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Neurotransmitters and Receptors

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Questions and Answers

Which enzyme is primarily responsible for metabolizing dopamine in the central nervous system?

Catechol-O-Methyltransferase (COMT)

Monoamine Oxidase-B (MAO-B) (correct)

Monoamine Oxidase-A (MAO-A)

Dopamine Beta-Hydroxylase (DBH)

Which of the following neurotransmitters is NOT primarily metabolized by Monoamine Oxidase-A (MAO-A)?

Serotonin

Dopamine (correct)

Epinephrine

Norepinephrine

What is the primary difference between Monoamine Oxidase-A (MAO-A) and Monoamine Oxidase-B (MAO-B)?

MAO-A metabolizes dopamine, while MAO-B metabolizes serotonin

MAO-A is found in the peripheral nervous system, while MAO-B is found in the central nervous system (correct)

MAO-A is primarily found in the central nervous system, while MAO-B is primarily found in the peripheral nervous system

MAO-A is involved in the degradation of catecholamines, while MAO-B is involved in the degradation of trace amines

Which of the following is NOT a substrate for Monoamine Oxidase-A (MAO-A)?

Phenylethylamine Signup and view all the answers

What is the role of Monoamine Oxidase-B (MAO-B) in the central nervous system?

To degrade trace amines and phenylethylamine Signup and view all the answers

Which antibiotic has a disulfiram-like action?

Metronidazole Signup and view all the answers

What type of antibiotic is Griseofulvin?

Antifungal Signup and view all the answers

Which antibiotic is not mentioned as having a disulfiram-like action?

Tetracycline Signup and view all the answers

What is a common characteristic of ketoconazole and metronidazole?

They are both antibacterial antibiotics with a disulfiram-like action Signup and view all the answers

Which of the following is a side effect that propranolol is least likely to cause?

Insomnia Signup and view all the answers

Study Notes

Neurotransmitters and Enzymes

Glutamate is an excitatory neurotransmitter that induces synapse neurotransmission.
Topiramate is a blocker of voltage-dependent Na channels and increases the activity of GABA and glutamate receptors.
Norepinephrine, serotonin, and dopamine are degraded by both MAO (monoamine oxidase) and COMT (catechol-O-methyltransferase).

MAO Isoforms and Substrates

MAO-A primarily acts on epinephrine, norepinephrine, and serotonin.
MAO-B, mainly found in the CNS, primarily acts on dopamine, phenylethylamine, and trace amines.

Antibiotics and Seizures

Gentamicin is the least likely antibiotic to induce seizures.
Gentamicin is considered safe for use in patients with a history of seizures.

Factors that Decrease Seizure Threshold

Antibiotics can decrease seizure threshold.

Drugs with Disulfiram-Like Action

The following drugs have disulfiram-like action:
- Griseofulvin
- Cotrimoxazole
- Metronidazole
- Ketoconazole
- Cephalosporins
- Chloramphenicol
- Propranolol

Side Effects

Some antibiotics can cause insomnia as a side effect, but:
- The least likely antibiotic to cause insomnia as a side effect is not specified.

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Description

This quiz covers the functions of glutamate and GABA neurotransmitters, as well as the effects of topiramate on voltage-dependent Na channels and neurotransmitter receptors.