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Questions and Answers
During retrograde transport, which motor protein is responsible for moving cargo towards the negative end of microtubules?
During retrograde transport, which motor protein is responsible for moving cargo towards the negative end of microtubules?
What type of bond is formed between amino acids during a condensation reaction?
What type of bond is formed between amino acids during a condensation reaction?
Which of the following is NOT a step in the process of protein synthesis?
Which of the following is NOT a step in the process of protein synthesis?
Which level of protein structure involves the formation of α-helices and β-pleated sheets due to hydrogen bonding?
Which level of protein structure involves the formation of α-helices and β-pleated sheets due to hydrogen bonding?
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Which of the following is a characteristic of amino acids?
Which of the following is a characteristic of amino acids?
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What is the difference between β-amyloid plaques and neurofibrillary tangles?
What is the difference between β-amyloid plaques and neurofibrillary tangles?
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What is the primary function of the hydrophobic tails of phospholipids in the plasma membrane?
What is the primary function of the hydrophobic tails of phospholipids in the plasma membrane?
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Which of the following is NOT a characteristic of the plasma membrane?
Which of the following is NOT a characteristic of the plasma membrane?
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Which of these components is NOT part of the SNARE complex?
Which of these components is NOT part of the SNARE complex?
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What is the primary function of a ligand in the context of neuronal signaling?
What is the primary function of a ligand in the context of neuronal signaling?
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Which of the following BEST describes the role of a neurotransmitter in the neuromuscular junction?
Which of the following BEST describes the role of a neurotransmitter in the neuromuscular junction?
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What is the primary function of Acetylcholinesterase in the synaptic cleft?
What is the primary function of Acetylcholinesterase in the synaptic cleft?
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Which of the following BEST describes the difference between endogenous and exogenous substances in the context of brain function?
Which of the following BEST describes the difference between endogenous and exogenous substances in the context of brain function?
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How do antagonists influence the activity of a receptor?
How do antagonists influence the activity of a receptor?
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What is the role of synaptic vesicles in neurotransmission?
What is the role of synaptic vesicles in neurotransmission?
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Which of the following is an example of an agonist?
Which of the following is an example of an agonist?
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Which of the following events is directly responsible for repolarization during an action potential?
Which of the following events is directly responsible for repolarization during an action potential?
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What is the primary function of tetrodotoxin (TTX)?
What is the primary function of tetrodotoxin (TTX)?
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Which of the following describes the state of a neuron during the refractory period?
Which of the following describes the state of a neuron during the refractory period?
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What would be the consequence of a mutation that prevents the inactivation of voltage-gated sodium channels?
What would be the consequence of a mutation that prevents the inactivation of voltage-gated sodium channels?
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What is the primary difference between voltage-gated channels and ligand-gated channels?
What is the primary difference between voltage-gated channels and ligand-gated channels?
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What is the role of the threshold in action potential generation?
What is the role of the threshold in action potential generation?
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Why is the undershoot phase of an action potential more negative than the resting membrane potential?
Why is the undershoot phase of an action potential more negative than the resting membrane potential?
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Which of the following best describes the role of leak channels in maintaining the resting membrane potential?
Which of the following best describes the role of leak channels in maintaining the resting membrane potential?
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What is the primary consequence of calcium entry into postsynaptic neurons following NMDA receptor activation?
What is the primary consequence of calcium entry into postsynaptic neurons following NMDA receptor activation?
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Which task primarily assesses spatial memory and involves navigating a pool?
Which task primarily assesses spatial memory and involves navigating a pool?
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In the context of learning and memory, classical conditioning primarily involves which of the following processes?
In the context of learning and memory, classical conditioning primarily involves which of the following processes?
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What occurs during Long-Term Depression (LTD) in terms of AMPA receptors?
What occurs during Long-Term Depression (LTD) in terms of AMPA receptors?
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Which type of memory does the radial arm maze test for in rats?
