Neuroscience Quiz on Glial Cells and Neurons

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Questions and Answers

Which glial cell type is primarily responsible for forming the myelin sheath in the Peripheral Nervous System (PNS)?

  • Oligodendrocytes
  • Schwann Cells (correct)
  • Astrocytes
  • Microglia

Astrocytes are involved in the regulation of extracellular fluid by controlling levels of potassium ions and neurotransmitters.

True (A)

What is the primary function of the axon hillock in a neuron?

Initiates action potentials

The ______ is the most abundant glial cell in the Central Nervous System (CNS).

<p>astrocyte</p> Signup and view all the answers

Match the glial cell type with its primary function:

<p>Schwann Cells = Myelination in the PNS Oligodendrocytes = Myelination in the CNS Astrocytes = Support and regulation in the CNS Microglia = Immune response in the CNS Ependymal Cells = CSF production and circulation</p> Signup and view all the answers

Which of the following techniques is used to visualize specific proteins in neurons and glia?

<p>Immunohistochemistry (A)</p> Signup and view all the answers

A single oligodendrocyte can myelinate multiple axons.

<p>True (A)</p> Signup and view all the answers

The process of injecting substances like GFP or viruses into neurons is known as ______.

<p>Neuron Filling</p> Signup and view all the answers

Which of the following is NOT a function of the facial nerve (CN VII)?

<p>Motor innervation to the diaphragm (B)</p> Signup and view all the answers

The Facial Motor Nucleus provides motor supply for facial muscles and receives its innervation from the ipsilateral motor cortex.

<p>False (B)</p> Signup and view all the answers

What is the name of the sensory nucleus that receives pain information from the pharynx and posterior third of the tongue?

<p>Spinal Trigeminal Nucleus</p> Signup and view all the answers

The ___ nerve carries sensory information from the outer ear.

<p>Glossopharyngeal</p> Signup and view all the answers

Match the following structures with their primary function:

<p>Supratrigeminal nucleus = Motor innervation for facial muscle Solitary nucleus = Processes visceral sensory input including taste Spinal trigeminal nucleus = Processes pain and temperature information from the pharynx Facial motor nucleus = Motor innervation for facial muscle</p> Signup and view all the answers

Which association areas are involved in complex cognitive functions such as executive functions and decision-making?

<p>Multimodal Association Areas (D)</p> Signup and view all the answers

Lesions in the Primary Visual Cortex (V1) can cause total or near-total loss of visual awareness.

<p>True (A)</p> Signup and view all the answers

What is the Brodmann area associated with the Primary Auditory Cortex?

<p>41</p> Signup and view all the answers

The _____ lobe is primarily responsible for processing auditory information.

<p>temporal</p> Signup and view all the answers

Which of the following structures is NOT part of the thalamus?

<p>Hypothalamus (C)</p> Signup and view all the answers

Which disorder is characterized by an inability to recognize objects using certain senses?

<p>Agnosia (B)</p> Signup and view all the answers

The thalamus serves as the primary relay center for sensory information to the cerebral cortex.

<p>True (A)</p> Signup and view all the answers

Match the Brodmann areas with their associated cortex:

<p>Primary Somatosensory Cortex = S1 - Brodmann area 3, 1, 2 Primary Motor Cortex = M1 - Brodmann area 4 Primary Visual Cortex = V1 - Brodmann area 17 Primary Auditory Cortex = A1 - Brodmann area 41</p> Signup and view all the answers

The Supplementary Motor Area (SMA) is part of Brodmann area 6.

<p>True (A)</p> Signup and view all the answers

What is the name of the nucleus in the thalamus responsible for auditory processing?

<p>Medial geniculate nucleus (MG)</p> Signup and view all the answers

What is the main output pathway associated with the Primary Motor Cortex?

<p>Corticospinal tract</p> Signup and view all the answers

The ______ is a small area of grey matter located between the thalamus and subthalamic nucleus.

<p>zona incerta</p> Signup and view all the answers

Match the following thalamic nuclei with their respective functions:

<p>Anterior nucleus (A) = Memory and learning Dorsomedial nucleus (DM) = Integration of sensory, motor, and emotional information Ventral anterior nucleus (VA) = Motor control Ventrolateral nucleus (VL) = Motor control Ventroposterolateral nucleus (VPL) = Somatosensory information from the body Ventroposteromedial nucleus (VPM) = Somatosensory information from the face Pulvinar nucleus (Pul) = Visual attention and integration Lateral geniculate nucleus (LG) = Visual processing Medial geniculate nucleus (MG) = Auditory processing</p> Signup and view all the answers

Which of the following statements is TRUE about the thalamic reticular nucleus?

<p>It provides regulatory GABAergic projections to other thalamic nuclei. (C), It is located between the internal medullary lamina and the external capsule. (D)</p> Signup and view all the answers

The thalamus is responsible for the conscious perception of all sensory information.

<p>False (B)</p> Signup and view all the answers

What is the function of the habenula?

