13 Questions
Where is dopamine mainly synthesized?
Inside dopaminergic neurons
What triggers the release of dopamine from vesicles?
Signal reaching the presynaptic neuron's terminal
How is the action of dopamine terminated?
Re-uptake, enzymatic degradation, and diffusion
Where does released dopamine bind after being released from vesicles?
Postsynaptic receptors on the target neuron
What are the enzymes involved in dopamine breakdown?
Monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT)
What is responsible for the reabsorption of dopamine back into the presynaptic neuron?
The dopamine transporter (DAT)
What is the main function of the vesicular monoamine transporter (VMAT-2)?
It transports dopamine into vesicles
What is the process by which dopamine is released into the synaptic cleft?
Exocytosis
Which type of receptor is located on the presynaptic neuron and plays a role in regulating the amount of dopamine released?
Autoreceptor
What is the main effect of activating D1 family receptors?
Increase in cyclic AMP (cAMP) levels
Which enzyme is associated with mitochondrial membranes and responsible for breaking down neurotransmitters, including dopamine, into inactive metabolites?
Monoamine oxidase (MAO)
Where is Catechol-O-methyltransferase (COMT) localized within the cell?
Cytosol
What is the primary role of Catechol-O-methyltransferase (COMT) in dopamine metabolism?
Converting dopamine into inactive metabolites
This quiz covers the synthesis, storage, and release of neurotransmitters, focusing on dopamine as a specific example. It explores the enzymatic reactions involved in dopamine synthesis, the storage of newly synthesized dopamine in vesicles, and the release process into the synaptic cleft.
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