25 Questions
What is the main function of Nuclear Hormone Receptors (NHRs)?
Transcriptional regulation
Which type of cancer involves the molecular basis of glucocorticoids' therapy?
Leukemia
What is the main functional domain of the Estrogen Receptor (ER)?
DNA-binding domain (DBD)
Which of the following is NOT a therapeutic approach used to treat different stages of prostate cancer?
Hormone replacement therapy
What is the molecular mechanism of action of SERMs in breast cancer treatment?
Modulating estrogen receptor activity
Which hormone is associated with the molecular basis of androgens function?
Testosterone
What are Steroid Response Elements (SRE) involved in?
Regulation of gene expression
Which type of cancer involves the molecular basis of estrogens function?
Breast cancer
(Patho)physiology, pharmacology, research evidence, and clinical expertise are integrated as part of clinical decision-making and problem solving for which learning objective?
Integrate knowledge of (patho)physiology and pharmacology, high quality research evidence, clinical expertise and patient values as part of clinical decision-making and problem solving
What is the most common form of joint disease?
Osteoarthritis
Which type of cells are associated with insulin and glucagon production?
Pancreatic cells
What is the key biological drug target associated with bone and joint disease?
Synovium
Which hormone is known as the 'FUEL STORAGE HORMONE'?
Insulin
Which joint disease results in structural and functional failure of synovial joints?
Osteoarthritis
What is the prevalence of osteoarthritis among the elderly?
Common
Which of the following is a symptom of osteoarthritis?
Stiffness following rest
What is the main cause of gout?
Elevated levels of uric acid in blood
Which factor is NOT associated with an increased risk of osteoarthritis?
Younger age
What is the most common age of onset for gout in men?
40-50 years
Which treatment is NOT recommended for osteoarthritis?
Acupuncture as a primary treatment
What are the common symptoms of osteoarthritis?
Swelling and stiffness after rest
What is the prevalence of gout in adult male Maori's?
10%
Which gene is associated with gout according to the text?
ABCG2
What is the primary treatment recommendation for gout?
Topical NSAIDs
What is one of the non-pharmacological treatment recommendations for osteoarthritis?
Therapeutic exercise
Explore the role of nuclear hormone receptors as therapeutic targets for hormone regulated cancers such as leukemia, breast cancer, and prostate cancer. Learn about the molecular basis of glucocorticoids therapy for leukemia and the significance of estrogen receptor in breast cancer.
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