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Questions and Answers
What is the name for the point of communication between neurons?
What is the name for the point of communication between neurons?
What is the direction of transmission of an action potential at a synapse?
What is the direction of transmission of an action potential at a synapse?
What type of synapse occurs when the terminal bouton of one neuron synapses on the dendrite of another neuron?
What type of synapse occurs when the terminal bouton of one neuron synapses on the dendrite of another neuron?
What type of synapse occurs when the terminal bouton of one neuron synapses on the soma of another neuron?
What type of synapse occurs when the terminal bouton of one neuron synapses on the soma of another neuron?
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What type of synapse occurs when the terminal bouton of one neuron synapses on the terminal bouton of another neuron?
What type of synapse occurs when the terminal bouton of one neuron synapses on the terminal bouton of another neuron?
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What is the function of astrocytes in the synapse?
What is the function of astrocytes in the synapse?
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What is the effect of presynaptic inhibition?
What is the effect of presynaptic inhibition?
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What is the name of the structures that contain thousands of molecules of neurotransmitters?
What is the name of the structures that contain thousands of molecules of neurotransmitters?
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Which of the following is NOT a characteristic of metabotropic receptors?
Which of the following is NOT a characteristic of metabotropic receptors?
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What is the primary role of second messengers in the context of neurotransmission?
What is the primary role of second messengers in the context of neurotransmission?
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Which of the following is an example of how an ionotropic receptor can influence cellular function?
Which of the following is an example of how an ionotropic receptor can influence cellular function?
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Which type of ionotropic receptor leads to hyperpolarization of the post-synaptic cell?
Which type of ionotropic receptor leads to hyperpolarization of the post-synaptic cell?
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What is the mechanism by which metabotropic receptors can influence ion channel activity?
What is the mechanism by which metabotropic receptors can influence ion channel activity?
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Which of the following is NOT a characteristic of terminal autoreceptors?
Which of the following is NOT a characteristic of terminal autoreceptors?
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What is the primary function of somatodendritic autoreceptors?
What is the primary function of somatodendritic autoreceptors?
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What is the key difference between co-release and co-transmission?
What is the key difference between co-release and co-transmission?
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Which of the following is NOT a method of neurotransmitter inactivation?
Which of the following is NOT a method of neurotransmitter inactivation?
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Which type of neurotransmitter inactivation is commonly observed for acetylcholine (ACh)?
Which type of neurotransmitter inactivation is commonly observed for acetylcholine (ACh)?
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What is the primary mechanism behind "differential Ca++ sensitivity" in co-transmission?
What is the primary mechanism behind "differential Ca++ sensitivity" in co-transmission?
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Which of the following statements best describes Dale's Principle?
Which of the following statements best describes Dale's Principle?
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Which of the following best explains the concept of "spatial segregation" in co-transmission?
Which of the following best explains the concept of "spatial segregation" in co-transmission?
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What is the primary function of calcium ions (Ca2+) in neurotransmitter release?
What is the primary function of calcium ions (Ca2+) in neurotransmitter release?
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What is the function of autoreceptors in neurotransmitter release?
What is the function of autoreceptors in neurotransmitter release?
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How does botulinum toxin affect neurotransmitter release?
How does botulinum toxin affect neurotransmitter release?
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Which of the following is NOT a factor that regulates neurotransmitter release?
Which of the following is NOT a factor that regulates neurotransmitter release?
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What are neuromodulators, and how do they differ from neurotransmitters?
What are neuromodulators, and how do they differ from neurotransmitters?
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Which of the following neurotransmitters is often considered a neuromodulator of glutamate and GABA?
Which of the following neurotransmitters is often considered a neuromodulator of glutamate and GABA?
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What is the location of autoreceptors?
What is the location of autoreceptors?
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How does the rate of neuron firing influence neurotransmitter release?
How does the rate of neuron firing influence neurotransmitter release?
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Which of the following is NOT a hallmark symptom of Schizophrenia?
Which of the following is NOT a hallmark symptom of Schizophrenia?
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What is the significance of the 50% concordance rate for schizophrenia in monozygotic twins?
What is the significance of the 50% concordance rate for schizophrenia in monozygotic twins?
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How do second messengers contribute to the development of psychiatric disorders like schizophrenia?
How do second messengers contribute to the development of psychiatric disorders like schizophrenia?
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What is the major premise regarding the development of schizophrenia?
What is the major premise regarding the development of schizophrenia?
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What is the key role of epigenetics in the context of schizophrenia?
What is the key role of epigenetics in the context of schizophrenia?
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Which of the following is NOT a class of neurotransmitters?
