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Questions and Answers
Where do nociceptive axons synapse with second-order neurons?
Where do nociceptive axons synapse with second-order neurons?
- Lamina VII, VIII, and IX of the dorsal horn
- Lamina X of the dorsal horn
- Lamina III, IV, and VI of the dorsal horn
- Lamina I, II, and V of the dorsal horn (correct)
What neurotransmitter is released by moderate pain axons?
What neurotransmitter is released by moderate pain axons?
- Dopamine and serotonin
- Glutamate (correct)
- Substance P and ATP
- GABA and glycine
What is released by stronger pain axons?
What is released by stronger pain axons?
- ATP and serotonin
- Glycine and dopamine
- Glutamate and GABA
- Glutamate and substance P (correct)
What is the function of local inhibitory interneurons?
What is the function of local inhibitory interneurons?
What is the characteristic of the action of stronger pain axons?
What is the characteristic of the action of stronger pain axons?
In which lamina of the dorsal horn do nociceptive axons synapse with second-order neurons?
In which lamina of the dorsal horn do nociceptive axons synapse with second-order neurons?
What is the primary neurotransmitter released by moderate pain axons?
What is the primary neurotransmitter released by moderate pain axons?
What is the characteristic of the action of moderate pain axons?
What is the characteristic of the action of moderate pain axons?
What is the role of local inhibitory interneurons in the dorsal horn?
What is the role of local inhibitory interneurons in the dorsal horn?
What is the difference between stronger pain axons and moderate pain axons?
What is the difference between stronger pain axons and moderate pain axons?
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Study Notes
Synaptic Transmission of Pain Signals
- Nociceptive axons form synapses with second-order neurons in specific laminae of the dorsal horn in the spinal cord, namely lamina I, II, and V.
- Moderate pain transmission involves the release of glutamate from axons, resulting in fast action.
- Stronger pain transmission involves the release of both glutamate and substance P (and ATP) from axons, resulting in slower and sustained actions.
- Local inhibitory interneurons play a regulatory role by releasing GABA and glycine, which counteract the excitatory effects of pain transmission.
Synaptic Transmission of Pain Signals
- Nociceptive axons form synapses with second-order neurons in specific laminae of the dorsal horn in the spinal cord, namely lamina I, II, and V.
- Moderate pain transmission involves the release of glutamate from axons, resulting in fast action.
- Stronger pain transmission involves the release of both glutamate and substance P (and ATP) from axons, resulting in slower and sustained actions.
- Local inhibitory interneurons play a regulatory role by releasing GABA and glycine, which counteract the excitatory effects of pain transmission.
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