Questions and Answers
What is the function of Tamoxifen in breast cancer cells?
Preventing the interaction with corepressors
What determines whether Tamoxifen binds with corepressors or coactivators in breast cancer cells?
The amount of coactivators or corepressors present in the cell
What happens in breast tumor cells when more co-repressors are expressed?
Inhibition of transcription and cell death
In which type of cells does the conformation of the ligand binding domain favor interaction with coactivators or corepressors?
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What is the function of the co-repressor in the absence of ligand?
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What is the conserved motif found in co-repressors such as NCoR?
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What happens to RXR NRs when a ligand binds?
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What is the function of CBP/p300 in the context of transcription regulation?
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What does the LBD (Ligand Binding Domain) have when not bound to a ligand?
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What is the purpose of the System Bias assay?
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What does the crystal structure of a receptor LBD indicate about different members of the nuclear receptor superfamily?
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What does Coactivator SRC-1 bind to in relation to the TRb LBD?
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