Non-metal Radionuclides Presentation

Questions and Answers

Boron-11 (correct)

Oxygen-16

Carbon-12

Nitrogen-14

He2

Cl2

N2 (correct)

Production of [11C]serine

Production of [11C]acetate (correct)

Production of [11C]sodium chloride

Production of [11C]glutamate

Analyzing tumor metabolism Signup and view all the answers

Bubbling through MeMgBr Signup and view all the answers

Quantification of amyloid plaques Signup and view all the answers

[13N]NH3 Signup and view all the answers

Beta-plus decay Signup and view all the answers

Reduction processes Signup and view all the answers

4 minutes after injection Signup and view all the answers

Study Notes

Carbon-11 decays to Boron-11 (11B) via beta-plus decay.
Production initiated using nitrogen-14 (14N) gas; reaction: 14N(p,α)11C.
Target gas is enriched with 0.5% O2 or H2 to form [11C]CO2 or [11C]CH4.
[11C]CO2 can produce [11C]acetate and [11C]palmitate through common reactions.
11C-Methylation produces compounds like [11C]CH3I and [11C]Pittsburgh Compound B ([11C]PiB).
[11C]Acetate is metabolized to acetyl-CoA, utilized in energy production or lipid synthesis in cells.
[11C]Choline, derived from dimethylaminoethanol, aids in detecting tumors with its high membrane incorporation.
[11C]PiB binds to amyloid plaques, facilitating detection of Alzheimer's disease.

Nitrogen-13 has a half-life of 9.96 minutes and undergoes beta-plus decay.
Produced using reactions such as 16O(p,α)13N and 13C(p,n)13N.
Target is filled with 16O2 gas, generating [13N]NOx and sometimes [13N]NH3.
[13N]NH3 is synthesized via reduction methods, often with DeVarda’s alloy.
[13N]NH3 PET imaging evaluates myocardial blood flow, crucial for diagnosing coronary artery disease (CAD).

Oxygen-15 has a short half-life of 122.24 seconds and decays entirely by beta-plus decay.
Produced using 14N(d,n)15O among other methods.
[15O]H2O is formed via catalyzed reactions with H2, providing an important marker for blood flow studies.
[15O]CO and [15O]O2 are utilized for assessing blood volume and oxygen extraction, respectively.

Iodine-124 has a half-life of 4.2 days and decays through beta-plus and electron capture modes.
Produced using 124Te(p,n)124I reaction.
[124I]NaI is a common source for radiopharmaceutical synthesis, employing electrophilic and nucleophilic methods.
[124I]MIBG PET/CT imaging is effective in tracking pulmonary lesions and response to therapies.