Development of CNS - CNS الجزء الأول أناتومي الـ

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

Failure of the cranial neuropore to close around the 25th day of development results in which condition?

  • Microcephaly
  • Spina bifida occulta
  • Hydrocephalus
  • Anencephaly (correct)

Which of the following developmental structures gives rise to the ganglia of the body?

  • Neuroblasts (correct)
  • Chromaffin cells
  • Melanocytes
  • Spongioblasts

The ventricular system of the brain is derived from which of the following?

  • The cranial part of the neural tube.
  • The cavity of the neural tube. (correct)
  • The caudal part of the neural tube.
  • The neural crest cells.

During neurulation, what structure is formed by the fusion of neural folds?

<p>Neural tube (D)</p> Signup and view all the answers

Which of the following best describes the origin of neural crest cells?

<p>They separate from the ectoderm during neural fold fusion. (B)</p> Signup and view all the answers

Chromaffin cells, which contribute to the suprarenal medulla and carotid bodies, are derived from what embryonic structure?

<p>Neural crest cells (C)</p> Signup and view all the answers

A defect in the closure of the caudal neuropore during neural tube development would most likely result in which condition?

<p>Spina bifida (C)</p> Signup and view all the answers

What is the correct order of the following structures during the process of neurulation?

<p>Neural plate → Neural groove → Neural fold → Neural tube (C)</p> Signup and view all the answers

Which of the following structures is derived from the prosencephalon?

<p>Cerebral hemisphere (B)</p> Signup and view all the answers

The obstruction of the aqueduct of Sylvius is most directly associated with which of the following conditions?

<p>Hydrocephalus (C)</p> Signup and view all the answers

Which part of the developing neural tube forms the spinal cord?

<p>Caudal part (C)</p> Signup and view all the answers

What is the defining characteristic of spina bifida occulta?

<p>It is an asymptomatic condition, often indicated by a tuft of hair. (C)</p> Signup and view all the answers

From which primary brain vesicle does the pons and cerebellum originate?

<p>Metencephalon (D)</p> Signup and view all the answers

Which structure directly precedes the formation of the neural tube during embryonic development?

<p>Neural plate (B)</p> Signup and view all the answers

Which of the following gives rise to the pia and arachnoid mater?

<p>Spongioblasts (B)</p> Signup and view all the answers

What brain region is derived from the mesencephalon?

<p>Midbrain (B)</p> Signup and view all the answers

Which of the following anomalies is characterized by an abnormal ventricular system due to CSF accumulation?

<p>Hydrocephalus (B)</p> Signup and view all the answers

The telencephalon gives rise to what structure?

<p>Cerebral hemisphere (D)</p> Signup and view all the answers

During neurulation, the neural groove is located:

<p>At the center of the neural plate (B)</p> Signup and view all the answers

Failure of the caudal neuropore to close properly can result in:

<p>Spina Bifida (B)</p> Signup and view all the answers

Considering the derivatives of the neural crest cells, if a genetic mutation disrupted the normal development of spongioblasts, which of the following structures would most likely be affected?

<p>The structural integrity of Schwann cells and the pia and arachnoid mater. (B)</p> Signup and view all the answers

During neurulation, the neural tube separates from the ectoderm. What cellular process is most critical for ensuring this separation occurs correctly, preventing neural tube defects?

<p>Apoptosis of cells linking the neural tube and surface ectoderm. (C)</p> Signup and view all the answers

Which of the following scenarios would most directly lead to hydrocephalus?

<p>Excessive production of cerebrospinal fluid (CSF) by the choroid plexus without a corresponding increase in reabsorption. (C)</p> Signup and view all the answers

A research team is studying the expression of specific transcription factors during the formation of the neural tube. If they observe a complete absence of Pax6 expression, which of the following processes would most likely be disrupted?

<p>Ventral induction and subsequent motor neuron specification within the neural tube. (C)</p> Signup and view all the answers

During a prenatal ultrasound, a physician observes that a fetus has an abnormally small head circumference (microcephaly). Considering the developmental origins of the brain, which of the following underlying cellular processes is most likely impaired in this case?

<p>Reduced proliferation of neural progenitor cells in the ventricular zone. (D)</p> Signup and view all the answers

A researcher is investigating the role of cell adhesion molecules during neural tube closure. If they introduce a mutation that disrupts the function of N-cadherin specifically in the neural folds, what would be the most likely outcome?

