Normal Immune Response Overview
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Questions and Answers

What immunological process is activated when the body mistakenly identifies a substance like pollen as harmful?

  • Type 3 hypersensitivity reaction
  • IgE antibody production (correct)
  • Rh incompatibility reaction
  • Hemolytic transfusion reaction
  • Which of the subsequent reactions do not involve red blood cells?

  • Hemolytic transfusion reactions
  • Poison ivy reactions (correct)
  • Rh incompatibility transfusion reactions
  • Autoimmune reactions
  • What is the role of mast cells and basophils in allergic reactions?

  • They release antibodies to mark the allergen for destruction by other immune cells.
  • They directly attack the allergen, neutralizing its harmful effects.
  • They bind to IgE antibodies and release substances that cause inflammation and itching. (correct)
  • They initiate the production of red blood cells to combat the allergen.
  • Which condition is least associated with immune complexes building up in the body?

    <p>Atopic dermatitis (C)</p> Signup and view all the answers

    What characterizes chronic lesions that resemble atopic dermatitis?

    <p>Thickened, scaly, and lichenified skin caused by prolonged inflammation. (B)</p> Signup and view all the answers

    Which function of immunity involves the removal of damaged cellular substances to maintain uniformity among cell types?

    <p>Homeostasis (D)</p> Signup and view all the answers

    Which type of immunity is present at birth and involves a nonspecific response?

    <p>Innate immunity (A)</p> Signup and view all the answers

    What is the mechanism of natural passive acquired immunity?

    <p>Transplacental and colostrum transfer (B)</p> Signup and view all the answers

    An immune system that overreacts against its own tissues is an example of what?

    <p>Hypersensitivity (C)</p> Signup and view all the answers

    What characterizes artificial active acquired immunity?

    <p>Immunization with antigens (D)</p> Signup and view all the answers

    Which of the following describes the surveillance function of a normal immune response?

    <p>Recognizing and destroying mutations (D)</p> Signup and view all the answers

    What happens to the immune system when immunocompetence occurs?

    <p>It can identify and inactivate or destroy foreign substances. (B)</p> Signup and view all the answers

    Which type of hypersensitivity response occurs when the body reacts against self-antigens?

    <p>Autoimmune disease (D)</p> Signup and view all the answers

    IgE antibodies cause the body to recognize which of the following during subsequent exposure?

    <p>Mismatched blood cells as invaders. (B)</p> Signup and view all the answers

    Which of the following is a primary function of mast cells and basophils when triggered by allergens?

    <p>Releasing chemicals like histamine. (D)</p> Signup and view all the answers

    What is the direct consequence of the immune system attacking mismatched blood cells?

    <p>Hemolytic reaction. (B)</p> Signup and view all the answers

    Which of the following is the crucial difference between atopic and contact dermatitis?

    <p>Atopic dermatitis is widespread, while contact dermatitis is localized. (C)</p> Signup and view all the answers

    In the context of allergic reactions, what is the role of histamine?

    <p>To cause inflammation and other allergy symptoms. (D)</p> Signup and view all the answers

    Where are mast cells and basophils typically found in the body?

    <p>In places like the skin, lungs, and intestines. (B)</p> Signup and view all the answers

    What immunological event occurs during the 'Subsequent Exposure' phase of an allergic reaction?

    <p>The body's immune system recognizes the allergen due to IgE antibodies. (D)</p> Signup and view all the answers

    What is the initial step in a hemolytic reaction when the body encounters a mismatched blood type?

    <p>The immune system recognizes the foreign blood cells as harmful. (C)</p> Signup and view all the answers

    In Type I hypersensitivity reactions, which laboratory result is most likely?

    <p>Elevated eosinophil count and elevated serum IgE level. (B)</p> Signup and view all the answers

    A patient is undergoing allergy skin testing. Which assessment finding would be a contraindication to performing the skin test?

    <p>Reports of taking beta blockers for angina. (D)</p> Signup and view all the answers

    Following an intradermal skin test, a patient develops a severe reaction. Which immediate nursing intervention is most appropriate?

    <p>Apply a tourniquet proximal to the injection site and prepare for epinephrine administration. (D)</p> Signup and view all the answers

    A patient experiencing anaphylaxis is prescribed epinephrine. Which route of administration is most appropriate?

    <p>Intramuscular (B)</p> Signup and view all the answers

    A patient with anaphylaxis is receiving epinephrine. Which of the following adverse effects should the nurse monitor for?

    <p>Hypotension and bradycardia (A)</p> Signup and view all the answers

    A patient is prescribed an antihistamine for allergic rhinitis. What information should the nurse include when educating the patient about this medication?

    <p>Antihistamines relieve itching and hives by blocking histamine at H1-receptor sites. (B)</p> Signup and view all the answers

    What is the primary purpose of obtaining sputum and nasal/bronchial secretions for testing in the context of allergic disorders?

    <p>To assess for the presence of eosinophils. (B)</p> Signup and view all the answers

    A complete blood count (CBC) with WBC differential is ordered as part of diagnostic studies for allergic disorders. What specific information from this test is most relevant in identifying an allergic response?

