Podcast
Questions and Answers
What can trigger a non-specific inflammatory response resulting in the production of activated cytokines and organized granulomas?
What can trigger a non-specific inflammatory response resulting in the production of activated cytokines and organized granulomas?
- Foreign materials/antigens (correct)
- Activated TLR receptors
- Complements
- Antibodies
Which condition is commonly associated with recurrent bacterial infections and autoimmune disorders due to low IgA/IgG/IgM?
Which condition is commonly associated with recurrent bacterial infections and autoimmune disorders due to low IgA/IgG/IgM?
- Selective IgA deficiency
- Vruton’s agammaglobulinemia
- HIV infection
- Common variable immune deficiency (CVID) (correct)
What is the function of complements in the immune system?
What is the function of complements in the immune system?
- Produce antibodies
- Activate T cells
- Eliminate granulomas
- Boost immediate immune defense (correct)
Which of the following is NOT a common primary antibody deficiency?
Which of the following is NOT a common primary antibody deficiency?
What type of immune deficiency may result from treatment interventions like immunosuppressive therapy and corticosteroids?
What type of immune deficiency may result from treatment interventions like immunosuppressive therapy and corticosteroids?
Which condition involves low levels of IgA accompanied by recurrent respiratory tract infections in some individuals?
Which condition involves low levels of IgA accompanied by recurrent respiratory tract infections in some individuals?
'Sticky coats' that assist in phagocytosis, opsonization, lysis of bacteria, and elimination of immune complexes are known as:
'Sticky coats' that assist in phagocytosis, opsonization, lysis of bacteria, and elimination of immune complexes are known as:
'Failure of protein synthesis' can be observed in which group of diseases related to immunodeficiency?
'Failure of protein synthesis' can be observed in which group of diseases related to immunodeficiency?
Which type of response results when antigens trigger a non-specific inflammatory response leading to granuloma formation?
Which type of response results when antigens trigger a non-specific inflammatory response leading to granuloma formation?
What role do foreign materials/antigens play in the activation of macrophages and T lymphocytes?
What role do foreign materials/antigens play in the activation of macrophages and T lymphocytes?
Which of the following is a characteristic of Toll Like Receptors (TLRs)?
Which of the following is a characteristic of Toll Like Receptors (TLRs)?
What is the consequence of TLR dysfunction?
What is the consequence of TLR dysfunction?
How do TNF inhibitors work?
How do TNF inhibitors work?
What is the function of biologic drugs?
What is the function of biologic drugs?
What can be a consequence of using biologic drugs?
What can be a consequence of using biologic drugs?
What type of transplant rejection occurs minutes to hours after transplantation?
What type of transplant rejection occurs minutes to hours after transplantation?
Which type of transplant rejection is mediated by CD4 and CD8 T cells?
Which type of transplant rejection is mediated by CD4 and CD8 T cells?
What is the mechanism of action of Pembrolizumab?
What is the mechanism of action of Pembrolizumab?
Which type of transplant rejection is characterized by vasculitis and de novo antibody and complement fixation?
Which type of transplant rejection is characterized by vasculitis and de novo antibody and complement fixation?
What is the pathology of chronic allograft failure?
What is the pathology of chronic allograft failure?
Which type of receptor is used by macrophages to recognize pathogen-associated molecular patterns (PAMPs)?
Which type of receptor is used by macrophages to recognize pathogen-associated molecular patterns (PAMPs)?
What type of drugs are used to inhibit the activity of TNF, a pro-inflammatory cytokine?
What type of drugs are used to inhibit the activity of TNF, a pro-inflammatory cytokine?
Which type of drugs are produced from living organisms or contain components of living organisms?
Which type of drugs are produced from living organisms or contain components of living organisms?
What is the condition characterized by the body's inability to fight off infections and diseases?
What is the condition characterized by the body's inability to fight off infections and diseases?
What type of immune response is responsible for the rejection of transplanted organs or tissues?
What type of immune response is responsible for the rejection of transplanted organs or tissues?
Which type of transplant rejection is characterized by the presence of antibodies against the transplanted organ or tissue?
Which type of transplant rejection is characterized by the presence of antibodies against the transplanted organ or tissue?
Which type of transplant rejection is characterized by the infiltration of immune cells into the transplanted organ or tissue?
