NSAIDs Pharmacology

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What is pain?

An unpleasant sensation that can range from mild, localized discomfort to agony. (correct)

A localized physical discomfort

An emotional response to injury

A response to nerve stimulation.

What is the primary cause of nociceptive pain?

Inflammation of the affected area

Direct stimulation of peripheral nerve endings by a noxious stimulus (correct)

Damage to nerve endings

Psychological factors such as anxiety and fear

What type of pain is characterized by diffuse discomfort, as seen in disorders like fibromyalgia?

Visceral pain

Neuropathic pain

Nociceptive pain (correct)

Somatic pain

What are the two main types of pain classified?

Nociceptive and neuropathic Signup and view all the answers

What is not a characteristic of pain?

Pleasant sensation Signup and view all the answers

What is the primary objective of learning outcome number 3?

To explain the pharmacological actions of NSAIDs Signup and view all the answers

What is the common indication for the contraindication of non-selective COX inhibitors in patients with peptic ulcer?

Gastrointestinal toxicity Signup and view all the answers

What is the primary objective of learning outcome number 7?

To choose an appropriate NSAID for a given clinical condition Signup and view all the answers

What is the primary objective of learning outcome number 9?

To apply the toxicokinetics of paracetamol and pathology of paracetamol poisoning Signup and view all the answers

Which of the following is NOT a condition where non-selective COX inhibitors are contraindicated?

Children above 18 years of age Signup and view all the answers

What is the primary objective of learning outcome number 10?

To list topical NSAIDs and analgesic combinations used in pain management Signup and view all the answers

What is paracetamol preferred for in reducing elevated body temperature in fever?

Because it does not cause GI symptoms and doesn't cause Reye's syndrome in children Signup and view all the answers

What is used in mild cases of osteoarthritis?

Paracetamol Signup and view all the answers

What is the drug of choice for acute rheumatic fever?

Aspirin Signup and view all the answers

What is used to prevent cardiac complications in acute rheumatic fever?

Long-acting penicillin Signup and view all the answers

What is the drug of choice in thromboembolic disorders?

Aspirin Signup and view all the answers

What is used to close a patent ductus arteriosus (PDA)?

Indomethacin or ibuprofen Signup and view all the answers

Why are salicylates contraindicated in children below 15 years?

Because they can cause severe toxicity in children with viral fever Signup and view all the answers

What is the preferred medication in children?

Paracetamol Signup and view all the answers

What is the effect of therapeutic dose aspirin on respiration?

It stimulates respiration and produces hyperventilation Signup and view all the answers

What is the characteristic of salicylism?

Headache, vertigo, tinnitus, hyperventilation, nausea, and vomiting Signup and view all the answers

What is the effect of a plasma level of 500 microgram to 1 mg of aspirin?

It causes respiratory acidosis Signup and view all the answers

What is the potential consequence of chronic consumption of aspirin and other NSAIDs?

Irreversible renal damage Signup and view all the answers

Why should NSAIDs be avoided in asthmatics?

Due to increased production of leukotrienes Signup and view all the answers

What is a potential consequence of taking NSAIDs near term?

Increased chances of post-partum hemorrhage Signup and view all the answers

What is a potential consequence of long-term use of aspirin?

Decreased prothrombin levels Signup and view all the answers

What is the effect of aspirin on uric acid excretion?

Decreases uric acid excretion Signup and view all the answers

What is a potential consequence of using aspirin in children with viral infections?

Reye's syndrome Signup and view all the answers