Podcast
Questions and Answers
What type of sensory receptor is primarily responsible for detecting pressure?
What type of sensory receptor is primarily responsible for detecting pressure?
- Chemoreceptors
- Photoreceptors
- Mechanoreceptors (correct)
- Thermoreceptors
Which type of receptor adapts slowly and provides continuous information about a stimulus?
Which type of receptor adapts slowly and provides continuous information about a stimulus?
- Slowly adapting receptors (correct)
- Fast receptors
- Non-adapting receptors
- Rapidly adapting receptors
What neural mechanism enhances the contrast of sensory input by inhibiting neighboring neurons?
What neural mechanism enhances the contrast of sensory input by inhibiting neighboring neurons?
- Receptive fields
- Lateral inhibition (correct)
- Relay transmission
- Population coding
Which of the following best describes a 'labeled line' in sensory processing?
Which of the following best describes a 'labeled line' in sensory processing?
What role does the thalamus NOT play in sensory processing?
What role does the thalamus NOT play in sensory processing?
How does population coding contribute to sensory perception?
How does population coding contribute to sensory perception?
In which part of the brain does initial processing of sensory information occur before reaching the cortex?
In which part of the brain does initial processing of sensory information occur before reaching the cortex?
What type of receptor is involved in detecting changes in temperature?
What type of receptor is involved in detecting changes in temperature?
What type of pain arises from actual or threatened damage to non-neuronal tissue?
What type of pain arises from actual or threatened damage to non-neuronal tissue?
Which type of pain is mistakenly perceived as originating from a somatic location due to visceral organ damage?
Which type of pain is mistakenly perceived as originating from a somatic location due to visceral organ damage?
In gate control theory, which type of receptors can inhibit signals from nociceptive c-fibers?
In gate control theory, which type of receptors can inhibit signals from nociceptive c-fibers?
Which aspect of pain relates to its sensory qualities, such as intensity and location?
Which aspect of pain relates to its sensory qualities, such as intensity and location?
What phenomenon describes the progressive increase in neuronal discharge rates due to repeated low-frequency activations?
What phenomenon describes the progressive increase in neuronal discharge rates due to repeated low-frequency activations?
Which endogenous compounds mainly reduce pain by inhibiting ascending nociceptive signaling?
Which endogenous compounds mainly reduce pain by inhibiting ascending nociceptive signaling?
What term is used to describe the phenomenon where stimuli that are usually not painful evoke pain?
What term is used to describe the phenomenon where stimuli that are usually not painful evoke pain?
Which type of pain results from a lesion or disease affecting the somatosensory nervous system?
Which type of pain results from a lesion or disease affecting the somatosensory nervous system?
What occurs when the hair bundle is displaced towards the tallest stereocilia?
What occurs when the hair bundle is displaced towards the tallest stereocilia?
What is the primary role of K+ in hair cells?
What is the primary role of K+ in hair cells?
What do first-order neurons in the spinal cord primarily transport?
What do first-order neurons in the spinal cord primarily transport?
Which part of the cochlea is primarily responsible for detecting high-frequency sounds?
Which part of the cochlea is primarily responsible for detecting high-frequency sounds?
Where does the synapse between first-order and second-order neurons occur?
Where does the synapse between first-order and second-order neurons occur?
Which principle describes how different regions of the basilar membrane are sensitive to specific frequencies?
Which principle describes how different regions of the basilar membrane are sensitive to specific frequencies?
What limitation does phase locking have at higher frequencies?
What limitation does phase locking have at higher frequencies?
Which structures carry sensory inputs from the lower body?
Which structures carry sensory inputs from the lower body?
What term describes the crossing over of second-order neurons to the opposite side of the spinal cord?
What term describes the crossing over of second-order neurons to the opposite side of the spinal cord?
What happens to auditory nerve fibers that are related to the apical end of the cochlea?
What happens to auditory nerve fibers that are related to the apical end of the cochlea?
What is a consequence of the mechanical force transduction by hair cells being remarkably sensitive?
What is a consequence of the mechanical force transduction by hair cells being remarkably sensitive?
Which tract is responsible for transmitting pain and temperature sensations to the brain?
Which tract is responsible for transmitting pain and temperature sensations to the brain?
What is the role of third-order neurons in the sensory pathway?
What is the role of third-order neurons in the sensory pathway?
How do the structures in the hair bundle primarily respond to mechanical stimuli?
How do the structures in the hair bundle primarily respond to mechanical stimuli?
What part of the brain is indicated as the primary somatosensory cortex?
What part of the brain is indicated as the primary somatosensory cortex?
Which of the following is NOT a function of second-order neurons?