Which type of transplant rejection is characterized by the infiltration of immune cells into the transplanted organ or tissue?
Which type of transplant rejection is characterized by the gradual loss of function of the transplanted organ or tissue over time?
Which type of transplant rejection is characterized by the gradual loss of function of the transplanted organ or tissue over time?
Which type of immunity is responsible for the production of antibodies against specific pathogens?
Which type of immunity is responsible for the production of antibodies against specific pathogens?
Which type of immunity is responsible for the activation of memory B and T cells upon subsequent exposure to the same pathogen?
Which type of immunity is responsible for the activation of memory B and T cells upon subsequent exposure to the same pathogen?
What is the most likely underlying condition in this patient?
What is the most likely underlying condition in this patient?
Which of the following is NOT a potential side effect of Methotrexate treatment?
Which of the following is NOT a potential side effect of Methotrexate treatment?
Which of the following is used to monitor treatment for Rheumatoid arthritis?
Which of the following is used to monitor treatment for Rheumatoid arthritis?
Which of the following is a potential complication of Anti TNF therapy?
Which of the following is a potential complication of Anti TNF therapy?
Which of the following is NOT a potential treatment for Osteoarthritis?
Which of the following is NOT a potential treatment for Osteoarthritis?
Which of the following is a potential side effect of Methotrexate treatment?
Which of the following is a potential side effect of Methotrexate treatment?
Which of the following is NOT a potential treatment for Rheumatoid arthritis?
Which of the following is NOT a potential treatment for Rheumatoid arthritis?
Which of the following is a potential side effect of Anti TNF therapy?
Which of the following is a potential side effect of Anti TNF therapy?
Which of the following is NOT a potential treatment for Osteoarthritis?
Which of the following is NOT a potential treatment for Osteoarthritis?
Which of the following is a potential treatment for Rheumatoid arthritis?
Which of the following is a potential treatment for Rheumatoid arthritis?
Granulomas can also be caused by:
Granulomas can also be caused by:
What is a potential cause of granuloma formation?
What is a potential cause of granuloma formation?
Which of the following is not a characteristic of natural killer (NK) cells?
Which of the following is not a characteristic of natural killer (NK) cells?
Primary antibody deficiencies can lead to:
Primary antibody deficiencies can lead to:
Which of the following is a potential consequence of antibody deficiencies?
Which of the following is a potential consequence of antibody deficiencies?
Complement system deficiencies can result in:
Complement system deficiencies can result in:
'Sticky coats' that assist in phagocytosis and elimination of immune complexes are known as:
'Sticky coats' that assist in phagocytosis and elimination of immune complexes are known as:
'Failure to eliminate immune complexes' can be observed in individuals with:
'Failure to eliminate immune complexes' can be observed in individuals with:
What is a possible effect of impaired complement system function?
What is a possible effect of impaired complement system function?
What contributes to the formation of organized granulomas?
What contributes to the formation of organized granulomas?
What is the main function of NK cells in the immune system?
What is the main function of NK cells in the immune system?
Which type of hypersensitivity reaction leads to the formation of granulomas?
Which type of hypersensitivity reaction leads to the formation of granulomas?
What is a common characteristic of primary antibody deficiencies?
What is a common characteristic of primary antibody deficiencies?
Which component of the immune system plays a crucial role in opsonization, lysis of bacteria, and elimination of immune complexes?
Which component of the immune system plays a crucial role in opsonization, lysis of bacteria, and elimination of immune complexes?
Which condition is characterized by low levels of IgA and frequent respiratory tract infections?
Which condition is characterized by low levels of IgA and frequent respiratory tract infections?
In the immune system, what role do granulomas play?
In the immune system, what role do granulomas play?
What is the consequence of deficiencies in the complement system?
What is the consequence of deficiencies in the complement system?
How do primary antibody deficiencies differ from secondary antibody deficiencies?
How do primary antibody deficiencies differ from secondary antibody deficiencies?
Which immune cells play a crucial role in eradicating cancer cells without the need for antigen specificity?
Which immune cells play a crucial role in eradicating cancer cells without the need for antigen specificity?
What is the primary mechanism through which NK cells recognize their target cells?
What is the primary mechanism through which NK cells recognize their target cells?
What triggers a non-specific inflammatory response resulting in the activation of macrophages and T lymphocytes, ultimately leading to granuloma formation?
