Neuroscience and Hormones Study Guide
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Questions and Answers

What develops when a zygote splits or two zygotes implant simultaneously?

  • Twins will develop (correct)
  • The pregnancy will become ectopic
  • The zygote will become aneuploidy
  • Miscarriage will occur
  • Which term describes the mass of circulating nuclei that move into the uterine lining, allowing the developing embryo to follow?

  • Hypoblast
  • Cytotrophoblast
  • Syncytiotrophoblast (correct)
  • Hypoblastocyst
  • What two structures are formed when the embryoblast splits during the bilaminar embryonic phase?

  • Hypoblast and syncytiotrophoblast
  • Epiblast and embryoblast
  • Hypoblast and epiblast (correct)
  • Cytotrophoblast and syncytiotrophoblast
  • What is contained within the trophoblastic lacunae?

    <p>Maternal blood (B)</p> Signup and view all the answers

    Which group of specialized cells migrates through the primitive node towards the prechordal plate?

    <p>Notochordal process (B)</p> Signup and view all the answers

    What does the mesoderm migrate to become as it moves cranially and laterally to the prechordal plate?

    <p>Lateral plate mesoderm (B)</p> Signup and view all the answers

    What is the most common neonatal tumor that arises from the primitive streak?

    <p>Teratoma (B)</p> Signup and view all the answers

    What signaling molecule influences the right-left body patterning?

    <p>Nodal (A)</p> Signup and view all the answers

    What is the primary function of acetylcholinesterase (AChE) in synaptic transmission?

    <p>AChE breaks down acetylcholine into acetate and choline, terminating the signal transmission. (C)</p> Signup and view all the answers

    Which type of receptor does adrenocorticotropic hormone (ACTH) bind to stimulate cortisol release?

    <p>G-protein coupled receptor (C)</p> Signup and view all the answers

    What physiological changes are typically observed during non-REM sleep in healthy adults?

    <p>Decreased body temperature and muscle tone. (B)</p> Signup and view all the answers

    What physiological changes are associated with the onset of non-rapid eye movement (NREM) sleep?

    <p>Decreased core body temperature and reduced metabolic rate. (C)</p> Signup and view all the answers

    How does the anterior pituitary gland regulate physiological processes?

    <p>Through release of hormones like ACTH, part of a feedback loop with cortisol. (B)</p> Signup and view all the answers

    What role does the suprachiasmatic nucleus (SCN) play in the hypothalamic-pituitary-adrenal (HPA) axis?

    <p>It indirectly influences the HPA axis through neural pathways regulating circadian rhythms. (B)</p> Signup and view all the answers

    What is the primary difference between rods and cones in the human visual system?

    <p>Rods are highly sensitive to low light and do not differentiate colors, while cones provide color vision. (A)</p> Signup and view all the answers

    Which part of the brain is primarily responsible for integrating olfactory information with memory formation?

    <p>Hippocampus (C)</p> Signup and view all the answers

    Which of the following statements is false regarding anal development and the pectinate line?

    <p>The pectinate line is formed by an outpouching of the rectal pit. (C)</p> Signup and view all the answers

    Which of the following is the last unpaired arterial branch to come off of the abdominal aorta?

    <p>Inferior mesenteric (B)</p> Signup and view all the answers

    Which structure divides the anterior and posterior chambers of the cloaca?

    <p>The urorectal septum, formed by ectoderm (A)</p> Signup and view all the answers

    Which of the following best describes imperforate anus?

    <p>When the anal membrane remains intact (B)</p> Signup and view all the answers

    What is the primary physiological action of vasopressin in the human body?

    <p>Increase in water reabsorption in the kidneys to concentrate urine (C)</p> Signup and view all the answers

    Which of the following statements is false regarding congenital megacolon?

    <p>It is always permanent without treatment. (A)</p> Signup and view all the answers

    How do mutations in the RAS gene contribute to cancer development?

    <p>By resulting in the constant activation of RAS protein, leading to unchecked cell division (C)</p> Signup and view all the answers

    Which of the following is false regarding renal and reproductive development?

    <p>The urogenital ridges serve as primordia for kidneys, not gonads. (D)</p> Signup and view all the answers

    Which of the following statements is false regarding the nephrogenic cords?

    <p>They are primordia of the gonads. (B)</p> Signup and view all the answers

    Which organ is primarily responsible for converting vitamin D3 into its active form?

    <p>Kidneys (A)</p> Signup and view all the answers

    What type of cell junction allows ions and small molecules to pass directly between cells?

    <p>Gap junctions (A)</p> Signup and view all the answers

    Which receptor does luteinizing hormone (LH) bind to in the ovaries and testes?

