Neuroscience Methods Final Exam Review
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Questions and Answers

What is the most accurate estimate of the capacity of working memory?

  • Approximately 4 items (correct)
  • Approximately 7 items
  • Unlimited capacity
  • Approximately 10 items

Which type of map is specifically related to the prediction of eye movements based on the relative interest of scene regions?

  • Saliency Map (correct)
  • Priority Map
  • Spatial Map
  • Cognitive Map

What is a key characteristic of change blindness?

  • An automatic response to visual stimuli
  • The inability to detect a change when it occurs slowly
  • A distortion introduced by exogenous stimuli (correct)
  • Failing to notice salient stimuli

In which part of the brain is the striatum located, which plays a role in motor output gating?

<p>Basal Ganglia (B)</p> Signup and view all the answers

What phenomenon describes the inability to see a salient stimulus while focusing on another task?

<p>Inattentional Blindness (B)</p> Signup and view all the answers

What does bradykinesia specifically refer to within the context of Parkinson's disease?

<p>Inability to initiate movement quickly (C)</p> Signup and view all the answers

What is the primary function of mirror neurons?

<p>To respond to observed or performed actions (D)</p> Signup and view all the answers

What is the main purpose of performing split-brain surgery?

<p>To reduce seizures in patients with severe epilepsy (A)</p> Signup and view all the answers

Which of the following describes structural brain deficits?

<p>Physical changes in brain tissue detectable by imaging (D)</p> Signup and view all the answers

Which hemisphere of the brain is primarily associated with logical thinking and language production?

<p>The left hemisphere (C)</p> Signup and view all the answers

What is a significant impact of orbitofrontal damage on social cognition?

<p>Impaired Theory of Mind (D)</p> Signup and view all the answers

Which area of the brain is primarily associated with executive functions such as cognitive flexibility and planning?

<p>Dorsolateral prefrontal cortex (D)</p> Signup and view all the answers

Which brain region is involved in emotion regulation and conflict monitoring during social interactions?

<p>Anterior cingulate cortex (B)</p> Signup and view all the answers

What cognitive phenomenon illustrates the interference between automatic processes and less practiced tasks?

<p>Stroop Effect (C)</p> Signup and view all the answers

Which brain structure is specifically mentioned as being involved in motor control and action inhibition?

<p>Basal ganglia (C)</p> Signup and view all the answers

What is a primary advantage of ECoG compared to EEG?

<p>ECoG offers significantly better spatial resolution (A)</p> Signup and view all the answers

Which of the following best describes the primary use of fMRI?

<p>It measures brain activity by detecting changes in blood oxygen levels. (D)</p> Signup and view all the answers

What limitation does EEG face due to the Inverse Problem?

<p>It struggles to pinpoint the exact location of brain activity. (B)</p> Signup and view all the answers

What is one of the key characteristics of TMS?

<p>It allows for the stimulation of specific brain areas non-invasively. (A)</p> Signup and view all the answers

Which imaging technique is primarily used for assessing brain structure rather than function?

<p>Structural MRI (B)</p> Signup and view all the answers

In what way does DWI differ from standard structural MRI?

<p>DWI measures white matter integrity rather than just anatomical structures. (A)</p> Signup and view all the answers

What does the term BOLD in fMRI stand for?

<p>Blood oxygenation level dependent (A)</p> Signup and view all the answers

Which method is most sensitive to detecting currents occurring on the surface of the scalp?

<p>MEG (B)</p> Signup and view all the answers

What is a notable drawback of CT scans compared to other imaging techniques?

<p>It provides images that are less detailed than MRI scans. (A)</p> Signup and view all the answers

What is the definition of a gyrus in the cerebral cortex?

<p>A bulge in cerebral cortex (C)</p> Signup and view all the answers

Which hypothesis suggests that a single neuron can recognize complex objects?

<p>Grandmother cell hypothesis (D)</p> Signup and view all the answers

What role does the fusiform face area play in the brain?

<p>Responsible for facial recognition (C)</p> Signup and view all the answers

Around what age does the cognitive ability to represent the beliefs of others develop?

<p>4 years old (A)</p> Signup and view all the answers

Which area of the brain is involved in reasoning about the intentions and beliefs of others?

<p>Dorsal medial prefrontal cortex (mPFC) (B)</p> Signup and view all the answers

What is the main distinction between the 'grandmother cell' hypothesis and ensemble coding hypothesis?

<p>One suggests multiple neurons for recognition; the other suggests a single neuron. (C)</p> Signup and view all the answers

What does the term 'sparse coding' refer to in the context of neural representation?

<p>Only a few neurons are activated for many objects. (B)</p> Signup and view all the answers

The RTPJ is involved in which aspect of social cognition?