    <p>The absolute lymphocyte count and eosinophil count. (D)</p> Signup and view all the answers

    Which medication is most effective for alleviating the signs and symptoms of allergic rhinitis?

    <p>Corticosteroids (D)</p> Signup and view all the answers

    A patient with allergic rhinitis is prescribed cromolyn. What is the primary mechanism of action of this drug?

    <p>Inhibiting the release of histamine (B)</p> Signup and view all the answers

    In which of the following scenarios is immunotherapy most definitively indicated?

    <p>Anaphylactic reaction to insect venom (B)</p> Signup and view all the answers

    What is a known potential adverse effect of immunotherapy in patients with allergic disorders?

    <p>Worsening of eczema (C)</p> Signup and view all the answers

    A patient with a known latex allergy experiences an allergic reaction after consuming certain foods. What is this phenomenon known as?

    <p>Latex-food syndrome (B)</p> Signup and view all the answers

    Which of the following is the recommended first-line treatment for multiple chemical sensitivity (MCS)?

    <p>Psychotherapy (C)</p> Signup and view all the answers

    What is the primary consideration when matching organ transplant recipients with available donors?

    <p>HLA typing (A)</p> Signup and view all the answers

    During tissue typing for organ transplantation, which factor is NOT essential for compatibility between donor and recipient?

    <p>Rh factor (C)</p> Signup and view all the answers

    What is the primary mechanism of action for calcineurin inhibitors like tacrolimus and cyclosporine in preventing organ rejection?

    <p>Preventing a cell-mediated immune response against the transplanted organ. (C)</p> Signup and view all the answers

    Why is the consumption of grapefruit or grapefruit juice a concern for patients taking tacrolimus or cyclosporine?

    <p>Grapefruit inhibits the metabolism of these drugs, potentially increasing their toxicity. (A)</p> Signup and view all the answers

    Which of the following best describes the role of calcineurin inhibitors in immunosuppressive regimens?

    <p>They serve as the foundation of most immunosuppression regimens. (A)</p> Signup and view all the answers

    Besides corticosteroids, which other medication is commonly used in combination with calcineurin inhibitors like tacrolimus?

    <p>Mycophenolate mofetil. (A)</p> Signup and view all the answers

    Which of the following is NOT a typical component of a standard immunosuppression regimen that includes a calcineurin inhibitor?

    <p>Interferon alpha (D)</p> Signup and view all the answers

    A patient taking tacrolimus regularly consumes grapefruit juice. What is the most appropriate immediate action a healthcare provider should take?

    <p>Monitor the patient for signs of tacrolimus toxicity and consider adjusting the dose. (A)</p> Signup and view all the answers

    Why are calcineurin inhibitors considered a 'foundation' of immunosuppression regimens?

    <p>They effectively prevent the activation of T cells, a key step in organ rejection. (C)</p> Signup and view all the answers

    Which of the following statements accurately describes the clinical use of tacrolimus?

    <p>Tacrolimus is widely used as a key agent in preventing organ rejection after transplantation. (B)</p> Signup and view all the answers

    Flashcards

    Poison Ivy

    A plant that can cause allergic skin reactions upon contact.

    Type 3 Reactions

    Immune responses involving the formation of immune complexes that can cause damage.

    IgE Antibody

    A specific antibody produced during an allergic response that binds to allergens.

    Mast Cells

    Cells in the immune system that release histamine during allergic reactions.

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    Basophils

    A type of white blood cell that releases chemicals during allergic reactions.

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    Immunity

    The body's ability to resist disease and infections.

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    Defense in Immunity

    The body protects itself against microorganisms and infections.

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    Homeostasis in Immunity

    Digesting and removing damaged cellular substances to maintain balance.

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    Surveillance in Immunity

    The immune system detects and destroys mutated or foreign cells.

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    Innate Immunity

    Immunity present at birth responding quickly to pathogens.

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    Acquired Immunity

    Immunity developed from exposure or vaccinations.

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    Hypersensitivity

    An overreaction of the immune system to foreign antigens or self-tissues.

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    Autoimmune Disease

    A type of hypersensitivity where the body attacks its own tissues.

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    CBC with WBC differential

    A test measuring the levels of different types of white blood cells to assess immune function.

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    T-cell and B-cell quantification

    A diagnostic test that quantifies T-cells and B-cells to identify immunodeficiency syndromes.

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    Eosinophil count

    A blood test measuring eosinophils, elevated in allergic reactions and parasitic infections.

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    Serum IgE level

    A measure of IgE antibodies; high levels indicate atopic diseases like asthma or hay fever.

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    Skin testing

    A method to identify specific allergens by applying them to the skin and monitoring reactions.

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    Anaphylaxis management

    Immediate steps to manage anaphylaxis include recognizing symptoms and administering epinephrine.

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    Epinephrine in anaphylaxis

    The first-line treatment for anaphylactic reactions, administered IM or IV.

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    Antihistamines

    Medications that manage allergic symptoms by blocking histamine's effects, mainly for rhinitis and hives.

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    Corticosteroids

    Medications used to relieve symptoms of allergic rhinitis.

