Nitrates in Cardiology

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Questions and Answers

When should a nitrate-free interval be incorporated into chronic nitrate use?

  • Every 2 hours
  • Not necessary to incorporate a nitrate-free interval
  • During nighttime hours (correct)
  • During daytime hours

What is the primary effect of nitrates in the body?

  • Increased preload
  • Decreased vasodilation
  • Reduced oxygen demand (correct)
  • Increased myocardial wall tension

How long does it typically take for relief to occur after administering sublingual NTG during an acute angina episode?

  • 15 minutes
  • 2 hours
  • 1 hour
  • 30 minutes (correct)

Which long-acting nitrates are commonly prescribed for long-term prevention of angina episodes?

<p>Transdermal patches (A)</p> Signup and view all the answers

What is the purpose of prescribing long-acting nitrates (or CCBs) when β-blockers are contraindicated or cause unacceptable side effects?

<p>To reduce oxygen demand (B)</p> Signup and view all the answers

How far apart should extended-release ISMN products that are dosed twice daily be given?

<p>7 hours apart (D)</p> Signup and view all the answers

What is the recommended administration schedule for 8-Transdermal NTG patches?

<p>On in the AM and off in the PM without specific times (B)</p> Signup and view all the answers

Why should nitrates not be used routinely as monotherapy for stable IHD?

<p>Due to potential reflex tachycardia during the nitrate-free interval (A)</p> Signup and view all the answers

What can prevent rebound ischemia during the nitrate-free interval?

<p>Concomitant β-blocker or diltiazem therapy (B)</p> Signup and view all the answers

How can headache caused by nitrates be treated?

<p>With acetaminophen (C)</p> Signup and view all the answers

What are common side effects of nitrates?

<p>Headache and flushing (B)</p> Signup and view all the answers

How can skin erythema and inflammation from transdermal NTG be minimized?

<p>Initiating therapy with smaller doses and/or rotating application site (C)</p> Signup and view all the answers

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