGLT) in intestinal cells?

<p>The sodium electrochemical gradient (A)</p> Signup and view all the answers

What is the composition of intestinal gas primarily a result of?

<p>Bacterial fermentation in the colon (D)</p> Signup and view all the answers

How does the absorption of water occur in the colon?

<p>Following the osmotic gradient created by solute absorption (A)</p> Signup and view all the answers

The role of colonic bacteria does NOT include:

<p>Emulsifying fats (D)</p> Signup and view all the answers

What is the likely consequence of decreased smooth muscle tone in the GI tract due to aging?

<p>Weaker general motility and contractions (A)</p> Signup and view all the answers

Epithelial stem cell division rate decreases with aging. Which of the following is the MOST LIKELY outcome?

<p>Epithelium becomes more susceptible to damage (A)</p> Signup and view all the answers

Which of the following is the most direct cause of intestinal gas formation?

<p>Bacterial fermentation in the colon (C)</p> Signup and view all the answers

Which response accurately describes the role of microvilli in the small intestine?

<p>Increasing the surface area for absorption (D)</p> Signup and view all the answers

Following a cholecystectomy (removal of the gallbladder), which aspect of nutrient digestion would be MOST significantly affected?

<p>Fat digestion (A)</p> Signup and view all the answers

Which statement best describes the function of lacteals in nutrient absorption?

<p>Transport digested fats away from the intestine. (C)</p> Signup and view all the answers

How does a high HDL:LDL ratio influences cardiovascular health?

<p>Promotes the transport of cholesterol to the liver for removal (A)</p> Signup and view all the answers

In the small intestine, which mechanism primarily drives the absorption of fructose?

<p>GLUT5 Facilitated Diffusion (D)</p> Signup and view all the answers

What is the specific fate of excess chylomicrons (CMs) following lipid component delivery to tissues?

<p>Uptake by the liver, which packages them into VLDL and LDL (D)</p> Signup and view all the answers

How does the colon primarily absorb sodium ions (Na+)?

<p>By active transport mechanisms (B)</p> Signup and view all the answers

The absorption of which nutrient relies heavily on specialized transport mechanisms within the ileum?

<p>Vitamin B12 (B)</p> Signup and view all the answers

Consider an individual with a mutation causing non-functional SGLT1 transporters. Knowing that the mutation is only expressed in the small intestine, which outcome is MOST likely?

<p>Impaired absorption of glucose and galactose (B)</p> Signup and view all the answers

An individual is administered a drug that non-competitively inhibits the Na+/K+ ATPase pump in intestinal cells. This drug will most directly interfere with the absorption of _______.

<p>Glucose (D)</p> Signup and view all the answers

A researcher is investigating a novel genetic mutation that results in a complete absence of GLUT2 transporter proteins in the basolateral membrane of intestinal epithelial cells. What is the MOST LIKELY consequence?

<p>A buildup of glucose inside the intestinal cells and impaired glucose transport into the bloodstream (B)</p> Signup and view all the answers

A patient with a history of chronic pancreatitis experiences severe malabsorption, particularly of fats. If you were to analyze the contents of their small intestine, you would MOSTLY expect to see an increase in:

<p>Un-hydrolyzed triglycerides (D)</p> Signup and view all the answers

Approximately what percentage of total nutrient absorption occurs in the small intestine?

<p>90% (C)</p> Signup and view all the answers

Which of the following nutrients does NOT get absorbed from the contents in the small intestine?

<p>Cellulose (D)</p> Signup and view all the answers

In which sections of the small intestine does MOST nutrient absorption occur?

<p>Duodenum and jejunum (C)</p> Signup and view all the answers

What kind of specialized transport mechanisms exist in the ileum?

<p>Vitamin B12 and bile salts (A)</p> Signup and view all the answers

Which structural modification in the small intestine serves to increase the surface area for absorption?

<p>Microvilli (D)</p> Signup and view all the answers

Where do the capillary networks of the small intestine drain to for nutrient processing?

<p>Hepatic portal system (D)</p> Signup and view all the answers

What is the role of lacteals in the small intestine?

<p>Absorption of fats (D)</p> Signup and view all the answers

Which process describes how absorption can occur in the small intestine?

<p>All of the above (D)</p> Signup and view all the answers

What primarily drives passive diffusion in nutrient absorption?

