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Questions and Answers
Which of the following is NOT a type of mechanoreceptor discussed in the text?
Which of the following is NOT a type of mechanoreceptor discussed in the text?
Which of the following is an example of a mechanoreceptor that is opened by proteins that link to the ion channel?
Which of the following is an example of a mechanoreceptor that is opened by proteins that link to the ion channel?
Which of the following submodalities of somatosensation is not directly related to the sense of one's body in space?
Which of the following submodalities of somatosensation is not directly related to the sense of one's body in space?
Which of the following statements is true about mechanoreceptors?
Which of the following statements is true about mechanoreceptors?
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What is the primary function of mechanoreceptors?
What is the primary function of mechanoreceptors?
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What is the primary function of sensory receptors?
What is the primary function of sensory receptors?
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How are mechanoreceptors different from thermoreceptors and nociceptors?
How are mechanoreceptors different from thermoreceptors and nociceptors?
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Which of the following is not a primary type of sensory receptor?
Which of the following is not a primary type of sensory receptor?
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Which of the following statements accurately describes the relationship between somatosensation and photoreceptors?
Which of the following statements accurately describes the relationship between somatosensation and photoreceptors?
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What is the function of the 'barrel-like structure' in mechanoreceptors?
What is the function of the 'barrel-like structure' in mechanoreceptors?
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What is the role of the 'tethers' in the mechanoreceptor of hair cells in the inner ear?
What is the role of the 'tethers' in the mechanoreceptor of hair cells in the inner ear?
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What is the main difference between interoception and proprioception?
What is the main difference between interoception and proprioception?
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Why are mechanoreceptors highly selective for the type of stimulus they detect?
Why are mechanoreceptors highly selective for the type of stimulus they detect?
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Which of the following best describes how sensory receptors transmit information to the brain?
Which of the following best describes how sensory receptors transmit information to the brain?
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Which of the following scenarios demonstrates the principle of exteroception?
Which of the following scenarios demonstrates the principle of exteroception?
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What is the main function of the somatosensory system?
What is the main function of the somatosensory system?
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What are the three main ascending pathways in the spinal cord?
What are the three main ascending pathways in the spinal cord?
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Which of the following accurately describes the pathway of information in the dorsal column medial lemniscal system?
Which of the following accurately describes the pathway of information in the dorsal column medial lemniscal system?
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What type of sensory information does the anterolateral system convey?
What type of sensory information does the anterolateral system convey?
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What type of fibers contribute to the stretch reflex?
What type of fibers contribute to the stretch reflex?
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What is the primary function of the stretch reflex?
What is the primary function of the stretch reflex?
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Which of the following accurately describes the mechanism of the stretch reflex?
Which of the following accurately describes the mechanism of the stretch reflex?
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What is the main difference between the local and distal branches of the neurons in the ascending pathways?
What is the main difference between the local and distal branches of the neurons in the ascending pathways?
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Which of the following is NOT true about the dorsal column medial lemniscal system and the anterolateral system?
Which of the following is NOT true about the dorsal column medial lemniscal system and the anterolateral system?
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What is the primary function of the Dorsal Root Ganglion (DRG)?
What is the primary function of the Dorsal Root Ganglion (DRG)?
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Which of the following is NOT a characteristic of dermatomes?
Which of the following is NOT a characteristic of dermatomes?
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What is the main reason why spinal nerve damage can be difficult to locate?
What is the main reason why spinal nerve damage can be difficult to locate?
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Which sensory modality is NOT transmitted through the dorsomedial columns?
Which sensory modality is NOT transmitted through the dorsomedial columns?
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What type of information is conveyed by the lateral spinothalamic tract?
What type of information is conveyed by the lateral spinothalamic tract?
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Why are receptive fields larger for spinal nerves compared to individual sensory receptors?
Why are receptive fields larger for spinal nerves compared to individual sensory receptors?
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What does the term "referred pain" refer to?
What does the term "referred pain" refer to?
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What is the primary function of the anterior spinothalamic tract?
What is the primary function of the anterior spinothalamic tract?
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Which of the following touch mechanoreceptors is most closely associated with the sense of pressure and edges?
Which of the following touch mechanoreceptors is most closely associated with the sense of pressure and edges?