Which of the following is NOT a class of neurotransmitters?
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What is the primary role of the axon terminal in neurotransmission?
What is the primary role of the axon terminal in neurotransmission?
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Which of the following statements about neuropeptide synthesis is TRUE?
Which of the following statements about neuropeptide synthesis is TRUE?
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What is the difference between classical neurotransmitters and neuropeptides?
What is the difference between classical neurotransmitters and neuropeptides?
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Which neurotransmitter is primarily associated with the rewarding effects of drugs?
Which neurotransmitter is primarily associated with the rewarding effects of drugs?
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Which of the following is a neurotransmitter involved in the effects of hallucinogens?
Which of the following is a neurotransmitter involved in the effects of hallucinogens?
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Flashcards
Neurotransmitter
Neurotransmitter
Chemicals that transmit signals across a synapse between neurons.
Exocytosis
Exocytosis
Process by which vesicles fuse with the cell membrane to release neurotransmitters.
Voltage-gated Ca2+ channels
Voltage-gated Ca2+ channels
Channels that open in response to membrane depolarization, allowing Ca2+ entry.
Botulinum Toxin
Botulinum Toxin
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Neuromodulators
Neuromodulators
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Autoreceptors
Autoreceptors
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Factors regulating neurotransmitter release
Factors regulating neurotransmitter release
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Glutamate
Glutamate
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Terminal autoreceptors
Terminal autoreceptors
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Somatodendritic autoreceptors
Somatodendritic autoreceptors
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Dale's Principle
Dale's Principle
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Co-Release
Co-Release
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Co-Transmission
Co-Transmission
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Enzymatic degradation
Enzymatic degradation
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Neurotransmitter reuptake
Neurotransmitter reuptake
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Inactivation of neurotransmitters
Inactivation of neurotransmitters
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Ionotropic Na+ Channels
Ionotropic Na+ Channels
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Ionotropic Ca2+ Channels
Ionotropic Ca2+ Channels
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Ionotropic Cl- Channels
Ionotropic Cl- Channels
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Metabotropic Receptors
Metabotropic Receptors
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Second Messengers
Second Messengers
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Presynaptic Facilitation
Presynaptic Facilitation
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Chemical Signaling
Chemical Signaling
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Classes of Neurotransmitters
Classes of Neurotransmitters
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Neurotransmitter Synthesis
Neurotransmitter Synthesis
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Neuropeptides
Neuropeptides
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Vesicles in Neurotransmission
Vesicles in Neurotransmission
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Dopamine
Dopamine
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Epigenetics
Epigenetics
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Schizophrenia
Schizophrenia
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Chromatin Remodeling
Chromatin Remodeling
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Genetic-Environmental Interaction
Genetic-Environmental Interaction
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Synapse
Synapse
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Presynaptic Cell
Presynaptic Cell
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Postsynaptic Cell
Postsynaptic Cell
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Axodendritic Synapse
Axodendritic Synapse
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Axosomatic Synapse
Axosomatic Synapse
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Axoaxonic Synapse
Axoaxonic Synapse
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Presynaptic Inhibition
Presynaptic Inhibition
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Study Notes
Module 1: Foundations
- Principles of pharmacology are covered
- Structure and function of the nervous system are discussed
- Chemical signaling of neurotransmitters is examined
Chemical Signaling by Neurotransmitters
- Chemical Signaling Between Neurons: Neurotransmitters facilitate communication between neurons
- Neurotransmitter Synthesis, Release, and Inactivation: This process involves different classes of neurotransmitters, their synthesis, release, and inactivation mechanisms
- Neurotransmitter Receptors and Second-Messenger Systems: This section discusses the different types of neurotransmitter receptors and their roles in signaling
- Putting it all Together: This section integrates the concepts of chemical signaling to understand the broader picture
Structure of Neuron
- Neuron structure includes axons, dendrites, a soma (cell body), and a myelin sheath
- Dendrites receive signals, axons transmit signals, and the soma maintains the functions of the neuron
- The synaptic cleft is the space between the axon terminal and the receiving dendrite
- Chemical signals are exchanged at this synapse
Synapse
- Neurons aren't physically connected
- The synapse is the point of connection, where neurons communicate
- Transmission of action potentials occurs in one direction, from the presynaptic cell to the postsynaptic cell
- Synaptic vesicles in the presynaptic neuron release neurotransmitters into the synaptic cleft
- Neurotransmitters bind to receptors on the postsynaptic neuron.
