C21- Neuroendocrine system, Hypothalmaus

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Questions and Answers

The prefrontal cortex is the primary origin of networks that facilitate higher cognitive functions and appropriate social behavior.

True (A)

The amygdala is directly involved in the regulation of the circadian rhythm.

False (B)

The solitary tract is primarily related to emotional drive.

False (B)

The suprachiasmatic nucleus solely influences the sleep-wake cycles, and does not connect to the periventricular zone.

<p>False (B)</p> Signup and view all the answers

The hypothalamus solely receives integrated information from second-order neurons of the solitary tract nucleus.

<p>False (B)</p> Signup and view all the answers

The behavior neural column has anterior sections involved in death stimulation, and posterior sections in signaling reproduction time.

<p>False (B)</p> Signup and view all the answers

The parabrachial nucleus is a component of the thalamus.

<p>False (B)</p> Signup and view all the answers

The hypothalamus acts to maintain a constant set point for body temperature throughout the day.

<p>False (B)</p> Signup and view all the answers

Vasoconstriction in response to cold is a conscious, behavioral response driven by the hypothalamus.

<p>False (B)</p> Signup and view all the answers

The limbic lobe, which includes the insula and cingulate gyrus, receives direct input from the pons.

<p>False (B)</p> Signup and view all the answers

The suprachiasmatic nucleus of the hypothalamus acts as an internal clock, setting the body's circadian rhythms, including temperature variations.

<p>True (A)</p> Signup and view all the answers

The vegetative system consists purely of preganglionic and postganglionic neurons in the periphery, with no CNS involvement.

<p>False (B)</p> Signup and view all the answers

Shivering, as a response to cold, is an example of a cognitive reaction controlled by the hypothalamus.

<p>False (B)</p> Signup and view all the answers

The hypothalamic-hypophyseal axis involves neurotransmitters mixing with the systemic blood before reaching the anterior hypophysis.

<p>False (B)</p> Signup and view all the answers

Parvocellular neurons, located solely in the arcuate nucleus, give rise to fibers that form the tuberohypophyseal tract.

<p>False (B)</p> Signup and view all the answers

The hypophysis decides when to release its hormones, acting independently of the hypothalamus.

<p>False (B)</p> Signup and view all the answers

The releasing hormone from the hypothalamus directly acts on the target organ, bypassing the anterior hypophysis.

<p>False (B)</p> Signup and view all the answers

In the endocrine system, the hypophysis is the primary conductor, dictating hormonal release.

<p>False (B)</p> Signup and view all the answers

Hormones are released only when there is an environmental need, not constantly or tonically.

<p>False (B)</p> Signup and view all the answers

The sensory domain of the vegetative system receives input from interoceptors, with afferents entering via posterior roots into the spinal cord.

<p>True (A)</p> Signup and view all the answers

Hormones primarily target one specific organ to ensure maximum effect.

<p>False (B)</p> Signup and view all the answers

The motor domain of the vegetative system controls skeletal muscle, cardiac muscle, glands, and adipose tissue.

<p>False (B)</p> Signup and view all the answers

The hypothalamic-hypophyseal axis is only active during times of physiological stress, not constantly.

<p>False (B)</p> Signup and view all the answers

A single, easily measurable parameter is always available to check the effectiveness of hormone action.

<p>False (B)</p> Signup and view all the answers

Visceral reflexes operate solely on a simple input-sensory-efferent-output model without any influence from supraspinal organs.

<p>False (B)</p> Signup and view all the answers

The blood from the first capillary bed directly enters systemic circulation without intermediary steps.

<p>False (B)</p> Signup and view all the answers

During intense physical exercise, the increase in heart rate and blood flow to muscles is solely due to the decreased levels of CO2 in the blood resulting from inadequate ventilation.

<p>False (B)</p> Signup and view all the answers

In stressed conditions, the vegetative system shifts its balance significantly towards the parasympathetic nervous system.

<p>False (B)</p> Signup and view all the answers

The hypothalamic region is primarily responsible for the coordination of activity between the vegetative system and the endocrine system.

<p>True (A)</p> Signup and view all the answers

Neuroendocrine reflexes are a type of visceral reflex which inhibits hormone release in response to a specific stimulus.

<p>False (B)</p> Signup and view all the answers

Preganglionic neurons, acting as the lower motoneurons of the vegetative system, receive inputs exclusively from interoceptors.

<p>False (B)</p> Signup and view all the answers

Central autonomic regulatory systems only impact visceral functions, and they do not affect neuroendocrine outflow.

<p>False (B)</p> Signup and view all the answers

The coordination of appropriate autonomic responses is facilitated solely by sensory information without any adjustments based on ongoing needs.

<p>False (B)</p> Signup and view all the answers

The forebrain is comprised of the amygdala, limbic cortex, and cerebellum.