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Which of the following statements accurately describes the adaptation rate of Meissner corpuscles?
Which of the following statements accurately describes the adaptation rate of Meissner corpuscles?
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Which type of mechanoreceptor is characterized by its onion-like structure and ability to detect very fast vibrations?
Which type of mechanoreceptor is characterized by its onion-like structure and ability to detect very fast vibrations?
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Which of the following mechanoreceptors is most sensitive to sustained pressure and stretching?
Which of the following mechanoreceptors is most sensitive to sustained pressure and stretching?
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Which of the following mechanoreceptors is positioned deepest in the skin, making it best suited for detecting vibrations and pressure changes?
Which of the following mechanoreceptors is positioned deepest in the skin, making it best suited for detecting vibrations and pressure changes?
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Which of the following statements accurately describes the role of Ruffini endings in sensation?
Which of the following statements accurately describes the role of Ruffini endings in sensation?
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Which of the following statements correctly contrasts the properties of Aδ fibers and C fibers?
Which of the following statements correctly contrasts the properties of Aδ fibers and C fibers?
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Which type of sensory receptor is primarily responsible for detecting the velocity of muscle stretch?
Which type of sensory receptor is primarily responsible for detecting the velocity of muscle stretch?
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Which of the following statements accurately describes the role of myelin in nerve conduction?
Which of the following statements accurately describes the role of myelin in nerve conduction?
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Which type of sensory receptor is most sensitive to changes in temperature?
Which type of sensory receptor is most sensitive to changes in temperature?
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Which of the following is NOT a characteristic of C fibers?
Which of the following is NOT a characteristic of C fibers?
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What is the primary function of peripheral nerves in the sensory system?
What is the primary function of peripheral nerves in the sensory system?
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Which of the following is a TRUE statement about the compound action potential?
Which of the following is a TRUE statement about the compound action potential?
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Which of the following statements accurately describes the relationship between myelin and conduction velocity?
Which of the following statements accurately describes the relationship between myelin and conduction velocity?
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Which of the following factors contributes to the faster conduction velocity of action potentials in muscle nerves compared to skin nerves?
Which of the following factors contributes to the faster conduction velocity of action potentials in muscle nerves compared to skin nerves?
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What is the main reason why skin nerves have less myelin than muscle nerves?
What is the main reason why skin nerves have less myelin than muscle nerves?
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Which of the following correctly describes the role of the spinal nerves in the sensory system?
Which of the following correctly describes the role of the spinal nerves in the sensory system?
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Which type of nerve fibers is MOST likely to contribute to the compound action potential?
Which type of nerve fibers is MOST likely to contribute to the compound action potential?
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Which of the following statements accurately describes how the intensity of a stimulus is encoded in the nervous system?
Which of the following statements accurately describes how the intensity of a stimulus is encoded in the nervous system?
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Which of these is a TRUE statement regarding the compound action potential?
Which of these is a TRUE statement regarding the compound action potential?
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Which of the following sensory receptors are responsible for the ability to detect pain?
Which of the following sensory receptors are responsible for the ability to detect pain?
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Flashcards
Pain receptors
Pain receptors
Specialized neurons detecting pain stimuli.
Mechanoreceptors
Mechanoreceptors
Sensory receptors responding to mechanical pressure.
Meissner corpuscles
Meissner corpuscles
Touch receptors for initial contact and motion.
