Nuclear Hormone Receptors and Cancer Therapy
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Questions and Answers

What is the main function of Nuclear Hormone Receptors (NHRs)?

  • Protein synthesis
  • Metabolic activation
  • Signal transduction
  • Transcriptional regulation (correct)

Which type of cancer involves the molecular basis of glucocorticoids' therapy?

  • Prostate cancer
  • Leukemia (correct)
  • Breast cancer
  • Lung cancer

What is the main functional domain of the Estrogen Receptor (ER)?

  • Hormone Binding Domain (HBD)
  • Nuclear Translocation Domain (NTD)
  • Ligand Activation Domain (LAD)
  • DNA-binding domain (DBD) (correct)

Which of the following is NOT a therapeutic approach used to treat different stages of prostate cancer?

<p>Hormone replacement therapy (C)</p> Signup and view all the answers

What is the molecular mechanism of action of SERMs in breast cancer treatment?

<p>Modulating estrogen receptor activity (C)</p> Signup and view all the answers

Which hormone is associated with the molecular basis of androgens function?

<p>Testosterone (A)</p> Signup and view all the answers

What are Steroid Response Elements (SRE) involved in?

<p>Regulation of gene expression (A)</p> Signup and view all the answers

Which type of cancer involves the molecular basis of estrogens function?

<p>Breast cancer (B)</p> Signup and view all the answers

(Patho)physiology, pharmacology, research evidence, and clinical expertise are integrated as part of clinical decision-making and problem solving for which learning objective?

<p>Integrate knowledge of (patho)physiology and pharmacology, high quality research evidence, clinical expertise and patient values as part of clinical decision-making and problem solving (C)</p> Signup and view all the answers

What is the most common form of joint disease?

<p>Osteoarthritis (C)</p> Signup and view all the answers

Which type of cells are associated with insulin and glucagon production?

<p>Pancreatic cells (B)</p> Signup and view all the answers

What is the key biological drug target associated with bone and joint disease?

<p>Synovium (C)</p> Signup and view all the answers

Which hormone is known as the 'FUEL STORAGE HORMONE'?

<p>Insulin (A)</p> Signup and view all the answers

Which joint disease results in structural and functional failure of synovial joints?

<p>Osteoarthritis (A)</p> Signup and view all the answers

What is the prevalence of osteoarthritis among the elderly?

<p>Common (A)</p> Signup and view all the answers

Which of the following is a symptom of osteoarthritis?

<p>Stiffness following rest (C)</p> Signup and view all the answers

What is the main cause of gout?

<p>Elevated levels of uric acid in blood (D)</p> Signup and view all the answers

Which factor is NOT associated with an increased risk of osteoarthritis?

<p>Younger age (B)</p> Signup and view all the answers

What is the most common age of onset for gout in men?

<p>40-50 years (C)</p> Signup and view all the answers

Which treatment is NOT recommended for osteoarthritis?

<p>Acupuncture as a primary treatment (A)</p> Signup and view all the answers

What are the common symptoms of osteoarthritis?

<p>Swelling and stiffness after rest (A)</p> Signup and view all the answers

What is the prevalence of gout in adult male Maori's?

<p>10% (A)</p> Signup and view all the answers

Which gene is associated with gout according to the text?

<p>ABCG2 (D)</p> Signup and view all the answers

What is the primary treatment recommendation for gout?

<p>Topical NSAIDs (C)</p> Signup and view all the answers

What is one of the non-pharmacological treatment recommendations for osteoarthritis?

<p>Therapeutic exercise (D)</p> Signup and view all the answers

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