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Questions and Answers
Which of the following structures is NOT part of the brain stem?
Which of the following structures is NOT part of the brain stem?
The hypothalamus is responsible for regulating body temperature, thirst, and hunger.
The hypothalamus is responsible for regulating body temperature, thirst, and hunger.
True (A)
What is the primary function of the cerebellum?
What is the primary function of the cerebellum?
The cerebellum monitors and enhances information from the major motor system of the brain.
The ______ is located posterior to the brain stem and plays a key role in motor control.
The ______ is located posterior to the brain stem and plays a key role in motor control.
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Match the following brain regions with their primary functions:
Match the following brain regions with their primary functions:
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What is the primary function of the sodium-potassium pump?
What is the primary function of the sodium-potassium pump?
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Phosphorylation of the pump protein causes a shape change that allows sodium ions to be expelled out of the cell.
Phosphorylation of the pump protein causes a shape change that allows sodium ions to be expelled out of the cell.
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What is the role of the electrochemical gradient in ion transport?
What is the role of the electrochemical gradient in ion transport?
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The ______ equation calculates the membrane potential at which there is no net movement of an ion across the membrane.
The ______ equation calculates the membrane potential at which there is no net movement of an ion across the membrane.
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Match the following ions with their corresponding Nernst potential values based on the given concentrations:
Match the following ions with their corresponding Nernst potential values based on the given concentrations:
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Which of the following statements accurately describes the Goldman Equation?
Which of the following statements accurately describes the Goldman Equation?
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The Goldman Equation considers only the concentration gradients of ions, neglecting the permeability of the cell membrane.
The Goldman Equation considers only the concentration gradients of ions, neglecting the permeability of the cell membrane.
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What is the significance of the Goldman Equation in understanding membrane potential?
What is the significance of the Goldman Equation in understanding membrane potential?
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Which type of glial cell is most abundant in the central nervous system (CNS)?
Which type of glial cell is most abundant in the central nervous system (CNS)?
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Ependymal cells are responsible for forming myelin sheaths around nerve fibers in the CNS.
Ependymal cells are responsible for forming myelin sheaths around nerve fibers in the CNS.
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What is the primary role of microglia in the CNS?
What is the primary role of microglia in the CNS?
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The protective barrier that is highly selective in the CNS is called the ______.
The protective barrier that is highly selective in the CNS is called the ______.
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Match the following types of glial cells with their functions:
Match the following types of glial cells with their functions:
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Which ion has the highest permeability at rest?
Which ion has the highest permeability at rest?
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The action potential is caused by a sudden decrease in membrane permeability for Na+.
The action potential is caused by a sudden decrease in membrane permeability for Na+.
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What is the typical resting membrane potential of a neuron?
What is the typical resting membrane potential of a neuron?
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The action potential is a ______ electrical current that propagates along the neuron.
The action potential is a ______ electrical current that propagates along the neuron.
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Match the following ions with their typical resting membrane potential.
Match the following ions with their typical resting membrane potential.
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What does the term 'Em' refer to in the context of the neuron?
What does the term 'Em' refer to in the context of the neuron?
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The permeability of an ion (P) is directly proportional to the concentration gradient of that ion.
The permeability of an ion (P) is directly proportional to the concentration gradient of that ion.
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What is the primary role of the action potential in neuronal communication?
What is the primary role of the action potential in neuronal communication?
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The sudden opening and closing of ion channels causes changes in the membrane ______ for an ion.
The sudden opening and closing of ion channels causes changes in the membrane ______ for an ion.
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What is the main function of the Na+/K+ pump in maintaining the resting membrane potential?
What is the main function of the Na+/K+ pump in maintaining the resting membrane potential?
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What triggers a graded potential?
What triggers a graded potential?
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Graded potentials can be either excitatory or inhibitory.
Graded potentials can be either excitatory or inhibitory.
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What is the main difference between an EPSP and an IPSP?
What is the main difference between an EPSP and an IPSP?
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The integration of multiple EPSPs and IPSPs over time and space is called ______.
The integration of multiple EPSPs and IPSPs over time and space is called ______.
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Match the following neurotransmitters with their classification by function:
Match the following neurotransmitters with their classification by function:
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What is a neuromodulator's effect on synaptic transmission?
What is a neuromodulator's effect on synaptic transmission?
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Which of the following is an example of a neuromodulator?
Which of the following is an example of a neuromodulator?
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MAOIs (Monoamine Oxidase Inhibitors) decrease the duration of effect of neurotransmitters like norepinephrine, dopamine, and serotonin.
MAOIs (Monoamine Oxidase Inhibitors) decrease the duration of effect of neurotransmitters like norepinephrine, dopamine, and serotonin.
