NURS 207 Skin Quiz - Tortora Ch. 5

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Questions and Answers

What is the initial precursor for the synthesis of the biologically inactive form of vitamin D?

  • Cholesterol found in the skin (correct)
  • Keratin produced in the epidermis
  • Melanin produced in the dermis
  • Vitamin D3 from dietary sources

Which phase is NOT part of deep wound healing?

  • Migratory phase
  • Inflammatory phase
  • Proliferative phase
  • Epidermal phase (correct)

What triggers the stop of growth and migration of basal cells during epidermal wound healing?

  • Contact inhibition (correct)
  • Scarring of the dermis
  • Increased oxygen supply
  • Nutrient depletion

What is a characteristic of deep wound healing compared to epidermal wound healing?

<p>It can lead to scar tissue formation (A)</p> Signup and view all the answers

What role do topical steroids play in relation to the skin?

<p>They promote epidermal wound healing (D)</p> Signup and view all the answers

Which statement about skin structure is FALSE?

<p>There are more sudoriferous glands in thick than thin skin (A)</p> Signup and view all the answers

Which of the following is NOT a function of skin?

<p>Production of keratin to protect UV damage (D)</p> Signup and view all the answers

Which process does NOT occur during epidermal wound healing?

<p>Dermal layers contribute to the central portion of the wound (B)</p> Signup and view all the answers

During deep wound healing, which statement is NOT accurate?

<p>Angiogenesis occurs only in the inflammatory phase (B)</p> Signup and view all the answers

Which of the following describes a common misconception about skin?

<p>Sebaceous glands are absent in thick skin (C)</p> Signup and view all the answers

What is the primary function of the tight junctions in epithelial cells?

<p>To limit movement of substances between cells (D)</p> Signup and view all the answers

Which layer of the epidermis contains flattened dead keratinocytes?

<p>Stratum corneum (C)</p> Signup and view all the answers

Which membrane of the transporting epithelial cell faces the extracellular fluid (ECF)?

<p>Basolateral membrane (B)</p> Signup and view all the answers

What is a primary function of the stratum lucidum?

<p>To serve as a barrier in thick skin (A)</p> Signup and view all the answers

Paracellular transport primarily involves movement through which of the following?

<p>Tight junctions between adjacent cells (D)</p> Signup and view all the answers

Which characteristic is true of thick skin compared to thin skin?

<p>Thick skin contains the stratum lucidum. (A)</p> Signup and view all the answers

What term is used to describe the transport of substances from the lumen to the extracellular fluid?

<p>Absorption (C)</p> Signup and view all the answers

How does the skin contribute to thermoregulation?

<p>Through the dilatation or constriction of blood vessels (B)</p> Signup and view all the answers

Which structure in the epithelial cells is specialized for absorption?

<p>Microvilli on the apical membrane (A)</p> Signup and view all the answers

What type of transport involves proteins that direct movement across the epithelium?

<p>Directional transport (A)</p> Signup and view all the answers

Which type of skin is generally hairless?

<p>Thick skin (C)</p> Signup and view all the answers

What is the main role of microvilli on the epithelial cells?

<p>Increasing surface area for absorption (A)</p> Signup and view all the answers

What function does keratin perform in the skin?

<p>It protects underlying tissues. (C)</p> Signup and view all the answers

Which of the following has fewer glandular structures?

<p>Thin skin (B)</p> Signup and view all the answers

Which of the following transport processes is categorized as transcellular absorption?

<p>Transport through transport proteins (B)</p> Signup and view all the answers

What structure in the skin is involved in the immune response?

<p>Intraepidermal macrophages (B)</p> Signup and view all the answers

What is the process by which transcellular transport occurs?

<p>Transcytosis involving endocytosis and exocytosis (C)</p> Signup and view all the answers

During transcytosis, what role do caveolae play?

<p>They concentrate plasma proteins during endocytosis. (D)</p> Signup and view all the answers

Which of the following describes the role of carrier proteins in transcellular transport?

<p>They facilitate movement through cell membranes. (C)</p> Signup and view all the answers

Which mechanism is primarily responsible for the transport of macromolecules across cell membranes?

<p>Transcytosis (B)</p> Signup and view all the answers

What component of the cell is crucial for vesicular transport during transcytosis?

<p>Cytoskeleton (A)</p> Signup and view all the answers

Which fluid is primarily involved in the transcellular transport process in capillaries?

<p>Interstitial fluid (C)</p> Signup and view all the answers

What happens to vesicles after they cross the cell during transcytosis?

<p>They fuse with the plasma membrane and release their contents. (B)</p> Signup and view all the answers

Which membranes are involved in transcellular transport?

<p>Both apical and basolateral membranes (B)</p> Signup and view all the answers

What role do neutrophils and monocytes (macrophages) play in the inflammatory phase of wound healing?

<p>They phagocytize microbes and dead tissues. (A)</p> Signup and view all the answers

What is the primary function of fibroblasts during the migratory phase of deep wound healing?

<p>To lay down collagen fibers and glycoproteins. (A)</p> Signup and view all the answers

Which of the following occurs during the proliferative phase of deep wound healing?