Merkel cells
Merkel cells
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Pacinian corpuscles
Pacinian corpuscles
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Somatosensation
Somatosensation
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Interoception
Interoception
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Proprioception
Proprioception
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Exteroception
Exteroception
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Sensory Receptors
Sensory Receptors
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Photoreceptors
Photoreceptors
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Nociceptors
Nociceptors
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Types of Mechanoreceptors
Types of Mechanoreceptors
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Tension-opened Mechanoreceptors
Tension-opened Mechanoreceptors
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Link-opened Mechanoreceptors
Link-opened Mechanoreceptors
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Second messenger systems
Second messenger systems
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Unsheathed Nerve Endings
Unsheathed Nerve Endings
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Ion Channel Structure
Ion Channel Structure
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Mechanical Deformation
Mechanical Deformation
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Spinal Nerves
Spinal Nerves
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Dermatomes
Dermatomes
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Dorsal Root Ganglion (DRG)
Dorsal Root Ganglion (DRG)
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Referred Pain
Referred Pain
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Dorsomedial Columns
Dorsomedial Columns
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Lateral Spinothalamic Tract
Lateral Spinothalamic Tract
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Anterior Spinothalamic Tract
Anterior Spinothalamic Tract
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Signal Transduction
Signal Transduction
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A delta and C fibers
A delta and C fibers
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Local vs Distal Terminals
Local vs Distal Terminals
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Ascending Pathways
Ascending Pathways
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Dorsal column medial lemniscal system
Dorsal column medial lemniscal system
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Anterolateral system
Anterolateral system
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Ruffini endings
Ruffini endings
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Proprioceptors
Proprioceptors
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Aδ fibers
Aδ fibers
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C fibers
C fibers
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Thermoreceptors
Thermoreceptors
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Peripheral Nerves
Peripheral Nerves
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A fibers (Myelinated)
A fibers (Myelinated)
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C fibers (Unmyelinated)
C fibers (Unmyelinated)
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Conduction Velocity
Conduction Velocity
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Compound Action Potential
Compound Action Potential
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Larger Axons vs. Smaller Axons
Larger Axons vs. Smaller Axons
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Muscle vs. Skin Nerves
Muscle vs. Skin Nerves
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Action Potential Overlap
Action Potential Overlap
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Study Notes
Neurophysiology: Somatosensory System
- The somatosensory system is responsible for our sense of body, both self and in relation to the world around us.
- It's a beautifully organized and conserved neurocircuit, making it highly suitable for study in humans.
- The word "soma" means body in Greek.
Sensory Experience
- Sensory experience is shaped by receptor systems encoding stimuli as electrical signals.
- Receptors respond to broad ranges of stimuli from different modalities.
- Receptor fields overlap, enabling a wide variety of sensory perceptions based on the various stimulus combinations.
Somatosensation Functions
- Interoception: Sense of one's organs, useful for monitoring function and potential damage. Mostly unconscious.
- Proprioception: Sense of one's body in time and space, both static and moving.
- Exteroception: Relationship between the body and the external world, eg., the warmth of the sun.
Sensory Receptors
- Sensory modalities are defined by the receptors encoding stimuli.
- Four major receptor types: photoreceptors, chemoreceptors, thermoreceptors, mechanoreceptors.
- Somatosensation utilizes all but photoreceptors.
Somatosensory Receptor Transmission
- Sensory receptors encode various stimuli as electrical signals, e.g., pressure changes.
- These signals are transmitted along spinal cord, brain stem, and CNS, generating thoughts and behaviors.
Types of Somatosensory Receptors
- Receptors are characterized by submodality, notably high-frequency vibration, and fiber groups.
- Mechanoreceptors are diverse, with "sheathed" and "unsheathed" types. Depth from surface is a major factor.
- Thermoreceptors and nociceptors exhibit exposed nerve endings and are unsheathed.
Mechanoreceptors: Ion Channels
- Mechanoreceptors are ion channels, crystolographically resolved.
- Each mechanoreceptor has 6 subunits forming a barrel-like structure, opening ion pores in response to mechanical deformations.
- Receptors are highly selective for the type of stimulus.
Types of Mechanoreceptors
- Opened through plasma membrane tension: E.g., cellular swelling.
- Opened by proteins linking to the ion channel: E.g., hair cells in the inner ear.
- Opened by secondary messengers: Activated by mechanical forces, e.g., pain receptors.
- Three types of mechanoreceptors differ by speed of mechanisms: fast, medium, and slow.
Touch Mechanoreceptors
- Touch mechanoreceptors vary based on morphology, location, receptive field, conduction velocity, and adaptation.
- Four types: Meissner corpuscles, Merkel cells, Pacinian corpuscles, and Ruffini endings.
Proprioceptors
- Mechanoreceptors that detect muscle movement.
- Found on muscle spindles.
- Wrap around muscles and open/close efficiently during stretching.
- Respond to stretch velocity and adapt to constant stretch and rate of change of stretch.
Nociceptors
- Pain receptors necessary for detecting current and past damage, often with intensity-dependent firing rates that adapt to constant force.
- Activated by mechanical, thermal, and chemical signals.
- Two classes: Αδ fibers and C fibers.