<p>It plays a role in aversion and avoidance behaviors.</p> Signup and view all the answers

Which portion of the spinal cord white matter primarily conveys sensory information from the lower body?

<p>Gracile Fasciculus (C)</p> Signup and view all the answers

The Dorsal Horn is primarily responsible for motor functions.

<p>False (B)</p> Signup and view all the answers

What are the two types of streams present in the sensory pathways of the dorsal horn?

<p>Medial Stream and Lateral Stream</p> Signup and view all the answers

The __________ contains motor neurons that innervate muscles.

<p>Anterior (Ventral) Horn</p> Signup and view all the answers

Match the following components of gray matter with their primary functions:

<p>Substantia Gelatinosa = Involved in pain modulation Intermediate Gray = Contains interneurons and some autonomic neurons Ventral Horn = Contains motor neuron pools Dorsal Horn = Involved in sensory processing</p> Signup and view all the answers

Which organization of the spinal cord white matter contains mixed ascending and descending tracts?

<p>Lateral Funiculus (A)</p> Signup and view all the answers

Rexed laminae IV is involved in motor neuron functions.

<p>False (B)</p> Signup and view all the answers

The __________ contains cerebrospinal fluid in the spinal cord.

<p>Central Canal</p> Signup and view all the answers

What is the primary function of ascending sensory pathways?

<p>To carry sensory information to the brain (C)</p> Signup and view all the answers

The lumbosacral enlargement is necessary for innervating the arms.

<p>False (B)</p> Signup and view all the answers

What are dermatomes?

<p>Spinal segments that maintain connectivity with nearby somites and correspond to specific areas of the body.</p> Signup and view all the answers

The ___ carries information from the lower body in the spinal cord.

<p>Fasciculus Gracilis</p> Signup and view all the answers

Match the spinal cord structures with their functions:

<p>Ventral Horn = Contains lower motor neurons Dorsal Horn = Receives sensory information Cervical Enlargement = Innervates the arms Lumbosacral Enlargement = Innervates the legs</p> Signup and view all the answers

What is the main role of ventricular ligaments?

<p>To keep the spinal cord in place horizontally (D)</p> Signup and view all the answers

White matter increases in higher spinal cord levels due to more sensory and motor information passing through.

<p>True (A)</p> Signup and view all the answers

What divides the dorsal columns into Fasciculus Gracilis and Fasciculus Cuneatus?

<p>Dorsal Intermediate Sulcus</p> Signup and view all the answers

Flashcards

Immunohistochemistry

A technique using antibodies to visualize specific proteins in cells.

Neuron Filling

Injection methods that trace neuronal pathways using substances.

Schwann Cells

Glial cells in the PNS that myelinate axons and support neurons.

Oligodendrocytes

CNS cells that myelinate multiple axons and support neuronal insulation.

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Astrocytes

Abundant CNS glial cells that provide support and regulate extracellular fluid.

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Microglia

Small CNS glial cells that respond to injury and clear debris.

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Ependymal Cells

Cells lining brain ventricles; help produce and move cerebrospinal fluid.

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Neuron Parts

Components include dendrites, cell body, axon, axon hillock, and synaptic terminals.

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Ventricular Ligaments

Structures that hold the spinal cord in a horizontal position.

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Spinal Cord Function

Houses lower motor neurons, receives sensory info, and carries motor commands.

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Ascending Sensory Pathways

Pathways that carry sensory information to the brain from the body.

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Descending Motor Pathways

Pathways that carry motor commands from the brain to the body.

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Reflex Arcs

Neural pathways that mediate reflex actions without brain involvement.

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Dermatomes

Specific spinal segments that correspond to sensory areas on the skin.

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Cervical Enlargement

Spinal cord area (C5-T1) important for arm innervation.

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Ventral Medial Fissure

Deep groove on the front of the spinal cord housing the anterior spinal artery.

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Funiculi

Regional divisions of spinal cord white matter containing nerve tracts.

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Dorsal Funiculus

Part of the spinal cord that contains sensory tracts for the lower and upper body.

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Gracile Fasciculus

Conveys sensory information from the lower body to the brain.

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Lateral Funiculus

Contains mixed ascending and descending nerve tracts.

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Posterior Horn

Gray matter section responsible for sensory processing.

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Rexed Laminae

Classification of gray matter in the spinal cord based on function and cell type.

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Sensory Pathways

Tracts that transmit sensory information such as touch, pain, and temperature.

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Spinal Tracts

Physiologically distinct pathways carrying specific types of sensory or motor information.

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Epithalamus

Part of the diencephalon that includes the pineal gland and habenula.

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Pineal Gland

Unpaired structure that secretes melatonin, regulating circadian rhythms.

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Thalamus

A large mass in the diencephalon that relays sensory information to the cortex.

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Subthalamus

Contains nuclei involved in motor control and regulatory functions.

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Thalamic Inputs

Facilitating communication between thalamus and cortex; includes specific and regulatory input.

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Pulvinar Nucleus

Thalamic nucleus associated with visual attention and processing.

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Medial Geniculate Nucleus

Thalamic nucleus that processes auditory information.

