Chapter 44 and 10 Pharm

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Questions and Answers

Which NSAID should be avoided by patients with a Sulpha allergy?

  • Celecoxib (correct)
  • Diclofenac sodium
  • Ibuprofen
  • Nabumetone

Which medication is specifically mentioned for arthritis and is available over the counter as a topical cream?

  • Ibuprofen
  • Colchicine
  • Diclofenac sodium (correct)
  • Acetaminophen

Which medication is used for gout and works by inhibiting the reabsorption of uric acid in the kidney?

  • Ibuprofen
  • Colchicine
  • Probenecid (correct)
  • Allopurinol

What is a common adverse effect of antigout medications mentioned in the text?

<p>Diarrhea (C)</p> Signup and view all the answers

What should patients taking NSAIDs or antigout medications do if they experience ringing in the ears, persistent GI pain, or easy bruising/bleeding?

<p>Immediately tell their doctor (D)</p> Signup and view all the answers

What is one condition a patient may have that would cause us to use caution giving an opioid?

<p>Elevated intracranial pressure (C)</p> Signup and view all the answers

Which medication can be an alternative for individuals who cannot take aspirin?

<p>Acetaminophen (C)</p> Signup and view all the answers

What is the recommended action regarding NSAIDs prior to any procedures?

<p>Discontinue NSAIDs 1 week prior to procedures (D)</p> Signup and view all the answers

Which of the following is a potential consequence of Colchicine use?

<p>Low white blood cell count (A)</p> Signup and view all the answers

What is a contraindication for the use of Acetaminophen?

<p>Liver dysfunction (C)</p> Signup and view all the answers

What are the main adverse effects of Opioid medications mentioned in the text?

<p>CNS depression, respiratory depression, and severe constipation (B)</p> Signup and view all the answers

Which medication is stated as the antidote to Opioid overdose in the text?

<p>Naloxone Naproxen (A)</p> Signup and view all the answers

What is one of the symptoms a patient may experience during opioid withdrawal according to the text?

<p>Chills/hot flashes and joint pain (B)</p> Signup and view all the answers

Which medication should be avoided in children with flu-like symptoms due to the risk of Reye’s syndrome?

<p>Aspirin (A)</p> Signup and view all the answers

What is the prophylactic usage of Aspirin primarily indicated for?

<p>Cardiovascular protection (A)</p> Signup and view all the answers

Which medication is an antigout medication that prevents uric acid production?

<p>Allopurinol (C)</p> Signup and view all the answers

What is the best course of action for patients experiencing persistent GI upset when taking NSAIDs?

<p>Take the NSAIDs with food, milk, or antacids (B)</p> Signup and view all the answers

What is a potential consequence of consuming aspirin for a patient with a viral illness such as the flu?

<p>Development of neurologic deficits (A)</p> Signup and view all the answers

Which medication can be used prophylactically for acute gout?

<p>Colchicine (C)</p> Signup and view all the answers

Why is it important to avoid giving opioids to patients with severe asthma?

<p>Opioids may exacerbate respiratory depression (D)</p> Signup and view all the answers

What can be a potential fatal skin condition associated with Allopurinol/Zyloprim use?

<p>Exfoliative dermatitis (D)</p> Signup and view all the answers

Which NSAID is highlighted as being better tolerated on the gastrointestinal (GI) system compared to others?

<p>Nabumetone (B)</p> Signup and view all the answers

What effect does Aspirin have concerning the risk of death after a Myocardial Infarction (MI)?

<p>Decreases (C)</p> Signup and view all the answers

In which situation should caution be exercised when administering opioids?

<p>When the patient is morbidly obese (B)</p> Signup and view all the answers

What is the maximum daily dose of Acetaminophen recommended for an older adult or a patient with liver disease?

<p>2 grams per day (B)</p> Signup and view all the answers

Which medication is most suitable for inflammation like a sprained ankle according to the text?

<p>Ibuprofen (D)</p> Signup and view all the answers

What should be the immediate action if a patient experiences respiratory depression due to opioids?

<p>Give an opioid antagonist (D)</p> Signup and view all the answers

What is a key difference between NSAIDs and Acetaminophen based on the information provided?

<p>While both are antipyretic, Acetaminophen is first line. (D)</p> Signup and view all the answers

What is a secondary use of opioids mentioned in the text besides pain relief?

<p>Management of cough (B)</p> Signup and view all the answers

Why is it essential for patients to be educated not to crush or chew medications based on the information provided?

<p>Crushing or chewing medications can alter their effectiveness. (C)</p> Signup and view all the answers

NSAIDs are most used for Analgesic, Anti-inflammatory, Antipyretic, Aspirin-Platelet inhibition

<p>True (A)</p> Signup and view all the answers

Full therapeutic effect of NSAIDs may take _______ or longer.

<p>1 week (A)</p> Signup and view all the answers

The maximum daily dose of Acetaminophen for a healthy adult is _____ grams per day.

<p>3 (D)</p> Signup and view all the answers

Opioids are most often used to alleviate _______ pain.

