Neuroscience Chapter on Neurons

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Questions and Answers

What is the primary role of microtubules in neurons?

  • They directly conduct electrical impulses.
  • They provide structural support to the neuron.
  • They are responsible for neurotransmitter synthesis.
  • They facilitate intracellular transport. (correct)

Which part of the neuron is primarily responsible for receiving information from neighboring cells?

  • Dendrites (correct)
  • Myelin sheath
  • Cell body
  • Axon

What occurs at the synapse?

  • Intracellular transport of proteins happens.
  • Neurotransmitters are released to communicate with the postsynaptic neuron. (correct)
  • Myelin sheath insulation is formed.
  • Electrical impulses are generated within the cell body.

Where in the neuron does the axon hillock primarily function?

<p>To integrate incoming signals and generate output signals. (A)</p> Signup and view all the answers

What is NOT a function of the myelin sheath?

<p>Facilitating neurotransmitter release. (C)</p> Signup and view all the answers

What is the fundamental purpose of metabolic energy in the context of neuronal function?

<p>To maintain ionic gradients across the membrane (D)</p> Signup and view all the answers

What occurs during depolarization of a neuron's membrane potential?

<p>Membrane potential becomes less negative than the resting potential (D)</p> Signup and view all the answers

Which equation is used to determine the equilibrium potential of an ion based on its concentration gradient?

<p>Nernst equation (D)</p> Signup and view all the answers

Which of the following types of neurons is primarily responsible for transmitting signals from sensory receptors to the central nervous system?

<p>Sensory neurons (A)</p> Signup and view all the answers

What distinguishes pseudounipolar neurons from other types of neurons?

<p>They possess a single process called an axon (B)</p> Signup and view all the answers

What is the primary role of interneurons in the central nervous system?

<p>Integrating information within the CNS (A)</p> Signup and view all the answers

According to the Goldman-Hodgkin-Katz equation, what factors determine the membrane potential of a neuron?

<p>Permeability to K+, Na+, and Cl- and their concentrations (C)</p> Signup and view all the answers

What neuronal structure is primarily responsible for receiving stimuli?

<p>Dendrites (D)</p> Signup and view all the answers

During repolarization, the membrane potential of a neuron returns to which state?

<p>Resting membrane potential (C)</p> Signup and view all the answers

What percentage of cell body processes are typically branched in a multipolar neuron?

<p>More than 75% (C)</p> Signup and view all the answers

Which structure typically conveys information to the central nervous system (CNS)?

<p>Sensory neuron (A)</p> Signup and view all the answers

Which type of information does an axon transmit?

<p>Both electrical and chemical information (B)</p> Signup and view all the answers

What determines the true trigger zone of a neuron?

<p>Axon hillock (A)</p> Signup and view all the answers

What occurs during hyperpolarization?

<p>The membrane potential becomes more negative than the resting potential (C)</p> Signup and view all the answers

Which process involves the membrane potential being less negative than its resting state?

<p>Depolarization (B)</p> Signup and view all the answers

What is the primary function of the axon in a neuron?

<p>To transmit electrical signals to presynaptic axon terminals (B)</p> Signup and view all the answers

Which part of the neuron is primarily involved in receiving signals?

<p>Dendrites (A)</p> Signup and view all the answers

What role do dendritic spines play in neurons?

<p>They dynamically change their morphology and are associated with learning and memory (B)</p> Signup and view all the answers

Which structure in the neuron determines if electrical signals can proceed through the axon?

<p>Axon hillock (B)</p> Signup and view all the answers

What happens at the presynaptic axon terminal?

<p>Chemical neurotransmission occurs (B)</p> Signup and view all the answers

Which component of axons is involved in transporting molecules like neurotransmitters?

<p>Axonal transport (D)</p> Signup and view all the answers

What is contained within the presynaptic axon terminal?

<p>Mitochondria and membrane-bound vesicles (B)</p> Signup and view all the answers

What is the initial segment of the axon called?

<p>Axon hillock (C)</p> Signup and view all the answers

Which color typically represents inhibitory synapses in diagrams?