    <p>LH receptor (B)</p> Signup and view all the answers

    What does the Purkinje effect refer to in visual perception?

    <p>The shift in peak sensitivity of rod cells from green to blue wavelengths under low-light conditions (D)</p> Signup and view all the answers

    What distinguishes cones in the fovea from rods in the retina?

    <p>Cones facilitate color vision and high acuity, while rods are more sensitive to low light (D)</p> Signup and view all the answers

    Which function do opsins serve in photoreceptor cells?

    <p>Undergo a conformational change upon absorbing light, activating a G-protein signaling cascade (B)</p> Signup and view all the answers

    What is the role of neural crest cells during the formation of the suprarenal gland?

    <p>To become the medulla and surround cortical cells (B)</p> Signup and view all the answers

    Which condition is associated with Potter sequence?

    <p>Lung underdevelopment (D)</p> Signup and view all the answers

    What best describes the allantois in embryonic development?

    <p>It develops into a thin layer associated with the urogenital sinus (A)</p> Signup and view all the answers

    Which cell type gives rise to glands associated with the bladder or urethra?

    <p>Endodermal cells from the urogenital sinus (D)</p> Signup and view all the answers

    What is the fate of the mesonephric ducts in males during development?

    <p>They transform into the vas deferens (C)</p> Signup and view all the answers

    Which statement accurately describes a consequence of the allantois not disappearing properly during development?

    <p>It can lead to anomalies related to the umbilical cord (A)</p> Signup and view all the answers

    Which of the following is not typically a result of oligohydramnios in prenatal development?

    <p>Excessive amniotic fluid accumulation (A)</p> Signup and view all the answers

    What is the result of three waves of cell migration from the urogenital ridge?

    <p>Development of a trilaminar suprarenal gland (D)</p> Signup and view all the answers

    Which phase in the metabolic response to trauma is characterized by a hypermetabolic state?

    <p>Flow phase (A)</p> Signup and view all the answers

    What primarily describes juxtacrine signaling in cellular physiology?

    <p>Direct contact through membrane-bound molecules (A)</p> Signup and view all the answers

    What is the primary function of cytokines in cell physiology?

    <p>Mediating communication between cells (A)</p> Signup and view all the answers

    Which process involves the movement of molecules across a permeable membrane without cellular energy?

    <p>Simple diffusion (D)</p> Signup and view all the answers

    What role do peripheral integral proteins play in cell membranes?

    <p>Cell signaling and maintaining shape (D)</p> Signup and view all the answers

    What distinguishes endocrine signaling from paracrine and autocrine mechanisms?

    <p>Hormones acting on distant target cells (D)</p> Signup and view all the answers

    What is the function of cAMP in the signal transduction pathway initiated by GPCRs?

    <p>Acting as a second messenger activating protein kinase A (A)</p> Signup and view all the answers

    Which hormone is primarily released by the posterior pituitary gland?

    <p>Antidiuretic hormone (ADH) (A)</p> Signup and view all the answers

    Flashcards

    Acetylcholinesterase (AChE) function

    Breaks down acetylcholine, ending signal transmission.

    ACTH receptor type

    G-protein coupled receptor on adrenal gland cells.

    Sleep Physiological Change

    Decreased body temperature & muscle tone during NREM.

    NREM sleep onset change

    Decreased core temperature, reduced metabolic rate.

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    Anterior Pituitary Hormone Regulation

    ACTH release, part of a feedback loop with cortisol.

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    SCN influence on HPA axis

    Indirect influence via neural pathways, regulating circadian rhythms.

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    Rods vs. Cones (Light)

    Rods: sensitive to low light, no color vision; Cones: color vision, bright light.

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    Internal body clock control

    Hypothalamus, specifically the Suprachiasmatic Nucleus (SCN).

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    Metabolic Response to Trauma: Flow Phase

    Characterized by a heightened metabolic state with increased energy expenditure and enhanced protein breakdown.

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    Juxtacrine Signaling

    Requires direct contact between signaling and target cells via membrane-bound molecules.

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    Cytokine Function

    Cytokines primarily serve as signaling molecules to communicate between cells.

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    Simple Diffusion

    Movement of molecules across a permeable membrane without the need for cellular energy.

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    Peripheral Integral Protein Role

    Peripheral integral proteins contribute to cell signaling and maintain cell shape.

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    Endocrine, Paracrine, and Autocrine Signaling

    Endocrine signaling involves hormones acting on distant target cells, paracrine signaling involves localized action on nearby cells, and autocrine signaling involves responding to its own signal.

