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Questions and Answers
What is the primary mechanism of action for direct-acting nicotinic agonists?
What is the primary mechanism of action for direct-acting nicotinic agonists?
- Blocking dopamine reuptake
- Inhibiting the release of acetylcholine
- Enhancing the breakdown of acetylcholine
- Reacting directly with nicotinic receptor sites (correct)
Nicotine is classified as what type of agonist at the nicotinic receptor?
Nicotine is classified as what type of agonist at the nicotinic receptor?
- Antagonist
- Full agonist (correct)
- Partial agonist
- Inverse agonist
Which of the following is a partial agonist of the nicotinic receptor used for smoking cessation?
Which of the following is a partial agonist of the nicotinic receptor used for smoking cessation?
- Acetaminophen
- Propranolol
- Nicotine
- Varenicline (Chantix) (correct)
A known contraindication for direct-acting nicotinic agonists is:
A known contraindication for direct-acting nicotinic agonists is:
What cardiovascular effect is a potential adverse effect of direct-acting nicotinic agonists?
What cardiovascular effect is a potential adverse effect of direct-acting nicotinic agonists?
Which of the following is a potential neuropsychiatric adverse effect of direct-acting nicotinic agonists?
Which of the following is a potential neuropsychiatric adverse effect of direct-acting nicotinic agonists?
Direct-acting nicotinic agonists may interact with which common analgesic?
Direct-acting nicotinic agonists may interact with which common analgesic?
Due to dopamine releases, nicotinic agonists simulates what kind of response?
Due to dopamine releases, nicotinic agonists simulates what kind of response?
What is a common gastrointestinal side effect that can be caused by direct-acting nicotinic agonists?
What is a common gastrointestinal side effect that can be caused by direct-acting nicotinic agonists?
Which of the following is a potential integumentary (skin-related) adverse effect of direct-acting nicotinic agonists?
Which of the following is a potential integumentary (skin-related) adverse effect of direct-acting nicotinic agonists?
Flashcards
Direct-Acting Nicotinic Agonists
Direct-Acting Nicotinic Agonists
Directly interact with nicotinic receptors, mimicking ACh effects and triggering dopamine release.
Nicotine
Nicotine
Full agonist of nicotinic receptors, leading to sympathetic and dopamine release related effects.
Varenicline (Chantix)
Varenicline (Chantix)
Partial agonist of nicotinic receptors, used in smoking cessation.
Cautions for Nicotinic Agonists
Cautions for Nicotinic Agonists
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Adverse Effects of Nicotinic Agonists
Adverse Effects of Nicotinic Agonists
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Drug Interactions with Nicotinic Agonists
Drug Interactions with Nicotinic Agonists
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Study Notes
- Direct-acting nicotinic agonists directly interact with nicotinic receptor sites, mimicking acetylcholine (ACh) effects and triggering a sympathetic response
- These agonists also stimulate dopamine release, which activates the reward system and induces a sense of well-being
Specific Agonists
- Nicotine acts as a full agonist of the nicotinic receptor
- Varenicline (Chantix) is a partial agonist of the nicotinic receptor, used to aid in smoking cessation
Contraindications
- Hypersensitivity to direct-acting nicotinic agonists is a contraindication for their use
Cautions
- Cautions are related to withdrawal symptoms due to partial stimulation of nicotine receptors
Adverse Effects
- Cardiovascular effects include tachycardia and hypertension
- Neurological effects may include seizures and neuropsychiatric adverse events
- Other adverse effects: nausea, dry mouth, dizziness, skin rash, strange dreams, and hypertension
Drug-Drug Interactions
- Direct-acting nicotinic agonists can interact with: insulin, propranolol, acetaminophen, caffeine, adrenergic agonists, and alcohol
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