Noncovalent Interactions: Hydrogen Bonds, Van der Waals, Ionic Bonds
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Questions and Answers

Why is fluorine commonly used in drug design?

  • To decrease hydrogen bonding possibilities
  • To increase basicity of nearby amino groups
  • To take the place of hydrogen in a chemical structure (correct)
  • To form stronger van der Waals interactions

What type of interactions are mostly entropy driven at the water interface?

  • Ionic bonds
  • Van Der Waals interactions
  • Hydrogen bonds
  • Hydrophobic interactions (correct)

Which type of bonds are important in governing protein folding and membrane formation?

  • Van Der Waals interactions
  • Ionic bonds
  • Non-covalent interactions
  • Hydrogen bonds (correct)

What drives the hydrophobic effect in aqueous solutions?

<p>Van Der Waals interactions (B)</p> Signup and view all the answers

Which type of interaction can decrease the basicity of nearby amino groups in drug molecules?

<p>Fluorine substitution (C)</p> Signup and view all the answers

What type of noncovalent interaction is the weakest?

<p>Van der Waals interactions (D)</p> Signup and view all the answers

In which type of biological molecules do water-soluble compounds have greater interactions with water than with solute molecules?

<p>Proteins (D)</p> Signup and view all the answers

Which of the following is NOT a requirement for a hydrogen bond to form?

<p>A covalent bond between the electronegative atom and the H atom (A)</p> Signup and view all the answers

What is the driving force behind the hydrophobic effect?

<p>Entropy increase (B)</p> Signup and view all the answers

Which of the following is NOT a type of van der Waals interaction?

<p>Ion-dipole forces (B)</p> Signup and view all the answers

Why do oil and water not mix?

<p>Hydrophobic effect between water and oil molecules (C)</p> Signup and view all the answers

Which type of noncovalent interaction is the strongest?

<p>Ionic bonds (D)</p> Signup and view all the answers

What type of bond is formed between the oxygen atom of one water molecule and the hydrogen atom of another water molecule in a liquid state?

<p>Hydrogen bond (D)</p> Signup and view all the answers

What is the primary reason for the strong hydrogen bonding in water?

<p>The presence of lone pairs on the oxygen atom (D)</p> Signup and view all the answers

Which type of interaction is responsible for the unique solvent properties of water?

<p>Hydrogen bonds (D)</p> Signup and view all the answers

Which feature makes water molecules capable of forming hydrogen bonds with each other and with other hydrophilic substances?

<p>The dipole nature of the water molecule (A)</p> Signup and view all the answers

What type of geometry does a water molecule exhibit due to its sp3 hybridization?

<p>Tetrahedral (B)</p> Signup and view all the answers

What type of interaction is primarily responsible for maintaining the three-dimensional structure of many proteins?

<p>Hydrogen bonds (D)</p> Signup and view all the answers

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