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Questions and Answers
What is considered the secondary goal of lipid therapy when triglyceride levels are between 200-499 mg/dL?
How is Non-HDL-C calculated?
What is the desirable value for the Atherogenic Index?
Which factor is considered most preferable when collecting a plasma specimen for a blood lipid profile?
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What is the recommended fasting period before collecting a blood specimen for a lipid profile?
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Within how many months after a serious illness should you avoid a lipid profile test?
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For which of these conditions is the Atherogenic Index not used?
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At what age is it generally recommended to start doing lipid profile tests?
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Study Notes
Non-HDL Cholesterol
- Non-HDL-C represents the fraction of blood cholesterol in lipoproteins containing apo B (VLDL + LDL).
- At triglyceride levels of 200-499 mg/dL, most cholesterol in VLDL is highly atherogenic.
- Non-HDL-C is considered a secondary goal of lipid therapy when triglyceride levels are between 200-499 mg/dL.
- Non-HDL-C can be measured in a random blood sample (without fasting).
- Non-HDL-C is calculated by subtracting HDL-C from total cholesterol (TC).
Interpretation of Results
- Non-HDL-C goal is 30 mg/dL higher than LDL-C goal when triglyceride levels are between 200-499 mg/dL.
Atherogenic Index
- Atherogenic Index is not commonly used today, as it diverts priority from LDL-C.
- It is calculated by dividing total cholesterol (TC) by HDL-C.
- A desirable Atherogenic Index is < 5.
Specimen Collection for Blood Lipid Profile
- Plasma specimen with EDTA anticoagulant is preferred.
- Patients should have a normal diet and exercise routine for at least 2 weeks before the test.
- Blood specimen should be collected after an overnight fast of 10-14 hours.
- Venous stasis should be minimal.
- Avoid testing during or within 3 months following a serious illness.
- Testing within 12 hours after myocardial infarction may be useful.
- Stop taking drugs containing glycerol at least 24 hours before the test.
When to Perform Lipid Profile
- Measurement of LDL-C is used as a screening test during childhood, especially for those with a positive family history of dyslipoproteinemia or coronary heart disease.
- Everyone over 20 should undergo lipid profile testing.
- Follow-up lipid profile tests are recommended every 5 years for most people.
- More frequent testing may be necessary if lipid profile parameters are not desirable or if there are other concerns about heart disease.
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Description
Learn about non-HDL cholesterol, its representation, measurement, and interpretation in lipid therapy. Understand its importance in detecting atherogenic cholesterol.