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    cAMP Role in GPCR Signaling

    cAMP acts as a second messenger, activating protein kinase A (PKA) to phosphorylate target proteins.

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    Interleukin-1 (IL-1)

    Primarily involved in the inflammatory response following trauma.

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    Vasopressin's Main Action

    Vasopressin primarily increases water reabsorption in the kidneys, leading to concentrated urine production.

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    RAS Gene Mutation and Cancer

    Mutations in the RAS gene can cause its protein to become constantly activated, leading to uncontrolled cell division and potentially cancer.

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    Vitamin D3 Activation

    The kidneys are the primary organ responsible for converting inactive vitamin D3 (cholecalciferol) into its active form, calcitriol.

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    LH Receptor Location

    The LH receptor is found on cells in both the ovaries and testes, facilitating the action of luteinizing hormone.

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    Gap Junction Function

    Gap junctions directly connect cells, allowing the passage of ions and small molecules, enabling intercellular communication.

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    Tight Junction Purpose

    Tight junctions act as a barrier, restricting the movement of molecules between adjacent cells, preventing leakage.

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    G-protein Coupled Receptor

    G-protein coupled receptors activate G-proteins when a ligand binds to them, initiating signal transduction pathways.

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    Insulin's Receptor Type

    Insulin uses receptor tyrosine kinases to bind to cells and trigger its signal transduction pathway.

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    Trophoblast function

    The trophoblast is a layer of cells surrounding the blastocyst that helps with implantation, exchanging gases and metabolites with the mother's blood supply.

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    Twin development

    Twins can develop when a single zygote splits into two embryos or when two separate zygotes implant simultaneously.

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    Syncytiotrophoblast function

    The syncytiotrophoblast is a layer of fused trophoblast cells that invades the uterine wall, facilitating the exchange of gases and nutrients with the mother.

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    Bilaminar embryonic phase

    This phase is marked by the embryoblast splitting into two layers: the hypoblast and the epiblast.

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    Trophoblastic lacunae contents

    These spaces within the trophoblast contain maternal blood, providing a vital source of nutrients and oxygen for the developing embryo.

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    Notochordal process

    This is a group of specialized cells that migrate from the primitive node towards the prechordal plate, forming the basis for the vertebral column.

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    Lateral plate mesoderm

    This mesoderm layer forms the body walls, limbs, and circulatory system.

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    Teratoma

    This is a rare tumor that arises from the primitive streak and can contain multiple tissue types.

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    Pectinate Line

    A line in the anal canal that marks the transition from the ectoderm of the anus to the endoderm of the rectum. It is formed by an outpouching of the rectal pit and is important for understanding different blood supplies and potential developmental issues.

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    Inferior Mesenteric Artery

    The last unpaired arterial branch to come off the abdominal aorta. It supplies blood to the descending colon, sigmoid colon, and rectum.

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    Urorectal Septum

    A wall of mesoderm that divides the cloaca into an anterior chamber (urogenital sinus) and a posterior chamber (anal canal). It is essential for proper separation of the urinary and digestive systems.

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    Imperforate Anus

    A birth defect where the anal membrane remains intact, preventing the anus from opening. It is caused by the failure of the anal pit to meet the rectum.

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    Congenital Megacolon (Hirschsprung's Disease)

    A condition caused by the lack of ganglion cells in a segment of the colon, resulting in a failure of the muscle to relax and allow fecal material to pass. It is the most common cause of colon obstruction in newborns.

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    Urogenital Ridge

    The primordia of the gonads and kidneys during development. It is derived from intermediate mesoderm and represents the initial stage of both reproductive and urinary organ development.

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    Nephrogenic Cords

    Structures formed from intermediate mesoderm during development. They are the primordia of the kidneys. They form three sets of kidneys: pronephros, mesonephros and metanephros.

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    False: Nephrogenic Cords form Gonads

    Nephrogenic cords are only involved in kidney development, not the formation of gonads. The gonads develop from a separate part of the urogenital ridge.

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    Suprarenal gland development

    The adrenal gland develops through a series of cell migrations: neural crest cells and cells from the urogenital ridge. Two layers of cortex form around the medulla, which originates from the neural crest.

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    Potter sequence

    A group of abnormalities often associated with oligohydramnios, including lung problems, limb malformations, and facial abnormalities. It can also involve issues with adrenal gland development

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    Allantois role

    The allantois is a temporary structure that forms in the embryo. It connects to the developing bladder and extends into the umbilical cord. It plays a role in waste disposal and blood vessel development.

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    Urogenital sinus origin

    The urogenital sinus is a structure that develops into parts of the bladder, urethra, and reproductive system. It is involved in forming glands associated with these structures.

