Non-HDL Cholesterol
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Questions and Answers

What is considered the secondary goal of lipid therapy when triglyceride levels are between 200-499 mg/dL?

  • HDL-C
  • Atherogenic Index
  • Non-HDL-C (correct)
  • Total Cholesterol

How is Non-HDL-C calculated?

  • LDL-C - HDL-C
  • TG/HDL-C
  • TC - HDL-C (correct)
  • HDL-C + LDL-C

What is the desirable value for the Atherogenic Index?

  • < 5 (correct)
  • < 10
  • < 7
  • < 3

Which factor is considered most preferable when collecting a plasma specimen for a blood lipid profile?

<p>Using an EDTA anticoagulant (D)</p> Signup and view all the answers

What is the recommended fasting period before collecting a blood specimen for a lipid profile?

<p>10-14 hours (D)</p> Signup and view all the answers

Within how many months after a serious illness should you avoid a lipid profile test?

<p>3 months (B)</p> Signup and view all the answers

For which of these conditions is the Atherogenic Index not used?

<p>To divert priority from LDL-C (B)</p> Signup and view all the answers

At what age is it generally recommended to start doing lipid profile tests?

<p>20 years (D)</p> Signup and view all the answers

Study Notes

Non-HDL Cholesterol

  • Non-HDL-C represents the fraction of blood cholesterol in lipoproteins containing apo B (VLDL + LDL).
  • At triglyceride levels of 200-499 mg/dL, most cholesterol in VLDL is highly atherogenic.
  • Non-HDL-C is considered a secondary goal of lipid therapy when triglyceride levels are between 200-499 mg/dL.
  • Non-HDL-C can be measured in a random blood sample (without fasting).
  • Non-HDL-C is calculated by subtracting HDL-C from total cholesterol (TC).

Interpretation of Results

  • Non-HDL-C goal is 30 mg/dL higher than LDL-C goal when triglyceride levels are between 200-499 mg/dL.

Atherogenic Index

  • Atherogenic Index is not commonly used today, as it diverts priority from LDL-C.
  • It is calculated by dividing total cholesterol (TC) by HDL-C.
  • A desirable Atherogenic Index is < 5.

Specimen Collection for Blood Lipid Profile

  • Plasma specimen with EDTA anticoagulant is preferred.
  • Patients should have a normal diet and exercise routine for at least 2 weeks before the test.
  • Blood specimen should be collected after an overnight fast of 10-14 hours.
  • Venous stasis should be minimal.
  • Avoid testing during or within 3 months following a serious illness.
  • Testing within 12 hours after myocardial infarction may be useful.
  • Stop taking drugs containing glycerol at least 24 hours before the test.

When to Perform Lipid Profile

  • Measurement of LDL-C is used as a screening test during childhood, especially for those with a positive family history of dyslipoproteinemia or coronary heart disease.
  • Everyone over 20 should undergo lipid profile testing.
  • Follow-up lipid profile tests are recommended every 5 years for most people.
  • More frequent testing may be necessary if lipid profile parameters are not desirable or if there are other concerns about heart disease.

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Description

Learn about non-HDL cholesterol, its representation, measurement, and interpretation in lipid therapy. Understand its importance in detecting atherogenic cholesterol.

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