Podcast
Questions and Answers
What is the initial precursor for the synthesis of the biologically inactive form of vitamin D?
What is the initial precursor for the synthesis of the biologically inactive form of vitamin D?
- Cholesterol found in the skin (correct)
- Keratin produced in the epidermis
- Melanin produced in the dermis
- Vitamin D3 from dietary sources
Which phase is NOT part of deep wound healing?
Which phase is NOT part of deep wound healing?
- Migratory phase
- Inflammatory phase
- Proliferative phase
- Epidermal phase (correct)
What triggers the stop of growth and migration of basal cells during epidermal wound healing?
What triggers the stop of growth and migration of basal cells during epidermal wound healing?
- Contact inhibition (correct)
- Scarring of the dermis
- Increased oxygen supply
- Nutrient depletion
What is a characteristic of deep wound healing compared to epidermal wound healing?
What is a characteristic of deep wound healing compared to epidermal wound healing?
What role do topical steroids play in relation to the skin?
What role do topical steroids play in relation to the skin?
Which statement about skin structure is FALSE?
Which statement about skin structure is FALSE?
Which of the following is NOT a function of skin?
Which of the following is NOT a function of skin?
Which process does NOT occur during epidermal wound healing?
Which process does NOT occur during epidermal wound healing?
During deep wound healing, which statement is NOT accurate?
During deep wound healing, which statement is NOT accurate?
Which of the following describes a common misconception about skin?
Which of the following describes a common misconception about skin?
What is the primary function of the tight junctions in epithelial cells?
What is the primary function of the tight junctions in epithelial cells?
Which layer of the epidermis contains flattened dead keratinocytes?
Which layer of the epidermis contains flattened dead keratinocytes?
Which membrane of the transporting epithelial cell faces the extracellular fluid (ECF)?
Which membrane of the transporting epithelial cell faces the extracellular fluid (ECF)?
What is a primary function of the stratum lucidum?
What is a primary function of the stratum lucidum?
Paracellular transport primarily involves movement through which of the following?
Paracellular transport primarily involves movement through which of the following?
Which characteristic is true of thick skin compared to thin skin?
Which characteristic is true of thick skin compared to thin skin?
What term is used to describe the transport of substances from the lumen to the extracellular fluid?
What term is used to describe the transport of substances from the lumen to the extracellular fluid?
How does the skin contribute to thermoregulation?
How does the skin contribute to thermoregulation?
Which structure in the epithelial cells is specialized for absorption?
Which structure in the epithelial cells is specialized for absorption?
What type of transport involves proteins that direct movement across the epithelium?
What type of transport involves proteins that direct movement across the epithelium?
Which type of skin is generally hairless?
Which type of skin is generally hairless?
What is the main role of microvilli on the epithelial cells?
What is the main role of microvilli on the epithelial cells?
What function does keratin perform in the skin?
What function does keratin perform in the skin?
Which of the following has fewer glandular structures?
Which of the following has fewer glandular structures?
Which of the following transport processes is categorized as transcellular absorption?
Which of the following transport processes is categorized as transcellular absorption?
What structure in the skin is involved in the immune response?
What structure in the skin is involved in the immune response?
What is the process by which transcellular transport occurs?
What is the process by which transcellular transport occurs?
During transcytosis, what role do caveolae play?
During transcytosis, what role do caveolae play?
Which of the following describes the role of carrier proteins in transcellular transport?
Which of the following describes the role of carrier proteins in transcellular transport?
Which mechanism is primarily responsible for the transport of macromolecules across cell membranes?
Which mechanism is primarily responsible for the transport of macromolecules across cell membranes?
What component of the cell is crucial for vesicular transport during transcytosis?
What component of the cell is crucial for vesicular transport during transcytosis?
Which fluid is primarily involved in the transcellular transport process in capillaries?
Which fluid is primarily involved in the transcellular transport process in capillaries?
What happens to vesicles after they cross the cell during transcytosis?
