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Nitrates in Cardiology

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Questions and Answers

When should a nitrate-free interval be incorporated into chronic nitrate use?

Every 2 hours

Not necessary to incorporate a nitrate-free interval

During nighttime hours (correct)

During daytime hours

What is the primary effect of nitrates in the body?

Increased preload

Decreased vasodilation

Reduced oxygen demand (correct)

Increased myocardial wall tension

How long does it typically take for relief to occur after administering sublingual NTG during an acute angina episode?

15 minutes

2 hours

1 hour

30 minutes (correct)

Which long-acting nitrates are commonly prescribed for long-term prevention of angina episodes?

Transdermal patches Signup and view all the answers

What is the purpose of prescribing long-acting nitrates (or CCBs) when β-blockers are contraindicated or cause unacceptable side effects?

To reduce oxygen demand Signup and view all the answers

How far apart should extended-release ISMN products that are dosed twice daily be given?

7 hours apart Signup and view all the answers

What is the recommended administration schedule for 8-Transdermal NTG patches?

On in the AM and off in the PM without specific times Signup and view all the answers

Why should nitrates not be used routinely as monotherapy for stable IHD?

Due to potential reflex tachycardia during the nitrate-free interval Signup and view all the answers

What can prevent rebound ischemia during the nitrate-free interval?

Concomitant β-blocker or diltiazem therapy Signup and view all the answers

How can headache caused by nitrates be treated?

With acetaminophen Signup and view all the answers

What are common side effects of nitrates?

Headache and flushing Signup and view all the answers

How can skin erythema and inflammation from transdermal NTG be minimized?

Initiating therapy with smaller doses and/or rotating application site Signup and view all the answers