<p>Epithelial cells grow extensively beneath the scab. (A)</p> Signup and view all the answers

What marks the onset of the maturation phase in wound healing?

<p>Degradation of the scab. (A)</p> Signup and view all the answers

Which statement about epithelial transport is correct?

<p>It involves moving substances across the apical and basolateral membranes. (D)</p> Signup and view all the answers

What is the typical time frame for fibroblast proliferation to peak after a wound occurs?

<p>1 to 2 weeks (B)</p> Signup and view all the answers

Which of the following defines the apical membrane in epithelial tissue?

<p>Surface that faces the lumen of an organ. (A)</p> Signup and view all the answers

During which phase of wound healing does angiogenesis primarily occur?

<p>Migratory phase (D)</p> Signup and view all the answers

What typically corresponds with the healing of the epidermis during the maturation phase?

<p>Decreased fibroblast activity (D)</p> Signup and view all the answers

What is a characteristic of the inflammatory phase of wound healing?

<p>It includes steps like vasodilation and phagocyte emigration. (B)</p> Signup and view all the answers

Flashcards

Vitamin D Precursor

A precursor molecule needed to make inactive vitamin D, found in the skin.

Vitamin D Activation

The biologically inactive form of vitamin D is converted into the active form in the kidneys.

Epidermal Wound Healing

A type of wound healing that affects only the outer layer of skin (epidermis).

Basal Cell Migration

During epidermal wound healing, basal cells surrounding the wound detach from the basal membrane and migrate towards each other. This process stops when they meet.

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Deep Wound Healing

A type of wound healing that involves deeper layers of skin (dermis and subcutaneous tissue), potentially leading to scar formation.

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Thin Skin

A type of skin found in most parts of the body, characterized by a thinner epidermis and the presence of hair and sebaceous glands.

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Thick Skin

A type of skin found in areas like palms, soles, and fingertips. Its thicker epidermis lacks hair and sebaceous glands, but has a prominent stratum lucidum.

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Homeostasis

The process of maintaining a stable internal environment within the body, which is influenced by the skin's role in regulating body temperature, protecting from injury, and preventing fluid loss.

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Stratum Corneum

The outermost layer of the epidermis that consists of flattened, dead keratinocytes.

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Stratum Lucidum

A layer in the epidermis that is thicker in thick skin and helps protect against abrasion.

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Apoptosis

The process by which epidermal cells die and become flattened keratinocytes.

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Stratum Granulosum

The layer of epidermis where cells are undergoing apoptosis, containing keratinocytes that are flattened with granular appearance.

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Stratum Basale

The layer of epidermis where cells divide and migrate upwards, containing cells that are more actively involved in creating new skin cells.

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Paracellular transport

A type of transport across epithelial cells that occurs through the spaces between adjacent cells.

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Absorption

The process of moving substances from the lumen of an organ, like the gut or kidney, to the extracellular fluid.

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Transcellular transport

A type of transport across epithelial cells that occurs through the cells themselves.

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Secretion

The process of moving substances from the extracellular fluid to the lumen of an organ, like the gut or kidney.

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Tight junctions

Junctions between epithelial cells that regulate the movement of substances between the cells.

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Transport proteins

Proteins embedded in cell membranes that help transport substances across the membrane.

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Apical membrane

The side of an epithelial cell that faces the lumen of an organ.

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Basolateral membrane

The side of an epithelial cell that faces the extracellular fluid.

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Transcytosis

A type of transcellular transport where substances are enclosed in vesicles and move across the cell.

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Endocytosis

A process where cells take in substances by engulfing them in membrane-bound sacs called vesicles

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Exocytosis

The release of substances from a cell by fusion of vesicles with the plasma membrane.

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Vesicular transport

The movement of vesicles within the cytoplasm of a cell.

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Keratin

The protein that forms the structural framework of skin, hair, and nails.

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Melanin

A pigment that gives skin its color and protects it from UV radiation.

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Hypodermis

A layer of skin that contains fat cells and helps insulate the body.

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Thin Skin vs Thick Skin: Sweat Glands

Sweat glands are more abundant in areas covered by thin skin, contributing to its greater cooling capacity.

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Thin Skin vs Thick Skin: Sensory Receptors

Sensory receptors are concentrated in thick skin, enabling greater tactile sensitivity in areas like fingertips and soles.

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Sebaceous Glands: Thick and Thin Skin

Sebaceous glands, which produce oil, are present in both thick and thin skin, contributing to lubrication and protection.

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Wound Healing: Basal Cell Migration

The process of wound healing starts when basal cells break contact with the basement membrane and migrate towards each other to close the wound.

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Deep Wound Healing: Key Processes

Inflammatory response, vasodilation, and angiogenesis are crucial steps in deep wound healing, involving different phases of the process.

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Inflammatory Phase

The first phase of wound healing characterized by inflammation, a non-specific defensive response to tissue damage.

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Vasodilation and Increased Permeability

The stage in which blood vessels dilate and become more permeable, allowing immune cells and fluids to reach the injured area.

