Podcast
Questions and Answers
A neurotransmitter receptor is a membrane receptor protein that is activated by a ______.
A neurotransmitter receptor is a membrane receptor protein that is activated by a ______.
neurotransmitter
If a neurotransmitter bumps into its corresponding receptor, they will ______ and can trigger other events to occur inside the cell.
If a neurotransmitter bumps into its corresponding receptor, they will ______ and can trigger other events to occur inside the cell.
bind
The influx of ions through ion channels opened due to the binding of neurotransmitters to specific receptors can change the ______ potential of a neuron.
The influx of ions through ion channels opened due to the binding of neurotransmitters to specific receptors can change the ______ potential of a neuron.
membrane
AMPA is a specific agonist for the ______ receptor, where it mimics the effects of the neurotransmitter glutamate.
AMPA is a specific agonist for the ______ receptor, where it mimics the effects of the neurotransmitter glutamate.
AMPA generates fast excitatory ______ potentials (EPSP).
AMPA generates fast excitatory ______ potentials (EPSP).
AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near ______ mV.
AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near ______ mV.
The NMDA receptor is one of three types of ______ receptors
The NMDA receptor is one of three types of ______ receptors
The ligands for the NMDA receptor are ______ and glycine (or D-serine)
The ligands for the NMDA receptor are ______ and glycine (or D-serine)
The NMDA receptor acts as a 'coincidence detector' and only opens when both glutamate and glycine (or D-serine) are present and the neuron is sufficiently [blanked]
The NMDA receptor acts as a 'coincidence detector' and only opens when both glutamate and glycine (or D-serine) are present and the neuron is sufficiently [blanked]
γ-Aminobutyric acid (GABA) is the chief ______ neurotransmitter in the developmentally mature mammalian central nervous system.
γ-Aminobutyric acid (GABA) is the chief ______ neurotransmitter in the developmentally mature mammalian central nervous system.
GABAB receptors are ______ receptors, which are G protein-coupled receptors that open or close ion channels via intermediaries (G proteins)
GABAB receptors are ______ receptors, which are G protein-coupled receptors that open or close ion channels via intermediaries (G proteins)
Neurons that produce GABA as their output are called GABAergic neurons, and have chiefly ______ action at receptors in the adult vertebra.
Neurons that produce GABA as their output are called GABAergic neurons, and have chiefly ______ action at receptors in the adult vertebra.
Flashcards
Neurotransmitter Receptor
Neurotransmitter Receptor
A membrane receptor protein activated by a neurotransmitter.
Binding
Binding
The process where a neurotransmitter attaches to its corresponding receptor, triggering events inside the cell.
Membrane Potential Change
Membrane Potential Change
The electrical potential across a neuron's membrane, which can be altered by ion flow through channels opened by neurotransmitter binding.
AMPA
AMPA
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EPSP (AMPA)
EPSP (AMPA)
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AMPA Receptor Channels
AMPA Receptor Channels
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NMDA Receptor
NMDA Receptor
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NMDA Receptor Ligands
NMDA Receptor Ligands
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NMDA Receptor as 'Coincidence Detector'
NMDA Receptor as 'Coincidence Detector'
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GABA
GABA
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GABAB receptors
GABAB receptors
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GABAergic Neurons
GABAergic Neurons
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Study Notes
Neurotransmitter Receptors
- Membrane receptor proteins activated by neurotransmitters.
- Interaction with corresponding receptors can trigger intracellular events.
- Influx of ions through opened ion channels alters the membrane potential of neurons.
AMPA Receptor
- AMPA is an agonist for the glutamate receptor, mimicking glutamate's effects.
- Generates fast excitatory postsynaptic potentials (EPSP).
- Activates non-selective cationic channels, allowing Na+ and K+ passage.
- Equilibrium potential of AMPA receptors is approximately +60 mV.
NMDA Receptor
- One of three key types of glutamate receptors.
- Ligands include glutamate and glycine (or D-serine).
- Functions as a 'coincidence detector': only opens in the presence of both glutamate and glycine (or D-serine) while the neuron is adequately depolarized.
GABA and GABAB Receptors
- γ-Aminobutyric acid (GABA) serves as the primary inhibitory neurotransmitter in mature mammalian CNS.
- GABAB receptors are G protein-coupled receptors that modulate ion channels through G proteins.
- Neurons that release GABA are referred to as GABAergic neurons, primarily exerting inhibitory actions in adult vertebrates.
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