<p>Blue (A)</p> Signup and view all the answers

What are retrograde messengers in the context of neurons?

<p>Signals that return feedback from postsynaptic dendrites to presynaptic axon terminals (D)</p> Signup and view all the answers

What role do motor proteins play in axonal transport?

<p>They facilitate the transport of vesicles along microtubules. (C)</p> Signup and view all the answers

Which component of a motor protein is responsible for binding with microtubules?

<p>Head (D)</p> Signup and view all the answers

What is the energy source required for the walking mechanism of motor proteins?

<p>ATP (A)</p> Signup and view all the answers

In which direction does the anterograde transport mechanism move?

<p>From soma to axon terminals (C)</p> Signup and view all the answers

What typically happens to old membrane components in neurons?

<p>They are digested in lysosomes. (D)</p> Signup and view all the answers

How do electrical signals in neurons propagate after being initiated?

<p>Unidirectionally to the presynaptic terminal (D)</p> Signup and view all the answers

Which statement is true regarding the cytoplasmic continuity of neurons?

<p>Each neuron is an isolated unit with no cytoplasmic continuity. (C)</p> Signup and view all the answers

What characterizes the function of axons in neurons?

<p>They are specialized to carry electrical signals unidirectionally. (B)</p> Signup and view all the answers

What is the primary purpose of the Na+-K+ ATPase in a neuron?

<p>To create ionic concentration gradients (B)</p> Signup and view all the answers

What occurs during synaptic vesicle recycling?

<p>Vesicles are reused and refilled with neurotransmitters. (C)</p> Signup and view all the answers

Which statement best describes the resting membrane potential in a typical neuron?

<p>It results from the unequal distribution of ions across the membrane (B)</p> Signup and view all the answers

What is the role of K+ leak channels in maintaining the resting membrane potential?

<p>They enable K+ to flow out of the cell, contributing to a negative potential (D)</p> Signup and view all the answers

What triggers the migration of the varicella zoster virus from the neuron to the skin?

<p>Anterograde fast axonal transport (C)</p> Signup and view all the answers

What effect does the permeability of the membrane to ions have on resting membrane potential?

<p>Higher permeability to K+ leads to a more negative resting potential (C)</p> Signup and view all the answers

The electrical and concentration gradients for K+ ions are maintained by which of the following?

<p>Na+-K+ ATPase and K+ leakage channels (A)</p> Signup and view all the answers

Which ions are mainly found in extracellular fluid?

<p>Na+ and Cl- (B)</p> Signup and view all the answers

How does the selective permeability of the plasma membrane contribute to the resting membrane potential?

<p>It prevents negative ions from entering, trapping them inside (C)</p> Signup and view all the answers

What happens during the equilibrium potential state for K+ ions?

<p>Counteracting forces of concentration and electric gradients are balanced (A)</p> Signup and view all the answers

What type of molecules can freely cross the plasma membrane?

<p>Small uncharged polar molecules (A)</p> Signup and view all the answers

In which fluid are phosphate ions predominantly found?

<p>Intracellular fluid (C)</p> Signup and view all the answers

The condition where the extracellular fluid is set to 0 potential is referred to as what?

<p>Relative charge scale (A)</p> Signup and view all the answers

Which electrolyte is primarily responsible for generating the negative resting membrane potential?

<p>K+ (A)</p> Signup and view all the answers

When the membrane is described as a capacitor, what is primarily being referred to?

<p>Its capacity to store ionic charges across the membrane (D)</p> Signup and view all the answers

Which of the following ions is more concentrated inside a typical neuron?

<p>K+ (C)</p> Signup and view all the answers

What primarily prevents the free movement of charged molecules across the plasma membrane?

<p>The presence of phospholipids in the membrane (B)</p> Signup and view all the answers

Flashcards

Dynamic Steady State

A state where a cell maintains a stable internal environment despite external changes, with unequal concentrations of ions across its membrane.

Membrane Potential (Vm)

The difference in electrical potential between the inside and outside of a cell membrane. It is usually negative at rest.

Depolarization

A change in membrane potential making it less negative than the resting potential.

Repolarization

A change in membrane potential returning it back to the resting potential.