What triggers a non-specific inflammatory response resulting in the activation of macrophages and T lymphocytes, ultimately leading to granuloma formation?
Which condition is commonly associated with recurrent bacterial infections and autoimmune disorders due to low levels of IgA/IgG/IgM?
Which condition is commonly associated with recurrent bacterial infections and autoimmune disorders due to low levels of IgA/IgG/IgM?
What is an organised collection of activated macrophages and lymphocytes that form in response to foreign materials/antigens triggering an inflammatory response?
What is an organised collection of activated macrophages and lymphocytes that form in response to foreign materials/antigens triggering an inflammatory response?
Which proteins act as 'sticky coats' that boost immediate immune defense by assisting in phagocytosis, opsonization, and lysis of bacteria?
Which proteins act as 'sticky coats' that boost immediate immune defense by assisting in phagocytosis, opsonization, and lysis of bacteria?
What type of antibody deficiency presents with low levels of IgA and IgG, often causing recurrent respiratory tract infections?
What type of antibody deficiency presents with low levels of IgA and IgG, often causing recurrent respiratory tract infections?
Which condition is characterized by failure of protein synthesis seen in lymphoproliferative diseases like CLL, Myeloma, and NHL?
Which condition is characterized by failure of protein synthesis seen in lymphoproliferative diseases like CLL, Myeloma, and NHL?
In what process do foreign materials/antigens stimulate the production of activated cytokines leading to the formation of organized granulomas?
In what process do foreign materials/antigens stimulate the production of activated cytokines leading to the formation of organized granulomas?
'Protein losing enteropathy' and 'Nephrotic syndrome' are associated with which type of condition related to immunodeficiency?
'Protein losing enteropathy' and 'Nephrotic syndrome' are associated with which type of condition related to immunodeficiency?
Which component acts as 'sticky coats' that assist in various immune defense mechanisms such as phagocytosis and opsonization?
Which component acts as 'sticky coats' that assist in various immune defense mechanisms such as phagocytosis and opsonization?
What condition involves low levels of IgA, recurrent infections, and autoimmune disorders?
What condition involves low levels of IgA, recurrent infections, and autoimmune disorders?
Which cell type is primarily responsible for the formation of granulomas?
Which cell type is primarily responsible for the formation of granulomas?
Which component of the immune system is involved in opsonization, lysis of bacteria, and elimination of immune complexes?
Which component of the immune system is involved in opsonization, lysis of bacteria, and elimination of immune complexes?
Which of the following is NOT a characteristic of primary antibody deficiencies?
Which of the following is NOT a characteristic of primary antibody deficiencies?
Which immune cell type is involved in antibody-dependent cell-mediated cytotoxicity?
Which immune cell type is involved in antibody-dependent cell-mediated cytotoxicity?
In which condition is the formation of activated cytokines and organized granulomas triggered by non-specific inflammatory responses?
In which condition is the formation of activated cytokines and organized granulomas triggered by non-specific inflammatory responses?
Which type of receptor is used by macrophages to recognize pathogen-associated molecular patterns (PAMPs)?
Which type of receptor is used by macrophages to recognize pathogen-associated molecular patterns (PAMPs)?
What can be a common feature in patients with primary antibody deficiencies?
What can be a common feature in patients with primary antibody deficiencies?
Which of the following conditions is commonly associated with the presence of granulomas?
Which of the following conditions is commonly associated with the presence of granulomas?
Which type of vaccines require multiple doses due to the lack of clonal expansion of B and T cells?
Which type of vaccines require multiple doses due to the lack of clonal expansion of B and T cells?
Which type of vaccines are considered fragile and may be dangerous for immunocompromised individuals?
Which type of vaccines are considered fragile and may be dangerous for immunocompromised individuals?
Why might booster shots be needed for whole cell vaccines such as Polio and Cholera?
Why might booster shots be needed for whole cell vaccines such as Polio and Cholera?
What makes RNA Vaccines / DNA Vaccines potent and easy to make?
What makes RNA Vaccines / DNA Vaccines potent and easy to make?
Which type of vaccines elicit a localized and strong immune response with just one dose?
Which type of vaccines elicit a localized and strong immune response with just one dose?
What is the main advantage of virus like particles vaccines such as those against papillomavirus?
