50 Questions
Which molecule is the major energy source in cells?
ATP
Which enzyme is required for the de novo synthesis of nucleotides?
PRPP synthetase
Which molecule is the precursor for the synthesis of pyrimidine nucleotides?
dUMP
Which enzyme converts UMP to UDP and then UTP?
UTPase
Which enzyme is involved in the de novo synthesis of purine nucleotides?
PRPP synthetase
Which enzyme is negatively regulated by feedback inhibition from AMP and GMP?
CPS II
How do we convert RNA nucleotides to DNA nucleotides?
Convert ribose to deoxyribose
Which of the following is classified as a purine nucleobase commonly found in DNA and RNA?
Adenosine
Which of the following is classified as a pyrimidine nucleobase commonly found in DNA and RNA?
Cytidine
What is the difference between a nucleoside and a nucleotide?
A nucleoside contains a sugar and a base, while a nucleotide contains a sugar, a base, and a phosphate group.
Which of the following is an example of a deoxyribonucleoside?
Thymidine
What is the role of the enzyme Ribonucleotide Reductase?
It is involved in the synthesis of purines and pyrimidines.
Which of the following is true about the salvage pathway for purines?
It is an alternative pathway for the synthesis of purines.
What are the building blocks of DNA and RNA?
Nucleotides
During purine degradation, what is the end product?
Uric Acid
What is the starting material for purine degradation?
Adenine
What are the important enzymes involved in purine degradation?
Xanthine oxidase and adenosine deaminase
What are the steps involved in pyrimidine synthesis?
Ring closure, deamination, and phosphorylation
What is the end product of pyrimidine degradation?
Orotic Acid
What is the starting material for pyrimidine degradation?
Uracil
What are the important enzymes involved in pyrimidine synthesis?
Thymidylate synthase and dihydrofolate reductase
What is ribonucleotide reductase and what role does it play in nucleotide synthesis?
It converts ribonucleotides to deoxyribonucleotides
What are the rate limiting steps in purine synthesis?
Conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP)
Which pyrimidine is found in RNA only?
Uracil
Which of the following pairs are both pyrimidines?
Cytosine and Uracil
Which of the following is a purine base?
Adenosine
What are nucleotides made of?
Nitrogen Bases + Pentose Sugar + Phosphate
Which of the following is not a precursor for de novo purine biosynthesis?
Arginine
What is an activator of the enzyme 'Glutamine: Phosphoribosylpyrophosphate amidotransferase' (GPAT)?
Inosine Monophosphate
Are all deoxyribonucleotides synthesized from ribonucleotides?
False
Which pyrimidine is found in RNA only?
Uracil
Which of the following pairs are both pyrimidines?
Cytosine and Uracil
Which of the following is a purine base?
Adenosine
What are nucleotides made of?
Nitrogen Bases + Pentose Sugar + Phosphate
Which of the following is not the precursor for de novo purine biosynthesis?
Arginine
What is an activator of the enzyme 'Glutamine: Phosphoribosylpyrophosphate amidotransferase' (GPAT)?
Phosphoribosyl Pyrophosphate
All deoxyribonucleotides are synthesized from the ribonucleotides.
False
Which of the following is not the precursor for de novo purine biosynthesis?
Arginine
Which of the following is not the precursor for de novo purine biosynthesis?
Arginine
Which of the following is not the precursor for de novo purine biosynthesis?
Arginine
Which of the following is NOT a precursor of a purine ring?
Lysine
What is the final product of purine degradation in mammals?
Uric Acid
A 42-year-old male patient undergoing radiation therapy for prostate cancer develops severe pain in the metatarsal phalangeal joint of his right big toe. Monosodium urate crystals are detected by polarized light microscopy in fluid obtained from this joint by arthrocentesis. This patient’s pain is directly caused by the overproduction of the end product of which of the following metabolic pathways?
Purine salvage
What is the catabolic end product of pyrimidine nucleotides?
Both NH3 and CO2
Which of the following is NOT a precursor for de novo purine biosynthesis?
Lysine
Which molecule is the major energy source in cells?
ATP
Which pyrimidine is found in RNA only?
Uracil
What are nucleotides made of?
Nitrogenous bases
Which enzyme is required for the de novo synthesis of nucleotides?
Thymidylate synthase
Which enzyme converts UMP to UDP and then UTP?
Uridine diphosphate kinase
Test your knowledge on nucleotide synthesis and the role of enzymes involved in the process. Explore topics like purine degradation, HGPRT, Lesch-Nyhan syndrome, pyrimidine nucleotide synthesis, CTP synthetase, and deoxynucleotide synthesis.
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