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Hyperpolarization

A change in membrane potential making it more negative than the resting potential.

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Nernst Equation

An equation that calculates the equilibrium potential for a specific ion across a membrane based on its concentration gradient.

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Goldman-Hodgkin-Katz (GHK) Equation

An equation that calculates the membrane potential of a cell based on the permeability and concentrations of multiple ions.

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Neuron

The main functional unit of the nervous system, responsible for transmitting information within the body.

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Cell Body (Soma)

The central part of a neuron containing the nucleus and other organelles. It is responsible for maintaining the cell's life.

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Axon

A long, slender projection from the cell body that transmits signals to other neurons or target cells.

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Cytoskeleton (Microtubules)

A network of protein filaments, including microtubules, that provides structural support and helps transport materials within a neuron.

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Axon Hillock

The specialized region at the beginning of the axon where signals are generated and transmitted.

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Dendrites

Thin, branching extensions of a neuron that receive incoming signals from other neurons.

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Synapse

The site where a neuron communicates with another neuron or cell, transmitting signals across a tiny gap.

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Cell membrane

A phospholipid bilayer that encloses the cell. It controls what enters and exits the cell.

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Resting membrane potential

The difference in electrical charge between the inside and outside of a cell. It is negative at rest.

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Membrane permeability

The ability of the membrane to allow certain substances to pass through while blocking others.

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Electrolytes

Charged particles dissolved in fluids, such as Na+, K+, Cl-, and Ca++. They play a key role in generating membrane potential.

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Interstitial fluid

The space between cells, containing fluids and electrolytes.

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Intercellular fluid

The fluid inside a cell, containing electrolytes and other molecules.

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Na+-K+ ATPase

A mechanism that actively pumps sodium ions out of the cell and potassium ions into the cell. Requires ATP.

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Concentration gradient

The difference in the concentration of a substance between two regions. It drives the movement of substances across membranes.

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Electrical gradient

The difference in electrical potential between two points. It influences the movement of charged particles.

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K+ leak channels

Channels in the membrane that allow potassium ions to pass through freely. Contribute to membrane potential.

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Equilibrium potential

The electrical potential at which the movement of a specific ion across the membrane reaches equilibrium. It is determined by the concentration gradient and the electrical gradient of that ion.

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Electrochemical disequilibrium

An electric field created by a change in concentration of ions across a membrane. It is a key element in the generation of membrane potential.

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Channels

Special proteins in the cell membrane that allow certain molecules to pass through.

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Capacitance

The ability of a membrane to hold a charge. It is important for generating and maintaining membrane potential.

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Sensory Neuron

A type of neuron that relays information from sensory receptors to the central nervous system (CNS).

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Motor Neuron

A type of neuron that carries signals from the CNS to muscles or glands, causing a response.

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Dendritic Spines

Tiny projections on dendrites that increase the surface area for receiving signals.

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Presynaptic Axon Terminal

The swellings at the end of an axon that release neurotransmitters.

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Axonal Transport

The process of moving vesicles and mitochondria along the axon.

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Neurotransmitters

The chemical messengers released by neurons that transmit signals across synapses.

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Neuromodulator

A type of chemical messenger that can modify the effects of neurotransmitters.

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Neurohormone

A type of chemical messenger that travels through the bloodstream to reach target cells.

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Microtubule-associated motor proteins

Motor proteins that bind to microtubules and move vesicles along the cytoskeleton. They have two heads, a neck, and a tail that binds to organelles.

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Anterograde axonal transport

The movement of materials from the cell body (soma) towards the axon terminal.

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Retrograde axonal transport

The movement of materials from the axon terminal back towards the cell body.

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Shingles

A painful skin rash caused by the varicella zoster virus migrating from the nerve cell body (soma) to the skin.

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Fast axonal transport

A type of transport that moves vesicles quickly along microtubules, powered by ATP.

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Slow axonal transport

A type of transport that moves vesicles more slowly along microtubules.

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Axonal branching

A region of the neuron where its axon branches or splits.

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Synaptic vesicles

Tiny vesicles that hold neurotransmitters and release their contents into the synaptic cleft.