<p>Difference in concentration (B)</p> Signup and view all the answers

What assists the transport of solutes across the membrane in facilitated diffusion?

<p>Specialized proteins (D)</p> Signup and view all the answers

What directly powers active transport?

<p>Energy (A)</p> Signup and view all the answers

Which symporter is used by glucose and galactose for carbohydrate absorption?

<p>SGLT1/2 (C)</p> Signup and view all the answers

During carbohydrate absorption, how are Na+ and glucose carried across the membrane?

<p>Symport (B)</p> Signup and view all the answers

How does glucose enter the blood from intestinal cells?

<p>Passive transport using GLUT2 (D)</p> Signup and view all the answers

In fat digestion, what role do bile salts play?

<p>Act as detergents converting large fat globules into a lipid emulsion (B)</p> Signup and view all the answers

In fat digestion, what enzyme hydrolyzes triglycerides (TGs) to fatty acids (FAs) and monoglycerides?

<p>Pancreatic lipase (C)</p> Signup and view all the answers

What are the small droplets formed during fat digestion called?

<p>Micelles (A)</p> Signup and view all the answers

What is the composition of micelles?

<p>Digested triglycerides, cholesterol and fat-soluble vitamins (D)</p> Signup and view all the answers

How do components of micelles enter intestinal cells?

<p>The components of micelles are lipid-soluble, so they diffuse through the plasma membrane of the cells (B)</p> Signup and view all the answers

What happens to monoglycerides and fatty acids in the intestinal cells?

<p>They are re-synthesized into triglycerides (D)</p> Signup and view all the answers

After triglycerides are re-synthesized, what are they coated with?

<p>Lipoprotein (C)</p> Signup and view all the answers

Where do chylomicrons enter after being formed in intestinal cells?

<p>Lacteals (B)</p> Signup and view all the answers

Following absorption, how are chylomicrons primarily transported?

<p>Via the lymphatic system (A)</p> Signup and view all the answers

Which of the following is LEAST likely to be a destination for lipid components when delivered by chylomicrons?

<p>Brain (A)</p> Signup and view all the answers

Where are excess chylomicrons primarily processed after delivering lipids?

<p>Liver (C)</p> Signup and view all the answers

Where does the majority of nutrient absorption occur?

<p>Small intestine (A)</p> Signup and view all the answers

What substances are absorbed by the small intestine?

<p>Monosaccharides, amino acids, fatty acids and monoglycerides, electrolytes, vitamins and water (D)</p> Signup and view all the answers

In which parts of the small intestine does most absorption take place?

<p>Duodenum and jejunum (C)</p> Signup and view all the answers

Which adaptation of the small intestine increases the surface area for absorption?

<p>Microvilli (B)</p> Signup and view all the answers

Where does the capillary network of the small intestine drain?

<p>Hepatic portal system (B)</p> Signup and view all the answers

What are lacteals and what is their role in the small intestine?

<p>Modified lymphatic vessels for fat absorption (B)</p> Signup and view all the answers

By what process can absorption occur in the small intestine?

<p>Active or passive processes, or a combination of both (D)</p> Signup and view all the answers

What is 'passive diffusion' in the context of nutrient absorption?

<p>Movement of molecules from an area of high concentration to low concentration (D)</p> Signup and view all the answers

Which of the following assists the transport of solutes across the membrane in facilitated diffusion?

<p>Specialized proteins (A)</p> Signup and view all the answers

What is the energy source that directly powers active transport?

<p>ATP (D)</p> Signup and view all the answers

Which symporter do glucose and galactose use for absorption in the small intestine?

<p>SGLT1/2 (B)</p> Signup and view all the answers

In carbohydrate absorption, how are Na+ and glucose transported across the membrane simultaneously?

<p>Symport (D)</p> Signup and view all the answers

What is the function of bile salts in fat digestion?

<p>Convert large fat globules into a lipid emulsion (C)</p> Signup and view all the answers

What enzyme hydrolyzes triglycerides (TGs) to fatty acids (FAs) and monoglycerides in fat digestion?

<p>Pancreatic lipase (D)</p> Signup and view all the answers

What are micelles composed of?

<p>Digested triglycerides (FAs, monoglycerides), cholesterol, and fat-soluble vitamins (A)</p> Signup and view all the answers

What are triglycerides coated with after being re-synthesized in intestinal cells?

