NUTR 221 Advanced Nutrition Micronutrients

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Questions and Answers

Which of the following has an inhibitory effect on gastric emptying?

  • Dietary carbohydrate intake
  • Dietary protein intake
  • Dietary fiber intake
  • Dietary fat intake (correct)

What are some of the factors influencing digestion and absorption?

  • pH level of stomach contents
  • Chemical structure of dietary fibers
  • Amount of digestive enzymes present
  • Quantity and composition of gastrointestinal secretions (correct)

Which of the following hormones is NOT mentioned as a regulatory peptide affecting gastric emptying?

  • CRH
  • Leptin
  • Ghrelin
  • Insulin (correct)

Which factor does NOT contribute to adequate nourishment from the gastrointestinal tract?

<p>Normative gastric pH levels (A)</p> Signup and view all the answers

How is the Recommended Dietary Allowance (RDA) calculated from the Estimated Average Requirement (EAR)?

<p>RDA = EAR + 2SD (D)</p> Signup and view all the answers

Which of the following is NOT a part of the digestive tract?

<p>Gallbladder (C)</p> Signup and view all the answers

What role do the gastric juices serve in the stomach?

<p>They mix food while facilitating digestion. (C)</p> Signup and view all the answers

Which of the following structures is part of the mucosa layer of the digestive tract?

<p>Lamina propria (A)</p> Signup and view all the answers

During swallowing, which type of muscle contraction is responsible for moving the bolus through the esophagus?

<p>Peristaltic contractions (D)</p> Signup and view all the answers

What is the primary function of the small intestine?

<p>Absorption of nutrients (B)</p> Signup and view all the answers

Which accessory organ produces bile that is essential for fat digestion?

<p>Liver (B)</p> Signup and view all the answers

What type of tissue primarily makes up the submucosa layer of the digestive tract?

<p>Connective tissue (D)</p> Signup and view all the answers

Which structural feature of the small intestine increases its surface area for nutrient absorption?

<p>Plicae circulares (A), Microvilli (B)</p> Signup and view all the answers

What is the primary function of gastrin?

<p>Stimulates gastric acid secretion (B)</p> Signup and view all the answers

Which hormone is associated with stimulating gallbladder contraction?

<p>Cholecystokinin (A)</p> Signup and view all the answers

Which hormone primarily diminishes gastric acid secretion?

<p>Secretin (C)</p> Signup and view all the answers

What effect does somatostatin have on gastric and intestinal activities?

<p>Inhibits gallbladder contraction (D)</p> Signup and view all the answers

Which hormone promotes insulin secretion from the pancreas?

<p>Glucose-dependent insulinotropic peptide (A)</p> Signup and view all the answers

What is the main production site of motilin?

<p>Stomach and intestines (C)</p> Signup and view all the answers

Which hormone diminishes gastric motility and secretion?

<p>Peptide YY (C)</p> Signup and view all the answers

Which factor initiates peristaltic waves for digestion?

<p>Pacemaker cells (A)</p> Signup and view all the answers

What triggers the release of somatostatin after food has left the stomach?

<p>Decrease in chyme volume and pH (D)</p> Signup and view all the answers

Which of the following glands primarily secretes digestive enzymes into the duodenum?

<p>Acinar cells of the pancreas (D)</p> Signup and view all the answers

What role does bile play in digestion?

<p>Emulsifies fats (A)</p> Signup and view all the answers

Which process is NOT a method of absorption in the intestines?

<p>Filtration (D)</p> Signup and view all the answers

What primarily absorbs sodium and water in the colon?

<p>Proximal colonic mucosal cells (D)</p> Signup and view all the answers

Which organ is responsible for synthesizing bile?

<p>Liver (D)</p> Signup and view all the answers

What is a primary function of the myenteric plexus in the digestive system?

<p>Facilitates peristalsis and motility (C)</p> Signup and view all the answers

What is the primary function of goblet cells in the colon?

<p>Secrete mucus (C)</p> Signup and view all the answers

Flashcards

What is the digestive tract?

The digestive tract is a long tube responsible for breaking down food into smaller molecules that the body can absorb. It's made up of the oral cavity, esophagus, stomach, and small and large intestines.

What are accessory organs in digestion?

Accessory organs are not part of the digestive tract itself, but they play crucial roles in digestion. They include the pancreas, liver, and gallbladder.

Describe the Mucosa layer.

