Nuclear Hormone Receptors and Cancer Therapy
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Questions and Answers

What is the main function of Nuclear Hormone Receptors (NHRs)?

  • Protein synthesis
  • Metabolic activation
  • Signal transduction
  • Transcriptional regulation (correct)

    • Which type of cancer involves the molecular basis of glucocorticoids' therapy?

  • Prostate cancer
  • Leukemia (correct)
  • Breast cancer
  • Lung cancer

    • What is the main functional domain of the Estrogen Receptor (ER)?

  • Hormone Binding Domain (HBD)
  • Nuclear Translocation Domain (NTD)
  • Ligand Activation Domain (LAD)
  • DNA-binding domain (DBD) (correct)

    • Which of the following is NOT a therapeutic approach used to treat different stages of prostate cancer?

    <p>Hormone replacement therapy</p> Signup and view all the answers

    What is the molecular mechanism of action of SERMs in breast cancer treatment?

    <p>Modulating estrogen receptor activity</p> Signup and view all the answers

    Which hormone is associated with the molecular basis of androgens function?

    <p>Testosterone</p> Signup and view all the answers

    What are Steroid Response Elements (SRE) involved in?

    <p>Regulation of gene expression</p> Signup and view all the answers

    Which type of cancer involves the molecular basis of estrogens function?

    <p>Breast cancer</p> Signup and view all the answers

    (Patho)physiology, pharmacology, research evidence, and clinical expertise are integrated as part of clinical decision-making and problem solving for which learning objective?

    <p>Integrate knowledge of (patho)physiology and pharmacology, high quality research evidence, clinical expertise and patient values as part of clinical decision-making and problem solving</p> Signup and view all the answers

    What is the most common form of joint disease?

    <p>Osteoarthritis</p> Signup and view all the answers

    Which type of cells are associated with insulin and glucagon production?

    <p>Pancreatic cells</p> Signup and view all the answers

    What is the key biological drug target associated with bone and joint disease?

    <p>Synovium</p> Signup and view all the answers

    Which hormone is known as the 'FUEL STORAGE HORMONE'?

    <p>Insulin</p> Signup and view all the answers

    Which joint disease results in structural and functional failure of synovial joints?

    <p>Osteoarthritis</p> Signup and view all the answers

    What is the prevalence of osteoarthritis among the elderly?

    <p>Common</p> Signup and view all the answers

    Which of the following is a symptom of osteoarthritis?

    <p>Stiffness following rest</p> Signup and view all the answers

    What is the main cause of gout?

    <p>Elevated levels of uric acid in blood</p> Signup and view all the answers

    Which factor is NOT associated with an increased risk of osteoarthritis?

    <p>Younger age</p> Signup and view all the answers

    What is the most common age of onset for gout in men?

    <p>40-50 years</p> Signup and view all the answers

    Which treatment is NOT recommended for osteoarthritis?

    <p>Acupuncture as a primary treatment</p> Signup and view all the answers

    What are the common symptoms of osteoarthritis?

    <p>Swelling and stiffness after rest</p> Signup and view all the answers

    What is the prevalence of gout in adult male Maori's?

    <p>10%</p> Signup and view all the answers

    Which gene is associated with gout according to the text?

    <p>ABCG2</p> Signup and view all the answers

    What is the primary treatment recommendation for gout?

    <p>Topical NSAIDs</p> Signup and view all the answers

    What is one of the non-pharmacological treatment recommendations for osteoarthritis?

    <p>Therapeutic exercise</p> Signup and view all the answers

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