<p>Moderate to severe (C)</p> Signup and view all the answers

Physiologic adaptation of the body to the presence of an opioid.

<p>Physical dependence (A)</p> Signup and view all the answers

Opioid tolerance and physical dependence are expected with long-term opioid treatment.

<p>True (A)</p> Signup and view all the answers

Physical dependance and opioid tolerance are the same as psychologic dependence

<p>False (B)</p> Signup and view all the answers

A pattern of compulsive drug use characterized by a continued craving for an opioid and the need to use the opioid for effects other than pain relief.

<p>Psychologic Dependence (B)</p> Signup and view all the answers

When you mix codeine sulfate with acetaminophen you now have a class ____ medication.

<p>III (C)</p> Signup and view all the answers

We would use caution giving a schedule III opioid medication to a patient with

<p>Respiratory depression (A)</p> Signup and view all the answers

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Study Notes

NSAIDs and Allergies

  • Patients with a sulfa allergy should avoid the NSAID Sulfasalazine.

Arthritis Treatments

  • Topical NSAID available over the counter for arthritis: Diclofenac gel.

Gout Management

  • Medication for gout that inhibits uric acid reabsorption: Probenecid.
  • Common adverse effect of antigout medications: Diarrhea.

Side Effects Monitoring

  • Patients taking NSAIDs or antigout medications should report symptoms like ringing in the ears, persistent GI pain, or easy bruising/bleeding.

Opioid Considerations

  • Caution is advised when giving opioids to patients with a history of substance use disorder.
  • Aspirin can be substituted for individuals with aspirin intolerance.

Pre-procedure Recommendations

  • It is recommended to discontinue NSAIDs before any surgical procedures to minimize bleeding risk.

Colchicine Risks

  • Potential consequence of colchicine use includes gastrointestinal toxicity.

Acetaminophen Contraindications

  • Acetaminophen is contraindicated in patients with severe liver disease.

Opioid Adverse Effects

  • Main adverse effects of opioids include respiratory depression, constipation, and sedation.

Opioid Overdose Rescue

  • Naloxone is the antidote for opioid overdose.

Opioid Withdrawal Symptoms

  • Symptoms during opioid withdrawal may include anxiety and irritability.

Reye’s Syndrome

  • Aspirin should be avoided in children with flu-like symptoms due to the risk of Reye’s syndrome.

Aspirin Prophylaxis

  • Prophylactic use of aspirin is primarily indicated for preventing cardiovascular events.

Antigout Medications

  • Allopurinol is an antigout medication that prevents uric acid production.

Managing GI Upset

  • For persistent GI upset from NSAIDs, switching to a buffered or enteric-coated formulation is recommended.

Aspirin Risks with Viral Illnesses

  • Potential consequence of using aspirin with a viral illness includes increased risk of Reye's syndrome.

Acute Gout Prophylaxis

  • Colchicine can be used prophylactically for acute gout flares.

Opioids and Asthma

  • Avoiding opioids in patients with severe asthma is crucial due to the risk of respiratory depression.

Skin Conditions from Allopurinol

  • A fatal skin condition associated with Allopurinol is Stevens-Johnson syndrome.

NSAIDs and GI Tolerance

  • Ibuprofen is considered better tolerated in terms of gastrointestinal effects compared to other NSAIDs.

Aspirin and Myocardial Infarction

  • Aspirin's effect can lower the risk of death following a myocardial infarction.

Caution in Opioid Administration

  • Caution should be exercised when administering opioids to patients with a history of sleep apnea.

Acetaminophen Dosage Limits

  • The maximum daily dose of acetaminophen for older adults or those with liver disease is usually limited to 2 grams.

Inflammation Treatment

  • NSAIDs such as Ibuprofen are suitable for treating inflammation, like in sprained ankles.

Immediate Action for Respiratory Depression

  • Immediate action for respiratory depression due to opioids includes administering naloxone and providing oxygen.

NSAIDs vs. Acetaminophen

  • Key difference: NSAIDs provide anti-inflammatory benefits while acetaminophen primarily acts as an analgesic and antipyretic.

Secondary Use of Opioids

  • Besides pain relief, opioids may be used to relieve cough or diarrhea.

Medication Administration Education

  • Important for patients to understand not to crush or chew certain medications to avoid altering their release mechanisms.

NSAIDs and Therapy Timeline

  • Full therapeutic effect of NSAIDs may take several days or longer to manifest.

Acetaminophen Maximum Daily Dose

  • The maximum daily dose of acetaminophen for a healthy adult is 4 grams.

Opioids and Pain Management

  • Opioids are predominantly used to alleviate acute and chronic pain.

Opioid Tolerance and Dependence

  • Opioid tolerance indicates the body's adaptation to prolonged opioid use, which can lead to physical dependence; this should not be confused with psychological dependence.

Codeine and Acetaminophen Combination

  • The combination of codeine sulfate with acetaminophen forms a Schedule III medication classification.

Caution with Schedule III Opioids

  • Caution should be exercised when administering Schedule III opioids to patients with a history of substance use disorder.

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