<p>A layer of lipoprotein (B)</p> Signup and view all the answers

How are chylomicrons primarily transported after absorption?

<p>Via the lymphatic system (D)</p> Signup and view all the answers

What is the fate of excess chylomicrons in the body?

<p>Taken up by the liver and packaged into VLDL &amp; LDL (A)</p> Signup and view all the answers

VLDL and LDL have different roles when delivering fats. Which of the following answer options describes their functions?

<p>VLDL delivers TGs, LDL delivers cholesterol (C)</p> Signup and view all the answers

What does a high HDL:LDL ratio typically indicate?

<p>Reduced risk of a heart attack (C)</p> Signup and view all the answers

Imagine a scenario where a patient's lipase enzymes are functioning, but their intestinal cells are unable to properly re-synthesize triglycerides following absorption of fatty acids and monoglycerides. Which of the following is the MOST LIKELY consequence?

<p>Impaired formation of chylomicrons and subsequent fat malabsorption (D)</p> Signup and view all the answers

Which monosaccharides utilize the SGLT symporter for absorption in the small intestine?

<p>Glucose and galactose (D)</p> Signup and view all the answers

What provides the energy for the Na+/K+ pump involved in carbohydrate absorption?

<p>ATP hydrolysis (B)</p> Signup and view all the answers

How does glucose enter the bloodstream from intestinal cells?

<p>Facilitated diffusion via GLUT2 (B)</p> Signup and view all the answers

What is the function of bile salts in the digestion of fats?

<p>They emulsify large fat globules into smaller lipid droplets. (B)</p> Signup and view all the answers

Which enzyme is responsible for hydrolyzing triglycerides into fatty acids and monoglycerides?

<p>Lipase (C)</p> Signup and view all the answers

What is the ultimate fate of excess chylomicrons in the body?

<p>Taken up by the liver and packaged into VLDL and LDL (D)</p> Signup and view all the answers

Which statement accurately differentiates the primary roles of VLDL and LDL in fat delivery?

<p>VLDL delivers triglycerides, while LDL delivers cholesterol. (D)</p> Signup and view all the answers

If intestinal cells are unable to properly re-synthesize triglycerides following absorption of fatty acids and monoglycerides, what is the MOST LIKELY consequence?

<p>Accumulation of fatty acids within intestinal cells (B)</p> Signup and view all the answers

Where does the majority of nutrient absorption take place?

<p>Small intestine (A)</p> Signup and view all the answers

Which structural adaptation increases the surface area for absorption in the small intestine?

<p>Microvilli (B)</p> Signup and view all the answers

The capillary network of the small intestine drains into which system for nutrient processing?

<p>Hepatic portal system (C)</p> Signup and view all the answers

Where do intestinal gases primarily originate?

<p>Bacterial fermentation in the colon and swallowed air (B)</p> Signup and view all the answers

What is the primary function of the caecum at the junction of the small and large intestine?

<p>It is a blind-ended pouch at the junction of the small and large intestines (A)</p> Signup and view all the answers

Which vitamins are synthesized by bacteria in the colon and subsequently absorbed?

<p>Vitamins B and K (C)</p> Signup and view all the answers

How does the luminal surface of the colon differ from that of the small intestine?

<p>It has a smoother surface with less absorptive area. (C)</p> Signup and view all the answers

What is the role of the internal anal sphincter in the defecation reflex?

<p>It relaxes involuntarily to allow defecation. (A)</p> Signup and view all the answers

How does the rate of epithelial stem cell division in the GI tract change with age?

<p>It decreases, making the epithelium more susceptible to damage. (C)</p> Signup and view all the answers

Which of the following best describes how the small intestine is adapted for absorption?

<p>It has microvilli to increase the surface area for absorption. (A)</p> Signup and view all the answers

What is the role of the hepatic portal system in nutrient absorption?

<p>It directs blood from the small intestine to the liver for nutrient processing. (A)</p> Signup and view all the answers

Which transport mechanism relies on a difference in concentration across the membrane?

<p>Passive diffusion (C)</p> Signup and view all the answers

During carbohydrate absorption, which of the following is true regarding the Na+/K+ pump?

<p>It uses ATP to pump Na+ out of the cell, creating a concentration gradient. (A)</p> Signup and view all the answers

In carbohydrate absorption, what supplies the energy for the SGLT symporter to transport glucose?