<p>False (B)</p> Signup and view all the answers

The spinal cord's autonomic reflexes are triggered only by external stimuli.

<p>False (B)</p> Signup and view all the answers

The limbic system of the cortex can only act on the brainstem and hypothalamus and cannot generate behavioral responses.

<p>False (B)</p> Signup and view all the answers

The descending system from the hypothalamus involves hypothalamic-spinal and corticospinal pathways.

<p>False (B)</p> Signup and view all the answers

The primary role of the hypothalamus is to control cognitive behaviors.

<p>False (B)</p> Signup and view all the answers

Sensory information from the heart, lungs, and GU tract is sent directly to the spinal cord.

<p>False (B)</p> Signup and view all the answers

The telencephalon sends information to the lower brain stem to regulate the CV, respiratory, and GU systems.

<p>True (A)</p> Signup and view all the answers

Homeostatic regulation of respiration is primarily controlled by the upper brainstem.

<p>False (B)</p> Signup and view all the answers

The cardiovascular network sends signals only to sympathetic premotor or preganglionic neurons.

<p>False (B)</p> Signup and view all the answers

The two respiratory networks signal only the respiratory premotor neurons.

<p>True (A)</p> Signup and view all the answers

Flashcards

Pons functions

Contains nuclei like parabrachial, raphe, reticular, and periaqueductal gray, involved in various functions.

Hypothalamus input sources

Receives information from the solitary tract nucleus, third-order neurons, and raw data from the spinal cord.

Set point concept

Hypothalamus compares desired vs. actual values for physiological parameters and modulates hormone release.

Hypothalamus responses to cold

Induces behavioral (putting on clothes) and autonomic responses (shivering, vasoconstriction) to maintain temperature.

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Suprachiasmatic nucleus role

Acts as an internal clock, regulating time-dependent set points in the hypothalamus throughout the day.

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CNS and vegetative system

The central nervous system's vegetative system includes brain parts that connect with emotional drives and autonomic responses.

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Thalamus pathways

Processes sensory data and relays it to the limbic lobe and hypothalamus via third-order neurons.

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Hypothalamus functionality

Integrates processed data from hindbrain with raw data for comprehensive physiological regulation.

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Hypothalamic-Hypophyseal Axis

The connection between the hypothalamus and the anterior pituitary that regulates hormone release.

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Parvocellular Neurons

Small cells in the hypothalamus that produce releasing and inhibiting hormones.

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Tuberohypophyseal Tract

The pathway along which releasing hormones travel from the hypothalamus to the pituitary gland.

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Anterior Hypophysis

The front part of the pituitary gland that releases hormones in response to hypothalamic signals.

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Endocrine Glands

Glands that release hormones into the bloodstream, regulated by the pituitary.

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Hormonal Feedback

The process by which hormones communicate with target tissues to maintain balance.

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Releasing Hormones

Hormones produced by the hypothalamus that stimulate the release of pituitary hormones.

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Endocrine System Control

The hypothalamus controls the endocrine system through hormone release.

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Constant Hormone Release

Hormones are released continuously to maintain various body functions.

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Tissue Trophism

The maintenance of tissue health and renewal through hormonal action.

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Prefrontal Cortex

The brain region responsible for higher cognitive functions and appropriate behavior.

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Amygdala

A part of the limbic system associated with emotional drives.

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Suprachiasmatic Nucleus

The biological clock regulating circadian rhythms in the body.

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Autonomic System Output

Nuclei that balance parasympathetic and sympathetic activities based on context.

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Behavioral Column

Structure containing nuclei involved in survival behaviors like escape and reproduction.

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Autonomic Nervous System (ANS)

A self-regulating nervous system controlling involuntary actions.

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Visceral Reflexes

Involuntary responses to stimuli from internal organs.

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Supraspinal Structures

Brain regions that regulate autonomic functions.

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Preganglionic Neurons

Neurons transmitting signals from the CNS in autonomic pathways.

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Interceptors

Sensors that provide information about the internal state of the body.

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Sympathetic System

Part of the ANS that prepares the body for stress or emergencies.

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Parasympathetic System

Part of the ANS that conserves energy and promotes 'rest and digest'.

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Neuroendocrine Reflexes

Reflexes that trigger hormone release in response to stimuli.

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Central Autonomic Regulatory Systems

Systems in the brain that coordinate autonomic responses.

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Coherence of Systems

The synchronization between the vegetative and endocrine systems.

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Forebrain

The part of the brain that includes the amygdala, limbic cortex, and hypothalamus, involved in cognitive behaviors and emotional responses.

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Hypothalamus

A brain region that regulates motivational drives and homeostasis, influencing functions like hunger and temperature.

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Brainstem

The part of the brain that controls vital functions such as cardiac, respiratory, and gastrointestinal activity.

