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Questions and Answers
What is the rate-limiting enzyme in catecholamine biosynthesis?
What is the rate-limiting enzyme in catecholamine biosynthesis?
Tyrosine hydroxylase (TH, tyrosine 3-monooxygenase)
What are the cofactors required by tyrosine hydroxylase for catecholamine biosynthesis?
What are the cofactors required by tyrosine hydroxylase for catecholamine biosynthesis?
Tetrahydrobiopterin (BH4) and ferrous iron (Fe2+)
What is the primary function of dopamine in the brain?
What is the primary function of dopamine in the brain?
Dopamine functions independently as a neurotransmitter.
What are the structural components of tyrosine hydroxylase?
What are the structural components of tyrosine hydroxylase?
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What is the long-term, nearly irreversible type of end product inhibition of tyrosine hydroxylase?
What is the long-term, nearly irreversible type of end product inhibition of tyrosine hydroxylase?
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What is the alternate pathway for the formation of tyrosine in patients diagnosed with phenylketonuria?
What is the alternate pathway for the formation of tyrosine in patients diagnosed with phenylketonuria?
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What enzyme catalyzes the conversion of L-DOPA to dopamine?
What enzyme catalyzes the conversion of L-DOPA to dopamine?
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How is dopamine metabolized within the terminal?
How is dopamine metabolized within the terminal?
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What is the principal metabolite of dopamine resulting from MAO and aldehyde dehydrogenase activity?
What is the principal metabolite of dopamine resulting from MAO and aldehyde dehydrogenase activity?
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How are the physiological actions of catecholamines terminated?
How are the physiological actions of catecholamines terminated?
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