Podcast
Questions and Answers
What is the function of Tetrodotoxin (TTX) in relation to Na+ channels?
What is the function of Tetrodotoxin (TTX) in relation to Na+ channels?
- It blocks the pore of the Na+ channels (correct)
- It prevents the inactivation of Na+ channels
- It causes a conformational change to open the Na+ channels
- It lowers the activation threshold of Na+ channels
How does the structure of K+ channels differ from that of Na+ channels?
How does the structure of K+ channels differ from that of Na+ channels?
- K+ channels have a higher unitary conductance than Na+ channels
- K+ channels have S4 segments that are sensitive to membrane potential, unlike Na+ channels
- K+ channels have 4 subunits, while Na+ channels have 4 domains (correct)
- K+ channels open more rapidly than Na+ channels
What is the purpose of myelin in influencing conduction velocity?
What is the purpose of myelin in influencing conduction velocity?
- To prevent passive diffusion of Na+ ions in the longitudinal axis of the axon
- To enhance electrotonic conduction underneath myelin
- To provide insulation and prevent the leakage of ions out of the axon (correct)
- To increase the leakage of ions out of the axon
What happens during the refractory period of an action potential?
What happens during the refractory period of an action potential?
What is the role of Saxitoxin in relation to Na+ channels?
What is the role of Saxitoxin in relation to Na+ channels?
What is the neural code for transferring information over long distances?
What is the neural code for transferring information over long distances?
What is the term for the period during which a neuron cannot fire another action potential, no matter how strong the stimulus?
What is the term for the period during which a neuron cannot fire another action potential, no matter how strong the stimulus?
What causes the generation of an action potential?
What causes the generation of an action potential?
How can the frequency of discharge in the generation of action potential be influenced?
How can the frequency of discharge in the generation of action potential be influenced?
What is the purpose of patch-clamping in electrophysiology?
What is the purpose of patch-clamping in electrophysiology?
When does the K+ current enter during the action potential?
When does the K+ current enter during the action potential?
What is the mechanism of inactivation for Na+ channels?
What is the mechanism of inactivation for Na+ channels?
How does Tetrodotoxin (TTX) affect Na+ channels?
How does Tetrodotoxin (TTX) affect Na+ channels?
What is the role of Batrachotoxin in relation to Na+ channels?
What is the role of Batrachotoxin in relation to Na+ channels?
What is the function of Veratridine in relation to Na+ channels?
What is the function of Veratridine in relation to Na+ channels?
How do K+ channels differ from Na+ channels in terms of inactivation?
How do K+ channels differ from Na+ channels in terms of inactivation?
What is the typical conduction velocity of an action potential?
What is the typical conduction velocity of an action potential?
Where does the orthodromic propagation of action potentials occur?
Where does the orthodromic propagation of action potentials occur?
What is the role of myelin in influencing conduction velocity?
What is the role of myelin in influencing conduction velocity?
What are the factors that contribute to electrotonic conduction underneath myelin?
What are the factors that contribute to electrotonic conduction underneath myelin?
Where is the initiation zone of action potentials in sensory neurons?
Where is the initiation zone of action potentials in sensory neurons?
What is the importance of the permeabilities of Na+ and K+ in the model of an action potential?
What is the importance of the permeabilities of Na+ and K+ in the model of an action potential?
How did Hodgkin and Huxley study the generation of action potentials?
How did Hodgkin and Huxley study the generation of action potentials?
What is the significance of the inactivation of Na+ channels in the reality of action potentials?
What is the significance of the inactivation of Na+ channels in the reality of action potentials?
What are the techniques used to observe the electrical activity of a neuron?
What are the techniques used to observe the electrical activity of a neuron?
How does the voltage-clamp circuit operate?
How does the voltage-clamp circuit operate?
What is the purpose of using a voltage-clamp?
What is the purpose of using a voltage-clamp?
Why does the Na+ current seem to inactivate after depolarization?
Why does the Na+ current seem to inactivate after depolarization?
What is the main difference between current-clamp and voltage-clamp techniques?
What is the main difference between current-clamp and voltage-clamp techniques?
Why is it important to use a voltage-clamp circuit in electrophysiology experiments?
Why is it important to use a voltage-clamp circuit in electrophysiology experiments?
What is the role of the K+ current (IK) during an action potential?
What is the role of the K+ current (IK) during an action potential?
What is the significance of the experiments of Hodgkin and Huxley in understanding action potentials?
What is the significance of the experiments of Hodgkin and Huxley in understanding action potentials?
What is the challenge with determining the membrane current (Im) at a specific membrane potential (Vm) without a voltage-clamp circuit?
What is the challenge with determining the membrane current (Im) at a specific membrane potential (Vm) without a voltage-clamp circuit?
