Podcast
Questions and Answers
What is the primary mechanism of action for non-selective beta-adrenergic antagonists?
What is the primary mechanism of action for non-selective beta-adrenergic antagonists?
- Inhibition of calcium channels
- Enhancement of dopamine release
- Competitive blocking of beta-1 and beta-2 adrenergic receptors (correct)
- Stimulation of alpha-adrenergic receptors
Which of the following is a therapeutic effect of non-selective beta-blockers?
Which of the following is a therapeutic effect of non-selective beta-blockers?
- Blockade of beta-receptors in the heart (correct)
- Increased heart rate
- Vasoconstriction
- Bronchodilation
Which of the following medications is a non-selective beta-adrenergic antagonist?
Which of the following medications is a non-selective beta-adrenergic antagonist?
- Amlodipine
- Lisinopril
- Levothyroxine
- Propranolol (correct)
Which of the following is a common indication for propranolol?
Which of the following is a common indication for propranolol?
Which condition is a contraindication for non-selective beta-blockers?
Which condition is a contraindication for non-selective beta-blockers?
What is a potential adverse effect of non-selective beta-adrenergic antagonists?
What is a potential adverse effect of non-selective beta-adrenergic antagonists?
Which of the following drugs may interact with non-selective beta-blockers?
Which of the following drugs may interact with non-selective beta-blockers?
What is a possible adverse effect that patients taking non-selective beta-blockers should be cautioned about regarding blood pressure?
What is a possible adverse effect that patients taking non-selective beta-blockers should be cautioned about regarding blood pressure?
Which of the following conditions requires caution when prescribing non-selective beta-blockers due to the risk of bronchospasm?
Which of the following conditions requires caution when prescribing non-selective beta-blockers due to the risk of bronchospasm?
What effect might NSAIDs have when taken with non-selective beta-blockers?
What effect might NSAIDs have when taken with non-selective beta-blockers?
Flashcards
Non-Selective Beta-Blockers: Action
Non-Selective Beta-Blockers: Action
Competitive blocking of beta-1 and beta-2 adrenergic receptors in the SNS, reducing heart rate and blood pressure.
Non-Selective Beta-Blockers: Uses
Non-Selective Beta-Blockers: Uses
Hypertension, arrhythmias, migraine prophylaxis, angina, and restless leg syndrome (propranolol).
Non-Selective Beta-Blockers: Avoid
Non-Selective Beta-Blockers: Avoid
Bradycardia, heart blocks, shock, HF, bronchospasm, COPD, acute asthma, and pregnancy/lactation.
Non-Selective Beta-Blockers: Side Effects
Non-Selective Beta-Blockers: Side Effects
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Beta-Blockers & Calcium Channel Blockers
Beta-Blockers & Calcium Channel Blockers
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Beta-Blockers & NSAIDs
Beta-Blockers & NSAIDs
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Beta-Blockers & Anti-Diabetes Drugs
Beta-Blockers & Anti-Diabetes Drugs
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Common Non-Selective Beta Blockers
Common Non-Selective Beta Blockers
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Study Notes
- Non-selective beta-adrenergic antagonists competitively block beta-1 and beta-2 adrenergic receptors in the sympathetic nervous system (SNS).
- These drugs produce therapeutic effects by blocking beta-receptors in the heart and the juxtaglomerular apparatus of the nephron.
- Medications such as propranolol, nadolol, nebivolol, pindolol, penbutolol, sotalol, and timolol are non-selective beta-adrenergic antagonists.
- Non-selective beta blockers treat hypertension, arrhythmias, and angina.
- Propranolol also has indications for migraine prophylaxis and restless leg syndrome.
- Contraindications include bradycardia, heart blocks, shock, heart failure (HF), bronchospasm, chronic obstructive pulmonary disease (COPD), acute asthma, pregnancy and lactation, and renal or hepatic dysfunction.
- Adverse effects: Dizziness, fatigue, hypotension (including orthostatic hypotension), syncope, nausea/vomiting (N/V), arrhythmias, dyspnea, insomnia, and erectile dysfunction may occur.
- Drug interactions: Use caution when administering with calcium channel blockers, other antihypertensives (such as clonidine), nonsteroidal anti-inflammatory drugs (NSAIDs), epinephrine, ergot alkaloids, and insulin and antidiabetic medications.
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