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    Mesonephric duct fate

    The mesonephric ducts play a crucial role in the development of the male and female reproductive systems. In men, they develop into the vas deferens, while in women, they regress.

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    Allantois persistence

    If the allantois doesn't fully disappear, it can lead to various abnormalities. This can include bladder problems, urachal cysts, and urinary tract malformations.

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    Urogenital sinus gland origin

    Glands associated with the bladder and urethra develop from endodermal cells of the urogenital sinus

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    Oligohydramnios link

    Oligohydramnios, a condition where there is too little amniotic fluid, can lead to various problems including Potter Sequence due to lack of cushioning for the fetus and potential issues with limb development.

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    Study Notes

    Final Study Guide

    • Acetylcholinesterase (AChE) breaks down acetylcholine, terminating signal transmission.
    • Adrenocorticotropic Hormone (ACTH) binds to G-protein coupled receptors on adrenal gland cells to stimulate cortisol release.
    • Healthy adults typically experience decreased body temperature and muscle tone during non-REM sleep.
    • The anterior pituitary gland regulates physiological processes via hormone secretion, including ACTH, which interacts with cortisol via a feedback loop.
    • The suprachiasmatic nucleus (SCN) indirectly influences the hypothalamic-pituitary-adrenal (HPA) axis to regulate circadian rhythms.
    • Rods in the eye are highly sensitive to low light levels and do not differentiate colors, while cones perceive colors in well-lit conditions.
    • The hypothalamus, particularly the suprachiasmatic nucleus (SCN), regulates the body's internal clock.
    • The hippocampus integrates olfactory information with memory formation.
    • Stereocilia in vestibular hair cells transduce mechanical stimuli into electrical signals.
    • Childbirth uterine contractions are primarily stimulated by the hormone oxytocin.

    Additional Information

    • Parathyroid hormone regulates calcium homeostasis.
    • Rhodopsin kinase inactivates activated rhodopsin, ending phototransduction.
    • The utricle and saccule in the vestibular system detect linear acceleration and gravity.
    • Vitamin A is converted to retinal, which combines with opsin to form rhodopsin in the visual system.
    • Melatonin regulates the sleep-wake cycle.
    • REM sleep is characterized by rapid eye movement and vivid dreaming.
    • L-glutamate activates umami taste receptors, relayed to the gustatory cortex via the facial nerve.
    • The hypothalamus regulates the pituitary gland's hormone secretion.
    • Phosphoprotein phosphatases remove phosphate groups from phosphorylated proteins.
    • G-protein coupled receptors (GPCRs) activate protein kinase A (PKA) via cyclic AMP (cAMP) production.
    • Elevated energy expenditure and protein catabolism typically occur in response to trauma during the flow phase.
    • Juxtacrine signaling involves direct contact between cells for communication.
    • Cytokines are signaling molecules mediating cell communication.
    • Simple diffusion occurs across permeable membranes without energy consumption.
    • Peripheral integral proteins are involved in cell signaling and maintaining cell shape.
    • Endocrine signaling uses hormones, paracrine signaling uses local signals, and autocrine signaling uses signals within the same cell.
    • cAMP acts as a secondary messenger, activating protein kinase A (PKA).
    • Interleukin-1 (IL-1) is involved in the inflammatory response.
    • The posterior pituitary releases antidiuretic hormone (ADH).
    • The epithelial cells form protective barriers.
    • Calcitriol increases calcium absorption.
    • RAS mutations lead to constant activation of the protein leading to unchecked cell division.
    • Kidneys transform vitamin D3 into its active form.
    • LH (luteinizing hormone) interacts with receptors in ovaries and testes.
    • Gap junctions allow small molecules to pass directly between cells.
    • Tight junctions form barriers preventing molecule passage.
    • The lymphatic system maintains fluid balance and removes excess interstitial fluid.
    • Hemodynamics is influenced by blood vessel diameter.
    • Inotropic refers to the force of heart muscle contraction.
    • The Frank-Starling mechanism influences the contractile strength of the heart.
    • The sinoatrial (SA) node is the primary pacemaker of the heart.
    • Cardiac circulation supplies oxygenated blood to the heart muscle and removes carbon dioxide.
    • Stroke volume is determined by preload.

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    Final Study Guide PDF

    Description

    Explore the key concepts in neuroscience and hormonal regulation with this study guide. From the role of acetylcholinesterase to the influence of the suprachiasmatic nucleus on circadian rhythms, this guide encompasses essential topics for understanding physiological processes. Perfect for preparing for exams in neuroscience or related fields.

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