Podcast
Questions and Answers
What is a benefit of combining Trimethoprim and Sulfamethoxazole?
What is a benefit of combining Trimethoprim and Sulfamethoxazole?
- Synergistic effect, causing bacterial resistance to develop more slowly (correct)
- Reduced effectiveness against MRSA
- Increased risk of bacterial resistance
- Increased risk of Stevens-Johnson syndrome
What is a common side effect of Sulfonamides?
What is a common side effect of Sulfonamides?
- Anemia
- Tachycardia
- Hypertension
- GI distress (correct)
Why is it important to increase fluid intake when taking Sulfonamides?
Why is it important to increase fluid intake when taking Sulfonamides?
- To reduce the risk of Stevens-Johnson syndrome
- To reduce the risk of hypoglycemia
- To reduce the risk of crystalluria (correct)
- To increase the absorption of the medication
What is a contraindication for Sulfonamides?
What is a contraindication for Sulfonamides?
What laboratory test should be monitored when taking Sulfonamides?
What laboratory test should be monitored when taking Sulfonamides?
What is a potential interaction between Sulfonamides and another medication?
What is a potential interaction between Sulfonamides and another medication?
What is an important nursing intervention when administering Sulfonamides?
What is an important nursing intervention when administering Sulfonamides?
What is a caution when using Sulfonamides in older adults?
What is a caution when using Sulfonamides in older adults?
What is an assessment that should be performed when administering Sulfonamides?
What is an assessment that should be performed when administering Sulfonamides?
What is an alternative therapy for patients allergic to penicillin?
What is an alternative therapy for patients allergic to penicillin?
What should the patient be taught to do when taking sulfamethoxazole?
What should the patient be taught to do when taking sulfamethoxazole?
Why is it important to monitor a patient's renal function when taking sulfamethoxazole?
Why is it important to monitor a patient's renal function when taking sulfamethoxazole?
What is a common adverse reaction to sulfonamides?
What is a common adverse reaction to sulfonamides?
What is silver sulfadiazine used to treat?
What is silver sulfadiazine used to treat?
Why should a patient taking sulfamethoxazole avoid taking antacids?
Why should a patient taking sulfamethoxazole avoid taking antacids?
What should the patient be taught to report to the healthcare provider?
What should the patient be taught to report to the healthcare provider?
Why should a patient taking sulfamethoxazole wear sunglasses and sunblock?
Why should a patient taking sulfamethoxazole wear sunglasses and sunblock?
What is an important consideration when administering sulfamethoxazole to a pregnant patient?
What is an important consideration when administering sulfamethoxazole to a pregnant patient?
What is a unique characteristic of sulfonamides?
What is a unique characteristic of sulfonamides?
Why should a patient taking sulfamethoxazole increase fluid intake?
Why should a patient taking sulfamethoxazole increase fluid intake?
Why should dairy products or antacids not be taken at the same time as sulfonamides?
Why should dairy products or antacids not be taken at the same time as sulfonamides?
What type of effect results from taking co-trimoxazole/TMP-SMZ (Bactrim)?
What type of effect results from taking co-trimoxazole/TMP-SMZ (Bactrim)?
What is true about sulfonamide therapy?
What is true about sulfonamide therapy?
What happens when sulfonamides are used with sulfonylureas?
What happens when sulfonamides are used with sulfonylureas?
What happens when sulfonamides are used with warfarin?
What happens when sulfonamides are used with warfarin?
Why should antacids not be taken with sulfonamides?
Why should antacids not be taken with sulfonamides?
What is a complication of sulfonamide therapy?
What is a complication of sulfonamide therapy?
What should patients on sulfonamide therapy do to prevent complications?
What should patients on sulfonamide therapy do to prevent complications?
What is the effect of sulfonamides on the body?
What is the effect of sulfonamides on the body?
What is a benefit of taking co-trimoxazole/TMP-SMZ (Bactrim)?
What is a benefit of taking co-trimoxazole/TMP-SMZ (Bactrim)?
Study Notes
Uses of Sulfonamides
- Used in synergistic effect to delay bacterial resistance
- Used to treat urinary infections and MRSA
- Alternative therapy for patients allergic to penicillin
Routes of Administration
- Oral
- IV
- Topical
- Ophthalmic
Side Effects/Adverse Reactions
- GI distress
- Stomatitis
- Photosensitivity
- Hypoglycemia
- Blood dyscrasias (RBC's, WBC's, platelets)
- Crystalluria leading to renal failure
- Stevens-Johnson syndrome
Contraindications
- Renal or liver disease
- Anemia
- Caution in older adults and diabetes
Interactions
- Increases bleeding with warfarin
- Increases effect of hypoglycemics
- Increases digoxin level
Assessment
- Vital signs
- Renal function (urine output/labs)
- Medical history/medication history
- Allergies
- CBC (baseline)
Nursing Interventions
- Obtain C&S
- Administer with full glass of water
- Increase fluid intake to at least 2000 mL/day
- Monitor I&O, VS, and CBC
- Monitor for bleeding, CBC, and renal function
- Monitor for rash and superinfection
- Avoid during third trimester
- Best given on an empty stomach
Teaching
- Increase fluids to several quarts a day
- Do not take antacids with medication
- Warn patient if allergic to other sulfa drugs
- Teach to minimize side effects
- Teach to report adverse reactions (bruising or bleeding)
- Wear sunglasses and sunblock when outdoors
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Description
This quiz covers the uses of sulfonamides, including their synergistic effect with trimethoprim, and their application in treating urinary infections and MRSA. It's an alternative therapy for patients allergic to penicillin.
