Neuroscience Quiz on Brain Structures and Functions
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Questions and Answers

Which of the following structures is NOT part of the brain stem?

  • Amygdala (correct)
  • Midbrain
  • Pons
  • Medulla oblongata
  • The hypothalamus is responsible for regulating body temperature, thirst, and hunger.

    True (A)

    What is the primary function of the cerebellum?

    The cerebellum monitors and enhances information from the major motor system of the brain.

    The ______ is located posterior to the brain stem and plays a key role in motor control.

    <p>cerebellum</p> Signup and view all the answers

    Match the following brain regions with their primary functions:

    <p>Hypothalamus = Regulates body temperature, thirst, and hunger Cerebellum = Monitors and enhances information from the major motor system Prefrontal cortex = Decision making, higher mental functions Broca's area = Motor speech area</p> Signup and view all the answers

    What is the primary function of the sodium-potassium pump?

    <p>Maintaining the concentration gradient of sodium and potassium ions across the cell membrane. (C)</p> Signup and view all the answers

    Phosphorylation of the pump protein causes a shape change that allows sodium ions to be expelled out of the cell.

    <p>True (A)</p> Signup and view all the answers

    What is the role of the electrochemical gradient in ion transport?

    <p>The electrochemical gradient drives the movement of ions across the cell membrane. It is determined by both the concentration difference and the electrical potential difference across the membrane.</p> Signup and view all the answers

    The ______ equation calculates the membrane potential at which there is no net movement of an ion across the membrane.

    <p>Nernst</p> Signup and view all the answers

    Match the following ions with their corresponding Nernst potential values based on the given concentrations:

    <p>Na+ = -61 mV K+ = +61 mV Cl- = -61 mV</p> Signup and view all the answers

    Which of the following statements accurately describes the Goldman Equation?

    <p>The Goldman Equation calculates the membrane potential based on the relative permeability of the membrane to different ions. (D)</p> Signup and view all the answers

    The Goldman Equation considers only the concentration gradients of ions, neglecting the permeability of the cell membrane.

    <p>False (B)</p> Signup and view all the answers

    What is the significance of the Goldman Equation in understanding membrane potential?

    <p>It provides a more comprehensive and accurate model for determining membrane potential by taking into account the contributions of multiple ions and their permeability across the membrane.</p> Signup and view all the answers

    Which type of glial cell is most abundant in the central nervous system (CNS)?

    <p>Astrocytes (C)</p> Signup and view all the answers

    Ependymal cells are responsible for forming myelin sheaths around nerve fibers in the CNS.

    <p>False (B)</p> Signup and view all the answers

    What is the primary role of microglia in the CNS?

    <p>They act as immune cells that can move to areas of infection.</p> Signup and view all the answers

    The protective barrier that is highly selective in the CNS is called the ______.

    <p>Blood Brain Barrier</p> Signup and view all the answers

    Match the following types of glial cells with their functions:

    <p>Astrocytes = Protect neurons from harmful substances Oligodendrocytes = Form myelin sheaths in the CNS Schwann Cells = Form myelin sheaths in the PNS Satellite Cells = Protect neuron cell bodies in the PNS</p> Signup and view all the answers

    Which ion has the highest permeability at rest?

    <p>K+ (A)</p> Signup and view all the answers

    The action potential is caused by a sudden decrease in membrane permeability for Na+.

    <p>False (B)</p> Signup and view all the answers

    What is the typical resting membrane potential of a neuron?

    <p>-70mV</p> Signup and view all the answers

    The action potential is a ______ electrical current that propagates along the neuron.

    <p>propagated</p> Signup and view all the answers

    Match the following ions with their typical resting membrane potential.

    <p>Na+ = 60mV K+ = -90mV Cl- = -60mV</p> Signup and view all the answers

    What does the term 'Em' refer to in the context of the neuron?

    <p>Electrical membrane potential (D)</p> Signup and view all the answers

    The permeability of an ion (P) is directly proportional to the concentration gradient of that ion.

    <p>False (B)</p> Signup and view all the answers

    What is the primary role of the action potential in neuronal communication?

    <p>To transmit information over long distances in the neuron.</p> Signup and view all the answers

    The sudden opening and closing of ion channels causes changes in the membrane ______ for an ion.

    <p>permeability</p> Signup and view all the answers

    What is the main function of the Na+/K+ pump in maintaining the resting membrane potential?

    <p>To actively transport Na+ into the cell and K+ out of the cell (C)</p> Signup and view all the answers

    What triggers a graded potential?

