Nicardipine (Cardene) Flashcards
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Questions and Answers

What class does Nicardipine belong to?

  • Antianginal
  • Antihypertensive
  • Coronary vasodilator
  • All of the above (correct)
  • What is Nicardipine indicated for?

  • Management of hypertension
  • Angina pectoris
  • Vasospastic angina
  • All of the above (correct)
  • What is the mechanism of action for Nicardipine?

    Inhibits the transport of calcium into myocardial and vascular smooth muscle cells.

    What is the preparation for Nicardipine?

    <p>All of the above</p> Signup and view all the answers

    What is the dose range for Nicardipine?

    <p>2.5-15mg/hr, may titrate every 15 min.</p> Signup and view all the answers

    What are the hemodynamic effects of Nicardipine?

    <p>Systemic vasodilation resulting in decreased blood pressure.</p> Signup and view all the answers

    How is Nicardipine metabolized?

    <p>Mostly by the liver, with less than or equal to 10% excreted unchanged by the kidneys.</p> Signup and view all the answers

    What are the side effects of Nicardipine?

    <p>A and B</p> Signup and view all the answers

    What are some nursing considerations for Nicardipine?

    <p>Watch for hypotension and monitor hepatic enzymes.</p> Signup and view all the answers

    Study Notes

    Nicardipine Overview

    • Class: Antianginal, antihypertensive, and coronary vasodilator.

    Indications

    • Used for managing hypertension, angina pectoris, and vasospastic angina.

    Mechanism of Action

    • Inhibits calcium transport into myocardial and vascular smooth muscle cells, leading to reduced excitation-contraction coupling.

    Preparation Forms

    • Available in:
      • Single Concentration: 20mg/200ml D5W
      • Double Concentration: 40mg/200ml D5W
      • Maximum Concentration: 125mg/250ml D5W

    Dosage Range

    • Administered at 2.5-15mg/hr, with titration possible every 15 minutes.
    • Initial drip recommended at 6mg/hr, which can be increased by 2.5mg/hr up to a maximum of 15mg/hr.

    Hemodynamic Effects

    • Causes systemic vasodilation, resulting in lowered blood pressure.

    Metabolism and Pharmacokinetics

    • Primarily metabolized by the liver; less than 10% excreted unchanged via kidneys.
    • Onset time: minutes; Peak effect: 45 minutes; Duration: 5 hours; Half-life: 2-4 hours.

    Side Effects

    • Central Nervous System: Dizziness, headache.
    • Cardiovascular: Hypotension.

    Nursing Considerations

    • Monitor patients for hypotension.
    • Commonly used as a first-line treatment for post-operative hypertension, especially following CABG with LIMA, due to its role in preventing arterial spasms.
    • Similar effects to nitroglycerin (NTG) when using LIMA.
    • Prolonged therapy may elevate hepatic enzymes, which typically normalize after discontinuation.
    • Normal concentrations can be infused via peripheral IV if no central line is available.

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    Description

    This quiz focuses on Nicardipine, a medication used for managing hypertension and angina. You'll learn about its classification, clinical indications, and mechanism of action. Perfect for medical students and healthcare professionals looking to enhance their pharmacology knowledge.

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