Neural Threesome
- Astrocytes are glial cells that surround synapses and are involved in synaptic activity, influencing communication between neurons
- Signals at one synapse can propagate elsewhere
Chemical Signaling between Neurons (Axodendritic, Axosomatic, Axoaxonic)
- Axodendritic synapses: a terminal bouton of one neuron synapses onto a dendrite of another neuron
- Axosomatic synapses: a terminal bouton of one neuron synapses onto the soma (cell body) of another neuron
- Axoaxonic synapses: a terminal bouton of one neuron synapses onto a terminal bouton of another neuron
Chemical Signaling between nerve cells (Neuromuscular Junction)
- Neuromuscular junctions are synapses between neurons and muscle cells
- Neurotransmitters at neuromuscular junctions control muscle contraction.
Neurotransmitter Basics
- More than 100 neurotransmitter chemicals are identified
- Neurotransmitter classes include amino acids, monoamines, acetylcholine, neuropeptides, lipids, and gases
Major Categories of Neurotransmitters
- A table categorizes classic and non-classic neurotransmitters
- Examples of classic neurotransmitters listed include glutamate, GABA, glycine, and acetylcholine
Neurotransmitter Synthesis
- An individual neuron can produce multiple neurotransmitters.
- Vesicles can store multiple neurotransmitters.
- Small vesicles typically contain classic neurotransmitters while large vesicles contain neuropeptides.
Neurotransmitter Release
- A wave of depolarization opens calcium channels in the axon terminal, which causes neurotransmitters' release.
- Neurotransmitters' release occurs when vesicles fuse with the cell membrane.
Neurotransmitter Release- Botulinum Toxin
- Botulism is a bacterial toxin that blocks neurotransmitter release in neuromuscular junctions
- The toxin interferes with proteins involved in the release process.
Neurotransmitters Release
- Neuromodulators play an indirect role in transmitting signals, influencing actions of other neurotransmitters.
- Examples of neuromodulators include dopamine, serotonin, and norepinephrine.
Neurotransmitter Release- Regulation
- Regulation of neurotransmitter release is controlled by the firing rate of the neuron
- Some actions potentials that allow calcium into the cell might not trigger neurotransmitter release
- Autoreceptors are receptors for neurotransmitters released by the releasing neuron itself
Terminal and Somatodendritic Autoreceptors
- Terminal autoreceptors influence neurotransmitter release at the axon terminal.
- Somatodendritic autoreceptors regulate neuron firing rate.
Dale's Principle and Co-Release/Co-Transmission
- Dale's principle suggests that one neuron releases only one neurotransmitter
- Co-release/Co-Transmission: a single action potential can typically release different NTs to differing areas of the axon terminal.
Neurotransmitter Inactivation
- Neurotransmitters must leave the synaptic cleft for signal transmission to end
- Enzymes can break down neurotransmitters in the synapse
- Neurotransmitters are taken back up by transporter proteins in the membrane of the presynaptic neuron or glial cells
Neurotransmitter Receptors
- Neurotransmitter receptors are proteins in cell membranes
- Neurotransmitters bind to receptors, activating and resulting in either an excitatory or inhibitory effect
- Different receptor subtypes exist.
Neurotransmitter Receptors and Second-Messenger Systems
- Neurotransmitters bind to multiple receptor subtypes
- Drugs can be designed to affect specific receptor subtypes.
- Two major types are ionotropic and metabotropic receptors
Ionotropic Receptors
- Consist of 4-5 subunits with an ion channel at the center
- Binding opens ion channels, leading to an excitatory or inhibitory response
- Example: Acetylcholine, glutamate, GABA, cause Na+, Ca++, or Cl- permeation
- This allows for rapid transmission
- These channels are very fast, in the millisecond range
Metabotropic Receptors
- Consist of 7 trans-membrane domains
- They activate G-proteins, triggering a cascade of intracellular events
- Effects are slower but longer-lasting than ionotropic receptors
- Example: G-proteins activate or inhibit effector enzymes, leading to a cellular response
Second Messengers
- Second messengers activate protein kinases, causing phosphorylation of substrate proteins
- They initiate a cascade of events ultimately regulating cellular processes such as gene expression
Application: Second Messenger and Psychiatric Disorders
- Epigenetics may be related to psychiatric disorders as second messengers can affect gene regulation
- Neurotransmitters including GABA and glutamate are studied
- Candidate Genes that play a role in neurotransmitter function/regulation are important, including GABA and glutamate
- Brain imaging study findings show patterns in brain activity related to psychiatric illnesses.
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Description
Test your knowledge on synaptic communication in neuroscience with this quiz. Explore questions about synapse types, neurotransmitter functions, and receptor characteristics. Perfect for students studying neural connections and neurotransmission.