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Neurotransmitter Synthesis, Storage, and Release

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Neurotransmitter Synthesis, Storage, and Release

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Questions and Answers

Where is dopamine mainly synthesized?

In the synaptic cleft

Inside dopaminergic neurons (correct)

In the presynaptic neuron's terminal

Within the postsynaptic neuron

What triggers the release of dopamine from vesicles?

Enzymatic degradation

Re-uptake into the presynaptic neuron

Signal reaching the postsynaptic neuron

Signal reaching the presynaptic neuron's terminal (correct)

How is the action of dopamine terminated?

Synthesis from L-dopa

Storage in vesicles

Binding to postsynaptic receptors

Re-uptake, enzymatic degradation, and diffusion (correct)

Where does released dopamine bind after being released from vesicles?

Postsynaptic receptors on the target neuron Signup and view all the answers

What are the enzymes involved in dopamine breakdown?

Monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) Signup and view all the answers

What is responsible for the reabsorption of dopamine back into the presynaptic neuron?

The dopamine transporter (DAT) Signup and view all the answers

What is the main function of the vesicular monoamine transporter (VMAT-2)?

It transports dopamine into vesicles Signup and view all the answers

What is the process by which dopamine is released into the synaptic cleft?

Exocytosis Signup and view all the answers

Which type of receptor is located on the presynaptic neuron and plays a role in regulating the amount of dopamine released?

Autoreceptor Signup and view all the answers

What is the main effect of activating D1 family receptors?

Increase in cyclic AMP (cAMP) levels Signup and view all the answers

Which enzyme is associated with mitochondrial membranes and responsible for breaking down neurotransmitters, including dopamine, into inactive metabolites?

Monoamine oxidase (MAO) Signup and view all the answers

Where is Catechol-O-methyltransferase (COMT) localized within the cell?

Cytosol Signup and view all the answers

What is the primary role of Catechol-O-methyltransferase (COMT) in dopamine metabolism?

Converting dopamine into inactive metabolites Signup and view all the answers