<p>Understanding false beliefs (A)</p> Signup and view all the answers

What is the primary role of dopamine in the context of reward processing?

<p>To signal unexpected rewards (A)</p> Signup and view all the answers

In the context of fMRI observations during the Marshmallow Test, what was revealed about low delayers?

<p>They had exaggerated recruitment in the ventral striatum (A)</p> Signup and view all the answers

What does the term 'field of view' refer to in recording methods?

<p>The total extent of observations (B)</p> Signup and view all the answers

How does the amygdala relate to implicit bias in individuals?

<p>It triggers fast emotional responses to outgroup stimuli (D)</p> Signup and view all the answers

What type of memory retrieval is the hippocampus critically involved in?

<p>Recent long-term memory retrieval (C)</p> Signup and view all the answers

Which area is associated with anomia and its language-related functions?

<p>Inferior frontal gyrus (D)</p> Signup and view all the answers

Which component is considered the central part of the ventral striatum?

<p>Nucleus accumbens (A)</p> Signup and view all the answers

Which phenomenon describes the vulnerability of newer memories as opposed to older ones?

<p>Ribot's Law (D)</p> Signup and view all the answers

Flashcards

Working memory

The ability to hold a limited amount of information in mind for a short period, usually about 4 items.

Long Term Memory

Storing information for long periods; technically unlimited capacity, but retrieval can be complex due to factors like forgetting or interference.

Saliency Map

A theoretical representation that highlights the most attention-grabbing parts of a scene, helping our eyes focus on those areas first.

Priority Map

A neural mechanism that prioritizes specific sensory stimuli or actions for further processing, guided by attention.

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Change Blindness

A phenomenon where we fail to notice significant changes in a scene, even when we are looking directly at it.

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EEG (Electroencephalogram)

A technique that uses electrodes placed on the scalp to measure brain electrical activity. It's non-invasive and offers excellent temporal resolution but struggles with spatial localization.

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ERPs (Event-Related Potentials)

Scalp recordings of brain potentials evoked by specific events (like stimuli). They show positive or negative voltage peaks at specific time points after stimulus onset.

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fMRI (Functional Magnetic Resonance Imaging)

A functional neuroimaging method that measures brain activity based on changes in blood oxygen levels. It uses strong magnetic fields and is non-invasive, but has moderate temporal resolution.

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TMS (Transcranial Magnetic Stimulation)

A technique that uses magnetic pulses to stimulate specific brain regions. It's non-invasive, has moderate spatial resolution, and offers good temporal precision.

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ECoG (Electrocorticogram)

A neuroimaging method that uses surgically implanted electrodes to record brain electrical activity directly from the brain's surface. It's invasive but offers excellent spatial resolution.

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DWI (Diffusion-Weighted Imaging)

A technique that measures the diffusion of water molecules in brain tissue. It's a type of structural MRI and helps assess brain white matter integrity.

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CT (Computed Tomography)

A structural imaging technique that uses X-rays to create 3D images of the brain. It's non-invasive, relatively inexpensive, but provides less detailed images than MRI.

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PET (Positron Emission Tomography)

A functional neuroimaging method that measures brain activity by injecting radioactive tracers and detecting their distribution in the brain. It's non-invasive and offers information about brain metabolism.

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MEG (Magnetoencephalography)

A neuroimaging method that uses sensitive magnetometers to measure the magnetic fields generated by brain electrical activity. It's non-invasive and offers excellent temporal resolution.

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VLSM (Voxel-Based Lesion-Symptom Mapping)

A technique that combines structural MRI images with neuropsychological test data to identify brain regions associated with specific cognitive functions. It's used to understand the relationship between brain damage and cognitive deficits.

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Bradykinesia

A neurological disorder where neurons responsible for initiating movement are disrupted, resulting in slow and difficult movement initiation.

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Mirror Neuron

A type of brain cell that fires both when performing an action and when observing someone else perform the same action.

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Split Brain Surgery

A surgical procedure where the corpus callosum, the connecting bridge between the two brain hemispheres, is severed. This is usually done to treat severe epilepsy.

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Structural Brain Deficits

Physical changes in brain tissue that can be detected using imaging techniques like MRI and CT scans.

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Metabolic/Functional Brain Deficits

Alterations in brain activity or energy use without any visible structural damage, often investigated using fMRI, PET scans, and EEG.

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Orbitofrontal Cortex (OFC)

The frontal lobe area critical for social skills, decision-making, and emotional control. Damage here can lead to impulsive behavior, difficulty reading social cues, and impaired Theory of Mind.