<p>Failure of the neural folds to adhere and fuse properly. (C)</p> Signup and view all the answers

If the rhombencephalon failed to properly differentiate during embryonic development, which of the following structures would most likely be affected?

<p>Pons and medulla oblongata. (D)</p> Signup and view all the answers

During the formation of the ventricular system, an obstruction occurs at the cerebral aqueduct (aqueduct of Sylvius). Which of the following ventricles would be most directly affected?

<p>Third ventricle and lateral ventricles. (B)</p> Signup and view all the answers

A genetic study reveals a mutation affecting the expression of sonic hedgehog (SHH) specifically in the notochord. Which of the following developmental processes would be most directly impacted?

<p>Induction of the floor plate in the neural tube. (B)</p> Signup and view all the answers

Failure of neuroblasts to properly differentiate during neural crest development would most directly affect:

<p>The development of most body ganglia. (D)</p> Signup and view all the answers

Assuming a teratogen exposure specifically disrupts the development of the telencephalon, which resulting condition would be most anticipated?

<p>Cognitive and motor deficits due to abnormal cerebral hemisphere development. (A)</p> Signup and view all the answers

During early neural tube development, the alar plate and basal plate form. If the morphogenic signals guiding the development of the alar plate were disrupted, what type of neurons would be most affected?

<p>Sensory neurons (B)</p> Signup and view all the answers

If the expression of fibroblast growth factor 8 (FGF8) is significantly reduced at the anterior neural ridge during early brain development, which structure formation is most likely to be impaired?

<p>Development of the cerebral hemispheres (D)</p> Signup and view all the answers

In a scenario where the intermediate cell mass fails to develop properly during kidney formation, which related system could also exhibit abnormalities due to proximity during development?

<p>The reproductive system (C)</p> Signup and view all the answers

Which cellular event is an essential step in the transformation of the neural plate into the neural tube?

<p>Shaping through apical constriction of cells in the neural plate. (D)</p> Signup and view all the answers

If the diencephalon fails to develop properly, which sensory or motor function impairment would be most expected?

<p>Difficulty regulating body temperature (C)</p> Signup and view all the answers

Disruptions in the normal signaling pathways during mesencephalon development, leading to malformation, would most likely impact which function?

<p>Visual and auditory reflexes (A)</p> Signup and view all the answers

What specific developmental event is critically dependent on the proper functioning of the organizer region during neurulation?

<p>Induction of the neural plate (A)</p> Signup and view all the answers

In the context of neural tube defects, what distinguishes spina bifida with myelocele from spina bifida with meningocele?

<p>Myelocele involves the spinal cord protruding through the defect, whereas meningocele does not. (D)</p> Signup and view all the answers

What would be the most significant consequence if somite development was disrupted?

<p>Malformation of the axial skeleton and musculature. (C)</p> Signup and view all the answers

Flashcards

Neurulation

Formation of the neural tube in embryonic development.

Neural Plate

Thickened region of the epiblast above the notochord, forming the basis of the neural tube.

Neural Groove

Median groove at the center of the neural plate, eventually forming the neural tube.

Neural Fold

Two folds on each side of the neural groove that eventually fuse to form the neural tube.

Signup and view all the flashcards

Neural Tube

Structure formed by the fusion of neural folds, which later separates from the surface ectoderm.

Signup and view all the flashcards

Neural Crest Cells

Neuro-ectodermal cells that separate from the ectoderm during neural folds fusion.

Signup and view all the flashcards

Prosencephalon

Forebrain; divides into telencephalon and diencephalon.

Signup and view all the flashcards

Telencephalon

Gives rise to cerebral hemispheres and contains lateral ventricles.

Signup and view all the flashcards

Diencephalon

Gives rise to the thalamus, hypothalamus, and contains the third ventricle.

Signup and view all the flashcards

Mesencephalon

Gives rise to the midbrain and contains the aqueduct of Sylvius.

Signup and view all the flashcards

Rhombencephalon

Hindbrain; divides into metencephalon and myelencephalon.

Signup and view all the flashcards

Metencephalon

Gives rise to pons and cerebellum; part of the rhombencephalon.

Signup and view all the flashcards

Myelencephalon

Gives rise to the medulla oblongata.