The mucosa is the innermost layer of the digestive tract and is directly in contact with food. It's made of the mucosal membrane, lamina propria, and muscularis mucosa.

What are the components of the Submucosa layer?

The submucosa is found below the mucosa and is composed of connective tissue, blood vessels, lymphatic vessels, lymphoid tissue, and the submucosal plexus.

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What is the Muscularis Externa?

The muscularis externa is a layer of muscle tissue that helps move food through the digestive tract using peristalsis.

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What is the Serosa layer?

The serosa is the outermost layer of the digestive tract and is composed of flat mesothelial cells. It helps protect and lubricate the digestive system.

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What is the role of the oral cavity in digestion?

The oral cavity is the first part of the digestive tract, where food is initially broken down by chewing and saliva.

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How does food travel from the mouth to the stomach?

The esophagus is a muscular tube that connects the mouth to the stomach. It uses peristalsis to push food down towards the stomach.

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Gastrin

A hormone produced by the stomach and small intestine that stimulates gastric acid secretion and pepsinogen secretion.

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Cholecystokinin

A hormone released by the small intestine and enteric nerves that stimulates gallbladder contraction, sphincter of Oddi relaxation, and pancreatic enzyme secretion.

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Secretin

A hormone released by the small intestine that stimulates pancreas juice secretion, diminishes gastric emptying, and diminishes gastric acid secretion.

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Motilin

A hormone produced by the stomach and intestines that stimulates gastric and intestinal motility between meals.

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Glucose-dependent insulinotropic peptide

A hormone released by the small intestine that stimulates insulin secretion and may diminish gastric acid secretion.

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Peptide YY

A hormone produced by the small and large intestines that diminishes gastric acid secretion and gastric emptying.

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Somatostatin

A versatile hormone produced by the pancreas, stomach, and small intestine that inhibits various digestive activities.

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Glucagon-like peptides

A hormone released by the small and large intestines that stimulates insulin secretion, reduces digestive tract motility, and reduces gastric secretions.

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What are gastric glands?

Gastric glands are specialized epithelial cells in the stomach lining that secrete various substances involved in digestion. There are three main types: cardiac glands, oxyntic glands, and pyloric glands.

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What is the cephalic phase of gastric secretion?

The cephalic phase of gastric secretion occurs before food even reaches the stomach. It's triggered by signals like the sight, smell, or taste of food. This phase involves the release of acetylcholine and gastrin, both of which stimulate gastric juice production.

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What is the gastric phase of gastric secretion?

The gastric phase is the second phase of gastric secretion. It begins when food enters the stomach. Distension of the stomach walls and the presence of food chemicals stimulate the release of gastrin, acetylcholine, and histamine, leading to increased gastric juice secretion.

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What is the intestinal phase of gastric secretion?

The intestinal phase is the final phase of gastric secretion, occurring as chyme (partially digested food) enters the small intestine. It involves the release of hormones like cholecystokinin (CCK) and secretin, which have a regulatory effect on gastric secretions. CCK and secretin also influence the release of pancreatic juice and bile.

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What is the pancreas and what does it do?

The pancreas is an important accessory organ with both endocrine and exocrine functions. It releases digestive enzymes (exocrine) and hormones like insulin and glucagon (endocrine).

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What is bile and what does it do?

Bile is a fluid produced by the liver, stored in the gallbladder, and released into the small intestine. It helps in the digestion and absorption of fats by emulsifying them, making them easier to digest.

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What is the gallbladder and what does it do?

The gallbladder is a small, pear-shaped organ attached to the liver. Its main function is to store and concentrate bile produced by the liver. Bile is released into the small intestine to aid in fat digestion.

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What is absorption?

Absorption is the process where nutrients from digested food are taken up from the small intestine and transferred into the bloodstream. It happens primarily in the duodenum, jejunum, and ileum.

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How does dietary fat affect gastric emptying?

Dietary fat intake slows down the rate at which food leaves the stomach and enters the small intestine.

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What are paracrine and neurocrine signaling?

Paracrine signaling involves communication between nearby cells, while neurocrine signaling uses neurotransmitters to send messages along nerves.

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What are the roles of ghrelin and leptin?

Ghrelin is a hormone that stimulates appetite, while leptin signals fullness and reduces hunger.

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What are DRIs, EAR, and RDA?

DRIs are a set of nutrient reference values for different stages of life and genders. EAR is the average daily intake to meet the needs of 50% of individuals. RDA is the recommended intake to meet the needs of nearly all healthy individuals.

