Neuroscience: LTD and Eye-Blink Conditioning
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Questions and Answers

What is the role of the interpositus nucleus in eyeblink conditioning?

  • Initiating the eyeblink response directly
  • Learning the relationship between the conditioned stimulus (CS) and the unconditioned stimulus (US) (correct)
  • Learning the timing of the stimuli
  • Controlling the release of glutamate in the cerebellar cortex
  • What is the effect of pairing firing of climbing fibers with parallel fibers in the cerebellar cortex?

  • Increase in PKC activity
  • Increase in GABA release from Purkinje cells
  • Increase in synaptic strength in climbing fiber input
  • Decrease in synaptic strength in parallel fiber input (correct)
  • What cellular process is associated with long-term depression (LTD) in Purkinje cells?

  • Increase in NMDA receptor activity
  • Increase in synaptic strength in parallel fiber input
  • Increase in AMPA receptors in Purkinje neurons
  • Decrease in AMPA receptors in Purkinje neurons (correct)
  • Which molecule is crucial for activating PKC alpha in cellular plasticity processes?

    <p>Diacylglycerol (DAG)</p> Signup and view all the answers

    What happens to the response if Purkinje cells are blocked during eyeblink conditioning?

    <p>The response starts at tone onset</p> Signup and view all the answers

    What is the function of the cerebellar cortex in associative conditioning according to the text?

    <p>Learning the relationship between the CS and US</p> Signup and view all the answers

    What is the role of the interpositus nucleus in eyeblink conditioning?

    <p>Learning the relationship between the conditioned stimulus (CS) and unconditioned stimulus (US)</p> Signup and view all the answers

    Which type of neurons receive inputs from granule cells via parallel fibers in the cerebellum?

    <p>Purkinje neurons</p> Signup and view all the answers

    What is the effect of depression of inputs from granule cells on Purkinje cells?

    <p>Reduces their firing rate</p> Signup and view all the answers

    Which structure is responsible for learning the timing in eyeblink conditioning?

    <p>Cerebellar nucleus</p> Signup and view all the answers

    What neurotransmitter do Purkinje neurons release to prevent output neurons from firing?

    <p>GABA</p> Signup and view all the answers

    What is the evidence suggesting that LTD is caused by?

    <p>Phosphorylation of GluA2</p> Signup and view all the answers

    What mutation in mice engineered leads to the absence of LTD when climbing fibers and parallel fibers are coincidentally fired?

    <p>K882A mutation</p> Signup and view all the answers

    Which process is NOT necessary for eye-blink conditioning according to the text?

    <p>LTD</p> Signup and view all the answers

    What is suggested as the cellular mechanism underlying memory formation in the text?

    <p>LTP at CA3-CA1 synapses</p> Signup and view all the answers

    What is necessary for the timing of eyeblink conditioning?

    <p>PKC phosphorylation of AMPA receptors</p> Signup and view all the answers

    Which mutation allows mice to have normal eye-blink conditioning despite the absence of LTD?

    <p>K882A mutation</p> Signup and view all the answers

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