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Phagocyte Emigration

The process where white blood cells, like neutrophils and monocytes, leave the bloodstream and enter the tissue to engulf and destroy harmful microbes, foreign substances, and dead cells.

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Tissue Repair

The final stage of the inflammatory phase where tissues are repaired and the wound is prepared for healing.

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Phagocytes (Neutrophils & Monocytes)

Specialized cells that eliminate debris and microbes from the wound.

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Fibroblasts

Cells that produce collagen and extracellular matrix, forming the foundation for new tissue growth.

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Migratory Phase

The second stage of wound healing where a clot forms a scab, covering the wound and fibroblasts migrate to the injury site.

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Angiogenesis

The process of new blood vessel formation, crucial for delivering nutrients and oxygen to the healing area.

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Proliferative Phase

The third phase of wound healing where the wound starts to fill in with new tissue and the epithelium regenerates beneath the scab.

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Maturation Phase

The final stage of wound healing where the scab detaches, the epidermis (outer layer of skin) is restored to its normal thickness, and collagen fibers become organized, resulting in scar tissue formation.

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Study Notes

Skin (Cutaneous Membrane)

  • Skin type, function, wound healing, and epithelial transport are covered in NURS 207(N01)
  • Reading material is Tortora, 16th ed., Ch. 5 (October 7, 2024)

Objectives

  • Compare the structural and functional differences between thin and thick skin
  • List the physiological functions of skin
  • Describe how the integumentary system contributes to homeostasis
  • Explain how epidermal and deep wounds heal
  • Describe epithelial transport mechanisms, including transportation between compartments within the body across a layer of epithelial cells

Review: 5 Layers in a Typical Epidermis

  • Stratum corneum: Layers of flattened, dead keratinocytes; absence of nuclei and internal organelles
  • Stratum lucidum: Primarily in thick skin (fingertips, palms, soles); flattened keratinocytes undergoing apoptosis
  • Stratum granulosum: Flattened keratinocytes undergoing apoptosis
  • Stratum spinosum: Cells appear with thorn-like spines
  • Stratum basale: Deepest layer of the epidermis

Structural and Functional Differences in Thin and Thick Skin

  • Thin skin: Covers most of the body; thickness 0.10–0.15 mm; hairy; fewer sebaceous and sudoriferous glands; fewer sensory receptors
  • Thick skin: Found on palms, soles, and fingertips; thickness 0.6–4.5 mm; hairless; fewer sebaceous and sudoriferous glands; more sensory receptors

Functions of Skin (Homeostasis)

  • Thermoregulation: Skin regulates body temperature through blood vessel dilation or constriction.
  • Body protection: Keratin protects underlying tissues from damage; lamellar granules reduce evaporation and contain bactericidal chemicals; melanin protects from UV damage and intraepidermal macrophages play a role in immune system.
  • Cutaneous sensations: Skin provides sensory information (pleasure, pain, texture, etc.)
  • Vitamin D production: Skin produces a precursor to vitamin D, which is activated by UV-B light and converted to its active form in the kidneys.
  • Excretion: Skin excretes water, salts, ammonia, and urea
  • Absorption: Skin absorbs topical steroids

Epidermal Wounds and Deep Wounds Healing

  • Epidermal wound healing: Typically involves superficial injury of the epidermal layer; basal cells divide, detach, enlarge and migrate to close the wound.
  • Deep wound healing: Trauma extending to the dermis and subcutaneous layer; involves multiple phases:
  • Inflammatory phase: Blood clot adheres to wound edges; initiating inflammation to eliminate microbes, foreign substances, and dead tissues. Has three stages: vasodilation and increased permeability; phagocyte emigration; tissue repair
  • Migratory phase: Clot becomes a scab; fibroblasts migrate to the injury site; starts producing structural molecules (scar tissue) and collagen fibers; angiogenesis begins.
  • Proliferative phase: Extensive growth of epithelial cells beneath the scab; angiogenesis and fibroblast proliferation occur simultaneously; fibroblast proliferation peaks 1-2 weeks and ends at 2-4 weeks post-wounding; fibroblasts form collagen matrix and strengthen the wound.
  • Maturation phase: Scab degrades; epidermis thickness returns to normal; collagen fibers become organized; fibroblast population decreases; blood circulation returns to normal

Epithelial Transport

  • Epithelium lines cavities, organs, and surface structures.

  • Transport involves moving substances across two membranes:

  • Apical membrane: Faces the lumen

  • Basolateral membrane: Faces the extracellular fluid

  • Different transport proteins: allow for directional transport across epithelium.

  • Transport from lumen to extracellular fluid (ECF) is absorption; ECF to lumen is secretion.

  • Two types of epithelial transport:

  • Paracellular: Through junctions between adjacent cells.

  • Transcellular: Involves transport through the cell using endocytosis, vesicular transport, cytoplasm, exocytosis through apical and basolateral membranes via carrier proteins.

  • Transcytosis: Combination of endocytosis, vesicular transport across the cytoplasmic space, and exocytosis. Allows for transport of macromolecules or large molecules across apical-basolateral membranes.

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