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Dorsolateral Prefrontal Cortex (DLPFC)

Executive functions, including working memory, cognitive flexibility, and planning. Helps us switch between tasks and rules.

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Inhibitory Control

Inhibitory control plays a crucial role in helping us suppress unwanted actions or responses. It's like the 'brake pedal' of our brain, preventing us from blurting out inappropriate things or making poor decisions.

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Anterior Cingulate Cortex (ACC)

The part of the brain involved in error-detection, conflict monitoring, and adjusting behavior. It signals when we make mistakes or experience conflict.

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Sulcus

A groove or valley in the surface of the cerebral cortex, giving the brain its characteristic folded appearance.

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Gyrus

A ridge or bump on the surface of the cerebral cortex, separated by sulci.

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Fissure

A very deep groove in the cerebral cortex, larger than a sulcus.

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Hierarchical Coding Hypothesis

A hypothesis suggesting that neurons progressively encode more complex features as information flows through the visual system, culminating in specialized neurons recognizing specific objects.

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Gnostic Unit

A hypothetical neuron that responds specifically to a complex object, like recognizing your grandmother.

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Theory of Mind

The ability to represent and understand the mental states of others, including their beliefs, desires, and intentions.

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Right Temporo-Parietal Junction (RTPJ)

A brain region involved in understanding the mental states of others, particularly when those states differ from reality. It's crucial for reasoning about false beliefs.

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Medial Prefrontal Cortex (mPFC)

A brain region involved in reasoning about the thoughts, intentions, and desires of others. It's key for understanding social interactions.

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What is the role of dopamine in reward prediction?

Dopamine is released when a reward is unexpected and the amount released reflects the difference between the expected and actual reward. This difference is known as the reward prediction error (RPE).

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What is the role of the VTA?

The ventral tegmental area (VTA) is a brain region crucial in the reward system. It produces dopamine and sends projections to other areas involved in motivation, learning, and pleasure, including the nucleus accumbens.

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What is the functional role of the ventral striatum?

The ventral striatum is a brain area that is highly involved in processing rewards and motivation. It is also active in decision-making and goal-directed behavior. It is located underneath the cerebrum, near the base of the brain.

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What is the nucleus accumbens (NAc) and its role in reward?

The nucleus accumbens (NAc) is a key part of the ventral striatum. It plays a central role in processing reward and motivation, contributing to our desire and ability to seek out pleasurable experiences.

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What is the ventral part of the Putamen and its role in reward?

The ventral part of the Putamen is another part of the ventral striatum. It contributes to the reward and motivational functions of the overall ventral striatum, alongside the nucleus accumbens.

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How does the Implicit Association Test (IAT) work?

The Implicit Association Test (IAT) measures unconscious biases related to race, gender, religion, etc. It uses reaction times to assess how strongly we associate certain concepts, and people exhibiting greater bias show stronger activation in the amygdala, an area linked with fear and rapid emotional responses to outgroups.

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What brain area do individuals with greater implicit bias recruit to control their responses?

Individuals with stronger implicit biases tend to recruit the dorsolateral prefrontal cortex (DLPFC) to exert greater cognitive control over their responses, trying to suppress biased reactions.

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How is the error-related negativity (ERN) connected to implicit bias?

The error-related negativity (ERN) is a brain wave observed in response to errors. People who regulate their implicit biases tend to show a larger ERN, indicating a heightened sensitivity to mistakes, which is a sign of greater self-awareness and self-regulation.

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Study Notes

Neuro Final Exam - Cognitive Neuroscience Methods

  • Expect questions on the strengths and weaknesses of various cognitive neuroscience methods, including: EEG/ERP, ECOG, fMRI, TMS, VLSM, structural MRI, DTI/DWI, PET, MEG.
  • Assess factors of spatial resolution, timing resolution, causality, invasiveness, and sensitivity to neurotransmitters.

EEG (Electroencephalogram)

  • Measures brain waves via scalp recordings.
  • Records event-related potentials (ERPs), which are positive or negative voltage peaks occurring after a stimulus.
  • Non-invasive.
  • Better temporal resolution than spatial resolution.
  • Useful for precisely measuring when brain activity occurs but struggles to pinpoint precise location.
  • Neurotransmitters can affect EEG readings.
  • The inverse problem is a limitation; it's difficult to determine the exact locations and distributions of electrical sources in the brain based on electrode recordings.

ECOG (Electrocorticogram)

  • Intracranial EEG – electrodes implanted directly on the brain surface,
  • Invasive.
  • Better spatial resolution than EEG.
  • Used to record brain waves.

fMRI (Functional Magnetic Resonance Imaging)

  • Non-invasive.
  • Measures brain activity based on changes in blood oxygen level-dependent(BOLD) signal, as brain activity uses oxygen which changes the magnetic state of blood.
  • Modest temporal resolution.
  • Useful for robust signals.
  • Neurotransmitters can indirectly affect BOLD signal through their interaction with neurons and resulting blood flow changes.

