Nuclear Receptor Coactivators and Corepressors Quiz
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Questions and Answers

What is the function of Tamoxifen in breast cancer cells?

  • Activating coactivators to promote growth
  • Binding with estrogen to inhibit tumor growth
  • Maintaining bone density
  • Preventing the interaction with corepressors (correct)

    • What determines whether Tamoxifen binds with corepressors or coactivators in breast cancer cells?

  • The amount of coactivators or corepressors present in the cell (correct)
  • The activity of the tumor growth
  • The conformation of the ligand binding domain
  • The level of estrogen in the cell

    • What happens in breast tumor cells when more co-repressors are expressed?

  • Maintenance of bone density
  • Activation of coactivators for tumor growth
  • Promotion of active tumor growth
  • Inhibition of transcription and cell death (correct)

    • In which type of cells does the conformation of the ligand binding domain favor interaction with coactivators or corepressors?

    <p>Breast tumor cells</p> Signup and view all the answers

    What is the function of the co-repressor in the absence of ligand?

    <p>It represses transcription</p> Signup and view all the answers

    What is the conserved motif found in co-repressors such as NCoR?

    <p>(L/I)XX(I/V)I</p> Signup and view all the answers

    What happens to RXR NRs when a ligand binds?

    <p>They undergo a conformational shift that promotes co-activator binding</p> Signup and view all the answers

    What is the function of CBP/p300 in the context of transcription regulation?

    <p>They acetylate histones</p> Signup and view all the answers

    What does the LBD (Ligand Binding Domain) have when not bound to a ligand?

    <p>Conformations bound to coactivator and corepressor</p> Signup and view all the answers

    What is the purpose of the System Bias assay?

    <p>To reflect the selectivity of TR:GRIP1 interactions</p> Signup and view all the answers

    What does the crystal structure of a receptor LBD indicate about different members of the nuclear receptor superfamily?

    <p>They share rather similar overall structures</p> Signup and view all the answers

    What does Coactivator SRC-1 bind to in relation to the TRb LBD?

    <p>Receptor and Histone acetylase CBP</p> Signup and view all the answers

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