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Which structure is responsible for secreting cerebrospinal fluid (CSF)?
Which structure is responsible for secreting cerebrospinal fluid (CSF)?
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Hydrocephalus can result in brain damage in infants.
Hydrocephalus can result in brain damage in infants.
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What happens to cerebrospinal fluid after it circulates through the central nervous system?
What happens to cerebrospinal fluid after it circulates through the central nervous system?
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The _____ arteries supply the anterior three-fifths of the cerebrum.
The _____ arteries supply the anterior three-fifths of the cerebrum.
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Match the following blood flow structures with their respective regions of the brain:
Match the following blood flow structures with their respective regions of the brain:
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What is the significance of the Circle of Willis?
What is the significance of the Circle of Willis?
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Cerebrospinal fluid circulates through the central canal of the spinal cord but does not enter the subarachnoid space.
Cerebrospinal fluid circulates through the central canal of the spinal cord but does not enter the subarachnoid space.
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Name the two divisions of the peripheral nervous system.
Name the two divisions of the peripheral nervous system.
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Flashcards
Phosphorylation
Phosphorylation
The addition of a phosphate group to a protein, causing a shape change.
Electrochemical Gradient
Electrochemical Gradient
A gradient that combines chemical concentration and electrical charge effects on ions.
Nernst Equation
Nernst Equation
Equation that calculates the membrane potential for a specific ion.
Membrane Potential (Em)
Membrane Potential (Em)
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Goldman Equation
Goldman Equation
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Concentration Gradient
Concentration Gradient
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Ion Concentration (In/Out)
Ion Concentration (In/Out)
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Permeability
Permeability
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Hypothalamus
Hypothalamus
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Brain Stem
Brain Stem
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Cerebellum
Cerebellum
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Motor Areas
Motor Areas
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Primary Motor Cortex
Primary Motor Cortex
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Broca's Area
Broca's Area
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Prefrontal Cortex
Prefrontal Cortex
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Sensory Areas
Sensory Areas
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Membrane Potential
Membrane Potential
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Ion Channels
Ion Channels
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Action Potential
Action Potential
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Na+ Role
Na+ Role
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K+ Role
K+ Role
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Permeability Change
Permeability Change
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Chemical Work
Chemical Work
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Depolarization
Depolarization
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Repolarization
Repolarization
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Triggering the AP
Triggering the AP
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Astrocytes
Astrocytes
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Microglia
Microglia
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Ependymal Cells
Ependymal Cells
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Oligodendrocytes
Oligodendrocytes
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Schwann Cells
Schwann Cells
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Graded Potentials
Graded Potentials
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EPSP
EPSP
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IPSP
IPSP
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Action Potential Trigger
Action Potential Trigger
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Neuromodulator
Neuromodulator
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SSRI
SSRI
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MAOI
MAOI
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Dopamine Release Enhancement
Dopamine Release Enhancement
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CSF
CSF
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Choroid Plexus
Choroid Plexus
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Ventricles
Ventricles
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Arachnoid Villi
Arachnoid Villi
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Hydrocephalus
Hydrocephalus
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Circle of Willis
Circle of Willis
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Common Carotid Arteries
Common Carotid Arteries
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Peripheral Nervous System
Peripheral Nervous System
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Study Notes
Human Physiology 2 - Course Information
- Course name: Human Physiology 2
- Course code: PHYG 13383D
- Lectures: Mondays and Wednesdays, 12-2 pm
Evaluation Plan
- Assignment: 10%
- Quizzes (6): 15%
- Midterm exam 1: 25%
- Midterm exam 2: 25%
- Final exam: 25%
- Total: 100%
Lecture 1: Organization of the Nervous System
- Textbook: Sherwood & Ward 5th Edition, Chapters 3, 4, 5
- Topics covered: Levels of organization of the nervous system, structural and functional differences between neurons and neuroglia, mechanisms of brain homeostasis, and gross anatomical divisions of the brain (review of BIOL 19201).
Objectives
- Knowledge:
- Levels of organization of the nervous system
- Distinguishing between neurons and neuroglia
- Mechanisms of brain homeostasis
- Gross anatomical divisions of the brain (review BIOL 19201)
- Application:
- Describe how brain homeostasis can be altered
- Correlate pathophysiological changes in brain tissue with cerebral blood flow obstruction
Major Structures within the Brain and Nervous System
- Central nervous system (CNS): Brain and spinal cord. Integrative and control centers.
- Peripheral nervous system (PNS): Cranial nerves and spinal nerves. Communication lines between the CNS and the rest of the body.
- Sensory (afferent) division: Somatic and visceral sensory nerve fibers. Carry impulses from receptors to the CNS.