What happens to vesicles after they cross the cell during transcytosis?
Which membranes are involved in transcellular transport?
Which membranes are involved in transcellular transport?
What role do neutrophils and monocytes (macrophages) play in the inflammatory phase of wound healing?
What role do neutrophils and monocytes (macrophages) play in the inflammatory phase of wound healing?
What is the primary function of fibroblasts during the migratory phase of deep wound healing?
What is the primary function of fibroblasts during the migratory phase of deep wound healing?
Which of the following occurs during the proliferative phase of deep wound healing?
Which of the following occurs during the proliferative phase of deep wound healing?
What marks the onset of the maturation phase in wound healing?
What marks the onset of the maturation phase in wound healing?
Which statement about epithelial transport is correct?
Which statement about epithelial transport is correct?
What is the typical time frame for fibroblast proliferation to peak after a wound occurs?
What is the typical time frame for fibroblast proliferation to peak after a wound occurs?
Which of the following defines the apical membrane in epithelial tissue?
Which of the following defines the apical membrane in epithelial tissue?
During which phase of wound healing does angiogenesis primarily occur?
During which phase of wound healing does angiogenesis primarily occur?
What typically corresponds with the healing of the epidermis during the maturation phase?
What typically corresponds with the healing of the epidermis during the maturation phase?
What is a characteristic of the inflammatory phase of wound healing?
What is a characteristic of the inflammatory phase of wound healing?
Flashcards
Vitamin D Precursor
Vitamin D Precursor
A precursor molecule needed to make inactive vitamin D, found in the skin.
Vitamin D Activation
Vitamin D Activation
The biologically inactive form of vitamin D is converted into the active form in the kidneys.
Epidermal Wound Healing
Epidermal Wound Healing
A type of wound healing that affects only the outer layer of skin (epidermis).
Basal Cell Migration
Basal Cell Migration
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Deep Wound Healing
Deep Wound Healing
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Thin Skin
Thin Skin
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Thick Skin
Thick Skin
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Homeostasis
Homeostasis
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Stratum Corneum
Stratum Corneum
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Stratum Lucidum
Stratum Lucidum
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Apoptosis
Apoptosis
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Stratum Granulosum
Stratum Granulosum
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Stratum Basale
Stratum Basale
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Paracellular transport
Paracellular transport
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Absorption
Absorption
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Transcellular transport
Transcellular transport
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Secretion
Secretion
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Tight junctions
Tight junctions
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Transport proteins
Transport proteins
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Apical membrane
Apical membrane
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Basolateral membrane
Basolateral membrane
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Transcytosis
Transcytosis
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Endocytosis
Endocytosis
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Exocytosis
Exocytosis
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Vesicular transport
Vesicular transport
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Keratin
Keratin
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Melanin
Melanin
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Hypodermis
Hypodermis
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Thin Skin vs Thick Skin: Sweat Glands
Thin Skin vs Thick Skin: Sweat Glands
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Thin Skin vs Thick Skin: Sensory Receptors
Thin Skin vs Thick Skin: Sensory Receptors
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Sebaceous Glands: Thick and Thin Skin
Sebaceous Glands: Thick and Thin Skin
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Wound Healing: Basal Cell Migration
Wound Healing: Basal Cell Migration
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Deep Wound Healing: Key Processes
Deep Wound Healing: Key Processes
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Inflammatory Phase
Inflammatory Phase
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Vasodilation and Increased Permeability
Vasodilation and Increased Permeability
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Phagocyte Emigration
Phagocyte Emigration
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Tissue Repair
Tissue Repair
