10 Questions
Where do nociceptive axons synapse with second-order neurons?
Lamina I, II, and V of the dorsal horn
What neurotransmitter is released by moderate pain axons?
Glutamate
What is released by stronger pain axons?
Glutamate and substance P
What is the function of local inhibitory interneurons?
To release GABA and glycine
What is the characteristic of the action of stronger pain axons?
Slow and sustained
In which lamina of the dorsal horn do nociceptive axons synapse with second-order neurons?
Lamina I, II, and V
What is the primary neurotransmitter released by moderate pain axons?
Glutamate
What is the characteristic of the action of moderate pain axons?
Faster and shorter
What is the role of local inhibitory interneurons in the dorsal horn?
They release GABA and glycine
What is the difference between stronger pain axons and moderate pain axons?
Stronger pain axons release glutamate and substance P
Study Notes
Synaptic Transmission of Pain Signals
- Nociceptive axons form synapses with second-order neurons in specific laminae of the dorsal horn in the spinal cord, namely lamina I, II, and V.
- Moderate pain transmission involves the release of glutamate from axons, resulting in fast action.
- Stronger pain transmission involves the release of both glutamate and substance P (and ATP) from axons, resulting in slower and sustained actions.
- Local inhibitory interneurons play a regulatory role by releasing GABA and glycine, which counteract the excitatory effects of pain transmission.
Synaptic Transmission of Pain Signals
- Nociceptive axons form synapses with second-order neurons in specific laminae of the dorsal horn in the spinal cord, namely lamina I, II, and V.
- Moderate pain transmission involves the release of glutamate from axons, resulting in fast action.
- Stronger pain transmission involves the release of both glutamate and substance P (and ATP) from axons, resulting in slower and sustained actions.
- Local inhibitory interneurons play a regulatory role by releasing GABA and glycine, which counteract the excitatory effects of pain transmission.
This quiz covers the synaptic transmission of pain signals in the spinal cord, including the release of neurotransmitters such as glutamate and substance P. It also touches on the role of local inhibitory interneurons in pain modulation.
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