Neuroscience Definitions Quiz
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Questions and Answers

During retrograde transport, which motor protein is responsible for moving cargo towards the negative end of microtubules?

  • Kinesin
  • Myosin
  • Dynein (correct)
  • Actin
  • What type of bond is formed between amino acids during a condensation reaction?

  • Disulfide bond
  • Hydrogen bond
  • Peptide bond (correct)
  • Ionic bond
  • Which of the following is NOT a step in the process of protein synthesis?

  • Transcription
  • Replication (correct)
  • Translation
  • Post-translational modification
  • Which level of protein structure involves the formation of α-helices and β-pleated sheets due to hydrogen bonding?

    <p>Secondary (D)</p> Signup and view all the answers

    Which of the following is a characteristic of amino acids?

    <p>They are composed of carbon, hydrogen, oxygen, and nitrogen. (A)</p> Signup and view all the answers

    What is the difference between β-amyloid plaques and neurofibrillary tangles?

    <p>β-amyloid plaques are extracellular, while neurofibrillary tangles are intracellular. (B)</p> Signup and view all the answers

    What is the primary function of the hydrophobic tails of phospholipids in the plasma membrane?

    <p>They prevent the passage of water-soluble molecules across the membrane. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the plasma membrane?

    <p>It is rigid and inflexible. (D)</p> Signup and view all the answers

    Which of these components is NOT part of the SNARE complex?

    <p>Acetylcholinesterase (C)</p> Signup and view all the answers

    What is the primary function of a ligand in the context of neuronal signaling?

    <p>To bind to a receptor and initiate a signal transduction pathway (B)</p> Signup and view all the answers

    Which of the following BEST describes the role of a neurotransmitter in the neuromuscular junction?

    <p>To bind to receptors on muscle fibers and initiate contraction (A)</p> Signup and view all the answers

    What is the primary function of Acetylcholinesterase in the synaptic cleft?

    <p>To break down and inactivate acetylcholine, terminating its signal (D)</p> Signup and view all the answers

    Which of the following BEST describes the difference between endogenous and exogenous substances in the context of brain function?

    <p>Endogenous substances are produced by the body, while exogenous substances come from outside the body. (B)</p> Signup and view all the answers

    How do antagonists influence the activity of a receptor?

    <p>They block the receptor, preventing agonists from binding and activating it. (B)</p> Signup and view all the answers

    What is the role of synaptic vesicles in neurotransmission?

    <p>To store and release neurotransmitters into the synaptic cleft (D)</p> Signup and view all the answers

    Which of the following is an example of an agonist?

    <p>A medication that mimics the effects of acetylcholine (A)</p> Signup and view all the answers

    Which of the following events is directly responsible for repolarization during an action potential?

    <p>Closing of voltage-gated sodium channels and opening of voltage-gated potassium channels (A)</p> Signup and view all the answers

    What is the primary function of tetrodotoxin (TTX)?

    <p>To block the opening of voltage-gated sodium channels (A)</p> Signup and view all the answers

    Which of the following describes the state of a neuron during the refractory period?

    <p>The neuron is in a state of hyperpolarization, making it more difficult to fire an action potential (B)</p> Signup and view all the answers

    What would be the consequence of a mutation that prevents the inactivation of voltage-gated sodium channels?

    <p>Action potentials would be prolonged and sustained (A)</p> Signup and view all the answers

    What is the primary difference between voltage-gated channels and ligand-gated channels?

    <p>Voltage-gated channels open in response to a change in membrane potential, while ligand-gated channels open in response to a specific chemical (D)</p> Signup and view all the answers

    What is the role of the threshold in action potential generation?

    <p>The threshold determines whether an action potential will be fired (B)</p> Signup and view all the answers

    Why is the undershoot phase of an action potential more negative than the resting membrane potential?

    <p>Because the cell membrane is more permeable to potassium ions than sodium ions (B)</p> Signup and view all the answers

    Which of the following best describes the role of leak channels in maintaining the resting membrane potential?