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What is the UL?

The UL (Tolerable Upper Intake Level) is the maximum daily intake that is not expected to pose any health risks to most individuals.

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Study Notes

NUTR 221 Advanced Nutrition Micronutrients

  • Course taught by Dr. Christine M. Mills (she/her)
  • Slides cannot be shared or reproduced without permission
  • Adapted from slides by Dr. Brian Bandy, PhD

Dr. Mills' Background

  • Registered dietitian with experience in primary care, community health, and public health
  • Provost's Interdisciplinary Postdoctoral Fellow at the University of Waterloo
  • PhD in Aging & Health from Queen's University
  • MPH in Nutrition & Dietetics from the University of Toronto
  • BSc in Applied Human Nutrition and BEng in Biological Engineering from the University of Guelph
  • Military spouse
  • Owner of Sphynx cats
  • Runner
  • Group fitness instructor

Learning Objectives

  • Identify digestive tract organs and their roles in nutrient digestion and absorption
  • Describe secretions released by digestive organs, including accessory organs, and factors influencing their release
  • Describe structural features of the small intestine that facilitate nutrient absorption
  • Describe the roles of the nervous system and regulatory peptides in regulating the digestive process

Digestive Tract Structures

  • Main structures: Oral cavity, esophagus, stomach, small intestines, and large intestines
  • Accessory organs: Pancreas, liver, and gallbladder

Layers of the Lumen

  • Mucosa: Mucosal membrane, lamina propria, muscularis mucosa

  • Submucosa: Connective tissue, blood, lymphatic vessels, lymphoid tissue, submucosal plexus

  • Muscularis externa: Smooth muscles

  • Serosa: Flat mesothelial cells

  • Oral Cavity: Includes mouth and pharynx, salivary glands (parotid, submandibular, sublingual). Saliva contains enzymes which aid in digestion

  • Esophagus: Transports food from the oral cavity to the stomach

  • Swallowing: Voluntary, pharyngeal, esophageal

  • Peristalsis: Moves food through the digestive tract

  • Gastroesophageal sphincter Regulates the passage of food from esophagus to stomach

  • Disorders: GERD

  • The Stomach: Four main regions: cardia, fundus, body, antrum.

  • Stomach muscles: Mix food with gastric juices to form chyme

  • Gastric glands Cardiac, oxyntic, pyloric

  • Regulation of gastric secretions: Three phases: before food reaches stomach (acetylcholine, gastrin); once food is in stomach (stomach distension enhances secretions); after food leaves stomach (reduction in chyme volume and pH trigger release of somatostatin)

  • The Pancreas: Ductless endocrine cells secrete hormones into the blood, a crucial part of the digestive process. Acinar exocrine cells produce digestive enzymes, and pancreatic juice contains water, electrolytes, bicarbonate, and digestive enzymes

  • The Liver: Lobes made of lobules, portal circulation, bile canaliculi. The liver synthesizes bile composed of bile acids, salts, cholesterol, phospholipids, and bile pigments in an alkaline solution. Bile aids in lipid digestion by emulsifying lipid globules in the small intestine.

  • The Gallbladder: Concentrates and stores bile. Recirculation of bile involves the reabsorption of bile salts in the ileum.

  • The Absorptive Process: Begins in duodenum and continues through jejunum and ileum. Methods include diffusion, facilitated diffusion, active transport, and pinocytosis/endocytosis

  • Small Intestine Structures: Villi and microvilli structures increase surface area, enhancing absorption. These include cell membranes, tight junctions, desmosomes, and other structural components crucial for absorption.

  • The Colon (Large Intestine): Contracts to mix materials. Proximal colonic mucosal cells absorb sodium and water. Influenced by hormones, dehydrates materials. Goblet cells secrete mucus and bicarbonate is also part of the secretion

  • Coordination and Regulation of the Digestive Process: Neural regulation is by the myenteric and submucosal plexuses. Regulatory peptides (hormones and paracrines) play crucial roles.

Dietary Reference Intakes (DRIs)

  • Important for establishing an understanding of adequate amounts of nutrients in diet
  • Risk of inadequacy and excess are important considerations for setting appropriate intake ranges.
  • EAR is the estimated average amount of a nutrient required for good health for the average person.
  • RDA is calculated from EAR adding a safety factor
  • UL is the highest amount of a nutrient that will not cause toxicity in most healthy people

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