28 Questions
What is pain?
An unpleasant sensation that can range from mild, localized discomfort to agony.
What is the primary cause of nociceptive pain?
Direct stimulation of peripheral nerve endings by a noxious stimulus
What type of pain is characterized by diffuse discomfort, as seen in disorders like fibromyalgia?
Nociceptive pain
What are the two main types of pain classified?
Nociceptive and neuropathic
What is not a characteristic of pain?
Pleasant sensation
What is the primary objective of learning outcome number 3?
To explain the pharmacological actions of NSAIDs
What is the common indication for the contraindication of non-selective COX inhibitors in patients with peptic ulcer?
Gastrointestinal toxicity
What is the primary objective of learning outcome number 7?
To choose an appropriate NSAID for a given clinical condition
What is the primary objective of learning outcome number 9?
To apply the toxicokinetics of paracetamol and pathology of paracetamol poisoning
Which of the following is NOT a condition where non-selective COX inhibitors are contraindicated?
Children above 18 years of age
What is the primary objective of learning outcome number 10?
To list topical NSAIDs and analgesic combinations used in pain management
What is paracetamol preferred for in reducing elevated body temperature in fever?
Because it does not cause GI symptoms and doesn't cause Reye's syndrome in children
What is used in mild cases of osteoarthritis?
Paracetamol
What is the drug of choice for acute rheumatic fever?
Aspirin
What is used to prevent cardiac complications in acute rheumatic fever?
Long-acting penicillin
What is the drug of choice in thromboembolic disorders?
Aspirin
What is used to close a patent ductus arteriosus (PDA)?
Indomethacin or ibuprofen
Why are salicylates contraindicated in children below 15 years?
Because they can cause severe toxicity in children with viral fever
What is the preferred medication in children?
Paracetamol
What is the effect of therapeutic dose aspirin on respiration?
It stimulates respiration and produces hyperventilation
What is the characteristic of salicylism?
Headache, vertigo, tinnitus, hyperventilation, nausea, and vomiting
What is the effect of a plasma level of 500 microgram to 1 mg of aspirin?
It causes respiratory acidosis
What is the potential consequence of chronic consumption of aspirin and other NSAIDs?
Irreversible renal damage
Why should NSAIDs be avoided in asthmatics?
Due to increased production of leukotrienes
What is a potential consequence of taking NSAIDs near term?
Increased chances of post-partum hemorrhage
What is a potential consequence of long-term use of aspirin?
Decreased prothrombin levels
What is the effect of aspirin on uric acid excretion?
Decreases uric acid excretion
What is a potential consequence of using aspirin in children with viral infections?
Reye's syndrome
Test your knowledge on non-steroid anti-inflammatory drugs, including their classification, mechanism of action, and pharmacological actions. Apply your understanding to provide therapeutic solutions.
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