    <p>Leak channels allow for a slow, passive movement of ions, contributing to the steady-state membrane potential (D)</p> Signup and view all the answers

    What is the primary consequence of calcium entry into postsynaptic neurons following NMDA receptor activation?

    <p>Activation of intracellular signaling pathways (A)</p> Signup and view all the answers

    Which task primarily assesses spatial memory and involves navigating a pool?

    <p>Water Maze (B)</p> Signup and view all the answers

    In the context of learning and memory, classical conditioning primarily involves which of the following processes?

    <p>Associating a neutral stimulus with a naturally occurring stimulus (A)</p> Signup and view all the answers

    What occurs during Long-Term Depression (LTD) in terms of AMPA receptors?

    <p>Removal of AMPA receptors from the synapse (B)</p> Signup and view all the answers

    Which type of memory does the radial arm maze test for in rats?

    <p>Working and reference memory (B)</p> Signup and view all the answers

    What triggers the influx of Ca²⁺ in the axon terminal?

    <p>Action potential arriving at the axon terminal (B)</p> Signup and view all the answers

    How does a neurotransmitter that binds to a receptor opening Na+ channels affect the postsynaptic membrane potential?

    <p>It results in an excitatory postsynaptic potential (EPSP). (B)</p> Signup and view all the answers

    What effect do benzodiazepines have on the GABA receptor?

    <p>They enhance the frequency of Cl- channel opening. (D)</p> Signup and view all the answers

    What characterizes synaptic depression?

    <p>Decreased neurotransmitter release with repeated stimulation. (D)</p> Signup and view all the answers

    Which receptor requires both glutamate binding and membrane depolarization to relieve the Mg²⁺ block?

    <p>NMDA receptor (C)</p> Signup and view all the answers

    What occurs during long-term potentiation (LTP)?

    <p>Strengthening of synaptic connections with high-frequency stimulation. (C)</p> Signup and view all the answers

    What is the effect of a conditioned stimulus?

    <p>Elicits a response after conditioning. (B)</p> Signup and view all the answers

    How does sensitization differ from habituation?

    <p>Sensitization involves an increased response to a repeated stimulus. (C)</p> Signup and view all the answers

    What is a conditioned stimulus?

    <p>A neutral stimulus that elicits a learned response after association. (B)</p> Signup and view all the answers

    What does Hebb's Postulate primarily refer to?

    <p>The strengthening of synaptic connections through simultaneous activation. (D)</p> Signup and view all the answers

    What is the role of magnesium ions in synaptic transmission?

    <p>To block the NMDA receptor, regulating calcium influx. (D)</p> Signup and view all the answers

    What is the main effect of long-term potentiation (LTP)?

    <p>It increases the strength of connections between neurons long-term. (C)</p> Signup and view all the answers

    What defines habituation?

    <p>A decline in behavioral response after repeated exposure to a stimulus. (A)</p> Signup and view all the answers

    What is the significance of the glutamate receptor?

    <p>It triggers an excitatory signal when bound with glutamate. (C)</p> Signup and view all the answers

    What is the difference between sensitization and habituation?

    <p>Sensitization amplifies response after repeated exposure, while habituation diminishes it. (A)</p> Signup and view all the answers

    How does long-term depression (LTD) affect synaptic transmission?

    <p>It decreases the efficiency of synaptic transmission. (B)</p> Signup and view all the answers

    Flashcards

    Agonist

    A drug that binds to a receptor and mimics neurotransmitter/hormone action.

    Antagonist

    A substance that blocks receptor activity, preventing agonist action.

    Ligand

    A molecule that binds to a specific receptor on a neuron, triggering a cellular response.

    Exogenous

    Something originating from outside the body, influencing internal processes.

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    Endogenous

    Something that originates within the body, like naturally produced substances.

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    Neurotransmitter

    A chemical messenger released by neurons, transmitting signals across synapses.