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Thalamic Reticular Nucleus

Regulates thalamic activity without projecting to the cortex.

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Facial Nerve (CN VII)

A cranial nerve responsible for motor control of facial muscles and sensory input from taste.

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Peripheral Process in Facial Nerve

Extends to the face, connecting sensory inputs from facial regions.

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Pontine (Principal) Nuclei

Processes tactile information from the face and oronasal cavity.

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Spinal Nucleus

Receives sensory afferents from the mouth; processes pain and thermal information.

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Facial Motor Nucleus

Provides motor supply for facial muscles; loops around abducens nucleus.

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Supranuclear Lesion Effects

Causes contralateral motor weakness of the lower face.

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Glossopharyngeal Nerve (CN IX)

Primarily sensory, carries information from viscera; innervates part of the throat.

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Solitary Nucleus

Processes visceral sensory input from taste buds and sinus regions.

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Multimodal Association Areas

Areas that integrate multiple sensory inputs for complex cognitive functions.

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Primary Somatosensory Area (S1)

Located in the postcentral gyrus, processes tactile sensory information.

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Primary Visual Cortex (V1)

Brodmann area 17, essential for visual perception.

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Lesions Effects in V1

Can cause total or near-total loss of visual awareness.

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Auditory Association Cortex

Brodmann area 22, involved in processing and understanding sounds, including language.

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Agnoisa

Inability to recognize objects using certain senses, like visual agnosia.

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Apraxia

Inability to perform certain actions despite intact motor function.

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Study Notes

Neuroanatomy

  • Study of the anatomy and organization of the central nervous system (CNS)
  • Includes anatomical terminology such as:
    • Planes: Coronal (front/back), Sagittal (left/right), Horizontal (top/bottom)
    • Directional Terms: Anterior/Posterior, Medial/Lateral, Superior/Inferior, Dorsal/Ventral, Rostral/Caudal
  • Central Nervous System (CNS): Brain and spinal cord.
    • White matter: myelinated axons
    • Gray matter: cell bodies and dendrites
  • Peripheral Nervous System (PNS): Divided into autonomic (sympathetic, parasympathetic) and somatic systems
  • Cells of the Nervous System:
    • Neurons: Convey information electrically and chemically; functional units of the nervous system with limited ability to reproduce.
    • Glial Cells: Support system for neurons including Schwann cells (myelinate axons and support axon regeneration) ensuring proper neuronal function.
    • Astrocytes.
    • Microglia.
    • Ependymal cells.

Neuron Morphology

  • Parts of a Neuron: Dendrites; receive signals, Soma (cell body); synthesis of macromolecules and integration of electrical signals, Axon; conducts action potentials, Axon terminals; involved in neurotransmission.

Neuron Classification

  • Structure: Unipolar, Pseudo-unipolar, Bipolar, Multipolar
  • Function: Sensory (afferent), Motor (efferent); Autonomic (preganglionic/postganglionic), Interneurons, and Projection.

Visualizing Neurons

  • Golgi Staining: Stains a limited number of cells, developed by Camillo Golgi, used by Santiago Ramón y Cajal (Nobel Prize winners).
  • Immunohistochemistry: Uses antibodies to visualize specific proteins.
  • Neuron Filling: Injection methods to trace neuronal pathways using GFP, biotin or viruses.

Glial cells and their functions

  • Schwann Cells (PNS): Provide metabolic support to neurons, wrap axons to form myelin sheath (electrical insulation), and aid in peripheral axon regeneration.
  • Oligodendrocytes (CNS): Myelinate axons in the central nervous system (CNS). One oligodendrocyte can myelinate several axons simultaneously.
  • Astrocytes (CNS): The most abundant glial cell within CNS, comprising 75% of glial cells; provides mechanical support and metabolic support, regulates levels of potassium ions and neurotransmitters, aids in controlling blood-brain barrier, reacts to injuries.
  • Microglia (CNS): Smallest glial cell type (~10-15%) of CNS, plays an important role in surveying for damage, disease, and clearing debris post-CNS injury; transforms into macrophages (phagocytic cells) upon activation.
  • Ependymal Cells: Line the brain's ventricles and spinal canal, help move and produce cerebrospinal fluid (CSF).

Neuron and Nervous System Function Notes

  • Parts of a neuron: Dendrites (receive signals); Cell body (soma) (containing nucleus); Axon (transmit impulses); Axon hillock (initiates action potentials); Synaptic terminals (release neurotransmitters)
  • Neuron polarization: Neurons are polarized due to ion distribution across the cell membrane with the inside of the neuron being more negative compared to the outside; resting potential are approximate -70mV
  • Primary Role of Glial Cells: Critical for supporting and protecting neurons; ensure structural integrity; provide metabolic support; regulate extracellular environment; and respond to injury
  • Myelination: A process where glial cells form myelin sheaths around axons that speeds up electrical signal transmission, acting as insulation. Glial cells include Schwann cells in the PNS and oligodendrocytes in the CNS.

Ionic Basis of Action Potentials

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