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Spinal Cord

The central neural pathway for reflex actions, connecting the brain to the rest of the body.

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Autonomic reflexes

Involuntary responses triggered by sensory stimuli, processed by the spinal cord.

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Limbic System

A complex set of structures in the brain that supports emotional processing and memory.

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Interneurons

Neurons that connect sensory and motor pathways within the spinal cord, facilitating reflexes.

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Ponto-medullary networks

Networks in the lower brain stem responsible for managing respiration and cardiovascular functions.

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Homeostatic regulation

The process by which the body maintains a stable internal environment, regulating functions like blood pressure and breathing.

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Study Notes

Autonomic Actions and Motivational States

  • The vegetative system, parallel to the somatic system, has sensory and motor domains.
  • Sensory input comes from interoceptors. Afferents enter the spinal cord via posterior roots.
  • Motor output involves sympathetic and parasympathetic systems acting on smooth muscle, cardiac muscle, and glands.
  • Visceral reflexes are complex, controlled by supraspinous organs (like the hypothalamus).
  • A coherence exists between vegetative and endocrine activity, often through the hypothalamus.
  • Visceral reflexes have slow and rapid responses to stimuli from interoceptors.
  • Preganglionic neurons are the lower motor neurons of the autonomic nervous system.
  • Supraspinous structures coordinate autonomic responses by transmitting sensory information through central autonomic regulatory systems.
  • These systems coordinate actions affecting visceral functions and neuroendocrine outflow.

Hypothalamic Hierarchy

  • The forebrain, composed of the amygdala and limbic cortex, and the hypothalamus form a hierarchy.
    • Amygdala and limbic cortex: drive cognitive and emotional behavior.
    • Hypothalamus: central for drive states (motivational) and homeostasis.
  • Brainstem centers control cardiac, respiratory, and gastrointestinal functions.
  • Spinal cord mediates autonomic reflexes initiated by sensory inputs.
  • Two pathways relate to sensory stimulus and autonomic response:
    • Pathway 1: spinal interneurons in the lateral horn (lamina VII)
    • Pathway 2: hypothalamus, influencing brainstem with descending (hypothalamic-spinal and reticulospinal) systems that act on preganglionic neurons
  • Pathway 3: activating the brainstem and hypothalamus while also activating the limbic system of the cortex. The cortex can either act on the brainstem/hypothalamus or directly generate behavioral responses.

Hypothalamic Nuclei and Structures

  • The hypothalamus is divided into anterior, middle, and posterior regions; each with specific nuclei.
    • Anterior region: preoptic nucleus, supraoptic nucleus, paraventricular nucleus, and anterior nuclei; suprachiasmatic nucleus.
  • Middle region: dorsomedial nucleus, ventromedial nucleus.
  • Posterior region: mamillary nucleus.
  • Hypothalamus is also divided into three mediolaterally distributed zones: periventricular zone, medial zone, and lateral zone.
  • The periventricular zone contains important autonomic and endocrine nuclei.
  • The medial zone contains the suprachiasmatic nucleus (SCN), the biological clock.
  • The lateral zone includes hypocretin/orexin producing nuclei, important for hunger and cardiovascular control.

Hypothalamic Functions and Regulation

  • The hypothalamus regulates homeostasis (internal balance) via coordinated actions on endocrine and autonomic systems.
  • Homeostatic regulation is reflected in the lower brain stem anatomy and physiology.
  • The hypothalamus connects with other brain regions concerning emotional experience, motivation, sleep/wake cycles, and food intake.
  • The hypothalamus receives sensory information by several pathways. These include direct and indirect inputs, as well as hormonal signals from organs.

Hormone Release and Hypophysis

  • Endocrine portions of the hypothalamus communicate mainly with the pituitary gland.
  • The neurohypophysis originates from supraoptic and magnocellular nuclei. It is not composed of epithelial tissue, but from axons of neurons.
  • Neurosecretory cells synthesize and release hormones like vasopressin and oxytocin.
  • The hormones are released into extracellular space of median eminence, infundibular stalk, and posterior pituitary, then passing into general circulation.
  • Oxytocin has target cells in uterus and mammary glands, stimulating contractions and milk ejection.
  • Antidiuretic hormone (ADH) regulates blood osmolarity via kidney function and blood vessel constriction.
  • Hypothalamic nuclei (arcuate, paraventricular) release various releasing/inhibiting hormones that control hormone release from the anterior pituitary (adenohypophysis).

Hypothalamic-Hypophyseal Axis

  • Unlike posterior pituitary, the anterior pituitary does not receive direct hypothalamic axonal projections.
  • The hypothalamus communicates with the anterior pituitary via specialized portal vessels forming the hypothalamic-hypophyseal portal system
  • Releasing/inhibiting hormones are transported to the anterior pituitary without dilution, regulating glandular hormone release.

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