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Questions and Answers
What is the primary reason for the dietary requirement of protein?
What is the primary reason for the dietary requirement of protein?
- To compensate for the body's inability to synthesize certain amino acids (correct)
- To support the growth of new tissues
- To provide energy for the body
- To maintain optimal protein synthesis rates
What is the net result of continuous protein synthesis and breakdown in the body?
What is the net result of continuous protein synthesis and breakdown in the body?
- Maintenance of optimally functioning proteins (correct)
- An increase in the amount of damaged proteins
- A complete halt in protein synthesis
- A decrease in the total amount of protein in the body
What type of bond is formed between the first ubiquitin and the protein substrate in the ubiquitin/proteasome system?
What type of bond is formed between the first ubiquitin and the protein substrate in the ubiquitin/proteasome system?
- Isopeptide bond (correct)
- Disulfide bond
- Hydrogen bond
- Peptide bond
What is the primary function of the ubiquitin/proteasome system?
What is the primary function of the ubiquitin/proteasome system?
What is the term for the continual renewal or replacement of protein in the body?
What is the term for the continual renewal or replacement of protein in the body?
What is the name of the network that regulates protein synthesis and degradation?
What is the name of the network that regulates protein synthesis and degradation?
What is the primary function of the proteasome in the ubiquitin-proteasome system?
What is the primary function of the proteasome in the ubiquitin-proteasome system?
What is the typical number of ubiquitin molecules required to target a protein for destruction?
What is the typical number of ubiquitin molecules required to target a protein for destruction?
What is the energy requirement for the ubiquitin-proteasome system?
What is the energy requirement for the ubiquitin-proteasome system?
What is the primary function of the ubiquitin-like fold in ubiquitin?
What is the primary function of the ubiquitin-like fold in ubiquitin?
What is the result of ubiquitin serving as its own substrate?
What is the result of ubiquitin serving as its own substrate?
What is the first stage in the ubiquitin-proteasome system?
What is the first stage in the ubiquitin-proteasome system?
What energy source fuels the ubiquitination reaction?
What energy source fuels the ubiquitination reaction?
Which enzyme is responsible for transferring Ub to a cysteine residue?
Which enzyme is responsible for transferring Ub to a cysteine residue?
What is the function of the 19S regulatory particle (RP) in the proteasome?
What is the function of the 19S regulatory particle (RP) in the proteasome?
Which type of autophagy degrades soluble or unfoldable proteins in a molecule-by-molecule fashion?
Which type of autophagy degrades soluble or unfoldable proteins in a molecule-by-molecule fashion?
What is the criterion for a protein to be a putative CMA substrate?
What is the criterion for a protein to be a putative CMA substrate?
What is the term for the equilibrium between protein intake and losses?
What is the term for the equilibrium between protein intake and losses?
What is the term for a state where nitrogen intake exceeds nitrogen output?
What is the term for a state where nitrogen intake exceeds nitrogen output?
What is the optimal daily nitrogen balance for anabolism?
What is the optimal daily nitrogen balance for anabolism?
Which disease is caused by maternal deficiency of the E6-AP ubiquitin E3 ligase (UBE3A)?
Which disease is caused by maternal deficiency of the E6-AP ubiquitin E3 ligase (UBE3A)?
What is the term for the process by which cytoplasmic contents are degraded within the lysosome/vacuole?
What is the term for the process by which cytoplasmic contents are degraded within the lysosome/vacuole?
What is the primary component of nitrogen output?
What is the primary component of nitrogen output?
What is the recommended daily protein intake for a 72-kg man?
What is the recommended daily protein intake for a 72-kg man?
What is the constant used to account for nitrogen losses from the skin and feces?
What is the constant used to account for nitrogen losses from the skin and feces?
What is the term for the type of malnutrition caused by inadequate intake of both protein and energy?
What is the term for the type of malnutrition caused by inadequate intake of both protein and energy?
What is the purpose of dividing the daily protein intake by 6.25?
What is the purpose of dividing the daily protein intake by 6.25?
What is the term for the condition that results from a negative nitrogen balance?
What is the term for the condition that results from a negative nitrogen balance?
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