What is the main advantage of virus like particles vaccines such as those against papillomavirus?
What is the primary disadvantage of live attenuated vaccines like the MMR jab?
What is the primary disadvantage of live attenuated vaccines like the MMR jab?
What triggers the non-specific inflammatory response that leads to the formation of organized granulomas?
What triggers the non-specific inflammatory response that leads to the formation of organized granulomas?
Which condition is characterized by recurrent bacterial infections and autoimmune disorders due to low levels of IgA, IgG, and IgM?
Which condition is characterized by recurrent bacterial infections and autoimmune disorders due to low levels of IgA, IgG, and IgM?
Which component of the immune system acts as 'sticky coats' to boost immediate immune defense by assisting in phagocytosis, opsonization, lysis of bacteria, and elimination of immune complexes?
Which component of the immune system acts as 'sticky coats' to boost immediate immune defense by assisting in phagocytosis, opsonization, lysis of bacteria, and elimination of immune complexes?
What is the primary characteristic of primary antibody deficiencies?
What is the primary characteristic of primary antibody deficiencies?
Which immune cells play a crucial role in eradicating cancer cells without the need for antigen specificity?
Which immune cells play a crucial role in eradicating cancer cells without the need for antigen specificity?
What is an organized collection of activated macrophages and lymphocytes formed in response to foreign materials or antigens triggering a non-specific inflammatory response?
What is an organized collection of activated macrophages and lymphocytes formed in response to foreign materials or antigens triggering a non-specific inflammatory response?
What is the consequence of complement deficiency in terms of susceptibility to infections?
What is the consequence of complement deficiency in terms of susceptibility to infections?
What type of immune response can lead to the formation of organized granulomas in response to foreign materials or antigens?
What type of immune response can lead to the formation of organized granulomas in response to foreign materials or antigens?
Which condition is characterized by low levels of IgA and IgG, often resulting in recurrent respiratory tract infections?
Which condition is characterized by low levels of IgA and IgG, often resulting in recurrent respiratory tract infections?
Which component of the immune system acts as 'sticky coats' to enhance phagocytosis and opsonization of pathogens?
Which component of the immune system acts as 'sticky coats' to enhance phagocytosis and opsonization of pathogens?
Which type of receptor is used by macrophages to recognize pathogen-associated molecular patterns (PAMPs) for initiating immune responses?
Which type of receptor is used by macrophages to recognize pathogen-associated molecular patterns (PAMPs) for initiating immune responses?
In individuals with primary antibody deficiencies, what is a common characteristic regarding the levels of immunoglobulins?
In individuals with primary antibody deficiencies, what is a common characteristic regarding the levels of immunoglobulins?
What is the primary function of Natural Killer (NK) cells in the immune system?
What is the primary function of Natural Killer (NK) cells in the immune system?
Which mechanism is responsible for the recognition of target cells by Natural Killer (NK) cells?
Which mechanism is responsible for the recognition of target cells by Natural Killer (NK) cells?
In which type of transplant rejection do antibodies against the transplanted organ or tissue play a key role?
In which type of transplant rejection do antibodies against the transplanted organ or tissue play a key role?
What type of immune response is responsible for the formation of granulomas in non-specific inflammatory responses triggered by foreign materials or antigens?
What type of immune response is responsible for the formation of granulomas in non-specific inflammatory responses triggered by foreign materials or antigens?
Which immune cell type is primarily involved in the formation of granulomas?
Which immune cell type is primarily involved in the formation of granulomas?
Which of the following conditions is commonly associated with low IgA levels and frequent respiratory tract infections?
Which of the following conditions is commonly associated with low IgA levels and frequent respiratory tract infections?
Which of the following is a potential consequence of antibody deficiencies?
Which of the following is a potential consequence of antibody deficiencies?
Which type of hypersensitivity reaction leads to the formation of granulomas?
Which type of hypersensitivity reaction leads to the formation of granulomas?
Which of the following is NOT a characteristic of natural killer (NK) cells?
Which of the following is NOT a characteristic of natural killer (NK) cells?
Which of the following is a potential side effect of Anti TNF therapy?
Which of the following is a potential side effect of Anti TNF therapy?
Which of the following is NOT a characteristic of primary antibody deficiencies?
Which of the following is NOT a characteristic of primary antibody deficiencies?