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Phagocytes (Neutrophils & Monocytes)
Phagocytes (Neutrophils & Monocytes)
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Fibroblasts
Fibroblasts
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Migratory Phase
Migratory Phase
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Angiogenesis
Angiogenesis
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Proliferative Phase
Proliferative Phase
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Maturation Phase
Maturation Phase
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Study Notes
Skin (Cutaneous Membrane)
- Skin type, function, wound healing, and epithelial transport are covered in NURS 207(N01)
- Reading material is Tortora, 16th ed., Ch. 5 (October 7, 2024)
Objectives
- Compare the structural and functional differences between thin and thick skin
- List the physiological functions of skin
- Describe how the integumentary system contributes to homeostasis
- Explain how epidermal and deep wounds heal
- Describe epithelial transport mechanisms, including transportation between compartments within the body across a layer of epithelial cells
Review: 5 Layers in a Typical Epidermis
- Stratum corneum: Layers of flattened, dead keratinocytes; absence of nuclei and internal organelles
- Stratum lucidum: Primarily in thick skin (fingertips, palms, soles); flattened keratinocytes undergoing apoptosis
- Stratum granulosum: Flattened keratinocytes undergoing apoptosis
- Stratum spinosum: Cells appear with thorn-like spines
- Stratum basale: Deepest layer of the epidermis
Structural and Functional Differences in Thin and Thick Skin
- Thin skin: Covers most of the body; thickness 0.10–0.15 mm; hairy; fewer sebaceous and sudoriferous glands; fewer sensory receptors
- Thick skin: Found on palms, soles, and fingertips; thickness 0.6–4.5 mm; hairless; fewer sebaceous and sudoriferous glands; more sensory receptors
Functions of Skin (Homeostasis)
- Thermoregulation: Skin regulates body temperature through blood vessel dilation or constriction.
- Body protection: Keratin protects underlying tissues from damage; lamellar granules reduce evaporation and contain bactericidal chemicals; melanin protects from UV damage and intraepidermal macrophages play a role in immune system.
- Cutaneous sensations: Skin provides sensory information (pleasure, pain, texture, etc.)
- Vitamin D production: Skin produces a precursor to vitamin D, which is activated by UV-B light and converted to its active form in the kidneys.
- Excretion: Skin excretes water, salts, ammonia, and urea
- Absorption: Skin absorbs topical steroids
Epidermal Wounds and Deep Wounds Healing
- Epidermal wound healing: Typically involves superficial injury of the epidermal layer; basal cells divide, detach, enlarge and migrate to close the wound.
- Deep wound healing: Trauma extending to the dermis and subcutaneous layer; involves multiple phases:
- Inflammatory phase: Blood clot adheres to wound edges; initiating inflammation to eliminate microbes, foreign substances, and dead tissues. Has three stages: vasodilation and increased permeability; phagocyte emigration; tissue repair
- Migratory phase: Clot becomes a scab; fibroblasts migrate to the injury site; starts producing structural molecules (scar tissue) and collagen fibers; angiogenesis begins.
- Proliferative phase: Extensive growth of epithelial cells beneath the scab; angiogenesis and fibroblast proliferation occur simultaneously; fibroblast proliferation peaks 1-2 weeks and ends at 2-4 weeks post-wounding; fibroblasts form collagen matrix and strengthen the wound.
- Maturation phase: Scab degrades; epidermis thickness returns to normal; collagen fibers become organized; fibroblast population decreases; blood circulation returns to normal
Epithelial Transport
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Epithelium lines cavities, organs, and surface structures.
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Transport involves moving substances across two membranes:
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Apical membrane: Faces the lumen
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Basolateral membrane: Faces the extracellular fluid
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Different transport proteins: allow for directional transport across epithelium.
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Transport from lumen to extracellular fluid (ECF) is absorption; ECF to lumen is secretion.
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Two types of epithelial transport:
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Paracellular: Through junctions between adjacent cells.
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Transcellular: Involves transport through the cell using endocytosis, vesicular transport, cytoplasm, exocytosis through apical and basolateral membranes via carrier proteins.
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Transcytosis: Combination of endocytosis, vesicular transport across the cytoplasmic space, and exocytosis. Allows for transport of macromolecules or large molecules across apical-basolateral membranes.
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