<p>The sodium electrochemical gradient (A)</p> Signup and view all the answers

What is the primary role of bile salts in fat digestion?

<p>To emulsify large fat globules into smaller droplets (D)</p> Signup and view all the answers

What enzyme is responsible for hydrolyzing triglycerides (TGs) into fatty acids (FAs) and monoglycerides?

<p>Lipase (C)</p> Signup and view all the answers

How components of micelles enter the intestinal cells?

<p>Simple diffusion (A)</p> Signup and view all the answers

Monoglycerides and fatty acids are re-synthesized into what molecules inside intestinal cells?

<p>Triglycerides (B)</p> Signup and view all the answers

After triglycerides are re-synthesized, what are they coated with to form chylomicrons?

<p>Lipoprotein (A)</p> Signup and view all the answers

Where are excess chylomicrons primarily processed after delivering lipids to tissues?

<p>The liver (D)</p> Signup and view all the answers

VLDL and LDL have different roles when delivering fats. Which of the following accurately describes their functions?

<p>VLDL delivers triglycerides, while LDL delivers cholesterol. (A)</p> Signup and view all the answers

What is the MOST LIKELY consequence if a patient's intestinal cells are unable to properly re-synthesize triglycerides following absorption of fatty acids and monoglycerides?

<p>Accumulation of fatty acids and monoglycerides in intestinal cells (C)</p> Signup and view all the answers

In what part of the gastrointestinal tract is intestinal gas production minimal?

<p>Small intestine (A)</p> Signup and view all the answers

Which of the following is the primary function of the caecum at the junction of the small and large intestine?

<p>It is a blind-ended pouch, providing a space for the mixing of chyme with bacteria. (B)</p> Signup and view all the answers

Age-related effects in the GI tract can affect digestion. What happens to epithelial stem cell division rate with age?

<p>It decreases, making the epithelium more fragile. (C)</p> Signup and view all the answers

Which of of the following MOST accurately describes the composition of feces?

<p>67% Water, 33% Solids of which 11% is bacteria. (B)</p> Signup and view all the answers

A researcher is conducting an experiment on intestinal cells and discovers a complete absence of GLUT2 transporter proteins in the basolateral membrane of intestinal epithelial cells, but SGLT1 expression has not been affected. Assuming the GLUT2 deficit is the only abnormality, which of the following outcomes is MOST likely?

<p>Glucose would accumulate within the cell, potentially disrupting cellular function. (C)</p> Signup and view all the answers

Which of the following best describes how monosaccharides move across the intestinal cell membrane during absorption?

<p>They utilize both SGLT symporters and GLUT2 transporters. (C)</p> Signup and view all the answers

What is the primary role of pancreatic lipase in the process of fat digestion?

<p>Hydrolyzing triglycerides into fatty acids and monoglycerides. (A)</p> Signup and view all the answers

What is the primary role of bile salts in the digestive process?

<p>Emulsifying large fat globules into smaller droplets. (A)</p> Signup and view all the answers

A researcher develops a drug that completely blocks the SGLT1/2 symporter in the small intestine. What is the MOST LIKELY consequence of administering this drug?

<p>Significantly reduced absorption of glucose and galactose. (D)</p> Signup and view all the answers

A patient presents with lymphedema, resulting in impaired lymphatic drainage throughout their body. Which of the following processes will be MOST directly affected?

<p>Initial transport of chylomicrons. (D)</p> Signup and view all the answers

Flashcards

What does the small intestine absorb?

The small intestine absorbs monosaccharides, amino acids, fatty acids, monoglycerides, electrolytes, vitamins, and water.

Where does most absorption occur?

Most absorption occurs in the duodenum and jejunum. Very little absorption occurs in the ileum.

Small intestine adaptations

The small intestine is specially adapted for absorption with microvilli for increased surface area.

What do microvilli contain?

Microvilli contain enzymes like peptidases and lactase, and transport proteins that facilitate nutrient absorption into the intestinal capillary network.

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Hepatic portal system function

Capillary networks drain into the hepatic portal system, directing blood to the liver for nutrient processing.

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Lacteals function

Lacteals are modified lymphatic vessels in the small intestine responsible for fat absorption.

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Types of Absorption

Absorption can occur through passive diffusion (due to concentration differences), facilitated diffusion (using specialized proteins), or active transport (using energy).