Which type of memory does the radial arm maze test for in rats?
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What triggers the influx of Ca²⁺ in the axon terminal?
What triggers the influx of Ca²⁺ in the axon terminal?
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How does a neurotransmitter that binds to a receptor opening Na+ channels affect the postsynaptic membrane potential?
How does a neurotransmitter that binds to a receptor opening Na+ channels affect the postsynaptic membrane potential?
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What effect do benzodiazepines have on the GABA receptor?
What effect do benzodiazepines have on the GABA receptor?
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What characterizes synaptic depression?
What characterizes synaptic depression?
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Which receptor requires both glutamate binding and membrane depolarization to relieve the Mg²⁺ block?
Which receptor requires both glutamate binding and membrane depolarization to relieve the Mg²⁺ block?
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What occurs during long-term potentiation (LTP)?
What occurs during long-term potentiation (LTP)?
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What is the effect of a conditioned stimulus?
What is the effect of a conditioned stimulus?
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How does sensitization differ from habituation?
How does sensitization differ from habituation?
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What is a conditioned stimulus?
What is a conditioned stimulus?
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What does Hebb's Postulate primarily refer to?
What does Hebb's Postulate primarily refer to?
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What is the role of magnesium ions in synaptic transmission?
What is the role of magnesium ions in synaptic transmission?
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What is the main effect of long-term potentiation (LTP)?
What is the main effect of long-term potentiation (LTP)?
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What defines habituation?
What defines habituation?
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What is the significance of the glutamate receptor?
What is the significance of the glutamate receptor?
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What is the difference between sensitization and habituation?
What is the difference between sensitization and habituation?
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How does long-term depression (LTD) affect synaptic transmission?
How does long-term depression (LTD) affect synaptic transmission?
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Flashcards
Agonist
Agonist
A drug that binds to a receptor and mimics neurotransmitter/hormone action.
Antagonist
Antagonist
A substance that blocks receptor activity, preventing agonist action.
Ligand
Ligand
A molecule that binds to a specific receptor on a neuron, triggering a cellular response.
Exogenous
Exogenous
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Endogenous
Endogenous
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Neurotransmitter
Neurotransmitter
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Neuromuscular Junction
Neuromuscular Junction
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Acetylcholinesterase
Acetylcholinesterase
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Dynein
Dynein
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Kinesin
Kinesin
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Anterograde Transport
Anterograde Transport
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Retrograde Transport
Retrograde Transport
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Protein Synthesis Steps
Protein Synthesis Steps
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Protein Structure Levels
Protein Structure Levels
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β-Amyloid Plaques
β-Amyloid Plaques
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Neurofibrillary Tangles
Neurofibrillary Tangles
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Action Potential (AP)
Action Potential (AP)
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Rising Phase
Rising Phase
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Falling Phase
Falling Phase
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Repolarization
Repolarization
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Undershoot
Undershoot
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Refractory Period
Refractory Period
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Threshold
Threshold
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Tetrodotoxin (TTX)
Tetrodotoxin (TTX)
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Steps of Transmitter Release
Steps of Transmitter Release
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Role of Calcium in Neurotransmitter Release
Role of Calcium in Neurotransmitter Release
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Excitatory Neurotransmitters
Excitatory Neurotransmitters
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Inhibitory Neurotransmitters
Inhibitory Neurotransmitters
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Difference between AMPA and NMDA Receptors
Difference between AMPA and NMDA Receptors
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Long-Term Potentiation (LTP)
Long-Term Potentiation (LTP)
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Sensitization vs. Habituation
Sensitization vs. Habituation
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Conditioned vs. Unconditioned Stimulus
Conditioned vs. Unconditioned Stimulus
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Long-Term Depression (LTD)
Long-Term Depression (LTD)
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NMDA receptor activation effects
NMDA receptor activation effects
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Water Maze
Water Maze
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Radial Arm Maze
Radial Arm Maze
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Classical Conditioning
Classical Conditioning
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Conditioned Stimulus
Conditioned Stimulus
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Unconditioned Stimulus
Unconditioned Stimulus
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Hebb’s Postulate
Hebb’s Postulate
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Sensitization
Sensitization
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Habituation
Habituation
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Glutamate Receptor
Glutamate Receptor
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Study Notes
Definitions
- Affinity: The strength of binding between a molecule (e.g., neurotransmitter or drug) and its receptor.