Which of the following is NOT a function of second-order neurons?
What structure helps regulate the size of the pupil in response to varying light levels?
What structure helps regulate the size of the pupil in response to varying light levels?
Which part of the eye is responsible for phototransduction?
Which part of the eye is responsible for phototransduction?
What happens to the channels in photoreceptor cells during hyperpolarization?
What happens to the channels in photoreceptor cells during hyperpolarization?
What initiates the process of phototransduction?
What initiates the process of phototransduction?
Which muscle contracts in response to too much light entering the eye?
Which muscle contracts in response to too much light entering the eye?
What occurs during light adaptation in photoreceptor cells?
What occurs during light adaptation in photoreceptor cells?
What is the role of the retinal pigment epithelium?
What is the role of the retinal pigment epithelium?
How does aging affect the ciliary muscle in the eye?
How does aging affect the ciliary muscle in the eye?
What is the role of interphotoreceptor retinoid-binding protein (IRBP) in the visual cycle?
What is the role of interphotoreceptor retinoid-binding protein (IRBP) in the visual cycle?
How many bipolar cells do many rods synapse with compared to cones?
How many bipolar cells do many rods synapse with compared to cones?
What is the function of on-center ganglion cells?
What is the function of on-center ganglion cells?
What happens when there is a deficiency in one type of cone?
What happens when there is a deficiency in one type of cone?
What is the primary processing center for visual information after the retina?
What is the primary processing center for visual information after the retina?
How do off-center ganglion cells respond to light in their receptive field?
How do off-center ganglion cells respond to light in their receptive field?
What do ocular dominance regions in the brain signify?
What do ocular dominance regions in the brain signify?
What is the significance of receptive fields in ganglion cells?
What is the significance of receptive fields in ganglion cells?
Flashcards
Hair Cell Depolarization and Hyperpolarization
Hair Cell Depolarization and Hyperpolarization
Movement of the hair bundle in the direction of the tallest stereocilia stretches the tip links, directly opening cation-selective mechanoelectrical transduction (MET) channels and depolarizing the hair cell. Movement in the opposite direction compresses the tip links, closing the MET channels and hyperpolarizing the hair cell.
Hair Cell Transduction Efficiency
Hair Cell Transduction Efficiency
The transduction of mechanical forces by hair cells is remarkably fast and sensitive. Notably, potassium (K+) plays a dual role in both depolarization and repolarization, allowing the hair cell's K+ gradient to be maintained passively.
Tonotopic Organization
Tonotopic Organization
The auditory nerve fiber transmits information about a specific part of the audible frequency spectrum based on the location of the inner hair cell it innervates. This means different fibers are responsible for different frequencies.
Place Principle
Place Principle
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Phase Locking
Phase Locking
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Limitations of Phase Locking
Limitations of Phase Locking
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Mechanoreceptors
Mechanoreceptors
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Chemoreceptors
Chemoreceptors
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Photoreceptors
Photoreceptors
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Thermoreceptors
Thermoreceptors
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Slowly adapting receptors (SA)
Slowly adapting receptors (SA)
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Rapidly adapting receptors (RA)
Rapidly adapting receptors (RA)
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Lateral Inhibition
Lateral Inhibition
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The thalamus
The thalamus
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First-order neurons in somatosensory pathway
First-order neurons in somatosensory pathway
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Second-order neurons in somatosensory pathway
Second-order neurons in somatosensory pathway
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Third-order neurons in somatosensory pathway
Third-order neurons in somatosensory pathway
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Spinothalamic tract: Anterolateral System
Spinothalamic tract: Anterolateral System
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Lateral and Anterior Spinothalamic Tracts
Lateral and Anterior Spinothalamic Tracts
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Decussation of the Spinothalamic Tract
Decussation of the Spinothalamic Tract
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Postcentral Gyrus: Primary Somatosensory Cortex
Postcentral Gyrus: Primary Somatosensory Cortex
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Speed of Signal Transmission in Spinal Nerve
Speed of Signal Transmission in Spinal Nerve
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Nociceptive Pain
Nociceptive Pain
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Neuropathic Pain
Neuropathic Pain
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Referred Pain
Referred Pain
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Discriminative Pain
Discriminative Pain
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Gate Control Theory
Gate Control Theory
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Central Sensitization
Central Sensitization
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Peripheral Sensitization
Peripheral Sensitization
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Allodynia
Allodynia
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Cornea
Cornea
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Sclera
Sclera
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Retina
Retina
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Vitreous Humor
Vitreous Humor
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Iris
Iris
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Lens
Lens
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Phototransduction
Phototransduction
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Rhodopsin
Rhodopsin
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Retinal Regeneration
Retinal Regeneration
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On-center ganglion cell
On-center ganglion cell
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Off-center ganglion cell
Off-center ganglion cell
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Receptive field
Receptive field
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Ocular dominance
Ocular dominance
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Study Notes
Sensory Functions
- Different specialized sensory cells/receptors exist for various sensory modalities (touch, proprioception, pain, vision, hearing, balance, spatial orientation, taste, and smell). These receptors have unique anatomical and histological structures.
