17 Questions
What is the role of the interpositus nucleus in eyeblink conditioning?
Learning the relationship between the conditioned stimulus (CS) and the unconditioned stimulus (US)
What is the effect of pairing firing of climbing fibers with parallel fibers in the cerebellar cortex?
Decrease in synaptic strength in parallel fiber input
What cellular process is associated with long-term depression (LTD) in Purkinje cells?
Decrease in AMPA receptors in Purkinje neurons
Which molecule is crucial for activating PKC alpha in cellular plasticity processes?
Diacylglycerol (DAG)
What happens to the response if Purkinje cells are blocked during eyeblink conditioning?
The response starts at tone onset
What is the function of the cerebellar cortex in associative conditioning according to the text?
Learning the relationship between the CS and US
What is the role of the interpositus nucleus in eyeblink conditioning?
Learning the relationship between the conditioned stimulus (CS) and unconditioned stimulus (US)
Which type of neurons receive inputs from granule cells via parallel fibers in the cerebellum?
Purkinje neurons
What is the effect of depression of inputs from granule cells on Purkinje cells?
Reduces their firing rate
Which structure is responsible for learning the timing in eyeblink conditioning?
Cerebellar nucleus
What neurotransmitter do Purkinje neurons release to prevent output neurons from firing?
GABA
What is the evidence suggesting that LTD is caused by?
Phosphorylation of GluA2
What mutation in mice engineered leads to the absence of LTD when climbing fibers and parallel fibers are coincidentally fired?
K882A mutation
Which process is NOT necessary for eye-blink conditioning according to the text?
LTD
What is suggested as the cellular mechanism underlying memory formation in the text?
LTP at CA3-CA1 synapses
What is necessary for the timing of eyeblink conditioning?
PKC phosphorylation of AMPA receptors
Which mutation allows mice to have normal eye-blink conditioning despite the absence of LTD?
K882A mutation
Explore the connection between long-term depression (LTD) of granule cells to Purkinje cells and its role in eye-blink conditioning. Learn about the significance of phosphorylation of GluA2, and the effects of mutations like the K882A mutation on LTD and conditioning.
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