    <p>Synaptic neurotransmitter release (D)</p> Signup and view all the answers

    Graded potentials can be either excitatory or inhibitory.

    <p>True (A)</p> Signup and view all the answers

    What is the main difference between an EPSP and an IPSP?

    <p>EPSPs increase the likelihood of an action potential, while IPSPs decrease the likelihood.</p> Signup and view all the answers

    The integration of multiple EPSPs and IPSPs over time and space is called ______.

    <p>summation</p> Signup and view all the answers

    Match the following neurotransmitters with their classification by function:

    <p>Acetylcholine = Excitatory GABA = Inhibitory Dopamine = Excitatory Glutamate = Excitatory Glycine = Inhibitory</p> Signup and view all the answers

    What is a neuromodulator's effect on synaptic transmission?

    <p>Neuromodulators don't directly cause EPSPs or IPSPs, but they influence the strength of synaptic transmission by affecting the synthesis, release, degradation, or reuptake of neurotransmitters, or by altering the postsynaptic membrane's sensitivity to neurotransmitters.</p> Signup and view all the answers

    Which of the following is an example of a neuromodulator?

    <p>SSRI's (B)</p> Signup and view all the answers

    MAOIs (Monoamine Oxidase Inhibitors) decrease the duration of effect of neurotransmitters like norepinephrine, dopamine, and serotonin.

    <p>False (B)</p> Signup and view all the answers

    Which structure is responsible for secreting cerebrospinal fluid (CSF)?

    <p>Choroid plexuses (A)</p> Signup and view all the answers

    Hydrocephalus can result in brain damage in infants.

    <p>False (B)</p> Signup and view all the answers

    What happens to cerebrospinal fluid after it circulates through the central nervous system?

    <p>It returns to the blood via arachnoid villi.</p> Signup and view all the answers

    The _____ arteries supply the anterior three-fifths of the cerebrum.

    <p>internal carotid</p> Signup and view all the answers

    Match the following blood flow structures with their respective regions of the brain:

    <p>Common carotid arteries = Face and scalp Vertebrobasilar = Posterior cerebrum Internal carotid arteries = Anterior cerebrum Circle of Willis = Base of the brain</p> Signup and view all the answers

    What is the significance of the Circle of Willis?

    <p>It helps maintain blood flow in case of blockage. (A)</p> Signup and view all the answers

    Cerebrospinal fluid circulates through the central canal of the spinal cord but does not enter the subarachnoid space.

    <p>False (B)</p> Signup and view all the answers

    Name the two divisions of the peripheral nervous system.

    <p>Sensory and motor divisions.</p> Signup and view all the answers

    Flashcards

    Phosphorylation

    The addition of a phosphate group to a protein, causing a shape change.

    Electrochemical Gradient

    A gradient that combines chemical concentration and electrical charge effects on ions.

    Nernst Equation

    Equation that calculates the membrane potential for a specific ion.

    Membrane Potential (Em)

    The electrical potential difference across a cell membrane.

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    Goldman Equation

    Equation that calculates the overall membrane potential from multiple ions.

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    Concentration Gradient

    Difference in the concentration of ions across a membrane.

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    Ion Concentration (In/Out)

    The amount of a specific ion inside versus outside a cell.

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    Permeability

    The ability of a membrane to allow substances to pass through.

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    Hypothalamus

    A region in the brain that regulates homeostatic functions such as temperature, thirst, and hunger.

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    Brain Stem

    The part of the brain connecting the spinal cord, consisting of the pons, medulla oblongata, and midbrain, responsible for motor output and sensory perception integration.

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    Cerebellum

    A brain structure located behind the brain stem that monitors and enhances motor information.

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    Motor Areas

    Functional areas in the cerebral cortex responsible for movement control and muscle tone.

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    Primary Motor Cortex

    The area of the brain that directly controls voluntary movement.

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    Broca's Area

    A region in the left hemisphere that directs the muscles involved in speech production.

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    Prefrontal Cortex

    The area of the brain involved in decision making, planning, and personality traits.

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    Sensory Areas

    Regions in the cerebral cortex responsible for conscious awareness of sensations.

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    Membrane Potential

    The difference in electrical charge across a neuron's membrane.

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    Ion Channels

    Proteins that allow ions to pass through the membrane, influencing action potential.

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    Action Potential

    A rapid rise and fall in membrane potential that propagates along the neuron.

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    Na+ Role

    Sodium ions that enter the neuron, causing depolarization during an action potential.

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    K+ Role

    Potassium ions that exit the neuron, leading to repolarization after depolarization.

