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Neurotransmitters and Receptors
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Neurotransmitters and Receptors

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Questions and Answers

Which enzyme is primarily responsible for metabolizing dopamine in the central nervous system?

  • Catechol-O-Methyltransferase (COMT)
  • Monoamine Oxidase-B (MAO-B) (correct)
  • Monoamine Oxidase-A (MAO-A)
  • Dopamine Beta-Hydroxylase (DBH)
  • Which of the following neurotransmitters is NOT primarily metabolized by Monoamine Oxidase-A (MAO-A)?

  • Serotonin
  • Dopamine (correct)
  • Epinephrine
  • Norepinephrine
  • What is the primary difference between Monoamine Oxidase-A (MAO-A) and Monoamine Oxidase-B (MAO-B)?

  • MAO-A metabolizes dopamine, while MAO-B metabolizes serotonin
  • MAO-A is found in the peripheral nervous system, while MAO-B is found in the central nervous system (correct)
  • MAO-A is primarily found in the central nervous system, while MAO-B is primarily found in the peripheral nervous system
  • MAO-A is involved in the degradation of catecholamines, while MAO-B is involved in the degradation of trace amines
  • Which of the following is NOT a substrate for Monoamine Oxidase-A (MAO-A)?

    <p>Phenylethylamine</p> Signup and view all the answers

    What is the role of Monoamine Oxidase-B (MAO-B) in the central nervous system?

    <p>To degrade trace amines and phenylethylamine</p> Signup and view all the answers

    Which antibiotic has a disulfiram-like action?

    <p>Metronidazole</p> Signup and view all the answers

    What type of antibiotic is Griseofulvin?

    <p>Antifungal</p> Signup and view all the answers

    Which antibiotic is not mentioned as having a disulfiram-like action?

    <p>Tetracycline</p> Signup and view all the answers

    What is a common characteristic of ketoconazole and metronidazole?

    <p>They are both antibacterial antibiotics with a disulfiram-like action</p> Signup and view all the answers

    Which of the following is a side effect that propranolol is least likely to cause?

    <p>Insomnia</p> Signup and view all the answers

    Study Notes

    Neurotransmitters and Enzymes

    • Glutamate is an excitatory neurotransmitter that induces synapse neurotransmission.
    • Topiramate is a blocker of voltage-dependent Na channels and increases the activity of GABA and glutamate receptors.
    • Norepinephrine, serotonin, and dopamine are degraded by both MAO (monoamine oxidase) and COMT (catechol-O-methyltransferase).

    MAO Isoforms and Substrates

    • MAO-A primarily acts on epinephrine, norepinephrine, and serotonin.
    • MAO-B, mainly found in the CNS, primarily acts on dopamine, phenylethylamine, and trace amines.

    Antibiotics and Seizures

    • Gentamicin is the least likely antibiotic to induce seizures.
    • Gentamicin is considered safe for use in patients with a history of seizures.

    Factors that Decrease Seizure Threshold

    • Antibiotics can decrease seizure threshold.

    Drugs with Disulfiram-Like Action

    • The following drugs have disulfiram-like action:
      • Griseofulvin
      • Cotrimoxazole
      • Metronidazole
      • Ketoconazole
      • Cephalosporins
      • Chloramphenicol
      • Propranolol

    Side Effects

    • Some antibiotics can cause insomnia as a side effect, but:
      • The least likely antibiotic to cause insomnia as a side effect is not specified.

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    Description

    This quiz covers the functions of glutamate and GABA neurotransmitters, as well as the effects of topiramate on voltage-dependent Na channels and neurotransmitter receptors.

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