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Questions and Answers
Which enzyme is primarily responsible for metabolizing dopamine in the central nervous system?
Which enzyme is primarily responsible for metabolizing dopamine in the central nervous system?
- Catechol-O-Methyltransferase (COMT)
- Monoamine Oxidase-B (MAO-B) (correct)
- Monoamine Oxidase-A (MAO-A)
- Dopamine Beta-Hydroxylase (DBH)
Which of the following neurotransmitters is NOT primarily metabolized by Monoamine Oxidase-A (MAO-A)?
Which of the following neurotransmitters is NOT primarily metabolized by Monoamine Oxidase-A (MAO-A)?
- Serotonin
- Dopamine (correct)
- Epinephrine
- Norepinephrine
What is the primary difference between Monoamine Oxidase-A (MAO-A) and Monoamine Oxidase-B (MAO-B)?
What is the primary difference between Monoamine Oxidase-A (MAO-A) and Monoamine Oxidase-B (MAO-B)?
- MAO-A metabolizes dopamine, while MAO-B metabolizes serotonin
- MAO-A is found in the peripheral nervous system, while MAO-B is found in the central nervous system (correct)
- MAO-A is primarily found in the central nervous system, while MAO-B is primarily found in the peripheral nervous system
- MAO-A is involved in the degradation of catecholamines, while MAO-B is involved in the degradation of trace amines
Which of the following is NOT a substrate for Monoamine Oxidase-A (MAO-A)?
Which of the following is NOT a substrate for Monoamine Oxidase-A (MAO-A)?
What is the role of Monoamine Oxidase-B (MAO-B) in the central nervous system?
What is the role of Monoamine Oxidase-B (MAO-B) in the central nervous system?
Which antibiotic has a disulfiram-like action?
Which antibiotic has a disulfiram-like action?
What type of antibiotic is Griseofulvin?
What type of antibiotic is Griseofulvin?
Which antibiotic is not mentioned as having a disulfiram-like action?
Which antibiotic is not mentioned as having a disulfiram-like action?
What is a common characteristic of ketoconazole and metronidazole?
What is a common characteristic of ketoconazole and metronidazole?
Which of the following is a side effect that propranolol is least likely to cause?
Which of the following is a side effect that propranolol is least likely to cause?
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Study Notes
Neurotransmitters and Enzymes
- Glutamate is an excitatory neurotransmitter that induces synapse neurotransmission.
- Topiramate is a blocker of voltage-dependent Na channels and increases the activity of GABA and glutamate receptors.
- Norepinephrine, serotonin, and dopamine are degraded by both MAO (monoamine oxidase) and COMT (catechol-O-methyltransferase).
MAO Isoforms and Substrates
- MAO-A primarily acts on epinephrine, norepinephrine, and serotonin.
- MAO-B, mainly found in the CNS, primarily acts on dopamine, phenylethylamine, and trace amines.
Antibiotics and Seizures
- Gentamicin is the least likely antibiotic to induce seizures.
- Gentamicin is considered safe for use in patients with a history of seizures.
Factors that Decrease Seizure Threshold
- Antibiotics can decrease seizure threshold.
Drugs with Disulfiram-Like Action
- The following drugs have disulfiram-like action:
- Griseofulvin
- Cotrimoxazole
- Metronidazole
- Ketoconazole
- Cephalosporins
- Chloramphenicol
- Propranolol
Side Effects
- Some antibiotics can cause insomnia as a side effect, but:
- The least likely antibiotic to cause insomnia as a side effect is not specified.
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