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    Permeability Change

    Changes in the neuron's membrane that determine which ions can enter or exit.

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    Chemical Work

    The use of action potentials to create neurotransmitter release and other cellular activities.

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    Depolarization

    The process of the membrane potential becoming less negative due to Na+ influx.

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    Repolarization

    The return of the membrane potential to a negative value after depolarization due to K+ efflux.

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    Triggering the AP

    Occurs when the membrane reaches a certain threshold after Na+ enters.

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    Astrocytes

    Star-shaped glial cells that protect neurons and maintain the brain's chemical environment.

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    Microglia

    Immune cells of the CNS with spider-like projections that respond to infection.

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    Ependymal Cells

    Cells lining the brain's central cavities that help circulate cerebrospinal fluid (CSF).

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    Oligodendrocytes

    Glial cells that produce myelin sheaths to insulate nerve fibers in the CNS.

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    Schwann Cells

    Glial cells forming myelin sheaths around nerve fibers in the PNS, not CNS.

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    Graded Potentials

    Changes in the membrane potential caused by synaptic neurotransmitter release, leading to either increased or decreased likelihood of action potential.

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    EPSP

    Excitatory postsynaptic potential; a graded potential that makes a neuron more likely to fire an action potential.

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    IPSP

    Inhibitory postsynaptic potential; a graded potential that makes a neuron less likely to fire an action potential.

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    Action Potential Trigger

    An action potential is triggered by the integrated spatial and temporal summation of EPSPs and IPSPs.

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    Neuromodulator

    A chemical messenger released by neurons that modulates the effects of neurotransmitters without directly causing EPSPs or IPSPs.

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    SSRI

    Selective serotonin reuptake inhibitors; increase serotonin's availability to improve mood and sleep.

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    MAOI

    Monoamine oxidase inhibitors; prevent breakdown of neurotransmitters, prolonging their effects on mood.

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    Dopamine Release Enhancement

    To increase dopamine release, consider utilizing substances that inhibit monoamine oxidases to extend their effects.

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    CSF

    Cerebrospinal fluid, secreted by choroid plexuses, circulates in the CNS.

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    Choroid Plexus

    Network of blood vessels that produces CSF.

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    Ventricles

    Fluid-filled spaces in the brain that contain CSF.

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    Arachnoid Villi

    Structures that reabsorb CSF into the blood.

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    Hydrocephalus

    Condition where CSF accumulates, causing pressure on the brain.

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    Circle of Willis

    A circular network of arteries at the base of the brain.

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    Common Carotid Arteries

    Major arteries supplying blood to the head and neck, splits into internal and external.

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    Peripheral Nervous System

    Nervous system part that includes sensory and motor divisions.

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    Study Notes

    Human Physiology 2 - Course Information

    • Course name: Human Physiology 2
    • Course code: PHYG 13383D
    • Lectures: Mondays and Wednesdays, 12-2 pm

    Evaluation Plan

    • Assignment: 10%
    • Quizzes (6): 15%
    • Midterm exam 1: 25%
    • Midterm exam 2: 25%
    • Final exam: 25%
    • Total: 100%

    Lecture 1: Organization of the Nervous System

    • Textbook: Sherwood & Ward 5th Edition, Chapters 3, 4, 5
    • Topics covered: Levels of organization of the nervous system, structural and functional differences between neurons and neuroglia, mechanisms of brain homeostasis, and gross anatomical divisions of the brain (review of BIOL 19201).

    Objectives

    • Knowledge:
      • Levels of organization of the nervous system
      • Distinguishing between neurons and neuroglia
      • Mechanisms of brain homeostasis
      • Gross anatomical divisions of the brain (review BIOL 19201)
    • Application:
      • Describe how brain homeostasis can be altered
      • Correlate pathophysiological changes in brain tissue with cerebral blood flow obstruction

    Major Structures within the Brain and Nervous System

    • Central nervous system (CNS): Brain and spinal cord. Integrative and control centers.
    • Peripheral nervous system (PNS): Cranial nerves and spinal nerves. Communication lines between the CNS and the rest of the body.
    • Sensory (afferent) division: Somatic and visceral sensory nerve fibers. Carry impulses from receptors to the CNS.
    • Motor (efferent) division: Motor nerve fibers. Carry impulses from the CNS to effectors (muscles and glands).
    • Autonomic nervous system (ANS): Involuntary (visceral motor). Conducts impulses from the CNS to cardiac muscles, smooth muscles, and glands, and Sympathetic and parasympathetic divisions (e.g. emergency and nonemergency situations respectively).
    • Somatic nervous system: Voluntary (somatic motor). Conducts impulses from the CNS to skeletal muscles.