TMS (Transcranial Magnetic Stimulation)

  • Non-invasive.
  • Using a focal magnetic pulse to induce a current that flows through the tissue.
  • Relatively moderate spatial resolution.
  • Higher temporal precision.

VLSM (Voxel-Based Lesion-Symptom Mapping)

  • Combines structural brain images with neuropsychological tests to diagnose neurological damage.
  • Helps determine how brain damage affects cognitive and behavioral tasks.

Structural MRI

  • Non-invasive.
  • Provides static images of anatomy.
  • Can detect certain metals in the body.

DWI (Diffusion Weighted Imaging), DTI (Diffusion Tensor Imaging)

  • Part of a structural MRI
  • Measures water diffusion.
  • Can assess tissue integrity.
  • Used to detect cellular swelling etc.

CT (Computed Tomography)

  • X-ray based
  • Computes 3D images from 2D images.
  • Inexpensive.
  • Non-invasive.

PET (Positron Emission Tomography)

  • Injects a radioactive agent.
  • Measures metabolic activity in the brain.
  • Non-invasive.

MEG (Magnetoencephalography)

  • Measures magnetic fields produced by electrical currents in the brain.
  • More sensitive to scalp currents than EEG.
  • Better spatial resolution than EEG.
  • Non-invasive.

Long-Term Memory

  • Declarative Memory (explicit): consists of Episodic and Semantic memory.
  • Episodic - memories of personal events
  • Semantic - facts and general knowledge

Non-Declarative Memory (implicit):

  • Procedural memories

Working Memory

  • System that temporarily holds and manipulates information.
  • Prefrontal cortex plays a central role

Patient H.M.

  • Surgery resulted in severe anterograde amnesia (inability to form new declarative memories)

Memory Systems

  • Discuss the different memory systems:
  • Short-term memory
  • Sensory memory
  • Working memory
  • Long-term memory

Deep Brain Stimulation

  • Invasive
  • Electrodes placed in cortex.
  • Treatment for Parkinson's and Huntington's disease

Brain Structures (supporting memories).

  • Hippocampus-first person memory encoding, storage, and retrieval
  • PFC-working memory and executive function
  • Basal Ganglia-procedural memory
  • Medial Temporal Lobe-long term memory

Cognitive neuroscience methods (strengths and weaknesses).

  • Comparison of various methods.
  • How neuroimaging methods measure and asses neural processing

Representation and Transformation of information in the brain

  • Top down approach
  • Marr's 3 levels: Computation, Representation, and Hardware

Metabolic/Functional Brain Deficits

  • How brain activity and energy use can be impacted
  • Neurotransmitter imbalances and disorders (e.g., depression, schizophrenia, and Parkinson's) affect the proper functioning of the brain.
  • Use of brain imaging(e.g., fMRI, PET scan, EEG) to study brain function and metabolic activities

Saliency and Priority Map

  • Theoretical constructs used to predict eye movements of attention
  • Bottom-up map of scene regions of relative interest.

Split Brain Surgery

  • Corpus callosum cut to inhibit excess firing
  • Used to treat severe epilepsy

Language Network

  • Broca's area (non-fluent aphasia)
  • Wernicke's area (fluent aphasia)
  • Arcuate fasciculus
  • Different brain areas and functions associated with language processing

Face Processing

  • Fusiform face area (FFA) – facial recognition
  • Inferior temporal lobe – ventral/lateral pathway
  • Theory of mind and social cognition involves representation of others' intentions, perspectives, beliefs.

Implicit Bias

  • Unconscious stereotyping and discriminatory behaviors
  • Measured and assessed using reaction-time tasks like the Implicit Association Test.
  • Correlation between activation in the amygdala and implicit bias
  • Implications on social cognition.

Mentalization

  • Process by which we represent information in the minds of others
  • Role of the superior temporal sulcus, angular gyrus, and intraparietal sulcus in this process.
  • How mindblindness affects this process.
  • How injuries to this area affect social behaviour.
  • Role of different parts of the brain in mentalization (e.g., medial prefrontal cortex, posterior superior temporal sulcus, amygdala).

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Prepare for your final exam in Cognitive Neuroscience by exploring various methods such as EEG, ECOG, and fMRI. This quiz covers key strengths and weaknesses, focusing on spatial resolution, timing resolution, and other critical factors. Test your knowledge on how these techniques influence our understanding of brain function.

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