- Motor (efferent) division: Motor nerve fibers. Carry impulses from the CNS to effectors (muscles and glands).
- Autonomic nervous system (ANS): Involuntary (visceral motor). Conducts impulses from the CNS to cardiac muscles, smooth muscles, and glands, and Sympathetic and parasympathetic divisions (e.g. emergency and nonemergency situations respectively).
- Somatic nervous system: Voluntary (somatic motor). Conducts impulses from the CNS to skeletal muscles.
Major Structures within the Brain
- Cerebrum
- Diencephalon
- Brain stem
- Cerebellum
The Brain
- General anatomy: Cerebrum, Diencephalon, Brain stem, Cerebellum
- Diagram of The Brain (labeled parts)
Cerebrum
- 4 lobes (Frontal, parietal, temporal, and occipital lobes)
- Surface areas defined by gyri and sulci/fissures
- Contains cerebral cortex, Cerebral white matter, and Basal nuclei
- Each hemisphere acts contralaterally (related to the opposite side of the body)
- Functional areas (more detail on later slides)
- Motor areas: primary motor cortex, premotor cortex, frontal eye field, and prefrontal cortex which is involved in decision-making, higher mental functions, personality traits, and planning for voluntary activity, Broca's area (motor speech area)
- Sensory areas: somatosensory association cortex, primary somatosensory cortex, olfactory, gustatory, and vestibular cortices.
- Association areas: Integrate different areas
Cerebral White Matter
- Communication between cerebral areas and cortex.
- Classified by direction: Commissures (connect hemispheres), Association fibers (connect areas within the same hemisphere), and Projection fibers (connect cortex to other areas)
- Basal nuclei: masses of gray matter acting as a hub for movement through inhibition of muscle tone and suppression of useless muscle tone.
Diencephalon
- Thalamus: Relay station for sensory input. Screens signals, and determines consciousness and motor control (related to more detailed aspects of sensation and consciousness).
- Hypothalamus: Regulates homeostasis functions like temperature, thirst, urine control, hunger, sleep-wake cycle, and is connected to the endocrine system.
Brain Stem
- Connects the brain to the spinal cord
- Involved in integration of motor output and sensory information.
- Contains the pons. medulla oblongata, and midbrain.
Cerebellum
- Posterior to the brain stem.
- Monitors and enhances information coming from the major motor systems of the brain (especially pertaining to muscle control, balance, and coordination).
Quiz Questions
- Questions about the brain and spinal cord, brain lobes, motor control areas, diencephalon structures, brain stem structures, sensory neurons, afferent neuron directions, cells of the nervous system, neurons, neurotransmitters, neuromodulators, and applications (e.g., pre-workout supplements).
Nervous System Cells
- Neurons: Specialized for nerve impulse transmission. All neurons have a cell body (with the nucleus) and at least one of these processes: dendrites (that carry signals toward the cell body) or axons (that carry signals away from the cell body).
- Glial cells (supporting cells): Support neurons. More numerous than neurons but have much smaller branching.
Neurotransmitters & Neuromodulators
- Neurotransmitters: Chemicals that transmit signals across synapses (that are excitatory or inhibitory)
- Examples include norepinephrine, dopamine, serotonin, acetylcholine, GABA.
- Neuromodulators: Chemicals that alter but do not directly cause a synaptic response, but may affect synthesis, release, and degradation.
- Examples include selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs).
CNS Homeostasis
- Meninges: Protective membranes surrounding the CNS (Dura mater, Arachnoid mater, and Pia mater).
- Blood-Brain Barrier (BBB): Highly selective membrane that limits access of molecules to neurons (includes both non-fenestrated endothelial cells, capillary basement membrane, and astrocytes).
- Cerebrospinal Fluid (CSF): Fills ventricles and subarachnoid spaces providing cushioning, protection, nourishment, and waste removal. CSF flows through the ventricles, subarachnoid spaces, and the central canal of the spinal cord.
- Blood Supply: Constant supply of blood to provide adequate nutrients.
Clinical Cases
- Epidural hemorrhage: Blood accumulating due to trauma
- Neurotransmitter and neuromodulator effects on symptoms
Functional Areas of the Cerebral Cortex
- Motor areas, sensory areas, and association areas.
Action Potential
- Result of ion channel opening and closing.
- Graded potentials (EPSPs and IPSPs) lead to the action potential.
Additional Points
- Key terminology is also important
- Diagrams, figures, and tables need to be studied.
- Diagrams and figures are critical for your understanding.
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Description
Test your knowledge on the structures of the brain and their primary functions in this neuroscience quiz. Questions cover the brain stem, cerebellum, and ion transport mechanisms. Challenge yourself with matching exercises and calculations related to brain physiology.