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Passive diffusion

Passive diffusion occurs due to differences in concentration across the membrane.

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Facilitated diffusion

Facilitated diffusion uses specialized proteins to transport substances across the membrane.

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Active transport

Active transport uses energy to power transport against the concentration gradient.

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Glucose/galactose absorption

Glucose and galactose utilize the SGLT symporter for absorption.

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Na+/K+ pump

The Na+/K+ pump uses ATP to pump Na+ out of the cell, reducing cytoplasmic Na+ levels and creating a concentration gradient.

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SGLT protein function

Na+ and glucose are carried across the membrane together via the SGLT transport protein, using the energy of the Na+ concentration gradient.

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How does glucose enter the blood?

Glucose enters the blood passively by facilitated diffusion, using GLUT2 once concentrated within the cell.

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Bile salts act as?

Bile salts emulsify large fat globules into lipid emulsion

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Pancreatic lipase

Pancreatic lipase hydrolyzes triglycerides into fatty acids and monoglycerides.

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What are Micelles

Micelles are small droplets containing digested triglycerides, cholesterol, and fat-soluble vitamins

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Micelle components entry

Components of micelles are lipid-soluble and diffuse through the plasma membrane of cells.

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FAs & monoglycerides converted to?

Once inside cells, fatty acids and monoglycerides are re-synthesized into triglycerides.

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Lipoproteins

Triglycerides coalesce into droplets, coated with lipoprotein to form chylomicrons (CMs)

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Chylomicrons properties

Chylomicrons (CMs) are water-soluble, contain a hydrophobic core, and enter the lymphatics.

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CMs travel where?

Chylomicrons travel via the lymphatic system and are returned to the venous system near the heart.

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CMs deliver lipids to?

CMs deliver lipid components to adipose, cardiac, and skeletal muscle for storage and use.

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Excess CM processed by?

Excess CMs are taken up by the liver to be packaged into VLDL & LDL

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VLDL vs LDL

VLDL delivers triglycerides to skeletal muscle (SKM) and adipose tissue, while LDL delivers cholesterol.

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Study Notes

Absorption of Nutrients in the GI Tract

  • Nutrients are absorbed across the gastrointestinal (GI) tract.

Learning Objectives

  • Summarize how nutrients are absorbed across the GI tract.
  • Describe the role of the large intestine in absorption and defaecation.

Small Intestine Absorption

  • Approximately 90% of absorption happens in the small intestine.
  • The small intestine absorbs monosaccharides, amino acids, fatty acids and monoglycerides, electrolytes, vitamins, and water.
  • Calcium and iron absorption is adjusted based on bodily needs.
  • Absorption of the rest of the nutrients consumed is complete, with more absorption occurring as food intake increases.
  • Most absorption takes place in the duodenum and jejunum.
  • Very little absorption occurs in the ileum.
  • Vitamin B12 and bile salts in the ileum have specialized transport mechanism.

Small Intestine Adaptations

  • The small intestine is specifically adapted for absorption.
  • Microvilli increases the surface area for absorption.
  • There are 3000-6000 microvilli per epithelial cell approx.
  • Enzymes such as peptidases and lactase are contained in microvilli.
  • Transport proteins facilitate nutrient absorption into the intestinal capillary network.
  • Capillary network drains into the hepatic portal system, directing blood to the liver for nutrient processing.
  • Lacteals, which are modified lymphatic vessels are used for fat absorption.

Absorption Processes

  • Absorption can occur through active or passive processes, or a combination of both.

Passive Diffusion

  • Passive diffusion occurs due to differences in concentration across a membrane.

Facilitated Diffusion

  • Specialized proteins 'facilitate' transport across the membrane; used when solutes cannot cross unaided.

Active Transport

  • Energy is used to power transport against the concentration gradient.

Carbohydrate Absorption

  • Glucose and galactose use the SGLT symporter.
  • The Na+/K+ pump uses ATP to pump Na+ out of the cell into the interstitium against its concentration gradient.
  • This process reduces cytoplasmic Na+ levels.
  • Na+ and glucose are carried across the membrane simultaneously (symport) via the SGLT transport protein, using the 'energy' from the Na+ concentration gradient.
  • No ATP is used in this step.
  • Glucose enters the blood passively through facilitated diffusion using GLUT2 once concentrated in the cell.

