Non-Specific Inflammatory Disorders

Non-specific inflammatory disorders can be caused by exogenous factors such as biological agents (bacteria, viruses, parasites), chemical agents, physical agents (burns, radiation), and foreign bodies (suture material). They can also be caused by endogenous factors such as circulatory disturbances, enzymes activation, products of metabolism, autoimmune/allergic reactions, and neoplasia.

The body's defense reaction in response to inflammation is to eliminate or limit the spread of the injurious agent. This includes isolating the affected tissue, neutralizing aggressor factors, destroying invading microorganisms, inactivating toxins, and removing necrotic cells and tissues in order to prepare the affected tissue for healing.

The signs of inflammation include rubor (redness), calor (heat), tumor (swelling), dolor (pain), and functio lesa (loss/impairment of function).

<p>In acute inflammation, neutrophils predominate in the first 6-24 hours. They are then replaced with monocytes in the next 24-48 hours. Neutrophils have a short lifespan of 6-72 hours, contain lysozyme and collagenases, have a multilobed nucleus, cannot divide, and are the first to arrive at the injured spot.</p> Signup and view all the answers

<p>Exogenous factors that can cause non-specific inflammatory disorders include biological agents (bacteria, viruses, parasites), chemical agents, physical agents (burns, radiation), and foreign bodies (suture material). Endogenous factors include circulatory disturbances, enzymes activation, products of metabolism, autoimmune/allergic reactions, and neoplasia.</p> Signup and view all the answers