- Sensory receptors transduce stimuli into electrical signals. Specific pathways transport sensory information from different body parts.
- Sensory information is processed in distinct brain regions, determining how different sensory stimuli are perceived and modulated.
Hearing
- Sound is characterized by frequency (pitch) and amplitude (loudness, measured in decibels). A 150 dB sound can rupture the eardrum. The detectable frequency range is 20Hz to 20,000 Hz.
- The outer ear, composed of the pinna, concha, and external auditory meatus, directs sound waves.
- The middle ear, an air-filled cavity, transmits vibrations from the tympanic membrane to the inner ear. The middle ear has 3 small bones (malleus, incus, stapes) that amplify sound.
- The inner ear, including the cochlea, semicircular canals, and vestibular sacs, contains hair cells that convert sound vibrations into nerve impulses.
- The cochlea is the auditory portion, filled with fluid called perilymph, and contains the basilar membrane to transduce sound based on frequency.
- The vestibular system, also in the inner ear, is responsible for balance and spatial orientation.
Inner Ear
- The inner ear contains the cochlea (for hearing) and vestibular structures (for equilibrium).
- Hair cells in the cochlea, situated on the basilar membrane, detect sound vibrations.
- The vestibular system, containing otolithic organs (utricle and saccule) and semicircular canals, detects head movements and orientation.
Cochlea
- The cochlea is a fluid-filled spiral structure containing the basilar membrane.
- The basilar membrane vibrates in response to sound waves, causing hair cells to bend.
- Bending of hair cells triggers electrical signals that travel to the brain.
- The cochlea is tonotopically organized, meaning different parts respond to different frequencies. High frequencies at the base, low frequencies at the apex.
Vestibular System
- The vestibular system, including utricle, saccule, and semicircular canals, helps maintain balance and spatial orientation.
- Otolith organs (utricle and saccule) detect linear acceleration, head tilt, and position relative to gravity. They have otoconia (calcium carbonate crystals) to do this.
- Semicircular canals detect angular acceleration (rotational movements of the head.) They contain cupula and endolymph and the movement of the endolymph triggers the hair cells.
- Vestibular hair cells convert these movements into neural signals that travel to the brain.
Sensory Systems
- Sensory systems categorize information into exteroception (external stimuli), interoception (internal stimuli), and proprioception (self-perception).
- Sensory receptors have specific responses to certain stimuli.
- Types of receptors include mechanoreceptors, chemoreceptors, photoreceptors, and thermoreceptors.
- Important features associated with sensory systems include the concept of receptive fields, lateral inhibition, and labeled lines.
Pain
- Pain is a complex sensory and emotional experience associated with actual or potential tissue damage.
- Nociceptors are sensory receptors that detect noxious stimuli.
- Types of pain include nociceptive pain (from tissue damage) and neuropathic pain (from nerve damage).
- Pain signals are transmitted via the nervous system and processed in the central nervous system (CNS).
- Other modulating pain process include gate control theory, descending pathways, and sensitization.
Vision
- Vision involves light detection and processing.
- Detailed anatomy sections of the eye, including structures like cornea, lens, retina, and optic nerve, are used by the visual system for light perception.
- Phototransduction, a key process involving rhodopsin and photoreceptor cells, converts light into electrical signals.
- Different layers and types of cells in the retina are responsible for processing the visual stimuli that goes to the brain and resulting in vision.
- Concepts like receptive fields, and ocular dominance are important in how the brain processes the information of the vision.
Olfaction
- Olfaction is the sense of smell.
- Odorant molecules bind to olfactory receptor neurons (ORNs) in the olfactory epithelium.
- This binding initiates a signal transduction cascade that ultimately leads to neuronal action potentials.
- These signals travel to the olfactory bulb, where information is processed.
- The information then goes to various cortices in the brain that process it and give us the sensation of smell.
Gustation
- Gustation is the sense of taste.
- Taste buds contain taste receptor cells that respond to different tastes, such as sweet, sour, salty, bitter, and umami.
- Different receptors are activated by different molecules depending on what substance is associated with each taste.
- These stimuli then go to the brain to enable us to taste.
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