Fat Digestion

  • Bile salts act as detergents, converting large fat globules into a lipid emulsion.
  • Pancreatic lipase hydrolyses triglycerides (TGs) into fatty acids (FAs) and monoglycerides.
  • The small droplets become micelles.
  • Micelles contain digested triglycerides (FAs, monoglycerides), cholesterol, and fat-soluble vitamins.

Fat Absorption

  • Lipid-soluble components of micelles diffuse through the plasma membrane of cells.
  • Once inside, they are re-synthesized into triglycerides.
  • Triglycerides coalesce into droplets and are coated with lipoprotein forming chylomicrons (CMs).
  • CMs are water-soluble with a hydrophobic core and enter the lymphatics (not capillaries).
  • Chylomicrons travel via the lymphatic system and are returned to the venous system near the heart via the thoracic duct.
  • CMs deliver lipid components to adipose, cardiac, and skeletal muscle for use and storage.
  • Excess CMs are taken up by the liver and packaged into VLDL & LDL.

Overview of VLDL and LDL

  • VLDL delivers triglycerides to skeletal muscle (SKM) and adipose tissue.
  • LDL delivers cholesterol to peripheral tissues for steroid hormone synthesis.

Effects of Cholesterol

  • High LDL lead to developing LDL plaques in blood vessels and atherosclerosis.
  • HDL picks up excess cholesterol in the blood and transports it to the liver for removal in bile.
  • A high HDL:LDL ratio reduces the risk of a heart attack.

Intestinal Gases

  • Intestinal gases result from bacterial fermentation in the colon and swallowed air.

Eruction

  • Eruction, or burping,is useful for removing air from the stomach.
  • Very little gas is present in the small intestine; it either passes to the colon or is absorbed.

Flatus

  • Flatus is mainly derived from colonic bacteria.
  • Gas production depends on the type of food eaten.
  • Flatus has characteristics of colonic bacteria.

Small and Large Intestine Connection

  • The small intestine joins the colon at the caecum.
  • The caecum is a blind-ended pouch below the junction of the small and large intestines, at the ileocecal valve.
  • The ileocaecal valve opens when contents from the small intestine push forward.
  • The valve is forcibly closed by any backward movement.

Large Intestine Function

  • The large intestine receives 500ml of chyme per day.
  • The chyme consists of indigestible food residue, bile components, and water.
  • The colon extracts more water and electrolytes.
  • Bacterial flora ferment cellulose and undigested carbohydrates, producing gas.
  • Bacteria synthesize B vitamins and vitamin K, which are absorbed in the colon.
  • Remaining content is eliminated as faeces.
  • The luminal surface is smoother with less absorptive surface area than the small intestine.
  • Na+ is actively absorbed.
  • Chloride and water follow down electrochemical and osmotic gradients, respectively.
  • Mass movements occur 3-4 times per day, propelling faeces forward.
  • Ascending and transverse colons contract simultaneously, driving faeces one third to three quarters of the length of the colon in a few seconds.
  • Reflexes are initiated to move existing contents further along the tract when a new meal enters the digestive tract.
  • Gastrin triggers the gastro-colic reflex.

Defaecation

  • Distension of the rectum stimulates stretch receptors in the rectal wall, triggering the defaecation reflex.
  • This causes the internal anal sphincter to relax and the colon to contract more vigorously.
  • Defaecation occurs if the external anal sphincter is relaxed (a voluntary action).
  • Defaecation is assisted by simultaneous voluntary contraction of the abdominal muscles.
  • Faeces consist of approximately 67% water and 33% solids, with bacteria comprising about 11%.
  • Epithelial stem cell division rate decreases with age.
  • Epithelium becomes more susceptible to damage from abrasion, acid, and enzymes.
  • Peptic ulcers become more likely as tissue repair is less efficient.
  • The epithelium in the mouth, oesophagus, and anus becomes thinner and more fragile.
  • General motility and contractions weaken, and straining becomes more common.
  • Straining stresses less resilient blood vessels.
  • Sphincters weaken.
  • There may be a gradual loss of teeth due to dental caries or gingivitis, toxins such as alcohol can lead to liver cirrhosis and cancer.
  • Cancer is common due to high cell division and mutation levels.
  • Decreased GI motility and contraction strength also occur.

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