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    Mast Cell-Stabilizing Drugs

    Medications like cromolyn that inhibit histamine release in allergic reactions.

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    Immunotherapy

    A treatment for allergic symptoms when allergens can't be avoided and drugs fail.

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    Latex Food Syndrome

    Allergic reactions to certain foods in people with latex allergies.

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    Multiple Chemical Sensitivity (MCS)

    A subjective illness with vague symptoms from low chemical exposure.

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    S/S of Multiple Chemical Sensitivity

    Non-specific symptoms like headaches and dizziness due to chemicals.

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    Psychotherapy for MCS

    Recommended treatment for patients with multiple chemical sensitivity.

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    Tissue Typing in Transplantation

    Matching donor and recipient based on blood type and HLA.

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    Blood Type Mismatch

    A reaction when the immune system attacks foreign blood cells from a transfusion.

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    Subsequent Exposure

    The body's reaction to a repeated allergen or harmful substance after initial exposure.

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    Atopic Dermatitis

    A widespread allergic skin condition often connected to IgE reactions.

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    Contact Dermatitis

    Localized skin reaction resulting from direct contact with an allergen.

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    IgE Antibodies Function

    They identify and react to allergens, triggering allergic responses.

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    Hemolytic Reaction

    An immune attack on mismatched blood leading to destruction of red blood cells.

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    Mast Cell Role

    They release chemicals like histamine during allergic attacks.

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    Basophil Action

    Basophils release histamines and other chemicals during allergic reactions.

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    Calcineurin Inhibitors

    Drugs that prevent cell-mediated attacks against transplanted organs.

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    Tacrolimus

    A calcineurin inhibitor commonly used in organ transplant regimens.

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    Cyclosporin

    Another calcineurin inhibitor, often used similarly to Tacrolimus.

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    Immunosuppressive Regimens

    Treatment plans that use multiple drugs to reduce the immune response.

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    Mycophenolate Mofetil

    An immunosuppressant often used alongside calcineurin inhibitors.

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    Sirolimus

    An immunosuppressant used with calcineurin inhibitors for transplants.

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    Grapefruit Interaction

    Grapefruit juice can prevent the metabolism of certain immunosuppressants.

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    Study Notes

    Normal Immune Response

    • Immunity is the body's ability to resist disease

    • Three main functions of immunity:

      • Defense: Protects against pathogens and foreign invaders
      • Homeostasis: Removes damaged cells and substances
      • Surveillance: Identifies and destroys mutated cells
    • Two types of immunity:

      • Innate: Present at birth, non-specific, responds quickly to pathogens without prior exposure
      • Acquired: Developed over time, specific, requires prior exposure to a pathogen

    Types of Acquired Immunity

    • Active:
      • Natural: Acquiring immunity through infection (e.g., chicken pox)
      • Artificial: Acquiring immunity through vaccination (e.g., chicken pox vaccine)
    • Passive:
      • Natural: Transfer of antibodies from mother to child through placenta or breast milk
      • Artificial: Injection of antibodies from another individual (e.g., serum injections)

    Altered Immune Response

    • Immunocompetence: The body's immune system's ability to identify, inactivate, and destroy foreign substances. Problems with this create severe infections, cancers, and immunodeficiency

    • Hypersensitivity Reactions: The immune system overreacts and can destroy its own tissues

      • Four types:
        • Type I (IgE-mediated): Allergies (e.g., hay fever)
        • Type II (Cytotoxic/Cytolytic): Antibodies directly attacking cells
        • Type III (Immune Complex): Antibody-antigen complexes damaging tissues
        • Type IV (Delayed): Delayed response (e.g., contact dermatitis)

    Additional Information

    • ABO Incompatibility: Blood transfusion reaction where the recipient's immune system attacks foreign blood cells

    • Rh Incompatibility: Blood transfusion reaction with incompatibility regarding the Rh factor

    • Hemolytic Transfusion Reaction: When the immune system destroys red blood cells from a transfusion

    • Blood Type Mismatch: When the recipient and donor blood types are not compatible

      • Immune system attacks foreign blood cells
    • Allergic Reactions:

      • Anaphylaxis: Severe allergic reaction, potentially life-threatening
      • Atopic Reactions: Inherited tendency to become allergic to environmental allergens
    • Immunotherapy: Treatments that help train the immune system to tolerance an allergen

    • Multiple Chemical Sensitivity (MCS): A controversial disorder characterized by various symptoms purportedly caused by low levels of chemicals

    • Immunosuppressive Therapy: Drugs that reduce the immune response to prevent organ rejection after transplant

    • Graft-versus-Host Disease (GVHD): Potential immune response against the transplanted organ, especially in bone marrow or stem cell transplants

    • Diagnostic Studies: Procedures like complete blood counts, skin tests, blood tests used to diagnose immune disorders/reactions.

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    Description

    This quiz covers the fundamental aspects of the immune system, including its main functions and types of immunity. Understand the differences between innate and acquired immunity, as well as the mechanisms of active and passive immunity. Test your knowledge on how the immune response alters in various conditions.

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