Neutropenia and Chronic Benign Neutropenia

Neutropenia affects the bone marrow resulting in high levels of neutrophils in the blood.

Chronic benign neutropenia typically has a self-limiting course of 10-18 months.

Cyclic neutropenia is an autosomal dominant disorder affecting oral defense mechanisms against dental caries.

Individuals with Down's syndrome may develop severe aggressive periodontitis on the upper anterior region.

Leukocyte Adhesion Deficiency Syndrome results in impaired leukocyte adhesion and chemotaxis.

Papillon-Lefevre syndrome primarily affects the skin, leading to hyperkeratosis.

Chediak-Higashi syndrome is an autosomal dominant immunodeficiency disorder.

Histiocytosis X can present with punched-out necrotic ulcers, tissue necrosis, and marked bone loss in the periodontium.

Ehlers-Danlos syndrome type IV is characterized by a disorder of joints and skin but does not involve periodontal issues.

Individuals with Hypophosphatasia experience increased urinary excretion of phosphate and enhanced monocyte chemotaxis.