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Study Notes

Nervous System - Resting Membrane Potential and Neuron

  • Objectives:
    • Understand the basic principles of resting membrane potential generation.
    • Describe the anatomy of a typical neuron and its physiological functions.

Membrane Permeability

  • Phospholipid bilayers of cell membranes are impermeable to charged molecules (e.g., Na+, K+, Cl−, Ca²⁺).
  • These molecules are also insoluble in the hydrophobic membrane core.
  • Large water-soluble molecules (e.g., proteins, nucleic acids, sugars) also require channels to cross the cell membrane.
  • Small, uncharged, polar molecules (e.g., CO₂, O₂, NH₃, water) can freely cross the membrane, often with aquaporins.

Electrolyte Distribution

  • Interstitial fluid: Major electrolytes are Na+, Cl−, and HCO₃⁻.
  • Intracellular fluid: Major electrolytes are K+, HPO₄²⁻ (phosphate ion), and negatively charged proteins.

Dominant Ions

  • Extracellular fluid: Dominant cation is Na⁺, and anion is Cl⁻.
  • Intracellular fluid: Dominant cation is K⁺, and anions include phosphate ions and negatively charged proteins.

Electrical Properties

  • Plasma membranes are ionic conductors, allowing ion currents.
  • The concentration gradient dictates the direction of ion flow.
  • The membrane's capacity to hold charges generates the transmembrane potential (electrical voltage difference).

Generation of Membrane Potential

  • At equilibrium, the cell and solution are electrically and chemically balanced.
  • The cell membrane acts as an insulator, preventing free ion movement between compartments.
  • The Na+-K+ ATPase creates ionic concentration gradients (3 Na+ out, 2 K+ in).
  • This creates a negative intracellular potential.
  • K+ leak channels also contribute to the resting membrane potential.

K+ Leak Channels

  • The plasma membrane has more K+ leak channels than Na+ leak channels.
  • K+ leaks out due to the concentration gradient, with other ions following.
  • The impermeability of the membrane to negatively charged ions creates a negative intracellular environment.

Equilibrium Potential

  • Equilibrium potential (Eion) occurs when opposing forces (concentration and electrical gradients) balance the net ion movement.

Resting Membrane Potential

  • All living cells have a resting membrane potential.
  • Chemical and electrical disequilibrium exist at rest.
  • The resting membrane potential is the measurement of electric charge inside versus outside the cell.
  • A negative resting membrane potential is typical.

Neuron Anatomy & Functions

  • Neurons are the functional units of the nervous system, responsible for transmitting and integrating information.
  • Sensory neurons receive stimuli and carry signals to the central nervous system.
  • Interneurons integrate information within the central nervous system.
  • Motor neurons send signals from the central nervous system to muscles or glands.
  • Neurons are excitable cells whose membrane potential can change.

Neuron Structure

  • Cell body (soma): Contains the nucleus and organelles.
  • Dendrites: Receive incoming signals.
  • Axon: Transmits signals away from the cell body. -Axon hillock: Special region of the soma. -Presynaptic axon terminal: Swelling at axon's end with mitochondria and neurotransmitter.

Synapse

  • Synapse: The region where an axon terminal communicates with its postsynaptic target cell.
  • Neurotransmitters are released into the synaptic cleft, entering neighboring neurons.

Dendritic Spines

  • Dendritic spines are specialized protrusions that increase contact points.
  • Protein synthesis occurs in spines and can be transferred.

Signal Transmission and Axonal Transport

  • Information is transmitted electrically (graded potentials) to axon hillock to action potentials.
  • Signals are mostly unidirectional in the axon but bi-directional in the chemical synapses.
  • Axonal transport involves movement of vesicles along microtubules with motor proteins.

Important Concepts

  • Electrical signals are initiated and propagated unidirectionally along the axon.
  • There is no cytoplasmic continuity between neurons.

Additional Notes

  • The Goldman-Hodgkin-Katz (GHK) equation is used to calculate membrane potential, considering multiple ions' permeability.
  • The resting membrane potential of a mammalian neuron is −70 mV.

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