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    Neuromuscular Junction

    A specialized synapse where a motor neuron communicates with a muscle fiber.

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    Acetylcholinesterase

    An enzyme that breaks down acetylcholine at the synaptic cleft, terminating its signal.

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    Dynein

    A motor protein that moves cargo toward the negative (-) end of microtubules (retrograde transport).

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    Kinesin

    A motor protein that transports cargo toward the positive (+) end of microtubules (anterograde transport).

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    Anterograde Transport

    Movement of materials from the soma to the axon terminal, facilitated by kinesin.

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    Retrograde Transport

    Transport of materials from the axon terminal back to the soma, using dynein.

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    Protein Synthesis Steps

    Includes transcription, mRNA processing, translation, and post-translational modifications.

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    Protein Structure Levels

    Proteins have four levels: primary, secondary, tertiary, and quaternary structure.

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    β-Amyloid Plaques

    Extracellular deposits formed by the aggregation of β-amyloid proteins, associated with Alzheimer’s disease.

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    Neurofibrillary Tangles

    Intracellular tangles made of hyperphosphorylated tau protein, linked to Alzheimer’s disease.

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    Action Potential (AP)

    An electrical impulse that travels down an axon, carrying information away from the cell body.

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    Rising Phase

    Rapid depolarization of the neuron's membrane potential during an AP caused by opening voltage-gated sodium channels.

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    Falling Phase

    Rapid decrease in membrane potential during an AP as the neuron returns to resting state, involving closing of sodium and opening of potassium channels.

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    Repolarization

    The process that restores a neuron's resting membrane potential after an action potential.

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    Undershoot

    The phase where the membrane potential dips below its resting potential after the peak of an AP.

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    Refractory Period

    The period following an action potential where a neuron is unable to fire another AP, entering a state of recovery.

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    Threshold

    The minimum level of stimulus that causes a neuron to fire an action potential.

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    Tetrodotoxin (TTX)

    A potent neurotoxin that selectively blocks voltage-gated sodium channels on nerve cell membranes.

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    Steps of Transmitter Release

    Series of events from action potential to neurotransmitter binding.

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    Role of Calcium in Neurotransmitter Release

    Calcium enters axon terminal when action potential opens voltage-gated channels.

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    Excitatory Neurotransmitters

    Neurotransmitters that increase postsynaptic membrane potential, like opening Na+ channels.

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    Inhibitory Neurotransmitters

    Neurotransmitters that decrease postsynaptic membrane potential, like opening Cl- channels.

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    Difference between AMPA and NMDA Receptors

    AMPA opens with glutamate; NMDA needs glutamate and depolarization to activate.

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    Long-Term Potentiation (LTP)

    Strengthening of synaptic connections due to high-frequency stimulation.

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    Sensitization vs. Habituation

    Sensitization: Increased response; Habituation: Decreased response to repeated stimulus.

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    Conditioned vs. Unconditioned Stimulus

    Conditioned: Previously neutral stimulus that elicits a response; Unconditioned: Naturally triggers response.

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    Long-Term Depression (LTD)

    Weakening of synaptic connections through low-frequency stimulation.

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    NMDA receptor activation effects

    Influences AMPA receptor behavior based on calcium entry: insertion strengthens, removal weakens synaptic transmission.

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    Water Maze

    A spatial learning assay where rats find a hidden platform in a pool, testing memory and hippocampal function.

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    Radial Arm Maze

    A test for rats to explore a maze with arms for food, assessing working and reference memory.

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    Classical Conditioning

    A learning process where a neutral stimulus gains the ability to elicit a response by association with an unconditioned stimulus.

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    Conditioned Stimulus

    A neutral stimulus that triggers a learned response after association with an unconditioned stimulus.

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    Unconditioned Stimulus

    A stimulus that naturally triggers a response without any prior learning.

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    Hebb’s Postulate

    A principle stating that when two neurons fire together, their connection strengthens.