Signup and view all the flashcards

Hydrocephalus

Abnormal dilation of the ventricular system due to CSF accumulation

Signup and view all the flashcards

Anacephaly

Failure of cranial neuropore to close, resulting in absence of major portion of the brain.

Signup and view all the flashcards

Microcephally

Small head circumference than normal.

Signup and view all the flashcards

Spina Bifida

Failure of vertebral arch fusion especially in the lumbo-sacral region.

Signup and view all the flashcards

Spina Bifida Occulta

Asymptomatic spina bifida affecting 10% of newborns; covered by a tuft of hair.

Signup and view all the flashcards

Spina Bifida with Meningocele

Spina bifida where spinal cord is normal but meninges project via the deficient area.

Signup and view all the flashcards

Spina Bifida with Meningo-myelocele

Spina bifida where spinal cord and meninges project via the deficient area.

Signup and view all the flashcards

Fate of cranial neural tube

Becomes dilated to form the brain.

Signup and view all the flashcards

Fate of caudal neural tube

Forms the spinal cord.

Signup and view all the flashcards

Neuroblasts derivatives

Gives rise to almost all ganglia of the body

Signup and view all the flashcards

Melanocytes derivatives

Give rise to pigment cells of the skin

Signup and view all the flashcards

Spongioblasts derivatives

Give rise to Schwann cells, Pia & arachnoid mater

Signup and view all the flashcards

Chromaffin cells derivatives

Give rise to Suprarenal medulla, Carotid bodies cells

Signup and view all the flashcards

Odontoblast

Derivatives of neural crest cells, involved in tooth development

Signup and view all the flashcards

Study Notes

Neurulation

  • Neurulation is the formation of the neural tube
  • The neural plate is a thick epiblast located above the notochord
  • The neural groove is the median groove at the center of the neural plate
  • The neural fold has two folds on each side of the neural groove
  • Fusion of neural folds is followed by separation of the neural tube from the epiblast
  • The cranial and caudal neuropores close on the 25th and 27th days, respectively
  • The cranial part of the neural tube dilates to form the brain
  • The caudal part of the neural tube forms the spinal cord
  • The cavity of the neural tube forms the ventricular system

Neural Crest Cells

  • Neural crest cells are neuro-ectodermal cells that separate from the ectoderm during the fusion of neural folds to form the neural tube
  • Neuroblasts, melanocytes, spongioblasts, chromaffin cells and odontoblast are derived from neural crest cells
  • Neuroblasts give rise to almost all ganglia of the body
  • Melanocytes are pigment cells of the skin
  • Spongioblasts give rise to Schwann cells, pia, and arachnoid mater
  • Chromaffin cells give rise to the suprarenal medulla and carotid bodies cells.

Brain Division

  • The prosencephalon, or forebrain, subdivides into the telencephalon and diencephalon
  • The telencephalon forms the cerebral hemisphere and contains the lateral ventricle
  • The diencephalon forms the thalamus, hypothalamus, subthalamus, and epithalamus and contains the third ventricle
  • The mesencephalon forms the midbrain and contains the aqueduct of Sylvius
  • The rhombencephalon, or hindbrain, contains the fourth ventricle, and is divided into the metencephalon and myelencephalon
  • The metencephalon gives rise to the pons and cerebellum
  • The myelencephalon gives rise to the medulla

Anomalies

  • Hydrocephalus is abnormal dilation of the ventricular system due to CSF accumulation, often from obstruction of the aqueduct of Sylvius
  • Anacephally is caused by failure of the cranial neuropore to close by the 25th day
  • Microcephaly is a smaller than normal head circumference
  • Spina bifida involves failure of vertebral arch fusion, especially in the lumbo-sacral region, and has three types: occulta, meningocele, and meningo-myelocele
    • Spina bifida occulta is asymptomatic and affects 10% of newborns, where the deficient area is covered by a tuft of hair
    • Spina bifida with meningocele has normal spinal cord with meninges projecting via the deficient area
    • Spina bifida with meningo-myelocele involves the spinal cord and meninges projecting via the deficient area

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Neurulation and Organogenesis
24 questions
Neurulation Process in Embryonic Development
5 questions
Neurulation and Neural Tube Formation
25 questions
Neural Tube Formation
40 questions

Neural Tube Formation

LovableConnemara5413 avatar
LovableConnemara5413
Use Quizgecko on...
Browser
Browser