    Major Structures within the Brain

    • Cerebrum
    • Diencephalon
    • Brain stem
    • Cerebellum

    The Brain

    • General anatomy: Cerebrum, Diencephalon, Brain stem, Cerebellum
    • Diagram of The Brain (labeled parts)

    Cerebrum

    • 4 lobes (Frontal, parietal, temporal, and occipital lobes)
    • Surface areas defined by gyri and sulci/fissures
    • Contains cerebral cortex, Cerebral white matter, and Basal nuclei
    • Each hemisphere acts contralaterally (related to the opposite side of the body)
    • Functional areas (more detail on later slides)
      • Motor areas: primary motor cortex, premotor cortex, frontal eye field, and prefrontal cortex which is involved in decision-making, higher mental functions, personality traits, and planning for voluntary activity, Broca's area (motor speech area)
      • Sensory areas: somatosensory association cortex, primary somatosensory cortex, olfactory, gustatory, and vestibular cortices.
      • Association areas: Integrate different areas

    Cerebral White Matter

    • Communication between cerebral areas and cortex.
    • Classified by direction: Commissures (connect hemispheres), Association fibers (connect areas within the same hemisphere), and Projection fibers (connect cortex to other areas)
    • Basal nuclei: masses of gray matter acting as a hub for movement through inhibition of muscle tone and suppression of useless muscle tone.

    Diencephalon

    • Thalamus: Relay station for sensory input. Screens signals, and determines consciousness and motor control (related to more detailed aspects of sensation and consciousness).
    • Hypothalamus: Regulates homeostasis functions like temperature, thirst, urine control, hunger, sleep-wake cycle, and is connected to the endocrine system.

    Brain Stem

    • Connects the brain to the spinal cord
    • Involved in integration of motor output and sensory information.
    • Contains the pons. medulla oblongata, and midbrain.

    Cerebellum

    • Posterior to the brain stem.
    • Monitors and enhances information coming from the major motor systems of the brain (especially pertaining to muscle control, balance, and coordination).

    Quiz Questions

    • Questions about the brain and spinal cord, brain lobes, motor control areas, diencephalon structures, brain stem structures, sensory neurons, afferent neuron directions, cells of the nervous system, neurons, neurotransmitters, neuromodulators, and applications (e.g., pre-workout supplements).

    Nervous System Cells

    • Neurons: Specialized for nerve impulse transmission. All neurons have a cell body (with the nucleus) and at least one of these processes: dendrites (that carry signals toward the cell body) or axons (that carry signals away from the cell body).
    • Glial cells (supporting cells): Support neurons. More numerous than neurons but have much smaller branching.

    Neurotransmitters & Neuromodulators

    • Neurotransmitters: Chemicals that transmit signals across synapses (that are excitatory or inhibitory)
    • Examples include norepinephrine, dopamine, serotonin, acetylcholine, GABA.
    • Neuromodulators: Chemicals that alter but do not directly cause a synaptic response, but may affect synthesis, release, and degradation.
    • Examples include selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs).

    CNS Homeostasis

    • Meninges: Protective membranes surrounding the CNS (Dura mater, Arachnoid mater, and Pia mater).
    • Blood-Brain Barrier (BBB): Highly selective membrane that limits access of molecules to neurons (includes both non-fenestrated endothelial cells, capillary basement membrane, and astrocytes).
    • Cerebrospinal Fluid (CSF): Fills ventricles and subarachnoid spaces providing cushioning, protection, nourishment, and waste removal. CSF flows through the ventricles, subarachnoid spaces, and the central canal of the spinal cord.
    • Blood Supply: Constant supply of blood to provide adequate nutrients.

    Clinical Cases

    • Epidural hemorrhage: Blood accumulating due to trauma
    • Neurotransmitter and neuromodulator effects on symptoms

    Functional Areas of the Cerebral Cortex

    • Motor areas, sensory areas, and association areas.

    Action Potential

    • Result of ion channel opening and closing.
    • Graded potentials (EPSPs and IPSPs) lead to the action potential. 

    Additional Points

    • Key terminology is also important
    • Diagrams, figures, and tables need to be studied.
    • Diagrams and figures are critical for your understanding.

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    Description

    Test your knowledge on the structures of the brain and their primary functions in this neuroscience quiz. Questions cover the brain stem, cerebellum, and ion transport mechanisms. Challenge yourself with matching exercises and calculations related to brain physiology.

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