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    Sensitization

    A process where repeated exposure to a stimulus increases the response.

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    Habituation

    A process where repeated exposure leads to a decline in response.

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    Glutamate Receptor

    A protein that binds glutamate, triggering excitatory signals in neurons.

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    Study Notes

    Definitions

    • Affinity: The strength of binding between a molecule (e.g., neurotransmitter or drug) and its receptor.
    • Potency: The gene activation potential; a measure of the ability of a cell to differentiate.
    • Agonist: A drug or substance that mimics the action of a neurotransmitter, activating the receptor.
    • Antagonist: A drug or substance that blocks the action of a neurotransmitter, preventing receptor activation.
    • Ligand: A molecule that binds to a specific receptor, initiating a signal transduction pathway (e.g., neurotransmitters).
    • Exogenous: Originating from outside the body (e.g., drugs).
    • Endogenous: Originating within the body (e.g., neurotransmitters).
    • Neurotransmitter: A chemical messenger released by a neuron to transmit signals to another neuron, muscle, or gland.
    • Neuromuscular Junction: The synapse where a motor neuron connects to a muscle fiber, crucial for voluntary muscle contraction.

    Synaptic Transmission

    • Synaptic Vesicle: A small, membrane-bound sac in the presynaptic terminal that stores neurotransmitters.
    • SNARE Complex (syntaxin, SNAP25, synaptotagmin, synaptobrevin): Proteins facilitating synaptic vesicle fusion and neurotransmitter release.

    Action Potentials

    • Rising Phase: Rapid depolarization by Na⁺ influx via voltage-gated channels.
    • Falling Phase: Rapid repolarization by K⁺ efflux via voltage-gated channels.
    • Undershoot/Hyperpolarization: Temporary dip below resting potential due to continued K⁺ outflow.
    • Refractory Period: Time after an action potential where the neuron cannot fire another AP.

    Membrane Potentials

    • Membrane Potential (Vm): The difference in electrical charge across the plasma membrane (measured in mV).
    • Equilibrium Potential (Eion): The membrane potential where there's no net ion movement due to balanced electrical and concentration gradients.
    • Resting Membrane Potential (RMP): The steady-state voltage of the neuron (−70mV), primarily maintained by K⁺ leak channels and the Na+/K+ pump.
    • Concentration Gradient: Difference in ion concentration across the membrane.
    • Electrical Gradient: Difference in charge across the membrane.
    • Ion Channels: Proteins that allow ions to pass passively or actively across the membrane.
    • Sodium-Potassium Pump (Na+/K+ ATPase): A protein that actively moves sodium ions out and potassium ions in to maintain the gradients across the membrane.

    Neurological Disorders

    • Multiple Sclerosis (MS): An autoimmune disease with demyelination of CNS axons leading to slower AP conduction and symptoms like vision problems, muscle weakness, and fatigue.
    • Myasthenia Gravis: An autoimmune disorder where antibodies attack the Ach receptors at the neuromuscular junctions. Symptoms include muscle weakness and fatigue.

    Synaptic Plasticity

    • Long-Term Potentiation (LTP): Strengthening of synaptic connections with high-frequency stimulation.
    • Long-Term Depression (LTD): Weakening of synaptic connections with low-frequency stimulation. Neural plasticity Changes in neural structure and function in response to experience, learning, or environmental changes.

    Learning and Memory

    • Classical Conditioning: A learning process where a neutral stimulus becomes associated with a naturally occurring stimulus, triggering a learned response.
    • Hebbian Learning: A principle stating that "neurons that fire together wire together"—repeated co-activation of neurons strengthens their connection.
    • Synaptic Plasticity: Changes in synaptic strength (LTP and LTD) are core mechanisms in learning and memory.

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    Description

    Test your knowledge on key terms in neuroscience, including definitions related to neurotransmitters, agonists, and receptors. This quiz will help you understand critical concepts in synaptic transmission and the roles of various molecules in neural communication.

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