- Potency: The gene activation potential; a measure of the ability of a cell to differentiate.
- Agonist: A drug or substance that mimics the action of a neurotransmitter, activating the receptor.
- Antagonist: A drug or substance that blocks the action of a neurotransmitter, preventing receptor activation.
- Ligand: A molecule that binds to a specific receptor, initiating a signal transduction pathway (e.g., neurotransmitters).
- Exogenous: Originating from outside the body (e.g., drugs).
- Endogenous: Originating within the body (e.g., neurotransmitters).
- Neurotransmitter: A chemical messenger released by a neuron to transmit signals to another neuron, muscle, or gland.
- Neuromuscular Junction: The synapse where a motor neuron connects to a muscle fiber, crucial for voluntary muscle contraction.
Synaptic Transmission
- Synaptic Vesicle: A small, membrane-bound sac in the presynaptic terminal that stores neurotransmitters.
- SNARE Complex (syntaxin, SNAP25, synaptotagmin, synaptobrevin): Proteins facilitating synaptic vesicle fusion and neurotransmitter release.
Action Potentials
- Rising Phase: Rapid depolarization by Na⁺ influx via voltage-gated channels.
- Falling Phase: Rapid repolarization by K⁺ efflux via voltage-gated channels.
- Undershoot/Hyperpolarization: Temporary dip below resting potential due to continued K⁺ outflow.
- Refractory Period: Time after an action potential where the neuron cannot fire another AP.
Membrane Potentials
- Membrane Potential (Vm): The difference in electrical charge across the plasma membrane (measured in mV).
- Equilibrium Potential (Eion): The membrane potential where there's no net ion movement due to balanced electrical and concentration gradients.
- Resting Membrane Potential (RMP): The steady-state voltage of the neuron (−70mV), primarily maintained by K⁺ leak channels and the Na+/K+ pump.
- Concentration Gradient: Difference in ion concentration across the membrane.
- Electrical Gradient: Difference in charge across the membrane.
- Ion Channels: Proteins that allow ions to pass passively or actively across the membrane.
- Sodium-Potassium Pump (Na+/K+ ATPase): A protein that actively moves sodium ions out and potassium ions in to maintain the gradients across the membrane.
Neurological Disorders
- Multiple Sclerosis (MS): An autoimmune disease with demyelination of CNS axons leading to slower AP conduction and symptoms like vision problems, muscle weakness, and fatigue.
- Myasthenia Gravis: An autoimmune disorder where antibodies attack the Ach receptors at the neuromuscular junctions. Symptoms include muscle weakness and fatigue.
Synaptic Plasticity
- Long-Term Potentiation (LTP): Strengthening of synaptic connections with high-frequency stimulation.
- Long-Term Depression (LTD): Weakening of synaptic connections with low-frequency stimulation. Neural plasticity Changes in neural structure and function in response to experience, learning, or environmental changes.
Learning and Memory
- Classical Conditioning: A learning process where a neutral stimulus becomes associated with a naturally occurring stimulus, triggering a learned response.
- Hebbian Learning: A principle stating that "neurons that fire together wire together"—repeated co-activation of neurons strengthens their connection.
- Synaptic Plasticity: Changes in synaptic strength (LTP and LTD) are core mechanisms in learning and memory.
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Description
Test your knowledge on key terms in neuroscience, including definitions related to neurotransmitters, agonists, and receptors. This quiz will help you understand critical concepts in synaptic transmission and the roles of various molecules in neural communication.