Thermoreceptors
- Ion channels opening in response to temperature (cold, cool, warm, and hot) sensations.
- Also respond to certain chemicals, explaining why some foods feel hot or cold.
- Highly sensitive but slower responding than mechanoreceptors.
- They can have overlapping or mixed responses.
Peripheral Nerves
- Bundles of sensory axons from multiple modalities.
- Classified by axon diameter and myelin amount surrounding each nerve for different conduction velocities.
- Bundling axons significantly enhances conduction velocity.
- Classified by Charles Sherrington into myelinated and unmyelinated types (Aα, Aβ, Aδ, and C).
Different Conduction Demands
- Skin, with a vast surface area, requires many nerve endings and thus less myelin and no A alpha fibers.
- Muscles, capable of rapid changes, demand more myelin and fewer nerve endings.
Compound Action Potentials
- Space demands limit the amount of myelination a nerve can have.
- Thus, to enhance fine discrimination, nerve endings must be exposed and nerve responses to stimuli are only so fast, depending on distance.
- If nerves are close, their action potentials can sum.
- Larger axons fire sooner and are more sensitive to the stimuli than smaller ones.
Spinal Nerves
- Peripheral nerves combine into spinal nerves to enhance signal transduction.
- 31 pairs of spinal nerves (two per side).
- Named according to the vertebral segments they enter the spinal cord (e.g., lumbar 4, thoracic 6).
- Their function depends on the organs they innervate.
Dermatomes
- Overlapping receptive fields bundled into a single spinal nerve.
- Large receptive fields mean less spatial resolution.
- Thus, spinal nerves detect large tissue areas.
- Clinically useful for locating spinal cord damage.
Dorsal Root Ganglion (DRG)
- Spinal nerves separate into sensory and motor fibers at the DRG.
- The DRG is a swelling containing multiple cell bodies outside the spinal column.
- Fibers further separate into modality-specific fibers before entering the spinal cord.
Separate into submodalities in dorsal horn
- Specific anatomical regions in dorsal horn receive specific modality-related sensory information.
- Three main tracts for distinct types of sensory information:
- Dorsomedial columns: fine touch, proprioception, vibration.
- Lateral spinothalamic tract: pain and temperature.
- Anterior spinothalamic tract: light touch.
Local vs Distal Terminals
- Neurons terminate locally and distally.
- Local branches mediate pain, temperature detection through anterolateral systems, and involuntary movement (spinal reflexes) via A-delta and C fibers (anterolateral pathway).
- Distal branches support voluntary movement and complex involuntary pathways (e.g., dorsal column medial lemniscal pathway).
Stretch Reflex
- Responsible for simple involuntary movement.
- Proprioceptive sensory neurons from muscle spindles innervate excitatory motor neurons and inhibitory interneurons in the spinal cord.
- Excitation of extensor motor neurons and inhibition of flexor motor neurons cause a reflex, e.g., kicking.
Ascending Pathways
- Modality-specific fibers project to the midbrain through two tracts.
- Dorsal Column Medial Lemniscal System: conveys proprioceptive and tactile sensations, synapses/decussates in medulla, fast Aα/δ fibers.
- Anterolateral System: conveys thermal and painful sensations, generally slow C fibers.
Decussations
- Dorsal column medial lemniscal system decussates in medulla.
- Anterolateral system decussates in spinal cord.
- Decussation (crossing over) explains how one side of the body is represented by the opposite side of the brain.
- Somatic twist hypothesis: organs move to more protected side of the body.
Additional information
- Fiber addition in ascending pathways occurs progressively from outer to inner areas of the brain stem.
- Fibers differentiate and organize in the brain stem and thalamus to create a crude map of the body (somatotopically ordered).
- Full somatotopic maps are fully segregated in the cortex.
Conclusions
- Somatosensation informs the brain about body location and timing through highly sensitive receptors.
- Organized into peripheral nerves, then spinal nerves, and finally the brain for somatotopic mapping of body parts.
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Description
Explore the intricate workings of the somatosensory system, which allows us to perceive our bodies and their interactions with the environment. This quiz delves into the functions of somatosensation, including interoception, proprioception, and exteroception. Test your knowledge of sensory receptors and their roles in shaping our sensory experiences.